Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of meropenem powder in China. Welcome to wholesale bulk high quality meropenem powder for sale here from our factory. Good service and reasonable price are available.
Meropenem Powder is a sterile freeze-dried broad-spectrum carbapenem antibiotic. Its core value lies in addressing moderate to severe infections caused by various Gram-positive bacteria, Gram-negative bacteria (including Pseudomonas aeruginosa), and anaerobic bacteria. It exerts a potent bactericidal effect by efficiently inhibiting the synthesis of bacterial cell walls and is stable against most β-lactamases, making it a key treatment option for complex intra-abdominal infections, pneumonia, meningitis, and severe infections with neutropenia and fever. This drug needs to be re-solubilized with an appropriate solvent before use and administered via intravenous infusion. Strict adherence to standard preparation procedures is essential to ensure the stability and efficacy of the drug. As an important line of defense in the hospital's anti-infection treatment system, the rational use of Meropenem plays an irreplaceable clinical role in curbing bacterial resistance and improving the prognosis of critically ill patients.
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Additional information of chemical compound:
| Product Name | Meropenem Powder | Meropenem Tablets | Meropenem Injection 1000mg |
| Product Type | Powder | Tablet | liquid |
| Product Purity | ≥99% | ≥99% | ≥99% |
| Product Specifications | 100g/1kg/etc. | 1g/2g | 1g/2g |
| Product Form | Organic synthesis | Take Orally | Organic synthesis |
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Meropenem COA
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| Certificate of Analysis | ||
| Compound name | Meropenem | |
| Grade | Pharmaceutical grade | |
| CAS No. | 96036-03-2 | |
| Quantity | Customization | |
| Packaging standard | Customization | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090043 | |
| MFG | Jan 9th 2025 | |
| EXP | Jan 8th 2028 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.45% |
| Loss on drying | ≤1.0% | 0.28% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.90% |
| Single impurity | <0.8% | 0.47% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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Meropenem Powder (generic name: Meropenem) is a synthetic broad-spectrum carbapenem antibiotic belonging to the beta lactam antibiotic family. It exerts potent antibacterial effects by inhibiting bacterial cell wall synthesis, particularly highly active against gram-negative bacteria, and effective against some gram-positive and anaerobic bacteria. The following is a detailed explanation of its purpose:
Core use: Broad spectrum antibacterial treatment covering multiple infections
The core use of meropenem injection is to treat serious or life-threatening infections caused by sensitive bacteria. Its antibacterial spectrum covers Gram positive bacteria, Gram negative bacteria, and anaerobic bacteria, and is particularly suitable for the following scenarios:
Multidrug resistant bacterial infection: It has high stability against bacteria that produce β - lactams, such as Pseudomonas aeruginosa and Enterobacteriaceae, and is a first-line choice for treating drug-resistant bacterial infections.
Mixed infection: Single drug therapy can be used to treat mixed infections of aerobic and anaerobic bacteria (such as abdominal and pelvic infections), reducing the need for combination therapy.
Severe infection: suitable for critically ill cases with neutropenia accompanied by fever, sepsis, meningitis, etc. that require rapid control of infection.
Mechanism of action: Targeting key steps in bacterial cell wall synthesis
Meropenem exerts antibacterial effects through the following mechanisms:
Inhibition of Penicillin Binding Proteins (PBPs): Meropenem easily penetrates bacterial cell walls, covalently binds to PBPs (especially PBP2), inhibits transpeptidase activity, blocks peptidoglycan cross-linking, and leads to cell wall defects.
Highly stable to β - lactases: except for metallo β - lactases, it is stable to most β - lactases (including penicillinase and cephalosporinase) for hydrolysis, thus maintaining activity against enzyme producing strains.
Rapid bactericidal effect: After intravenous administration, the drug is widely distributed in the body with a half-life of about 1 hour, and can quickly reach an effective bactericidal concentration, especially suitable for emergency treatment of severe infections.
Indications: Covering all systemic infections throughout the body
According to the drug instructions and clinical guidelines, the indications for meropenem powder injection include:
respiratory infection
Hospital acquired pneumonia (HAP): HAP caused by drug-resistant bacteria such as Pseudomonas aeruginosa and Klebsiella pneumoniae, with meropenem being one of the preferred drugs.
Community acquired pneumonia (CAP): applicable to cases of severe CAP or suspected mixed infection (such as co infection of Streptococcus pneumoniae and anaerobic bacteria).
Acute exacerbation of chronic bronchitis: When combined with Pseudomonas aeruginosa infection, meropenem can effectively control the condition.
Abdominal infection
Complex abdominal infections, such as cholecystitis, cholangitis, liver abscess, peritonitis, etc., are often caused by Escherichia coli, Klebsiella pneumoniae, Bacteroides fragilis, etc. Meropenem can be treated with monotherapy or in combination with metronidazole.
Postoperative intra-abdominal infection: used for preventive or therapeutic purposes to reduce the risk of complications after abdominal surgery.
Urinary and reproductive system infections
Complex urinary tract infections: including pyelonephritis, cystitis, etc., especially suitable for Enterobacteriaceae infections that produce ESBLs (extended spectrum beta lactams).
Gynecological infections, such as endometritis, pelvic inflammatory disease, and uterine connective tissue inflammation, are often caused by mixed infections of aerobic and anaerobic bacteria. Meropenem can cover common pathogens.
Bone, joint, skin, and soft tissue infections
Osteomyelitis: Osteomyelitis caused by Staphylococcus aureus (excluding MRSA), Pseudomonas aeruginosa, etc. Meropenem is one of the optional drugs.
Cellulitis: Severe skin and soft tissue infections, especially when combined with the risk of sepsis, require intravenous use of broad-spectrum antibiotics.
Central nervous system infection
Bacterial meningitis: Meropenem can penetrate the blood-brain barrier and treat meningitis caused by Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, etc., especially suitable for strains resistant to penicillin or cephalosporins.
Brain abscess: often caused by mixed infection of aerobic and anaerobic bacteria, meropenem combined with metronidazole is a commonly used regimen.
Other serious infections
Sepsis: A bloodstream infection caused by sensitive bacteria that requires rapid control of the source of infection, and meropenem is one of the preferred drugs.
Neutropenia with fever: In patients with neutropenia after chemotherapy or bone marrow transplantation, meropenem can cover possible gram-negative bacterial infections and reduce mortality.
Clinical application scenario: full coverage from empirical treatment to targeted treatment
Empirical treatment
Initial treatment for severe infections: Meropenem can be used as the first-line empirical treatment until the pathogen is identified, covering possible gram-negative, gram-positive, and anaerobic bacteria.
Infection in immunosuppressed patients: For patients with neutropenia, meropenem can prevent or treat severe infections caused by drug-resistant bacteria.
Targeted therapy
Precision medication guided by drug sensitivity results: When the pathogen is identified and sensitive to meropenem, the dosage can be continued or adjusted.
Combination therapy: Used in combination with aminoglycosides (such as amikacin) or vancomycin to treat drug-resistant bacterial infections such as Pseudomonas aeruginosa or MRSA.
Preventive medication under special circumstances
Surgical prevention: In medical institutions with high incidence of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant bacterial infections, meropenem can be used as a preventive medication before certain high-risk surgeries, such as colorectal surgery.
Prevention of infection after organ transplantation: Patients undergoing liver transplantation, kidney transplantation, etc. may experience serious infections after surgery, and meropenem can be used as one of the preventive drugs.
Medication and precautions for special populations
Children's medication:
Dose adjustment: For children aged 3 months to 12 years, administer 10-20mg/kg every 8 hours based on the severity of infection and body weight; Children weighing over 50kg should be given the adult dose.
Meningitis treatment: The dosage for pediatric meningitis patients can be increased to 40mg/kg, once every 8 hours, to quickly control the infection.
Medication for the elderly:
Renal function monitoring: Elderly people often have decreased renal function, and the dosage should be adjusted according to creatinine clearance rate to avoid drug accumulation.
Adverse reaction monitoring: Elderly people have poor tolerance to adverse drug reactions and require close observation of liver and kidney function, neurological symptoms, etc.
Medication for patients with liver and kidney dysfunction:
Renal insufficiency: Meropenem is mainly excreted through the kidneys, and patients with renal insufficiency need to adjust the dosage according to creatinine clearance rate. For example, when the creatinine clearance rate is less than 50ml/min, the adult dose is halved.
Liver dysfunction: Patients with liver dysfunction generally do not need to adjust the dosage, but liver function indicators need to be monitored to be alert to drug-induced liver injury.
Medication for pregnant and lactating women:
Pregnant women's medication: Meropenem belongs to FDA pregnancy classification B, and animal experiments have not shown teratogenicity, but human research data is limited. Pregnant women should use it with caution and only use it when it is clearly necessary.
Medication for lactating women: Meropenem can be secreted in small amounts into breast milk. It is recommended to suspend breastfeeding during the medication period for lactating women.
Allergic reactions and contraindications:
Allergic reactions: It is contraindicated for individuals allergic to meropenem or other carbapenem antibiotics. Before taking medication, it is necessary to inquire about the history of allergies in detail and conduct a skin test (especially for those with a history of beta lactam allergies).
Drug interactions:
Probenecid: can reduce the plasma clearance rate of meropenem, prolong its half-life, and require dosage adjustment.
Antiepileptic drugs such as sodium valproate and Meropenem Powder may reduce their blood drug concentration and increase the risk of epileptic seizures, and should be avoided in combination.
Vaccine: When used together with live typhoid vaccine, it may interfere with the immune response and should be separated by at least 3 days.
Adverse reaction monitoring:
Common adverse reactions: allergic reactions such as rash and itching. Gastrointestinal reactions such as nausea, vomiting, and diarrhea. Abnormal liver function (such as elevated ALT and AST). Local reactions such as pain and swelling at the injection site.
Serious adverse reactions: neurological symptoms (such as seizures, consciousness disorders), especially in cases of renal insufficiency or high-dose medication. Pseudomembranous colitis (Clostridium difficile infection) requires immediate discontinuation of medication and treatment with vancomycin or metronidazole.
Frequently Asked Questions
What is meropenem used for?
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Meropenem may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection. Treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above.
What is meropenem used for?
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Meropenem is a powerful, broad-spectrum carbapenem antibiotic. It is primarily used to treat severe, complicated, or multi-drug resistant bacterial infections. Administered intravenously in a hospital or clinical setting, it acts by destroying bacterial cell walls.
How do we mix meropenem?
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If the meropenem 500mg vial is available (preferred): STEP ONE: Add 9.6mL of water for injection to the meropenem 500mg vial and shake gently to dissolve (total volume of 10mL). The resulting solution contains 50mg/mL meropenem.
What bacteria is killed by meropenem?
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Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.
What are the serious side effects of meropenem?
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This medicine may cause seizures, confusion, headaches, numbness or tingling sensation. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Do not take other medicines unless thy have been discussed with your doctor.
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