Rosmarinic acid powder, also known as casein, cinnamic acid, or rhodanic acid, is an organic compound that appears as a light yellow to brown powder at low concentrations and a white powder at high concentrations. It has a unique herbal aroma of rosemary, a melting point of 171-175 ℃, and a boiling point of 694.7 ± 55.0 ℃. It is a water-soluble substance with good temperature stability but is sensitive to light. It was originally isolated from the plant rosemary in the family Lamiaceae. It has strong antioxidant and antibacterial activity, and is often used as a food preservative to improve the shelf life of fresh seafood.
Additional information of chemical compound:
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Chemical Formula |
C18H16O8 |
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Exact Mass |
360.08 |
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Molecular Weight |
360.32 |
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m/z |
360.08 (100.0%), 361.09 (19.5%), 362.09 (1.8%), 362.09 (1.6%) |
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Elemental Analysis |
C, 60.00; H, 4.48; O, 35.52 |
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Melting point |
171-175 °C (lit.) |
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Boiling point |
694.7±55.0 °C(Predicted) |
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Density |
1.33 |
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Storage conditions |
2-8℃ |
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Rosmarinic acid is a natural phenolic acid compound widely found in plants such as the Lamiaceae and Verbenaceae families. Its chemical structure is formed by the condensation of caffeic acid and 3,4-dihydroxyphenyllactic acid, with a molecular formula of C ₁₈ H ₁₆ O ₈ and a molecular weight of 360.315. With its strong antioxidant, antibacterial, anti-inflammatory, and flavor regulating properties, it has become an indispensable natural additive in the food industry, widely used in fields such as preservation, flavor enhancement, health function enhancement, and special food development.
Core function: Natural antioxidant and anti-corrosion preservation
1. Oxidation protection of oily foods
By competitively binding to lipid peroxide groups, the free radical chain reaction is terminated, significantly inhibiting lipid oxidation and rancidity. Adding 0.02% -0.05% rosmarinic acid to animal and vegetable oils, fried foods, and nut products rich in unsaturated fatty acids can extend shelf life while maintaining product color and flavor. For example, Japanese companies use perilla extract (containing rosmarinic acid) for fresh seafood packaging, which extends the shelf life of fresh products such as salmon by 3-5 days by inhibiting microbial growth and oxidation reactions.
2. Preservation and Quality Improvement of Meat Products
In processed meat products such as sausages and ham, it can inhibit the rancid taste produced by fat oxidation, and also suppress the proliferation of pathogenic bacteria such as Staphylococcus aureus and Escherichia coli by disrupting the permeability of bacterial cell membranes. Experimental data shows that after storing beef jerky with 0.1% rosmarinic acid at 25 ℃ for 28 days, the peroxide value decreased by 62% compared to the control group, and the total bacterial count decreased by 4 orders of magnitude. In addition, it can also break down collagen in muscle fibers, improve meat tenderness, and enhance taste.
3. Stability and flavor optimization of baked goods
In baked goods such as bread and cake, by inhibiting the oxidative cross-linking of gluten in flour, preventing dough hardening, the volume of the finished product increases by 10% -15%, and the tissue structure becomes finer. At the same time, its unique herbal aroma can mask the odor caused by oil oxidation and enhance the flavor level of the product. For example, after adding rosmarinic acid to a certain brand of whole wheat bread, consumer sensory ratings showed a 23% increase in "aroma pleasure".
Flavor enhancement: natural spices and seasonings
1. Enhancing the aroma and freshness of soup ingredients and seasonings
It has a unique fresh herbal aroma, which can replace part of the synthetic essence and be used in soup, sauce and seasoning powder. When combined with spices such as black pepper and basil, it can synergistically enhance flavor complexity. For example, adding 0.05% rosmarinic acid to Italian tomato sauce can balance the sour and sweet flavors and enhance the aftertaste.
2. Improvement in taste and stability of beverages
In fruit juice, tea drinks, and functional drinks, not only can it prevent the oxidation and degradation of nutrients such as vitamin C, but it can also inhibit the formation of turbidity and precipitation by chelating metal ions (such as Fe ³ ⁺). After adding rosmarinic acid to a certain brand of orange juice, it remained clear and transparent even after being stored at 4 ℃ for 6 months, with a vitamin C retention rate of 92%, while the control group only had 68% remaining.
3. Texture protection of frozen food
In quick-frozen dumplings, rice dumpling and other products, prevent the products from cracking or hardening after thawing by inhibiting the retrogradation of starch. Experiments have shown that after storing frozen dumpling skins with 0.03% rosmarinic acid at -18 ℃ for 3 months, the steaming loss rate is reduced by 18% compared to the control group, and the taste toughness is improved.
What are the side effects?
Allergic reactions
It is safe for most people, but some may be allergic to it. Allergic reactions may include symptoms such as headache, nausea, vomiting, abdominal pain, and skin redness and swelling. Therefore, before using this organic compound, it is recommended to undergo a skin test or consult a doctor to ensure that you will not develop allergic reactions to it.
Gastrointestinal discomfort
Long term intake of high amounts of this substance may cause some degree of interference to the digestive system. This may manifest as symptoms such as stomach pain, heartburn, bloating, and gastrointestinal discomfort. Especially for those who already have digestive system problems, their intake should be restricted.
Affects red blood cells and blood
Some studies have also found that long-term or excessive intake of this organic compound may have an impact on the human blood. This may lead to a decrease in red blood cell count, impaired platelet function, etc. Although this situation is generally rare, it may pose certain risks for some individuals, such as anemic patients.
Liver burden
Its metabolism mainly occurs in the liver. Therefore, long-term intake of large amounts of this substance may impose a certain burden on the liver. This may lead to impaired liver function, and even cause problems such as hepatitis and liver dysfunction. Especially for those who already have liver disease or impaired liver function, caution should be exercised when using this organic compound.
Affects vitamin absorption
Excessive intake may interfere with the body's absorption of vitamins. For example, it may reduce the absorption rate of vitamin C, thereby lowering the body's effective intake of vitamin C. Therefore, when consuming foods or supplements containing this organic compound, attention should be paid to pairing them with other vitamin rich foods to ensure that the body receives sufficient vitamins.
Other potential risks
In addition to the aforementioned side effects, it may also interact with other drugs or compounds, leading to increased or decreased efficacy. Therefore, it is recommended to consult a doctor or pharmacist before use to ensure compatibility with other medications or supplements.
What drugs do Rosmarinic acid powder interact with?
As a natural compound with multiple pharmacological effects, it may interact with certain drugs when used together, affecting their efficacy or increasing the risk of adverse reactions. Here are some drug categories and precautions that may interact with it:
Anticoagulants
- It may have a certain anti platelet aggregation effect, so when used together with anticoagulant drugs such as warfarin, heparin, etc., it may increase the risk of bleeding.
- During use, if anticoagulants need to be taken simultaneously, consult a doctor and closely monitor coagulation function.
Antihypertensive drugs
- It has a certain antihypertensive effect, so when used together with antihypertensive drugs such as diuretics, ACE inhibitors, ARBs, etc., it may lead to low blood pressure.
- Hypertensive patients should regularly monitor their blood pressure and adjust the dosage of antihypertensive drugs as needed when using this organic compound.
Immunosuppressant
- It has immunomodulatory effects and may affect the efficacy of immunosuppressants such as cyclosporine and tacrolimus.
- When using immunosuppressants, if it is necessary to take the substance, consult a doctor and closely monitor immune function.
Chemotherapy drugs
- It has anti-cancer effects and may have synergistic or antagonistic effects with chemotherapy drugs.
- Cancer patients who need to use it as adjuvant therapy during chemotherapy should consult a specialist oncologist to ensure that the efficacy of chemotherapy drugs is not affected.
Sedative hypnotics
- It may have a certain neuroprotective effect, but it may also interact with sedative hypnotic drugs (such as benzodiazepines, non benzodiazepines, etc.), affecting sleep quality and drug metabolism.
- When using sedative hypnotic drugs, if it is necessary to take the substance, consult a doctor and closely monitor sleep quality and medication side effects.
Other drugs
- It may also interact with other medications such as hypoglycemic drugs, antidepressants, etc., and the specific effects vary depending on the type of medication and individual differences.
- During use, if other medications need to be taken simultaneously, please consult a doctor or pharmacist to ensure proper management of drug interactions.
Storage method
Temperature control: It should be stored in a low-temperature environment of 2 ℃ -8 ℃. This is to maintain its chemical stability and prevent decomposition or deterioration at high temperatures.
Avoid light storage: It is sensitive to light and prolonged exposure to light can lead to a decrease in its content. Therefore, the organic compound should be stored in a dark environment, such as using opaque containers or packaging materials.
Sealed storage: It should be stored in a sealed container to prevent oxygen, moisture, and other substances in the air from affecting it. Sealing can also prevent contamination from dust and microorganisms.
Dry environment: Maintaining a dry storage environment is also important for its stability. Excessive humidity may cause the organic matter to absorb moisture and undergo chemical reactions, thereby affecting its quality.
Avoid contact with metal ions: Some metal ions, such as Ca ² ⁺, Mg ² ⁺, etc., may affect their stability. Therefore, during storage and transportation, contact with these metal ions should be avoided as much as possible.
Pay attention to packaging materials: Choosing appropriate packaging materials is also crucial for its storage. For example, double-layer plastic bags with aluminum foil can be used for packaging, while cardboard drums can be used for external packaging to prevent moisture, light, and oxidation.
Follow product instructions: Rosmarinic acid powder products of different brands and specifications may have different storage requirements. Therefore, when storing rosmarinic acid, carefully read the product instructions and store according to the instructions.
FAQ
What is rosmarinic acid used for?
Rosmarinic acid (RA) is known for its excellent antioxidant properties and is safe and effective in preventing and inhibiting tumors. This review summarizes recent publications on culture techniques, extraction processes, and anti-tumor applications of RA-enriched dietary supplements.
What foods are high in rosmarinic acid?
It is found in species used commonly as culinary herbs such as Ocimum basilicum (basil), Ocimum tenuiflorum (holy basil), Melissa officinalis (lemon balm), Salvia rosmarinus (rosemary), Origanum majorana (marjoram), Salvia officinalis (sage), thyme and peppermint.
Is rosmarinic acid good for hair?
Is rosmarinic acid good for hair?
How fast will rosemary grow your hair?
Studies have shown that rosemary oil for hair has promising positive effects for people with male pattern baldness and alopecia areata [1-3]. In one study, 38% of men saw increases in hair growth after using rosemary oil for male pattern baldness after six months, while 100% of people saw decreased hair loss
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