Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of mk-677 powder cas 159752-10-0 in China. Welcome to wholesale bulk high quality mk-677 powder cas 159752-10-0 for sale here from our factory. Good service and reasonable price are available.
Announcement
This chemicals was banned to sell, our website only can check the basic info. of chemicals here, we don't sell them!
September 24th, 2025
MK-677 powder, another name is ibutamolen mesylate. Its core component is MK 677, white powder. As a drug, MK 677 solution is an effective non-peptide growth hormone secretory receptor (GHSR) agonist. MK-677 (l-163191) is an effective oral growth hormone-secreting drug, which simulates the role of growth hormone in stimulating endogenous hormones. Its chemical properties have been shown to increase the release and production of some hormones, which can continuously increase plasma levels, including growth hormone and insulin-like growth factor-1 (IGF-1), but do not affect cortisol levels.
|
Chemical Formula |
C28H40N4O8S2 |
|
Exact Mass |
624 |
|
Molecular Weight |
625 |
|
m/z |
624(100.0%), 625(29.2%), 626 (4.5%), 626 |
|
Elemental Analysis |
C, 53.83; H, 6.45; N, 8.97; O, 20.49; S, 10.26 |
 |
 |
MK-677 Powder COA
MK-677 powder, another name is ibutamoren mesylate. Its core component is MK 677, white powder. As a drug, it is an effective, nonpeptide growth hormone secretagogue receptor (GHSR) agonist. MK-677 (l-163191) is a drug that acts as a powerful, oral and effective growth hormone secretion, mimicking the role of GH in stimulating endogenous hormones. Its chemical book has been shown to increase the release of and produce some hormones that continuously increase plasma levels, including GH and insulin-like growth factor-1 (IGF-1), but does not affect cortisol levels. MK-677 (l-163191) is a drug that acts as a powerful, oral and effective growth hormone secretion, mimicking the role of GH in stimulating endogenous hormones. Chemical book it has been shown to increase the release and produce some hormones that continuously increase plasma levels, including GH and insulin-like growth factor-1 (IGF-1), but does not affect cortisol levels.
A brief description of the two common uses of MK-677. Please note that specific uses and effects may vary depending on individual differences and specific circumstances.
1. Promoting growth hormone release:
MK-677 is an oral non peptide growth hormone releasing agent (GHS) that has a significant effect on promoting the secretion of growth hormone. Growth hormone plays an important physiological function in the human body, such as promoting bone and muscle growth, improving protein synthesis, and increasing fat oxidation. By stimulating the activity of growth hormone releasing hormone (GHRH) receptors in the anterior pituitary gland, MK-677 can increase the secretion level of growth hormone, potentially increasing muscle mass, reducing fat storage, and improving bone density. Therefore, MK-677 is often used to improve muscle growth and promote weight gain.
2. Anti aging and improved metabolism:
MK-677 is also widely used in research on anti-aging and improving metabolism. As age increases, the secretion of growth hormone gradually decreases, which is related to the aging process and decreased metabolic function. By increasing growth hormone levels, MK-677 may counteract certain age-related changes and have benefits such as improving metabolism, increasing bone density, and improving cardiovascular function. Some clinical studies have shown that MK-677 can increase muscle mass, improve exercise ability, improve sleep quality, and enhance immune system function. However, it should be noted that research results are inconsistent regarding the effects of anti-aging and improving metabolism, and long-term use of MK-677 may come with some potential risks and side effects.
It should be emphasized that MK-677 is still in the research stage and has not been approved for medical or clinical treatment in many countries. Further research and verification are needed for its purpose and effectiveness. Before considering using MK-677, medical professionals should be consulted and relevant laws and regulations should be followed.
Chemical Fundamentals and Synthesis Principles
MK-677 powder, with the chemical name Ibutamoren Mesylate, CAS number 159752-10-0, molecular formula C₂₈H₄₀N₄O₈S₂, and molecular weight 624.77. This substance is a white to off-white powder and belongs to non-peptide growth hormone-stimulating hormone receptor (GHSR) agonists. By mimicking the activity of growth hormone-releasing peptide, it stimulates receptors in the pituitary gland and hypothalamus, promoting the secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1), without affecting cortisol levels. Its synthetic route involves multiple organic chemical reactions, including amino protection, acylation reaction, cyclization reaction and the salt formation step of methanesulfonate. The reaction should be carried out under anhydrous and oxygen-free conditions, using high-purity reagents and catalysts. Key intermediates need to be purified by chromatography or recrystallization. The final product is obtained in powder form through freeze-drying or spray drying.
Production Process Flow
Raw material preparation
The starting materials usually include amino acids, carboxylic acid derivatives, etc., which need to undergo strict quality inspection to ensure that the purity meets the requirements. The selection of solvents and catalysts is also crucial and needs to be optimized according to the reaction conditions. For instance, certain reactions may require the use of specific organic solvents to enhance reaction efficiency, and the type and amount of the catalyst directly affect the reaction rate and yield.
Reaction steps
Amino protection: Under specific conditions, the amino group of an amino acid is protected to prevent unnecessary side reactions in subsequent reactions. This step is crucial in the synthesis process because the amino group has high activity and is prone to react with other reagents, thereby affecting the purity and yield of the final product.
Acylation reaction: The protected amino acids are acylated with carboxylic acid derivatives to form intermediates. The conditions of the acylation reaction need to be precisely controlled, including temperature, reaction time and the proportion of reagents, etc., to ensure the smooth progress of the reaction.
Cyclization reaction: Under specific conditions, the intermediate undergoes a cyclization reaction to form a compound with a spiperidine structure. Cyclization reaction is the core step in the synthesis of MK-677. Its reaction conditions are rather harsh and it needs to be carried out under specific catalyst and solvent systems.
Salt formation of methanesulfonate: The cyclization product is reacted with methanesulfonate to form ibumoram methanesulfonate. The salt-forming reaction can enhance the stability and solubility of the product, facilitating subsequent purification and formulation preparation.
Purification and Crystallization
After the reaction is completed, the product needs to be purified by chromatography, recrystallization and other methods to remove impurities. Chromatography can separate the product from impurities based on its physical and chemical properties, while the recrystallization method can further enhance the purity of the product through differences in solubility.
The selection of crystallization conditions has a significant impact on the purity and yield of the product and needs to be optimized through experiments. For instance, factors such as crystallization temperature, the selection of solvent and crystallization time all affect the quality and yield of the crystals.
Drying and crushing
The purified product needs to undergo drying treatment to remove the residual moisture and solvent. The drying methods can be vacuum drying, freeze-drying, etc., to prevent the product from decomposing or deteriorating at high temperatures.
The dried product needs to be crushed to obtain the powder form that meets the requirements. During the crushing process, it is necessary to pay attention to controlling the particle size and uniformity of the crushed materials to ensure the quality of the product.
Quality Control Standards
Purity detection
The purity of the product was detected by high performance liquid chromatography (HPLC) and other methods to ensure that the purity reached above 98%. For some high-end applications, such as drug research and development, higher purity requirements may be needed, such as above 99%.
Conduct qualitative and quantitative analyses of impurities to ensure that the impurity content complies with the regulations. The presence of impurities may affect the safety and effectiveness of the product, so the content of impurities needs to be strictly controlled.
Physical property detection
Test the physical properties such as the appearance, melting point, boiling point and solubility of the product to ensure compliance with the regulations. The appearance should be white to off-white powder, free of impurities and foreign substances. The determination of melting point and boiling point can verify the purity and structure of the product. The determination of solubility is helpful for determining the usage method and formulation of the product.
Stability investigation
Accelerate tests and long-term tests were conducted on the product to investigate its stability under different conditions. Accelerated tests are usually conducted at 40°C/75% RH, while long-term tests are carried out at 25°C/60% RH. Through stability tests, the shelf life and storage conditions of the product can be determined.
Microbial limit detection
Microbial limit testing was conducted on the product to ensure compliance with pharmacopoeia standards. The total number of bacteria, the total number of molds and yeasts and other indicators must comply with the regulations to ensure the hygiene quality of the products.
Production Equipment and Environment
Production equipment
Production equipment such as reaction vessels, centrifuges, drying ovens and crushers must comply with GMP requirements. The reaction vessel should have good sealing and corrosion resistance to ensure the safety and stability of the reaction process. The centrifuge should have highly efficient separation performance to improve the purity of the product. The drying oven and the crusher should be capable of precisely controlling the temperature and particle size to ensure the quality of the products.
The equipment needs to be maintained and serviced regularly to ensure normal operation. Regular maintenance and upkeep can extend the service life of equipment, reduce the probability of malfunctions, and enhance production efficiency.
Production environment
The production workshop should be kept clean, dry and dust-free, and environmental parameters such as temperature and humidity should be controlled within the prescribed range. The air quality in the production workshop should comply with relevant standards and can be regulated and controlled through an air purification system.
The air purification system needs to be inspected and maintained regularly to ensure that the air quality meets the requirements. Regular inspection and maintenance can promptly identify and solve problems existing in the air purification system, ensuring the cleanliness of the production environment.
Packaging and Storage
Packaging materials
Double-layer aluminum foil bags or glass bottles and other packaging materials are adopted to ensure good sealing of the product. Packaging materials should meet food-grade or pharmaceutical-grade standards to ensure the safety and stability of the product.
The packaging should clearly mark the product name, specification, batch number, production date, shelf life and other information to facilitate the traceability and management of the product.
Storage conditions
The product should be stored in a cool, dry and dark place, with the temperature controlled between 2 and 8°C. Avoid contact with oxidants, acids and other substances to prevent chemical reactions.
During storage, the products should be inspected regularly. If any damage to the packaging or deterioration of the products is found, it should be dealt with promptly.
Research and Development and Improvement
Synthetic route optimization
By constantly optimizing the synthetic route, the purity and yield of the product can be improved. For instance, one can attempt to adopt new catalysts or reaction conditions to enhance the efficiency and selectivity of the reaction.
Explore new reaction conditions and catalysts to reduce production costs. For example, develop more efficient solvent recovery systems to reduce the usage of solvents; Look for cheaper raw materials to reduce production costs.
Formulation improvement
The research focus is on converting this powder into formulations such as micronization and sustained-release to enhance its bioavailability and stability. Micronization can increase the surface area of drugs, improve their solubility and absorption rate. Sustained-release dosage forms can prolong the duration of drug action and reduce the frequency of medication.
Explore the combined use with other drugs to exert a synergistic effect. For example, the combined use of MK-677 with other drugs that promote muscle growth or improve bone health may achieve better therapeutic effects.
Clinical research
Clinical trials were conducted on diseases such as growth hormone deficiency, osteoporosis and obesity to evaluate the efficacy and safety of this product. Through clinical trials, the optimal dosage, usage method and indications of the drug are determined.
Adjust the drug dosage and usage plan based on the results of clinical trials. If adverse reactions of the drug are found at certain doses, the dosage can be adjusted in a timely manner to enhance the safety and efficacy of the drug.
Market Supply and Supervision
Supplier situation
The major global suppliers are concentrated in places such as China, India and Eastern Europe. Suppliers need to have the corresponding production qualifications and quality control systems to ensure the quality of products and the stability of supply.
When choosing suppliers, consumers should comprehensively consider factors such as the supplier's reputation, product quality, price and service.
Regulatory requirements
MK-677 powder has not been approved as a drug by authoritative institutions such as the FDA at present and is only produced as a research chemical in most countries. Producers must abide by relevant laws and regulations to ensure that product labels clearly indicate warning statements such as "For research use only, not for human use".
Regulatory authorities should strengthen the supervision of the production and sale of MK-677 powder to prevent its illegal use on the human body.
Safety and Environmental Protection
Safe production
During the production process, safety operation procedures must be strictly followed to prevent accidents such as fire and explosion. Operators need to wear protective equipment, such as gas masks and protective suits, to ensure their own safety.
Regularly conduct safety inspections and maintenance of production equipment to promptly identify and eliminate potential safety hazards.
Environmental protection
Production wastewater must be treated and discharged up to standard to prevent pollution to the environment. Wastewater can be treated by physical, chemical and biological methods to remove harmful substances from it.
Waste gas needs to be treated by purification equipment to reduce the emission of harmful gases. For instance, methods such as activated carbon adsorption and catalytic combustion are adopted to treat waste gas, in order to reduce its impact on the atmospheric environment.
Hot Tags: mk-677 powder cas 159752-10-0, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, Tetrahydrobiopterin BH4 Powder, procaine powder, articaine hydrochloride powder, Organic Intermediate, 1 3 Dimethylpentylamine, iptg powder