Erythromycin powder, white or milky white crystal or powder, molecular formula C37H67NO13, CAS 114-07-8, stable at room temperature and pressure. Mainly used for lower respiratory tract infections caused by streptococcus such as tonsillitis, scarlet fever, diphtheria, carriers, gonorrhea, Listeria monocytogenes, Streptococcus pneumoniae, etc. (the above applies to penicillin resistant patients). For Legionella pneumonia and Mycoplasma pneumonia, this product can be used as the preferred medication. It can also be used for upper respiratory tract infections caused by influenza bacteria, Staphylococcus aureus skin and soft tissue infections, syphilis, intestinal amoebiasis, etc.
Chemical Formula |
C37H67NO13 |
Exact Mass |
733 |
Molecular Weight |
734 |
m/z |
733 (100.0%), 734 (40.0%), 735 (7.8%), 735 (2.7%), 736 (1.1%) |
Elemental Analysis |
C, 60.55; H, 9.20; N, 1.91; O, 28.34 |
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Erythromycin, as a classic macrolide antibiotic, has played an important role in clinical treatment since its inception. Its unique antibacterial mechanism and wide range of applications make it an important drug to treat a variety of infectious diseases.
Clinical application
Erythromycin powder plays an important role in the treatment of respiratory infections. It can be used to treat various respiratory infections caused by Gram positive bacteria, such as acute pharyngitis, tonsillitis, bronchitis, pneumonia, etc. Erythromycin inhibits the growth and reproduction of respiratory pathogenic bacteria, alleviates symptoms such as cough, sputum production, and fever, and promotes disease improvement. Especially in the treatment of mycoplasma pneumonia and chlamydia pneumonia, erythromycin is often used as the first choice drug.
Acute pharyngitis and tonsillitis: Erythromycin can effectively inhibit pathogens that cause these diseases, such as Streptococcus pyogenes and Streptococcus pneumoniae, thereby relieving symptoms such as sore throat and difficulty swallowing.
Bronchitis and pneumonia: For bronchitis and pneumonia caused by Gram positive bacteria, erythromycin can quickly control infection, reduce inflammatory response, and promote absorption and recovery of lung lesions.
Mycoplasma pneumonia and Chlamydia pneumonia: Erythromycin is highly sensitive to Mycoplasma and Chlamydia and is the preferred drug for treating these two types of pneumonia. By inhibiting the growth and reproduction of pathogens, erythromycin can significantly improve patients' symptoms and shorten the course of the disease.
Erythromycin also has significant therapeutic effects in the treatment of skin and soft tissue infections. It can be used to treat skin and soft tissue infections caused by Gram positive bacteria such as Staphylococcus aureus and Staphylococcus epidermidis, such as acne, boils, pustules, cellulitis, etc. External preparations such as erythromycin ointment can directly act on the infected area, killing local bacteria, preventing the spread of infection, and accelerating wound healing.
Acne: Erythromycin ointment can inhibit the growth and reproduction of Propionibacterium acnes, alleviate inflammatory reactions, and promote the regression of acne.
Swelling and pustule disease: Erythromycin can penetrate to the infected site, kill bacteria, promote the absorption and discharge of abscesses, and accelerate wound healing.
Cellulitis: For cellulitis caused by Gram positive bacteria, erythromycin can quickly control the infection, reduce the inflammatory response, and prevent the spread of infection.
3. Urinary and reproductive system infections
Erythromycin also plays an important role in the treatment of urinary and reproductive system infections. It can be used to treat urinary and reproductive system infections such as urethritis and cervicitis caused by chlamydia, mycoplasma, etc. Erythromycin alleviates symptoms such as frequent urination, urgency, pain during urination, and discomfort in the reproductive organs by inhibiting the growth and reproduction of pathogens.
Urethritis: Erythromycin can kill pathogens that cause urethritis, such as Chlamydia and Mycoplasma, thereby relieving symptoms of urethral irritation and promoting the repair of urethral mucosa.
Cervicitis: For cervicitis caused by chlamydia, mycoplasma, etc., erythromycin can inhibit the growth and reproduction of pathogens, alleviate cervicitis, and promote the recovery of cervical mucosa.
In addition to the above common infectious diseases, erythromycin can also be used to treat a variety of other infectious diseases. For example:
Otitis media: Erythromycin can inhibit pathogens that cause otitis media, such as Streptococcus pneumoniae and Haemophilus influenzae, thereby alleviating symptoms such as ear pain and hearing loss.
Periodontal disease: Erythromycin can inhibit the growth and reproduction of periodontal pathogens, reduce gum inflammation, and promote the repair of periodontal tissue.
Syphilis: Erythromycin has a certain inhibitory effect on Treponema pallidum and can be used to treat early syphilis. However, it should be noted that erythromycin is not the preferred treatment for syphilis and is usually considered for use in cases of penicillin allergy or inability to use penicillin.
Intestinal amoebiasis: Erythromycin has a certain killing effect on amoebids and can be used to treat intestinal amoebiasis. However, it should be noted that erythromycin is not the preferred treatment for amoebic disease and is usually used in combination with other anti amoebic drugs.
4. Eye infection
Erythromycin powder eye ointment and other preparations can be used to treat eye infections such as conjunctivitis, keratitis, etc. Erythromycin can directly act on infected lesions in the eyes, reducing symptoms such as redness, swelling, pain, and increased secretions.Conjunctivitis: Erythromycin eye ointment can inhibit pathogens that cause conjunctivitis, such as bacteria and chlamydia, thereby alleviating eye irritation symptoms and promoting conjunctival repair.
Keratitis: For keratitis caused by bacteria, erythromycin eye ointment can kill pathogens, alleviate keratitis symptoms, and promote corneal healing.
Special purpose
2. Immune regulatory effect
Erythromycin also has certain immunomodulatory effects. Research has shown that erythromycin can regulate the body's immune function, enhance its resistance, and aid in the recovery from infections. For example, in the treatment of chronic obstructive pulmonary disease (COPD), low-dose erythromycin can inhibit the secretion of bronchial glands, reduce the aggregation of neutrophils, alleviate the damage of elastase to tissues, inhibit the production of reactive oxygen species, promote the differentiation and maturation of macrophages, inhibit the activity of T lymphocytes, and thus exert the anti-inflammatory effect of steroids.

1. Alternative medications for patients allergic to penicillin
Erythromycin has important alternative therapeutic value for patients with penicillin allergy. When patients are allergic to penicillins, erythromycin can be used as a substitute to treat a variety of infectious diseases caused by gram-positive bacteria. For example, erythromycin can have a good therapeutic effect on upper respiratory tract infections, scarlet fever, and cellulitis caused by β - hemolytic streptococcus infection.
3. Anti allergic effect
Erythromycin has a certain inhibitory effect on certain allergic reactions. It can alleviate allergic symptoms such as rash, itching, urticaria, etc. However, it should be noted that erythromycin is not an anti allergic drug, and its anti allergic effect is relatively weak, so it is usually not the preferred treatment drug.
Dosage Form and Usage
Erythromycin has various dosage forms, including tablets, capsules, ointments, eye ointments, etc. Different formulations of erythromycin are suitable for different treatment needs.
Tablets and capsules:
Mainly used for oral treatment of systemic infectious diseases. Patients should strictly follow the doctor's instructions for medication and should not increase or decrease the dosage or change the medication method on their own.
Ointment:
Mainly used for topical treatment of skin and soft tissue infections. The patient should apply the ointment evenly to the infected area several times a day until the symptoms disappear.
Eye ointment:
Mainly used to treat eye infections. The patient needs to squeeze eye ointment into the conjunctival sac several times a day until the symptoms disappear.
Erythromycin, as a classic macrolide antibiotic, plays an important role in clinical treatment. Its unique antibacterial mechanism and wide range of applications make it an important drug to treat a variety of infectious diseases.
Production principle and steps of erythromycin powder:
Erythromycin is produced by fermentation of Saccharopolyspora rubra. The first was formerly known as erythromycin streptomyces. In production, the spore suspension is generally put into the seed tank, and the seeds are expanded for twice and then transferred to the fermentation tank for fermentation. After pretreatment, the fermentation liquid is separated and purified by solvent extraction, and finally the finished product is concentrated, crystallized and dried.
The production steps are generally: cultivation of erythromycin producing bacteria, biosynthesis of erythromycin, fermentation, pretreatment and filtration of fermentation broth, extraction of erythromycin, and purification of erythromycin.
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