Cocarboxylase, CAS 154-87-0, Molecular formula C12H19ClN4O7P2S, naturally found in rice bran, germ, yeast, and legumes. Thioamine pyrophosphate white crystalline powder. Dry products are stable, while aqueous solutions are unstable. Mp238-240 ℃, with maximum absorption at 242nm wavelength. This product is easily soluble in water, and the pH value of the aqueous solution is acidic; Difficult to dissolve in ethanol, acetone, and ether. Plays an important role in sugar metabolism, participating in the oxidation metabolism of sugars and the production of ATP. It can promote the decomposition and oxidation of carbohydrates to supply energy to the body. It is a coenzyme of transketolase and also participates in protein metabolism, promoting the transport and metabolism of amino acids, as well as the synthesis and breakdown of proteins. In addition, it also plays an important role in the nervous system, promoting the synthesis and release of neurotransmitters and maintaining normal nervous system function. Therefore, it is a very important coenzyme that has a significant impact on human health. Lack can lead to a series of diseases, such as athlete's foot, ischemic heart disease, stroke, etc.
|
Chemical Formula |
C12H19ClN4O7P2S+ |
|
Exact Mass |
460 |
|
Molecular Weight |
461 |
|
m/z |
460 (100.0%), 426 (13.0%), 462 (32.0%), 461 (13.0%), 462 |
|
Elemental Analysis |
C, 31.28; H, 4.61; N, 12.16; O, 24.31; P, 13.44; S, 7.54 |
|
|
|
Thiamine Pyrophosphate (TPP), also known as cocarboxylase, decarboxylase coenzyme, vitamin B1 pyrophosphate, etc., is an important bioactive substance that plays a wide range of roles in the human body and living organisms.
Biochemistry and physiological functions
1. Metabolic regulation:
As an active form of vitamin B1, it plays a crucial role in the body's metabolism. It participates in the metabolism of carbohydrates, promotes the breakdown and oxidation of sugars, generates ATP (adenosine triphosphate), and provides energy to the body. During this process, coenzymes acting as key enzymes such as transaminase and pyruvate dehydrogenase catalyze related chemical reactions, ensuring stable and efficient energy supply.
2. Energy production:
Plays a crucial role in sugar metabolism. It is a key coenzyme in energy production pathways such as glycolysis and citric acid cycle, promoting the breakdown of glucose and oxidative phosphorylation, generating a large amount of ATP. This is of great significance for maintaining normal physiological functions of cells, supporting physical activity and growth and development.
3. Neurotransmitter synthesis:
Also involved in the synthesis process of neurotransmitters. Neurotransmitters are important chemical substances that transmit information between neurons and are crucial for the normal functioning of the nervous system. As a coenzyme of certain neurotransmitter synthases, it promotes the synthesis and release of neurotransmitters, thereby maintaining the stability and sensitivity of the nervous system.
4. Neurological protection:
It has a protective effect on the nervous system. It can promote the growth and development of neurons, enhance their connectivity and function. At the same time, it can also reduce oxidative stress and inflammatory reactions in the nervous system, protecting neurons from damage and death. This is of great significance for the prevention and treatment of neurological diseases.
5. Anti beriberi function:
It is a key substance for preventing beriberi. Beriberi is a disease caused by a deficiency of vitamin B1, characterized by abnormal symptoms of the nervous and cardiovascular systems. By improving the absorption and utilization status of vitamin B1, the occurrence and development of beriberi can be prevented.
Clinical application
Cardiac arrhythmia treatment:
It can be used in clinical practice to treat cardiac arrhythmia. Cardiac arrhythmia refers to abnormalities in the frequency, rhythm, or origin of the heart's beating, which may lead to symptoms such as palpitations, chest tightness, and fainting. By regulating the metabolism and electrophysiological activity of myocardial cells, the symptoms and prognosis of arrhythmia can be improved.
Auxiliary treatment for myocardial infarction:
Myocardial infarction is a serious cardiovascular disease caused by insufficient blood supply to the coronary arteries, leading to myocardial cell necrosis. Can be used as an adjuvant therapy for myocardial infarction, by improving the energy metabolism and antioxidant capacity of myocardial cells, reducing myocardial damage and promoting myocardial repair.
Treatment of neurological diseases:
It can also be used to treat various neurological diseases, such as multiple neuritis, central nervous system injuries, etc. These diseases are usually associated with neuronal damage and dysfunction. By promoting the growth and repair of neurons, improving the synthesis and release of neurotransmitters, and reducing oxidative stress and inflammatory reactions in the nervous system, patients' symptoms and quality of life can be improved.
In addition, it can also be used to treat some other diseases, such as indigestion, loss of appetite, fatigue syndrome, etc. These diseases are usually related to metabolic abnormalities and insufficient energy supply in the body. By improving the body's metabolism and energy production, patients' physical fitness and immunity can be enhanced, thereby alleviating related symptoms.
Nutritional supplementation and health care
Nutritional supplements:
Can be used as nutritional supplements for the prevention and treatment of vitamin B1 deficiency. Vitamin B1 deficiency is usually manifested as abnormal symptoms of the nervous and cardiovascular systems, such as beriberi, arrhythmia, etc. Supplementing with thiamine pyrophosphate can increase the level of vitamin B1 in the body, thereby preventing and treating related diseases.
Enhance immunity:
It also has the function of enhancing immunity. It can promote the growth and differentiation of immune cells, enhance their activity and bactericidal ability. At the same time, it can also reduce oxidative stress and inflammatory response of the immune system, protecting immune cells from damage and death. This is of great significance for improving the body's disease resistance and preventing diseases.
Improving mental state:
It can also improve mental state. It can promote the synthesis and release of neurotransmitters, improve the sensitivity and stability of the nervous system. At the same time, it can also improve sleep quality, alleviate emotional problems such as anxiety and depression. This is of great significance for improving the quality of life and happiness.
It also plays an important role in promoting growth and development. It is one of the key coenzymes for metabolism and energy production in the body, and is of great significance for cell growth and division. By supplementing, it can promote children's growth and development and improve their physical fitness.
Biochemical Research and Industrial Applications
1. Biochemical research tools:
Widely used in biochemical research. Cocarboxylase serves as a coenzyme for various enzymes and participates in various biochemical reaction processes. By studying and utilizing the catalytic effect of thiamine pyrophosphate, we can gain a deeper understanding of the metabolic mechanisms and physiological functions of living organisms. Meanwhile, it can also serve as an indicator and probe in biochemical experiments for detecting and analyzing the structure and function of biomolecules.
2. Industrial catalyst:
It can also be used as a catalyst in industry. It can promote certain chemical reactions, increase reaction rates and yields. At the same time, it also has the advantages of good stability and selectivity, which can maintain catalytic activity in complex reaction systems and reduce the generation of by-products. This makes it widely applicable in the field of industrial catalysis.
3. Other industrial applications:
In addition, it can also be used to prepare other bioactive substances and drugs. For example, it can be used as a raw material for synthesizing bioactive substances such as vitamin B6 and vitamin B12; It can also be used as an intermediate for the preparation of certain antibiotics, anti-tumor drugs, and other drugs. These applications further expand their application areas and value.
Food Safety and Nutritional Fortification
1. Food safety additives: can be used as food safety additives. It can improve the nutritional value and taste quality of food, while also having certain anti-corrosion and antioxidant effects. Adding an appropriate amount during food processing can extend the shelf life of food and reduce the loss of nutrients.
2. Nutritional fortifier: It can also be used as a nutritional fortifier. It can be used to enhance the vitamin B1 content in infant and toddler food, cereal products, beverages, and other foods. By adding appropriate amounts, the nutritional value and health benefits of these foods can be improved, meeting the needs of different populations for vitamin B1.
Although the direct application of thiamine pyrophosphate in environmental protection and pollution control is relatively limited, cocarboxylase potential as a bioactive substance and catalyst cannot be ignored. In the future, with the continuous development of science and technology and the improvement of environmental protection awareness, the application in the field of environmental protection may be further expanded and deepened. For example, it can be used as a biodegradable agent to participate in the degradation process of organic pollutants; It can also serve as a catalyst to promote certain environmentally friendly chemical reactions. These applications will help reduce the emission and accumulation of environmental pollutants, protect the ecological environment and human health.
faq
What is the use of cocarboxylase?
Specifically, Cocarboxylase serves as a cofactor for the enzyme pyruvate dehydrogenase, which converts pyruvate into acetyl-CoA. This conversion is a vital step in cellular respiration, as acetyl-CoA enters the Krebs cycle to produce ATP, the primary energy currency of the cell.
What are the benefits of taking cocarboxylase?
Uses of Cocarboxylase Hydrochloride Injection
Metabolic Disorders: Supports metabolism in lactic acidosis and other metabolic disturbances. Alcohol-Related Disorders: Helps in treating complications associated with chronic alcoholism, such as Wernicke's encephalopathy.
What is a cocarboxylase injection used for?
In scientific applications, cocarboxylase hydrochloride is used to study metabolic pathways and to explore therapeutic interventions for metabolic disorders. Its role in augmenting thiamine activity is significant in research focused on conditions related to oxidative stress and mitochondrial dysfunction.
A:Computer Numberical Control (CNC) machining is a manufacturing process in which pre-programmed computer softeare dictates the movement of fact`ory tools and machinery. The process can be used to control a range of complex machinery, from girnders and lathes to mills and CNC routers.
Hot Tags: cocarboxylase cas 154-87-0, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, Baclofen Powder CAS 1134 47 0, Peptide, Pure Tetracaine, Camptothecin Powder CAS 7689 03 4, cholesterol powder, tetracaine powder