1,5-dimethylhexylamine(DMHA), chemical name is 6-Methyl-2-heptnaMine, viscous liquid, fishy smell, used as pesticides, dyes, pigments, surfactants, pesticides intermediates, but also used for the production of stabilizers, preservatives, emulsifiers. it is an organic compound with the chemical formula C8H19N. Has a pungent odor. It is a lipophilic substance that can be miscible with polar solvents such as water, ethanol, acetone, and dimethylformamide. The viscosity is relatively high, approximately 30-40 mPa · s. Due to its relatively high viscosity, it sometimes requires the addition of other compounds during the manufacturing process to reduce viscosity and improve production efficiency. The viscosity is relatively high, approximately 30-40 mPa · s. Due to its relatively high viscosity, it sometimes requires the addition of other compounds during the manufacturing process to reduce viscosity and improve production efficiency.
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Chemical Formula |
C8H19N |
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Exact Mass |
129 |
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Molecular Weight |
129 |
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m/z |
129 (100.0%), 130 (8.7%) |
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Elemental Analysis |
C, 74.34; H, 14.82; N, 10.84 |
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1,5-Dimethylhexylamine is an important intermediate compound commonly used in fields such as pharmaceuticals, pesticides, and surfactants, with broad application prospects. There are currently multiple methods available for synthesizing dmha, and the commonly used synthesis methods will be reviewed below.
1. succinic anhydride 1-methylcyclohexylamine method:
This method is a classic synthesis method for DMHA. The reaction raw materials of this method mainly include 1-methylcyclohexylamine, dimethyl succinate, sulfuric acid, aluminum trichloride, hydrogen chloride, etc. The specific reaction process is as follows: firstly, dimethyl succinate and 1-methylcyclohexylamine undergo cyclization reaction under the catalysis of sulfuric acid and aluminum trichloride to obtain 1,5-dimethylcyclohexanone; Then, 1,5-dimethylcyclooctanone is oxidized to the corresponding keto acid transition state compound by using alkaline oxidant such as sodium hydroxide; Finally, the target product it is obtained by hydrolysis in hydrogen chloride or acetic acid. This method is convenient for synthesis, with high reaction efficiency and a yield of over 80%.
2. Kertis cyclization method:
This method uses 2-pentanone as the raw material, generates 1,5-cyclohexanedione through the Kreiss cyclization reaction, and converts it to it through reduction. The reaction raw materials mainly include 2-pentanone, dimethyl succinate, aluminum trichloride, tetrahydrofuran, etc. The reaction process is as follows: first, dimethyl succinate is reacted with aluminum trichloride to obtain the corresponding dextral methyl succinate. After heating treatment, it is decarboxylated to form 2-pentanone; Then, 2-pentanone is reacted with tetrahydrofuran and aluminum trichloride to undergo the Kreiss cyclization reaction, resulting in 1,5-cyclohexanedione; Finally, the target product DMHA was obtained through hydrogenation reaction. The step-by-step operation of this method is cumbersome, but the reaction conditions are mild, the applicability is wide, and the yield is high.
If 2-amino-6-methylheptane is inhaled, move the patient to fresh air; In case of skin contact, take off the contaminated clothes, wash the skin thoroughly with soapy water and clear water, and see a doctor in case of discomfort; In case of eye contact, separate the eyelids, rinse with flowing water or normal saline, and seek medical attention immediately; If ingested, rinse your mouth immediately. Do not induce vomiting. See a doctor immediately. The advice to protect the rescuer is as follows: transfer the patient to a safe place and consult the doctor. If the conditions permit, please show this chemical safety technical manual to the doctor on site. In case of small leakage, collect the leaked liquid in airtight containers as much as possible, absorb it with sand, activated carbon or other inert materials, and transfer it to a safe place. It is forbidden to flush into the sewer; If a large number of leaks are found, the construction of a dike or digging pit shall be carried out. The drainage pipes should be closed, foam covered and evaporated, and explosion-proof pumps should be transferred to the tank trucks or special collector for recovery or transportation to the waste disposal sites.
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Melting point 25 ° C, Boiling point 154-156 ° C (lit.), Density 0.767 g / ml at 25 ° C (lit.), Refractive index N20 / D 1.422 (lit.), Flash point 120 ° f, Storage conditions flammables area, Acidity coefficient (PKA) PKA 10.28 ± 0.1 (H2O, t = 25 ± 0.2, I < 0.001) (uncertain), Form liquid.
1,5-dimethylhexylamine (CAS number 543-82-8) is a chemical substance with unique physical and chemical properties, which has been widely used in various fields in recent years. Especially in the fields of coatings and cleaning products, it has demonstrated unique advantages and potential.
As a coating additive
1. Improve the fluidity and wettability of coatings
As a coating additive, it can significantly improve the flowability and wettability of coatings. The amino functional groups in its molecular structure can interact with the resin, pigment and other components in the coating, reducing the surface tension of the coating system and making it easier for the coating to spread and penetrate on the substrate surface. This helps to improve the coverage and uniformity of the coating, reducing defects such as brush marks and bubbles.
2. Adjusting the viscosity of the coating
It also has a certain viscosity regulating effect. By adjusting its dosage in the coating, the viscosity of the coating can be flexibly controlled to meet the needs of different construction methods. For example, during spraying and rolling, the viscosity of the coating can be appropriately reduced to improve construction efficiency and coating quality; When brushing, the viscosity of the coating can be appropriately increased to avoid problems such as sagging and dripping.
3. Enhancing Coating Adhesion
It can interact with polar groups in coatings to form chemical or hydrogen bonds, thereby enhancing the adhesion between coatings and substrates. This helps to improve the durability and peel resistance of the coating, extending its service life.
Application examples：
A certain coating manufacturer added an appropriate amount of this product as a flowable and wetting agent when preparing water-based coatings. After testing, the flowability and wettability of the coating have been significantly improved, and the coverage and uniformity of the coating have also been greatly enhanced. At the same time, the viscosity of the coating has been effectively adjusted to meet the needs of different construction methods. In practical applications, the coating exhibits good adhesion and durability on substrates such as wood, metal, and plastic.
As a surfactant
1. Reduce surface tension
Has low surface tension and can significantly reduce the surface tension of water and other solvents. This makes it one of the commonly used surfactants in cleaning products. By reducing surface tension, the penetration and dispersion ability of cleaning products towards stains and dirt can be enhanced, improving the cleaning effect.
2. Enhance the performance of foam
It also has good foam performance. In cleaning products, the generation and stability of foam is crucial to improve cleaning efficiency and user experience. It can cooperate with other surfactants to form a stable and lasting foam layer, covering the surface of stains and dirt, which is helpful to effectively remove them.
3. Improve the mildness of cleaning products
Compared to other surfactants, it has less irritation and less damage to the skin and eyes. This makes it an ideal choice for preparing mild cleaning products. Adding an appropriate amount of this product to cleaning products can reduce irritation and harm to users while ensuring cleaning effectiveness.
4. As a cleaning enhancer
Not only can it be used as a surfactant, but it can also be used as a cleaning enhancer. By synergizing with other cleaning ingredients, the cleaning ability and efficiency of cleaning products can be significantly improved. For example, in hard surface cleaning agents, they can work synergistically with alkaline components and chelating agents to effectively remove grease, dust, and stains.
Application examples
1. Kitchen cleaner
Used as a surfactant and enhancer in kitchen cleaners. By reducing surface tension, enhancing the ability to penetrate and disperse oil stains; At the same time, it works synergistically with other cleaning ingredients to quickly remove oil stains and food residues. After adding a certain brand of kitchen cleaner, the cleaning effect is significantly improved, and the damage to the kitchen surface is minimal.
2. Glass cleaner
In glass cleaning agents, they are mainly used as surfactants. By reducing the surface tension of water, it makes it easier for cleaning agents to spread and penetrate on glass surfaces, effectively removing stains and dust. At the same time, it can also form a stable foam layer to cover the glass surface to prevent stains and dust from adhering again. After adding a certain brand of glass cleaner, the cleaning effect is more significant and will not cause damage to the glass surface.
3. Carpet cleaner
Used as a surfactant and enhancer in carpet cleaning agents. By reducing surface tension, enhancing the penetration and dispersion ability of stains in carpet fibers; At the same time, 1,5-Dimethylhexylamine works synergistically with other cleaning ingredients to effectively remove grease, dust, and pet hair from carpets. After adding a certain brand of carpet cleaner, the cleaning effect is more significant and will not cause damage to the carpet fibers.
Frequently Asked Questions
What is the drug Octodrine used for?
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Octodrine is an α-adrenergic agonist originally developed as a decongestant in the 1950s. It has resurfaced as an ingredient in sports supplements. It is a central nervous stimulant that increases the uptake of dopamine and noradrenaline, used as a pre-work out stimulant/fat burner.
Is octodrine a stimulant?
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Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline.
Is DMAE a banned substance?
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DMAA is on the DoD Prohibited Dietary Supplement Ingredients list. DMAA (short for 1,3-dimethylamylamine) is a stimulant similar to amphetamine and was originally developed in the 1940s as a nasal decongestant.
How does DMAE make you feel?
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DMAE benefits may include firmer skin, better mood, increased energy, and improved sleep, possibly by helping tissues hold water and raising levels of acetylcholine -a brain chemical important for memory and focus.
Does DMAA release dopamine?
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DMAA appears to provide a sympathomimetic effect in human subjects. It mimics the effects on the sympathetic nervous system of neurotransmitters such as epinephrine, norepinephrine and dopamine.
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