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Pramiracetam Powder (chemical name: N - [2- (diisopropylamino) ethyl] -2-oxo-1-pyrrolidine acetamide) is an artificially synthesized nootropic drug belonging to the Racetam class of drugs. The appearance is usually white or off white crystalline powder, odorless, bitter in taste, easily soluble in organic solvents (such as DMSO, ethanol), slightly soluble in water, stable under dry and cool conditions, and needs to be stored away from light.
It can promote the uptake of choline by presynaptic neurons, thereby increasing the synthesis and release of acetylcholine and enhancing cognitive function. May affect the activity of neurotransmitters such as dopamine and serotonin, improve mood and attention. It can increase blood flow to the cerebral cortex and hippocampus, promote glucose metabolism, and improve energy utilization efficiency.
It is also possible to optimize receptor function and signal transduction by altering the fluidity of neural cell membranes. It is used to improve memory, learning ability, and attention, especially for cognitive decline caused by aging, brain injury, or neurological disorders. In animal experiments, it has been shown to have a protective effect on brain ischemia, hypoxia, and other injuries, which may be achieved through antioxidant and anti-inflammatory mechanisms. There is still research exploring its potential as an adjuvant therapy for mental disorders such as depression and anxiety, but clinical evidence is not yet sufficient. It serves as a tool drug for neuroscience research, used to explore the molecular mechanisms of learning and memory.
At the same time, our company not only provides pure powders, but also tablets and injections. If needed, please feel free to contact us at any time.
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Additional information of chemical compound:
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Product Name |
Pramiracetam Supplement |
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Product Type |
Powder |
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Product Purity |
100g/1kg/etc. |
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Product Form |
Organic synthesis |
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Pramiracetam COA
Pramiracetam Powder is a synthetic intelligence enhancing drug belonging to the Racetam drug family. Since its development in the 1970s, it has received widespread attention for its potential improvement in cognitive function. The following is a detailed explanation of its purpose:
Improve cognitive function
Pramiracetam has shown significant effects in improving memory and learning abilities. Multiple studies have shown that both healthy adults and individuals with cognitive impairment have improved memory and learning abilities after receiving Pramiracetam treatment. For example, in animal experiments, Pramiracetam has been shown to enhance spatial learning and memory abilities in rats. In human research, it has also been reported that Pramiracetam can improve memory and attention in older adults.
Pramiracetam not only contributes to the formation and consolidation of short-term memory, but may also have a positive impact on the retention and retrieval of long-term memory. This is particularly important for students and professionals who need to memorize a large amount of information for a long time. By improving attention and focus, Pramiracetam can help individuals absorb and process information more efficiently, thereby enhancing learning efficiency.
This is particularly important for students and professionals who need to memorize a large amount of information for a long time. By enhancing attention and focus, Pramiracetam can help individuals absorb and process information more effectively, thereby improving learning efficiency. In modern society, distraction and lack of concentration are problems faced by many people.
Pramiracetam helps improve an individual's attention and attention levels by regulating the neurotransmitter system and improving cerebral blood flow. This is particularly important for tasks that require prolonged concentration, such as studying or working. Helps reduce the impact of external distractions on attention, allowing individuals to focus more on the current task. By improving focus, Pramiracetam can help individuals complete tasks more effectively and reduce error rates.
In modern society, distraction and lack of focus are problems faced by many people. Pramiracetam helps improve an individual's attention and concentration levels by regulating the neurotransmitter system and improving cerebral blood flow. This is particularly important for tasks that require long periods of focused attention, such as studying or working. Pramiracetam may help reduce the impact of external interference on attention, allowing individuals to focus more on the current task. By improving focus, Pramiracetam can help individuals complete tasks more efficiently and reduce error rates.
Traumatic brain injury may cause damage to the structure and function of the brain, leading to cognitive dysfunction. Pramiracetam helps restore impaired cognitive function by promoting the release of neurotransmitters and information transmission between neurons. Pramiracetam has been explored as a potential therapeutic drug in research on neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, etc. Although there is currently insufficient evidence for its clinical application in these diseases, animal experiments and preliminary clinical trials suggest that it may slow down disease progression and improve cognitive function through mechanisms such as antioxidant, anti-inflammatory, and neuroprotective effects.
Pramiracetam Powder may also help improve brain adaptability and flexibility. This means that individuals are able to adjust their cognitive strategies and behavioral patterns more quickly when facing new environments, tasks, or challenges. Pramiracetam may help enhance an individual's cognitive flexibility, enabling them to respond more flexibly to different cognitive tasks and requirements. Pramiracetam may help individuals adapt and integrate into new environments or situations more quickly, reducing cognitive stress caused by environmental changes.
neuroprotection
Mechanism of neuroprotective effect
Pramiracetam can significantly enhance the uptake of choline by presynaptic neurons, which is a key step in acetylcholine synthesis. Acetylcholine is an important neurotransmitter in the brain, closely related to cognitive functions such as learning, memory, and attention. By increasing the synthesis and release of acetylcholine, Pramiracetam not only improves cognitive function, but may also exert neuroprotective effects by maintaining the balance of the neurotransmitter system. In addition to acetylcholine, Pramiracetam may also affect other neurotransmitter systems such as dopamine and serotonin.
These neurotransmitters play important roles in regulating emotions, motivation, cognitive function, and neuroprotection. By regulating the activity of these neurotransmitters, Pramiracetam may help alleviate neuronal damage, promote nerve repair and regeneration. Pramiracetam can increase blood flow in the cerebral cortex and hippocampus, which are critical areas of the brain responsible for learning and memory. At the same time, it can also promote glucose metabolism, improve energy utilization efficiency, thereby helping to improve cognitive function of the brain and exert neuroprotective effects. The increase in cerebral blood flow and improvement in metabolism help provide neurons with sufficient oxygen and nutrients, reducing the damage to neurons caused by ischemia and hypoxia.
Mechanism of neuroprotective effect
Oxidative stress and inflammatory response are important factors leading to neuronal damage and neurodegenerative diseases. Pramiracetam may alleviate brain damage caused by oxidative stress and inflammatory response through antioxidant and anti-inflammatory mechanisms. For example, it may protect neurons from oxidative stress and inflammatory response attacks by clearing free radicals, inhibiting the release of inflammatory mediators, and other pathways. Neuronal apoptosis is a common phenomenon in neurodegenerative diseases and brain injuries. Pramiracetam may reduce neuronal death by inhibiting neuronal apoptosis pathways, such as regulating the expression of Bcl-2 family proteins and inhibiting caspase enzyme activity. This helps maintain the number and function of neurons, thereby exerting neuroprotective effects.
Multiple animal experiments have shown that Pramiracetam can improve cognitive impairment and neuronal damage caused by traumatic brain injury. For example, in a rat model of traumatic brain injury, Pramiracetam has been shown to enhance spatial learning and memory abilities, and alleviate damage to hippocampal neurons. These results indicate that Pramiracetam has potential application value in neuroprotection and cognitive recovery after traumatic brain injury. Pramiracetam also exhibits neuroprotective effects in animal models of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, etc. For example, in a rat model of Alzheimer's disease, Pramiracetam has been shown to improve memory impairment and alleviate amyloid deposition and neuronal damage in the brain. These findings provide experimental evidence for the application of Pramiracetam in the treatment of neurodegenerative diseases.
For example, in a rat model of middle cerebral artery occlusion, Pramiracetam can improve cerebral blood flow, alleviate neuronal apoptosis, and promote the recovery of neurological function.Traumatic brain injury is a common cause of neuronal damage and cognitive dysfunction. Pramiracetam Powder has potential application value in neuroprotection and cognitive recovery after traumatic brain injury. Future clinical trials can further evaluate the efficacy and safety of Pramiracetam in patients with traumatic brain injury, providing a basis for its widespread clinical application. Neurodegenerative diseases are a type of disease characterized by progressive neuronal death and cognitive decline.
Although there is currently insufficient evidence on the clinical application of Pramiracetam in neurodegenerative diseases, animal experiments and preliminary clinical trials suggest that it may slow down disease progression and improve cognitive function through mechanisms such as antioxidant, anti-inflammatory, and neuroprotective effects. Future research can further explore the optimal dosage, duration, and combination therapy of Pramiracetam in the treatment of neurodegenerative diseases.
Frequently Asked Questions
Which receptor does it "attack" in the brain? Why is it called a 'ghost'?
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It is indeed a 'ghost' because it does not directly attack any classical receptors. Research has confirmed that it has no affinity for dopaminergic, serotonergic, GABAergic, adrenergic, muscarinic, adenosine (IC50>10 μ M), or even benzodiazepine receptors (IC50>1 μ M). Its mechanism of action is still a mystery, and it is believed to indirectly enhance neurotransmission by regulating ion channels (such as enhancing calcium and sodium influx) or affecting neurotransmitter metabolism.
Is the improvement of memory treated equally? Which is more effective, long-term or short-term memory?
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No, it prefers long-term memory (reference memory). In the rat eight arm maze experiment, Praxitan significantly improved the animal's learning ability for fixed patterns (which arm always had food), namely reference memory; But it has no significant impact on the working memory that needs to be updated in real-time (which arm has just been there). This suggests that it may primarily function in the consolidation and storage of memory, rather than temporary processing.
Does its blood drug concentration peak come quickly? Why are there huge differences between people?
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The peak time after oral administration is about 2-3 hours. But it has a significant characteristic: significant individual differences. A pharmacokinetic study showed that its half-life varied from 2 hours to 8 hours among different subjects, and individual differences in plasma concentration and area under the drug time curve were also significant. This indicates that different people have vastly different metabolic abilities towards it.
What is the relationship between it and scopolamine? Can it detoxify?
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It can reverse the cholinergic transport disorder caused by scopolamine, but not directly detoxify. Scopolamine can disrupt the transport of choline through the blood-brain barrier, while continuous administration of Praxitan (100 mg/kg/d) for 14 days can completely prevent this disorder and increase cerebral blood flow. This suggests that it may protect the cholinergic system by regulating the function of cerebral vascular endothelial cells.
Is it effective for Alzheimer's disease? Why is clinical trial "high opening and low going"?
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It is basically ineffective and there is a "dose-response paradox". Animal experiments have shown that it has an inverted U-shaped dose-response curve (either too low or too high a dose is not effective). In the enrichment design of 10 Alzheimer's disease patients, although 8 cases found the "optimal dose" in the dose exploration stage, only 2 cases improved again in the subsequent repeated validation stage, and PET scans showed no changes in brain metabolism. The conclusion is that doses up to 4000mg/day are unlikely to bring about symptom improvement.
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