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Elsiglutide (Cas number: 914009-84-0) is an artificially synthesized glucagon like peptide-2 (GLP-2) analogue, belonging to selective GLP-2 receptor agonists. Its molecular weight is approximately 4317-4354 Da, composed of 39 amino acids. It specifically binds to the intestinal GLP-2 receptor, activates intracellular signaling routes, promotes intestinal epithelial cell proliferation, and inhibits apoptosis, thereby enhancing intestinal mucosal barrier function, increasing crypt depth and villus height, and maintaining intestinal integrity.
Elsiglutide COA
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| Certificate of Analysis | ||
| Compound name | Elsiglutide | |
| Grade | Pharmaceutical grade | |
| CAS No. | 914009-84-0 | |
| Quantity | 40g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090088 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure | N/A | |
| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.54% |
| Loss on drying | ≤1.0% | 0.42% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.52% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
| N/A | ||
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As an intestinal related peptide molecule, Elsiglutide's research and application mainly focus on multiple clinical scenarios such as protection against digestive system damage, management of cure-related complications, and recovery of intestinal function. Unlike traditional drugs that are guided by disease classification, they often revolve around a continuous process of "intestinal barrier disruption functional disorder repair and reconstruction".
Related uses of intestinal mucosal injury protection
It is widely used in research and intervention routes related to mucosal injury prevention in various disease states with intestinal structure destruction as the core pathological feature. Whether it is acute or chronic injury, its application revolves around the core goal of "maintaining mucosal integrity". In cases where the intestinal barrier is disrupted, this drug is used in relevant intervention systems to support the stability of the intestinal epithelial structure, thereby reducing further interference from external factors on the internal environment.
In clinical and experimental research, this use is not limited to a single disease model, but also widely exists in various injury backgrounds, such as inflammation, ischemia, or mucosal damage caused by exogenous stimuli. In these contexts, they are included in a comprehensive intervention route to construct gut management strategies centered around "protection maintenance recovery".
Intervention for gastrointestinal toxicity related to cure
During the process of tumor cure, gastrointestinal toxicity is one of the important factors affecting the continuity of cure. In this context, the intervention system used for chemotherapy and radiotherapy related gastrointestinal injuries is an important component of supporting cure routes in clinical research and practice.
In chemotherapy related intestinal injury, this drug is used to reduce the degree of mucosal damage and support the maintenance of intestinal function, thereby facilitating the continued implementation of cure plans. In radiation related injuries, its use has been further expanded to disease scenarios such as radiation enteritis, to support the stability of intestinal structure and functional recovery. In addition, it has also been used in various high-intensity cure regimens to support the overall cure system and reduce the impact of cure-related adverse reactions on the patient's condition.
Uses related to intestinal function recovery and reconstruction
In clinical contexts where intestinal function is impaired or lost, it is used in research and intervention routes related to functional recovery. This use is mainly reflected in various scenarios such as postoperative recovery, functional disorders, and chronic functional decline.
In the postoperative stage of intestinal surgery, the drug is included in the recovery route to support intestinal function reconstruction and promote the gradual recovery of normal digestion and absorption processes. In functional gastrointestinal diseases, it is used in related research systems to improve functional disorders. In the context of chronic functional decline, it is used in long-term management routes to support the maintenance and regulation of intestinal function.
Management of inflammation related intestinal diseases
In intestinal diseases with inflammation as the core pathological mechanism, it is used in comprehensive management systems as an auxiliary intervention to participate in disease control routes. In chronic diseases such as inflammatory bowel disease, its use is mainly reflected in supporting intestinal structural stability and maintaining long-term disease management strategies.
In acute inflammatory conditions, this drug is used in relevant intervention research routes to alleviate the damage of inflammation to intestinal structure. In chronic inflammatory states, its use is more reflected in research routes that maintain disease stability and reduce the risk of recurrent attacks.
In the postoperative stage of intestinal surgery, the drug is included in the recovery route to support intestinal function reconstruction and promote the gradual recovery of normal digestion and absorption processes. In functional gastrointestinal diseases, it is used in related research systems to improve functional disorders. In the context of chronic functional decline, it is used in long-term management routes to support the maintenance and regulation of intestinal function.
Related uses of intestinal barrier dysfunction
Abnormal intestinal barrier function is considered an important foundational link in various diseases, and elsiglutide is widely used in related experiments and clinical routes in this research field. Its main purpose is to support the integrity maintenance and functional recovery of barrier structures.
In the research model of increased intestinal permeability, this drug is used in relevant intervention systems to support barrier function recovery. In systemic diseases, such as changes in barrier function caused by infections or metabolic abnormalities, they are also used in related research routes to analyze the role of the gut in the overall disease process.
With the deepening of research on the gut systemic axis, its use has gradually expanded to various systemic diseases. Among these diseases, it mainly participates in the overall management route as part of intestinal supportive therapy.
In severe infection, trauma, or stress states, the intestine is considered one of the important target organs and is used in related research systems to support intestinal function and reduce secondary damage. In studies related to multiple organ dysfunction, this drug has also been included in supportive cure routes for maintaining the role of the gut in systemic homeostasis.
Uses related to nutrient absorption and metabolic support
In clinical contexts where nutrient absorption is impaired or metabolism is abnormal, it is used in relevant research routes as part of the metabolic regulatory system to support cure strategies. In the state of decreased intestinal absorption function, this drug is used to support the process of nutrient absorption and participate in related functional recovery routes.
In the study of metabolic diseases, its use has further expanded to the research system related to energy balance regulation, for analyzing the regulatory role of the intestine in overall metabolism. In nutritional support therapy, it is also used in comprehensive management routes to support the stability of the body's metabolic state.
Damage repair and regenerative medicine related applications
In the research of tissue injury and regenerative medicine, it is used in relevant experimental routes as an intervention tool to promote the repair process and participate in the research system. In intestinal injury models, its use is mainly focused on supporting tissue structure recovery and functional reconstruction.
In the study of ischemia-reperfusion injury, this drug is used in relevant models to analyze the process of tissue recovery. In the field of regenerative medicine, its use has further expanded to tissue engineering research, exploring routes for cell and tissue regeneration.
Development history
The development process reflects the overall evolution path of research on peptide drugs that regulate intestinal function. The origin of its research can be traced back to the discovery stage of endogenous regulatory peptides in the gut, during which researchers gradually recognized the important role of gut related peptide molecules in maintaining the structure and function of the digestive system.
With the deepening of intestinal biology research, the functions of related peptide molecules have gradually been systematically elucidated, which has promoted the development of artificially synthesized analogues. In this context, peptide molecules have been developed as optimized designs to exert more stable and controllable biological effects in vivo.
In the early stages of research, it was mainly applied in basic experimental systems to verify its role in maintaining intestinal structure and regulating function. In animal model studies, this molecule has been used in various intestinal injury and inflammation models to evaluate its potential applications under different conditions.
Subsequently, in the stage of translational medicine research, it gradually enters the preclinical and clinical research routes to evaluate its safety and application value in the human body. At this stage, its use gradually expanded to multiple fields such as chemotherapy related gastrointestinal injuries, inflammatory bowel disease, and postoperative recovery.
In the process of advancing clinical research, it has been included in multiple research projects to explore its application routes in different disease states and gradually form a systematic research data foundation. Meanwhile, its application value in the field of supportive therapy has gradually gained attention.
In recent years, with the development of precision medicine and translational medicine, research has gradually extended towards multimodal cure systems and personalized applications. In the new research framework, it not only exists as a single intervention method, but is also incorporated into complex cure systems to jointly construct comprehensive intervention routes with other cure methods.
Overall, the development history of elsiglutide reflects a complete path from basic discovery, molecular optimization, experimental validation to clinical exploration. Its research focus has gradually shifted from single functional validation to systematic application evaluation, and it occupies a certain position in the modern medical research system.
refence
1. Drucker DJ. GLP-2 analogs and intestinal function. Gastroenterology
2. Jeppesen PB. GLP-2 in intestinal disease. Gut
3. ClinicalTrials.gov (keyword: Elsiglutide)
4. Chance WT, et al. Intestinal protection studies
5. The Lancet Gastroenterology & Hepatology
6. Nature Reviews Gastroenterology & Hepatology
7. Goodman & Gilman's The Pharmacological Basis of Therapeutics
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