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Pure creatine powder is a nitrogen-containing organic acid with the chemical formula C4H9N3O2. It is a light yellow liquid. In biochemistry, it is a nitrogen-containing organic acid that naturally exists in vertebrates and can help provide energy for muscles and nerve cells. Michel Eug è ne Chevreul first discovered creatine in skeletal muscle in 1832, and later named it "Creatine" based on the Greek word "Kreas" (meat). Creatine is present in foods such as fish and meat, but its content is very low (half a kilogram of meat can only provide 1 gram of creatine). An endogenous amino acid metabolite that plays an important role in cellular energy, especially in muscles and the brain. It can quickly provide energy (the various activities of the human body rely on ATP, which is adenosine triphosphate, to provide energy, and the storage of ATP in the human body is very small. During exercise, ATP is quickly depleted, and creatine can quickly synthesize ATP to supply energy). The storage of adenosine triphosphate in the human body is very low and requires continuous synthesis, but the body's synthesis speed is very slow, which causes fatigue in the body. Therefore, timely supplementation of creatine can effectively improve muscle strength, speed, and endurance. Improve physical fitness and training level to prevent fatigue.
|
C.F |
C4H9N3O2 |
|
E.M |
131 |
|
M.W |
131 |
|
m/z |
131 (100.0%), 132 (4.3%), 132 (1.1%) |
|
E.A |
C, 73.97; H, 4.14; O, 21.89 |
If the family environment allows, patients with progressive muscular dystrophy can take creatine under the guidance of a doctor, and the dosage should not be excessive or arbitrarily increased to prevent side effects and drug resistance caused by excessive use. Pure Creatine Powder is the energy source for explosive force movements. So it is best to take it after exercise and exercise. After exercise, a large amount of adenosine triphosphate is consumed. Taking creatine can help the body accelerate the production and supplementation of adenosine triphosphate, which can effectively improve muscle strength, speed, and endurance. If one does not exercise, taking adenosine triphosphate before it is consumed will not achieve the effect of supplementation, and the effect will be worse. The demand for adenosine triphosphate during muscle exercise is hundreds of times higher than during rest. The greater the amount of exercise, the greater the consumption of adenosine triphosphate. The storage of adenosine triphosphate in the human body is very low and requires continuous synthesis, but the body's synthesis speed is very slow, which causes fatigue in the body. Therefore, timely supplementation of creatine can effectively improve muscle strength, speed, and endurance. Improve physical fitness and training level to prevent fatigue.
Make a substitute for creatine
A substitute for creatine. If the family environment does not allow for progressive muscular dystrophy, patients can also take ATP (adenosine triphosphate), a substance produced by creatine, under the guidance of a doctor. Its function is similar to creatine, which provides energy to muscle cells and can help muscles recover from fatigue. It is also a nutritional drug, and it is best to take it after exercise and exercise, for similar reasons as taking creatine. And the price is much cheaper, with 100 pieces usually priced under 30 yuan. If combined with other nutritional and cell protective drugs, the effect may be better. But it should be taken under the guidance of a professional doctor. For example, vitamin E that protects cell membranes, ATP, BT that nourishes and increases muscle cell energy, and various coenzymes. The biphenyl lipid, which lowers enzymes, has a stabilizing effect on the muscle cell membrane, can reduce muscle cell necrosis, protect the muscle cell membrane from enzyme leakage caused by damage, and is inexpensive. However, due to side effects, it should be taken for 20 days and stopped for 10 days, and the dosage should be strictly controlled under the guidance of a doctor, and it should not be taken year-round.
If creatine is taken after exercise and exercise, and the product adenosine triphosphate is not consumed before exercise, it will not achieve the effect of supplementation and the effect will be worse. If you can walk and exercise, you can use it. If you can't walk, you can use ATP (adenosine triphosphate) directly, which is cheaper. Creatine is a nutritional energy drug with no therapeutic effect. This should be clear, and hot water should not be used as it can damage creatine. Take and mix cold water before exercising to have a nutritional effect.
synthetic route
There are three different processes for preparing pure creatine powder from lime nitrogen:
01
Lorem ipsum dolor sit amet consectetur adipisicing elit.Calcium nitrogen reacts with sodium sarcosine aqueous solution to produce creatine directly.
02
Lime nitrogen reacts with methanol solution saturated with dry hydrogen chloride gas to obtain O-methylisourea hydrochloride, and O-methylisourea hydrochloride reacts with sarcosine to obtain creatine.
03
Lime nitrogen and hydrochloric acid aqueous solution generate chloroformamidine chloride under the condition of air, and then react with sodium sarcosine to obtain creatine.
The operation method is as follows: add 3.3mol urea and 6mL 50% H2SO4 into a 500mL four necked flask with agitator, thermometer, dropping funnel and condenser, heat it to 40 ℃, add 3mol dimethyl sulfate drop within 3h under mixing, control the temperature within 70 ℃ during feeding, mix it at 70 ℃ for 2h after feeding, and obtain 561.8g of O-methylisourea sulfate after cooling. Add 61.7g of 36% sodium sarcosine aqueous solution into a 500mL four necked flask equipped with agitator, thermometer, dropping funnel and condenser, adjust the pH to about 11. 0 with 30% HCl, and then add 50.0g of O-methylisourea sulfate drop within 2h at 20 ℃. Adjust the pH to about 11.0 with 25% NaOH solution during the drop adding process. After the drop adding, continue to stir at 40 ℃ for 2h, and then cool the mixture at 0~5 ℃ for 2h, filtering out the colorless crystals formed. Use 2 × Wash the filter cake with 15mL ice water to obtain crude creatine monohydrate. Put the crude product into a beaker, add 7-8 times of the amount of water in the crude product, heat it until it is completely dissolved, slowly cool the liquid at room temperature, crystallize, filter out crystals, and dry it below 50 ℃ to obtain the finished creatine monohydrate.
Creatine is a substance synthesized by arginine, glycine and methionine. It can be synthesized by the human body itself or ingested from food. Creatine, a naturally occurring amino acid derivative in human body, can rapidly increase muscle strength, accelerate fatigue recovery and improve explosive force. The more creatine is stored in the body, the stronger the strength and exercise ability are. It can not only provide energy quickly (various activities of the human body rely on ATP, that is, adenosine triphosphate, to provide energy, but the storage of ATP in the human body is very small. ATP is quickly consumed during exercise, and creatine can quickly synthesize ATP to supply energy). It can also increase strength, muscle and fatigue recovery. The more Pure Creatine Powder is stored in the human body, the more sufficient the energy supply is, the faster the fatigue recovery is, and the stronger the exercise energy is.
The discovery of Creatine can be traced back to early 19th century France. In 1832, the famous chemist Michel Eug è ne Chevreul first isolated a crystalline substance from skeletal muscle while analyzing meat extracts, and named it "creativity" (derived from the Greek word "kreas", meaning "meat"). This discovery marks the beginning of human research on muscle energy metabolites.
In 1847, German scientist Justus von Liebig further confirmed the widespread presence of creativity in mammalian muscle tissue and discovered its chemical formula as C ₄ H ₉ N ∝ O ₂. He also observed that when cooking meat, some creatine is converted into creatinine, which is a byproduct of creatine metabolism.
At the beginning of the 20th century, scientists began to study the role of creativity in energy metabolism:
In 1926, Otto Folin and Willey Glover Denis from Harvard University discovered that after the human body ingests creatine, most of it is stored in the muscles and may participate in energy supply.
In 1927, Fiske and Subbarow discovered phosphocreatine (PCr) and demonstrated its ability to rapidly regenerate ATP (adenosine triphosphate) during muscle contractions, providing energy for short-term high-intensity exercise.
In the 1930s and 1950s, creativity began to be explored for use in the fields of medicine and sports
Soviet scientists studied the impact of creativity on athletes after World War II and found that it may increase explosive power.
In the 1960s, medical research discovered that creatine could be used to treat certain muscle atrophy diseases, but due to its high extraction cost, it has not yet been widely applied.
Early creativity was mainly extracted from animal muscles, which was inefficient and costly. In the late 20th century, breakthroughs in chemical synthesis methods made large-scale production of creatine possible
In the 1970s, German scientists developed the creatinine reduction method, which allowed for industrial synthesis of creatinine.
In the 1990s, the more efficient Sarcosine+Cyanamid synthesis method was widely used, resulting in a purity of over 99% for creatine.
In 1992, Clinical Science published a milestone study demonstrating that supplementation with creatine can significantly increase muscle phosphocreatine levels and enhance athletic performance. Afterwards, Pure Creative Powder quickly became an essential supplement for athletes and fitness enthusiasts:
In 1993, the American company Experimental and Applied Sciences (EAS) launched the first commercial lotion supplement, Phosphaten.
In 1996, MuscleTech launched "Cell Tech", which combined creativity with carbohydrates to further enhance absorption rates.
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