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Aniracetam Powder is a cognitive enhancing drug (Nootropical) belonging to the Racetam class, with a chemical structure similar to Piracetam but stronger effects. It was initially developed by Swiss company Hofmann Roche in the 1970s as a potential cognitive improvement drug for research.
The appearance is usually white to off white crystalline powder, slightly soluble in water but easily soluble in organic solvents (such as ethanol, DMSO).This characteristic requires special attention to solvent selection when preparing solutions or formulations in the laboratory. There is no obvious odor, and if a pungent odor appears, it may indicate that the drug has deteriorated or been contaminated. It enhances the activity of AMPA type glutamate receptors, promotes glutamatergic neurotransmission, and may improve learning and memory function. Increase the release of acetylcholine, a neurotransmitter closely related to cognitive function. Regulating the release of dopamine and serotonin may affect mood and attention. It can be used for memory and cognitive decline caused by conditions such as Alzheimer's disease and vascular dementia, as well as for cognitive and functional recovery after stroke and traumatic brain injury. Its dosage form is usually taken orally in tablet or capsule form.
At the same time, our company not only provides pure powders, but also tablets and injections. If needed, please feel free to contact us at any time.
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Additional information of chemical compound:
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Aniracetam COA
Aniracetam Powder is a compound with a wide range of pharmacological effects and potential clinical application value, belonging to the family of laxitan drugs. The following will elaborate on the uses of Aniracetam from multiple perspectives:
Improve cognitive function
Alzheimer's disease, mainly including Alzheimer's disease, is a common neurodegenerative disease. With the aging of the population, its incidence rate is on the rise. The main symptoms of the patient include decreased memory, cognitive function, and impaired daily living abilities, which seriously affect the patient's quality of life and family burden. Aniracetam has a significant improvement effect on cognitive function in elderly dementia patients. For example, a clinical trial showed that 27 patients with vascular dementia took orally Aniracetam 0.6g every day for 8 consecutive weeks, and their memory quotient (81 points) was significantly higher after treatment than before treatment (75 points). At the same time, the total effective rate of Aniracetam is 75-90%, with minimal toxic side effects and an adverse reaction rate of about 3.5%. The main symptoms include headache, insomnia, anxiety, gastrointestinal discomfort, etc. After discontinuation, the symptoms can be relieved on their own, and no serious adverse reactions such as liver or kidney function damage have been found. Compared with similar drugs such as piracetam, Aniracetam has the characteristics of low dosage (about 1/8 of piracetam) and high efficacy, and its effect is 5-10 times stronger than piracetam. In addition, Aniracetam is a lipophilic drug that is more likely to enter the central nervous system through the blood-brain barrier to exert therapeutic effects, while piracetam is water-soluble and more difficult to enter the central nervous system than Aniracetam.
Improving cognitive function in the aftermath of brain injury
Brain injuries include cerebral hemorrhage, traumatic brain injury, cerebral thrombosis, etc. These diseases can cause damage to brain tissue, affecting the function of neurons and synaptic transmission, leading to cognitive impairment, motor impairment, and other sequelae. Patients may experience symptoms such as memory loss, lack of concentration, and delayed thinking, which seriously affect their daily life and work abilities. In clinical practice, Aniracetam is widely used to treat cognitive impairment caused by sequelae of brain injury. Many patients have experienced some degree of improvement in cognitive function, such as enhanced memory and improved attention, after taking Aniracetam. For example, for patients with memory impairment after stroke, Aniracetam can help them restore partial memory ability and improve their quality of life.
Factors such as hypoxia and alcohol poisoning can lead to impaired brain function and symptoms such as cognitive impairment. Hypoxia can affect the energy metabolism and neurotransmitter release in the brain, leading to neuronal dysfunction; Alcohol poisoning can have toxic effects on nerve cells in the brain, damaging the structure and function of neurons, leading to cognitive impairments such as memory loss, lack of concentration, and decreased thinking ability. In clinical practice, Aniracetam Powder is used to treat cognitive impairment caused by hypoxia and alcohol poisoning. Aniracetam can help improve memory and thinking abilities in patients with cognitive decline caused by hypoxia, such as carbon monoxide poisoning and suffocation. For patients with alcohol poisoning, long-term heavy drinking can lead to brain damage and cognitive impairment. Aniracetam can promote brain recovery and repair, and alleviate symptoms of cognitive impairment.
Adjuvant therapy for Attention Deficit Hyperactivity Disorder (ADHD)
Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder characterized by lack of concentration, hyperactivity, and impulsive behavior. These symptoms can affect patients' learning, work, and life, leading to decreased academic performance, low work efficiency, and tense interpersonal relationships. Although there are relatively few clinical studies on the treatment of ADHD with Aniracetam, some preliminary research results indicate that Aniracetam has a certain adjuvant therapeutic effect on some ADHD patients. It can improve patients' concentration, reduce hyperactivity and impulsive behavior, and enhance their learning and quality of life. However, more large-scale, multicenter clinical studies are needed to further validate its efficacy and safety.
As people age, middle-aged and elderly individuals may experience benign memory impairment, manifested as symptoms such as memory loss and forgetfulness. This type of memory impairment usually does not seriously affect daily living abilities, but it can cause certain difficulties for patients and affect their quality of life. In clinical practice, Aniracetam is used to improve benign memory impairment in middle-aged and elderly patients. Many middle-aged and elderly patients feel that their memory has improved and their forgetfulness symptoms have been relieved after taking Aniracetam. For example, some patients are able to remember daily affairs, the names of family and friends more clearly, and their quality of life is significantly improved.
Treating delayed brain development in children
Delayed brain development in children refers to the phenomenon where the speed of brain development lags behind that of normal children of the same age during their growth and development process. This may lead to problems such as intellectual disability, poor learning ability, and delayed motor development in children, seriously affecting their future development and quality of life. Aniracetam has a certain therapeutic effect on children with delayed brain development. However, due to the different physiological characteristics and drug metabolism of children compared to adults, it is necessary to strictly follow the doctor's advice when using Aniracetam, control the dosage and course of treatment to ensure the safety and effectiveness of the drug.
Emotional regulation
Aniracetam Powder can enhance the anti hypoxia ability of the cortex, prevent learning and memory loss caused by various chemicals, hypercapnia, scopolamine, or electroconvulsive therapy, and may also alleviate emotional stress reactions. When facing emotional stress, the metabolic demands of the brain increase, which can lead to situations such as hypoxia. Aniracetam enhances the cortex's ability to resist hypoxia, helps protect brain neurons from stress-induced damage, maintains normal brain function under stress, thereby reducing emotional stress responses and maintaining emotional stability.
Although there is currently relatively little research on the direct effects of Aniracetam on stress hormone levels, it may indirectly regulate the secretion of stress hormones by improving brain function and neurotransmitter systems. For example, by regulating the function of the hypothalamic pituitary adrenal axis (HPA axis), excessive secretion of stress hormones such as cortisol can be reduced. High levels of cortisol are associated with emotional instability, anxiety, and depression, and Aniracetam regulates stress hormone levels to help maintain emotional stability.
Regulation of neurotransmitters
Aniracetam can promote the release of dopamine and serotonin. Dopamine and serotonin are neurotransmitters closely related to emotion regulation. Dopamine is involved in the brain's reward system and motivation regulation, while serotonin is associated with emotional stability, sleep, and appetite. In patients with depression, there is often an imbalance in dopamine and serotonin levels. Aniracetam helps restore the balance of neurotransmitters in the brain by increasing the release of these two neurotransmitters, thereby improving depression related emotional symptoms such as low mood and decreased interest. In addition to affecting the dopamine and serotonin systems, Aniracetam's regulation of the glutamate system may also play a role in improving depressive symptoms. The dysfunction of the glutamate system is related to the pathogenesis of depression. Aniracetam, as a positive allosteric modulator of AMPA receptors, slows down receptor inactivation and enhances glutamatergic neurotransmission, which may help improve brain neuroplasticity and function, and alleviate symptoms of depression.
adverse reaction
Aniracetam (Aniracetam) is a type of antipsychotic drug, chemically named 1- (4-methoxybenzoyl) -2-pyrrolidone, with a molecular formula of C ₁ ₂ H ₁ ∝ NO ∝ and a molecular weight of 219.24. As a positive allosteric modulator of AMPA receptors, it exhibits anti anxiety, neuroprotective, and cognitive enhancing effects by slowing down receptor inactivation and acting on D2 receptors, 5-HT2A receptors, and nicotinic acetylcholine receptors (nAChRs). Despite its broad clinical application prospects, monitoring and management of adverse reactions are the core components to ensure medication safety.
Common adverse reactions and clinical characteristics
Neurological response
Dizziness and drowsiness: The incidence rate is about 15% -20%, which is more common in the early stages of medication or when the dosage is too high. The mechanism may be related to the imbalance of GABAergic system regulation, manifested as attention deficit and delayed response.
Insomnia: About 8% -12% of patients report difficulty falling asleep or waking up early, which may be related to the activation of the dopaminergic system leading to disrupted circadian rhythms.
Contradictory anxiety: Some patients (about 5%) experience worsening anxiety after medication, which may be related to incomplete 5-HT2A receptor antagonism or excessive glutamatergic excitation.
Emotional instability: manifested as irritability and depression, which needs to be distinguished from underlying mental illnesses.
Digestive system reactions
Dry mouth: The incidence rate is as high as 30%, and the activation of acetylcholine receptors leads to a decrease in salivary gland secretion, which can seriously affect swallowing function.
Appetite loss: About 20% of patients report weight loss, which may be related to abnormal regulation of the hypothalamic feeding center.
The incidence rate is about 10% -15%, and the mechanism involves inhibition of cholinergic receptors in intestinal smooth muscle and dysbiosis of intestinal microbiota.
Metabolic and Nutritional Disorders
Long term medication may lead to:
Reduced absorption of vitamin B12: due to inhibition of gastric acid secretion affecting cytokine binding;
Abnormal vitamin D metabolism: may be related to changes in 25 hydroxylase activity induced by liver enzymes.
Rare but cautious:
Hyponatremia: may be associated with Syndrome of Abnormal Antidiuretic Hormone Secretion (SIADH);
Hyperkalemia: seen in patients with renal insufficiency, potassium ion retention is caused by delayed drug excretion.
Allergic reactions
Rash: The incidence rate is about 3% -5%, mostly maculopapular, which can disappear on its own after discontinuation of medication;
Vascular neuroedema: rare but severe, requiring immediate discontinuation of medication and treatment with adrenaline.
Allergic shock: extremely rare but fatal, characterized by sudden drop in blood pressure and difficulty breathing, requiring emergency rescue.
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