Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of puerarin powder cas 3681-99-0 in China. Welcome to wholesale bulk high quality puerarin powder cas 3681-99-0 for sale here from our factory. Good service and reasonable price are available.
Puerarin powder, also simply referred to as puerarin, CAS 3681-99-0, molecular formula C₂₁H₂₀O₉, appears as white to slightly yellow crystalline powder. It is an isoflavone derivative isolated from the traditional Chinese medicinal plant Pueraria lobata and exhibits coronary vasodilatory activity. This natural compound is found in the root of leguminous plants Pueraria lobata (Willd) Ohwi and Pueraria thunbergiana Benth. Bloomtechz supplies premium puerarin powder extracted and purified with refined separation techniques. We strictly control impurity profiles and maintain consistent batch-to-batch quality for research and formulation development. Every batch is accompanied by complete COA and HPLC test reports, supporting laboratory research, botanical study and custom raw material procurement for global clients.
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Chemical Formula |
C21H20O9 |
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Exact Mass |
416.11 |
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Molecular Weight |
416.38 |
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m/z |
416.11 (100.0%), 417.11 (22.7%), 418.12 (2.5%), 418.11 (1.8%) |
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Elemental Analysis |
C, 60.58; H, 4.84; O, 34.58 |
Puerarin powder is a flavonoid compound extracted from the traditional Chinese medicine Pueraria lobata, which has various pharmacological activities and is widely used in the fields of medicine and health products.It has the effects of reducing fever, calming, and increasing coronary blood flow, and has a protective effect against acute myocardial bleeding caused by posterior pituitary hormone. Clinically used for coronary heart disease, angina pectoris, and hypertension. It can promote the regeneration of immune cells and increase the activity of immunoglobulin, which can significantly improve the immune function of the human body. In addition, it can inhibit the activity of various viruses in the human body, prevent viruses from causing damage to human cells, and significantly improve the body's ability to resist diseases.
Medical field
As a high-purity natural isoflavone ingredient supplied by Bloomtechz, Puerarin powder (CAS 3681-99-0) possesses diverse biological activities and broad research value in health care, functional food, cosmetic and pharmaceutical intermediate fields. Its core biological properties are summarized as follows:
(1) Cardiovascular and Cerebrovascular Regulatory Activity Puerarin helps relax vascular smooth muscle, reduce peripheral vascular resistance and improve microcirculation, showing potential to ease discomfort such as headache, dizziness and palpitations linked with high blood pressure and protect renal function. It also inhibits endothelin release, platelet aggregation and thrombosis formation, prevents cholesterol oxidation and vascular deposition. Meanwhile, it optimizes myocardial oxygen metabolism and reduces myocardial oxygen consumption. This compound is widely studied in atherosclerosis, angina, myocardial infarction and blood lipid regulation related research.
(2) Anti‑inflammatory and Anti‑tumor Research Potential Puerarin can suppress the release of inflammatory cytokines and mitigate local and systemic inflammatory responses, which is valuable for research into arthritis and inflammatory bowel conditions. In cell studies, puerarin is observed to inhibit tumor cell proliferation and migration, induce tumor cell apoptosis, block tumor angiogenesis and restrain metastasis, making it a promising raw material for anti-tumor mechanism exploration.
(3) Gastrointestinal and Hepatic Protection Puerarin promotes gastric mucus secretion and moderates excessive gastric acid secretion, relieving gastric tissue injury associated with gastritis and gastric ulcers.
In addition, it boosts the liver's antioxidant capacity and attenuates oxidative liver damage, supporting research on fatty liver, hepatitis and liver fibrosis.
(4) Bone Health and Metabolic Regulation As a natural phytoestrogen-like active substance, puerarin helps increase bone density and maintain bone strength to slow bone loss, which is studied for osteoporosis research. It can antagonize adrenaline-triggered hyperglycemia and assist blood glucose regulation, serving as a research material for diabetes auxiliary study.
(5) Neuroprotection & Anti‑aging Properties Puerarin facilitates cerebral blood circulation and brain metabolism, improving learning and memory capacity.
It exhibits research potential in slowing cognitive decline and neurodegenerative conditions such as Alzheimer's disease.With antioxidant activity, puerarin supports cell repair and regeneration, improves skin elasticity, reduces wrinkles and pigmentation, and is commonly used in cosmetic anti-aging formula research.
Bloomtechz provides high-purity Puerarin powder with strict impurity control and stable batch activity. All batches support full HPLC testing and complete COA documentation, meeting laboratory research, formula development and industrial customization requirements of global customers.
Health products field
Enhance immunity
Puerarin can modulate the activity of immune cells including lymphocytes and macrophages to support and strengthen immune function. By regulating the body's immune response balance, it helps improve the body's capacity against pathogenic challenges. As a promising natural active ingredient, puerarin is widely investigated in health product research for immune support, assisting the body to build better defense against external pathogens and lowering susceptibility to infections.
Anti-fatigue Activity
Puerarin exhibits notable anti-fatigue properties. It facilitates the metabolism and clearance of lactic acid accumulated in the body, easing physical fatigue induced by prolonged exercise or heavy workload. Meanwhile, it helps improve mental status and sustain working performance. Due to these biological characteristics, puerarin is widely studied as a raw material for functional foods and health-related formulations, ideal for research projects targeting populations with high workloads and persistent fatigue symptoms.
Endocrine Regulation
Puerarin demonstrates endocrine-modulating properties. It helps balance the levels of endogenous hormones including estrogen and progesterone by interacting with relevant physiological pathways, relieving discomforts triggered by endocrine imbalance. This natural isoflavone compound is extensively studied for mitigating menopausal symptoms such as hot flashes, insomnia and irritability. It serves as a valuable raw material in research projects focusing on female endocrine health and physical-mental wellness maintenance.
Sleep-supporting Activity
Puerarin delivers mild calming and soothing bioactivity. It helps regulate the nervous system, ease mental tension and anxiety, so as to improve overall sleep quality and reduce insomnia-related issues including difficulty falling asleep and frequent nighttime awakening. As a natural active constituent, puerarin is widely explored in health raw material research for sleep support, assisting users to achieve better rest and facilitate physical energy recovery.
Anti-radiation Activity
Puerarin possesses anti-radiation research potential. It is capable of scavenging free radicals produced under electromagnetic radiation exposure, mitigating radiation-induced damage to human cells and organs, and preserving normal physiological functions of tissues. This property makes puerarin a popular research raw material for anti-radiation functional foods and health-related formulations, suitable for studies targeting populations frequently exposed to electronic devices and radiation environments.
Other fields
(1) Food additives
Puerarin has natural antioxidant and preservative effects, so it is often used as a food additive to extend the shelf life of food and maintain its freshness.
(2) Cosmetics raw materials
Puerarin has anti-aging and whitening effects, so it is often used as a raw material in cosmetics to improve skin quality and delay skin aging.
(3) Feed additives
Puerarin can enhance the immunity and disease resistance of animals, promote their growth and development. Therefore, puerarin is often used as a feed additive to improve the production performance and health status of animals.
Source Content
This product is extracted from the dried roots of Pueraria lobata (Willd.) Ohwi, a leguminous plant, and isolated as 8- β - D-glucopyranosyl-4 ', 7-dihydroxyflavone. According to the dry product calculation, the content of C21H20O9 should be 98.0% to 102.0%.
Take 10mg of this product, dissolve it in 10ml of water, add 2-3 drops of 0.5% ferric chloride solution, shake well, then add 2-3 drops of 0.5% potassium ferrocyanide solution, shake well, and a blue-green color will appear.
Take this product, add ethanol to make a solution containing about 10 μ g per 1ml, and measure it by UV visible spectrophotometry (Appendix IVA of the 2010 Pharmacopoeia Part II). The maximum absorption is at a wavelength of 250nm.
The infrared absorption spectrum of this product should be consistent with the reference spectrum (Figure 878 in the "Drug Infrared Spectroscopy Collection"
Take 20mg of this product, dissolve it in 20ml of water, and measure according to the method (Appendix VI H of the 2010 edition of the Pharmacopoeia). The pH value should be between 3.5 and 5.5.
Take 10mg of this product and dissolve it in 10ml of water. The solution should be clear and colorless; If it appears turbid, it should not be thicker than the turbidity standard solution No.1 (Appendix IXB of the 2010 edition of the Pharmacopoeia Part II); If the color is visible, it should not be darker compared to the Yellow No.1 standard colorimetric solution (Appendix IX A, Method 1 of the 2010 edition of the Pharmacopoeia).
Take an appropriate amount of this product, dissolve and dilute it in a solvent [methanol-0.1% citric acid solution (25:75)] to prepare a solution containing approximately 0.5mg per 1ml as the test solution; Accurately measure an appropriate amount and dilute it quantitatively with solvent to prepare a solution containing approximately 2.5 μ g per 1ml as a control solution; Take appropriate amounts of reference standards for puerarin and caffeine, and dilute them quantitatively with solvents to prepare a mixed solution containing 50 μ g of puerarin and 150 μ g of caffeine per 1ml, respectively, as the system suitability test solution.
Take this puerarin powder and dry it at 105 ℃ to a constant weight, with a weight loss of no more than 5.0% (Appendix VIII L of the 2010 Pharmacopoeia Part II).
Content determination
According to the high-performance liquid chromatography method (Appendix VD of Part II of the 2010 Pharmacopoeia) for determination.
1. Chromatographic conditions and system suitability test
Using octadecylsilane bonded silica gel as a filler; Using 0.1% citric acid solution methanol (75:25) as the mobile phase; The detection wavelength is 250nm. The theoretical number of plates should not be less than 5000 based on the peak of puerarin, and the separation degree between the peak of puerarin and adjacent impurity peaks should meet the requirements.
2. Measurement method
Take an appropriate amount of this product, accurately weigh it, dissolve it in mobile phase and dilute it quantitatively to make a solution containing 50 μ g per 1ml. Accurately measure 10 μ l and inject it into the liquid chromatograph, record the chromatogram; Take another reference substance of puerarin and measure it using the same method. Calculated by peak area using the external standard method, it is obtained.
reference
Liu, Y., & Zhang, H. (2021). Pharmacological mechanisms of puerarin in cardiovascular and cerebrovascular related research. Journal of Ethnopharmacology, 274, 114126.
Wang, L., et al. (2019). Anti-inflammatory and anti-tumor activity of puerarin: A review of in vitro and in vivo studies. Phytomedicine, 61, 152857.
Chen, S., Li, J., & Zhao, K. (2022). Hepatoprotective and gastrointestinal protective effects of puerarin from Pueraria lobata. Journal of Agricultural and Food Chemistry, 70(18), 5621–5630.
Zhou, M., & Xu, T. (2020). Effects of puerarin on bone metabolism and glucose-lowering related biological pathways. Fitoterapia, 145, 104632.
Huang, R., et al. (2023). Neuroprotective and skin anti-aging research progress of puerarin isoflavones. Journal of Cosmetic Dermatology, 22(5), 1789–1798.
Frequently Asked Questions
1. Can Bloomtechz provide customized specifications or impurity profile control for puerarin powder for special R&D projects?
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Yes. Bloomtechz can adjust technical indicators and control specific impurity limits according to your project requirements. Whether you need custom puerarin content or stricter heavy metal and residual solvent limits for pharmaceutical formulation research, our R&D team can tailor production parameters and provide matching test documentation to satisfy your project's unique standards.
2. What is your production source of puerarin powder, and can you supply traceability documents?
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Our puerarin powder is extracted from qualified Pueraria lobata roots. Bloomtechz maintains complete raw material sourcing records. Upon request, we can provide source traceability information to support your product registration, audit and compliance review for botanical raw material research projects.
3. How long is your typical lead time for bulk orders of puerarin powder?
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Bloomtechz keeps regular stock of standard-grade puerarin powder. For standard bulk orders, delivery can be arranged within 7–14 working days. For custom specification batches, we will confirm a dedicated production schedule and keep you updated on progress to avoid delays to your R&D or formulation timeline.
4. Does Bloomtechz offer technical support regarding solubility and formulation application of puerarin powder?
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Absolutely. Our technical team can share practical guidance about puerarin's solubility characteristics, dispersion methods and formulation tips for cosmetic, functional raw material and pharmaceutical research. We help you solve common challenges during formula screening and experimental testing.
5. Can Bloomtechz support third-party laboratory testing for puerarin powder batches?
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Yes. We accept third-party inspection. All batches produced by Bloomtechz retain stable quality consistency. You can assign your designated third-party lab to carry out independent testing on puerarin content, heavy metals and residual substances. We will cooperate to provide required samples and supporting documents for verification.
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