DMHA powder is obtained by amination and catalytic hydrogenation. Our company is DMHA supply. In addition to DMHA, we also produce DMAA. And stored in a cool, dry and well ventilated warehouse. Keep away from fire and heat sources. Protect from direct sunlight. Package seals. It should be stored separately from acid and edible chemicals to avoid mixed storage. The storage area shall be equipped with suitable materials to contain leakage.
DMHA, chemically known as 1,5-dimethylhexylamine, is a liquid with a lower boiling point and higher melting point that forms white crystals at low temperatures. Density 0.78-0.79 g/cm ³. This is a lighter liquid with a lower density than water, so it gradually rises from the surface when added to water. This is a liquid with a lower boiling point and higher melting point, which is liquid at room temperature, but forms white crystals at low temperatures. It is an organic compound with the characteristics of alkyl amine, and its chemical formula is C8H19N. Its molecular structure includes an eight carbon straight chain, in which two carbon atoms are connected with an amino group and two methyl groups. It is a liquid with a pungent odor, lipophilicity, low density, low boiling point, moderate flash point, melting point, and viscosity, and low surface tension. These characteristics make 1,5-dimethylhexylamine widely used in chemical industry production and various application fields.
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CF |
C8H19N |
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EM |
129 |
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MW |
129 |
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m/z |
129 (100.0%), 130 (8.7%) |
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EA |
C, 74.34; H, 14.82; N, 10.84 |
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With the increasingly mature synthesis technology of DMHA bulk powder, there are more and more DMHA supplements producing more DMHA for sale. But it should be noted that each manufacturer's products have different purities due to different technologies, and buy dmha powder needs to be carefully distinguished.
Fatty acid reduction method:
This method uses fatty acids as raw materials, generates corresponding alcohols through reduction reactions, and then undergoes dehydration and catalytic hydrogenation reactions to ultimately obtain 1,5-dimethylhexylamine. The reaction raw materials mainly include fatty acids, ethanol, acetic acid, catalysts, etc. The reaction process is as follows: first, the fatty acid is reacted with ethanol to obtain the corresponding fatty acid ethyl ester; Then, acetic acid and catalyst are used for dehydration reaction to obtain corresponding fatty acid aldehydes; Finally, it is converted to 1,5-dimethylhexylamine through hydrogenation or oxidation of stannous cyclohexane. This method has a long reaction time, but the operation is simple, the raw materials are easily available, and it is suitable for large-scale production with a high yield.
Fatty amino acid reduction method:
This method uses fatty amino acids as raw materials, through reduction and alkylation reactions, to ultimately obtain 1,5-dimethylhexylamine. The reaction raw materials mainly include fatty amino acids, sodium borohydride, methyl sodium iodide, etc. The reaction process is as follows: first, the fatty amino acids are reacted with sodium borohydride to obtain the corresponding reduction products; The product is then reacted with methylsodium iodide to undergo alkylation reaction, resulting in the corresponding 1,5-dimethylhexylamine. This method utilizes a wide range of raw materials, mild reaction conditions, and has little impact on the environment, but the yield is low.
1,5-dimethylhexylamine (CAS number 543-82-8) is a chemical substance with specific physicochemical properties and potential pharmacological effects. In recent years, this compound has attracted widespread attention in the field of sports nutrition, and is believed to have the potential to improve exercise performance, promote fat oxidation, and enhance cognitive function. However, its use is also accompanied by potential health risks and ethical controversies.
Mechanism of action
Neurotransmitter regulation:
By inhibiting the activity of monoamine oxidase (MAO), the concentration of catecholamines (such as dopamine and norepinephrine) in synaptic cleft is increased. The increase of these neurotransmitters is associated with increased excitement, increased alertness, and improved athletic performance.
5-hydroxytryptamine release:
It has been proven to increase the release of serotonin in platelets. DMHA powder is a widely distributed neurotransmitter involved in various physiological functions such as emotion, appetite, and pain perception. However, the specific role of the impact on serotonin release in motor performance is still unclear.
β receptor agonistic effect:
Has partial agonist effects on β receptors, especially β 3 receptors. β 3 receptors are highly expressed in adipocytes, and stimulation of these receptors activates lipolysis, releasing fatty acids. These fatty acids can serve as energy substrates, providing fuel for exercise.
Acid sensitive ion channel (ASIC) blockade:
By blocking ASIC, the concentration of H+in synaptic cleft can be altered. ASIC is a non selective ion channel that is activated when the pH value is below 7. By blocking ASIC, the influx of H+ions into synaptic cleft can be reduced, leading to a decrease in neuronal excitability.
Anti inflammatory effect:
Has anti-inflammatory effects, can inhibit the production of inflammatory cytokines and reduce oxidative stress. These effects may help alleviate muscle damage and inflammation associated with vigorous exercise.
Appetite suppression:
By increasing the release of norepinephrine and dopamine to reduce hunger, it has an appetite suppressing effect. This effect may help control weight and maintain athletic performance.
The impact on athletic performance
Enhance alertness and attention:
By increasing the concentration of catecholamines in synaptic cleft, alertness and attention can be enhanced, thereby improving decision-making and response abilities during exercise. A study on 18 well-trained men found that after taking it, the 400 meter sprint time was shortened by 1.5%.
Enhance muscle strength:
The activation of beta receptors can promote fat breakdown, release fatty acids as energy substrates, and provide energy for muscle contraction. In addition, its anti-inflammatory effect may help reduce muscle damage, thereby indirectly enhancing muscle strength. A study of 12 strength trainers found that after taking it, the number of bench presses increased by 10%.
Promote fat oxidation:
By activating beta adrenergic receptors, fat cells are stimulated to release fatty acids, and by increasing the utilization rate of fatty acids, fat oxidation is promoted to provide energy for muscles. A study found that men who took it had an 18% higher rate of fat oxidation during 60 minutes of cycling compared to the placebo group. Another study found that women who took it had a 10% higher fat oxidation rate during 30 minutes of treadmill exercise compared to the placebo group.
Cognitive function enhancement:
Has cognitive enhancing effects, such as increased alertness, attention, and concentration, which can improve decision-making and reaction abilities during exercise. In addition, its anti-inflammatory effect may help alleviate inflammatory reactions in the brain and further improve cognitive function.
Potential risks
Cardiovascular complications:
May lead to cardiovascular complications such as arrhythmia, elevated blood pressure, and myocardial infarction. These risks are particularly significant among athletes as they are already in a high state of cardiovascular stress during exercise.
Anxiety and insomnia:
It has a neural excitatory effect and may cause neurological and psychiatric symptoms such as anxiety and insomnia. These symptoms may affect athletes' rest and recovery, thereby impacting their athletic performance.
Other health risks:
Long term use may lead to health problems such as liver damage, renal dysfunction, and endocrine system disorders. In addition, its potential carcinogenicity and mutagenicity have not been fully evaluated.
Purpose of pure DMHA:
Metal cleaning:
1,5-dimethylhexylamine can also be used for metal cleaning and corrosion prevention. Mixing it with alkaline substances such as sodium carbonate or sodium bicarbonate can remove oxides and other pollutants from metal surfaces.
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Warning word, Hazard description h226-h302-h315-h319-h301-h314-h318, Precautions P301 + p310a-p303 + p361 + p353-p405-p501a-p210-p301 + p312 + p330-p305 + P351 + p338-p370 + p378, Dangerous goods sign xn, Hazard category code 10-22-36 / 37 / 38, Safety instructions 26-36 / 37 / 39-37 / 39-16, Dangerous goods transport No. UN 1993 3 / PG 3, WGK Germany 3, RTECS No. mq4840000, F 10-34, TSCA Yes, HazardClass 3, PackingGroup III.
DMHA powder is an organic compound that is often used as an illegal stimulant in physical exercise due to its strong irritant and stimulant effects. Its discovery history is relatively short, dating back to 2009.
In 2009, a nutritional supplement called "Jack3d" was popular in the US market, and its main ingredients were advertised as "free of prohibited substances". However, the U.S. Anti-Doping Agency (USADA) has launched an investigation into the supplement after multiple athletes tested positive for banned substances. After testing and analysis, they found that the supplement contained 1,5-dimethylhexylamine, an illegal stimulant.
Since then, DMHA has received widespread attention and has been included in the anti-doping agency's list of prohibited substances. While the substance is still used in some countries, it is considered a health risk.
Mechanisms of Action
DMHA's stimulant effects are primarily attributed to its ability to influence the central nervous system (CNS). It is believed to act as a norepinephrine-dopamine reuptake inhibitor (NDRI), meaning it prevents the reuptake of these neurotransmitters into presynaptic neurons, thereby increasing their concentrations in the synaptic cleft. This leads to enhanced neuronal firing and the activation of downstream signaling pathways associated with increased alertness, energy, and mood.
Norepinephrine, a key neurotransmitter involved in the "fight or flight" response, enhances arousal, attention, and cognitive performance. Dopamine, on the other hand, is associated with reward, motivation, and motor control. By increasing the availability of these neurotransmitters, DMHA may promote feelings of euphoria, focus, and motivation, making it appealing for use in high-intensity workouts or tasks requiring sustained mental effort.
Additionally, DMHA has been suggested to possess weak adrenergic receptor agonist activity, particularly at α1 and α2 receptors. This could further contribute to its stimulant effects by promoting vasoconstriction and increasing blood pressure, although the clinical significance of this action remains unclear.
DMHA powder represents a complex and controversial topic within the fitness and supplement industries. While its stimulant properties may offer potential benefits in terms of energy, focus, and athletic performance, these must be weighed against the risks of side effects and regulatory uncertainty. The lack of global consensus on its regulatory status further complicates the issue, highlighting the need for greater transparency and consumer education.
As we move forward, it is essential for regulatory agencies, manufacturers, and consumers to work together to ensure the safety and efficacy of dietary supplements. By prioritizing evidence-based research, transparent labeling, and responsible marketing practices, we can help protect the health and well-being of individuals seeking to enhance their physical and mental performance. In the meantime, individuals considering the use of DMHA-containing supplements should proceed with caution and consult with healthcare professionals to make informed decisions about their health.
Frequently Asked Questions
Is DMHA legal or illegal?
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FDA considers DMHA to be a substance that does not meet the statutory definition of a dietary ingredient and is an unsafe food additive. Accordingly, we consider dietary supplements containing DMHA to be adulterated under the Federal Food, Drug, and Cosmetic Act (FD&C Act).
Is DMHA good for you?
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In the United States, the FDA considers DMHA to be an unsafe ingredient in dietary supplements.
Does DMAA increase dopamine?
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In transport assays in human embryonic kidney cells, DMAA inhibited dopamine uptake by the human dopamine transporter in a competitive manner.
What is the real name for DMHA?
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Octodrine, also known as dimethylhexylamine (DMHA), is a central nervous stimulant.
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