Pure Hyaluronic Acid Powder CAS 9004-61-9

Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of pure hyaluronic acid powder cas 9004-61-9 in China. Welcome to wholesale bulk high quality pure hyaluronic acid powder cas 9004-61-9 for sale here from our factory. Good service and reasonable price are available.

Pure hyaluronic acid powder, unstable under normal temperature and pressure, avoid humidity, high temperature and high temperature. It must be sealed with kraft paper or brown glass bottles lined with plastic bags to prevent moisture and sunshine. It is a high molecular polymer and high-grade polysaccharide, which is composed of unit D-glucuronic acid and N-acetylglucosamine. Between D-glucuronic acid and N-acetylglucosamine β- 1,3-glycosylation linkage, disaccharide unit through β- 1,4-glycosyl linkage. The disaccharide unit can reach 25000. In vivo, the molecular weight of hyaluronic acid is between 5000 and 20 million daltons.

There are two forms of hyaluronic acid, one is hyaluronic acid powder, which is a white amorphous solid, and the other is hyaluronic acid liquid that needs to be sub packed in a brown container. Soluble in water and insoluble in organic solvents. Biochemical drugs with high clinical value are widely used in various ophthalmic operations, such as lens implantation, corneal transplantation and anti glaucoma surgery. It can also be used to treat arthritis and accelerate wound healing. When used in cosmetics, hyaluronic acid liquid supply can play a unique role in protecting the skin, keeping the skin moist, smooth, delicate, tender and elastic, playing the role of anti wrinkle, anti wrinkle and beauty, which is very effective for the skin.

Biochemical drugs with high clinical value are widely used in various ophthalmic surgeries, such as lens implantation, corneal transplantation, and anti glaucoma surgery. Pure hyaluronic acid powder can also be used to treat arthritis and accelerate wound healing. When used in cosmetics, it can have a unique protective effect on the skin, keeping it moisturized, smooth, delicate, soft, and elastic. It has the functions of anti wrinkle, anti wrinkle, beauty and health care, and restoring skin physiological functions.

1. Pharmaceutical grade products
Hyaluronic acid is the main component of connective tissues such as intercellular matrix, vitreous humor, and synovial fluid in the human body. It plays an important physiological role in water retention, maintaining extracellular space, regulating osmotic pressure, lubrication, and promoting cell repair in the body. Hyaluronic acid molecules contain a large number of carboxyl and hydroxyl groups, which form hydrogen bonds within and between molecules in aqueous solutions, giving them strong water retention properties and the ability to bind to over 400 times their own amount of water;

At higher concentrations, due to the complex tertiary network structure formed by intermolecular interactions, its aqueous solution exhibits significant viscoelasticity. Hyaluronic acid, as the main component of the intercellular matrix, directly participates in the regulation of electrolyte exchange inside and outside the cell, playing a filtering role in physical and molecular information. Hyaluronic acid has unique physicochemical properties and physiological functions, and has been widely used in medicine.

After surgery for intrauterine adhesions, there are many measures to prevent re adhesion, and sodium hyaluronate is also one of them
Hyaluronic acid can be used as a viscoelastic agent for ophthalmic intraocular lens implantation surgery, as well as a filler for joint surgeries such as osteoarthritis and rheumatoid arthritis.

It is widely used as a medium in eye drops and is also used to prevent postoperative adhesion and promote skin wound healing. The compound formed by the reaction of hyaluronic acid with other drugs exerts a sustained release effect on the drug, achieving the goal of targeted and timed release. With the development of pharmaceutical technology, the application of hyaluronic acid in medicine will become increasingly widespread.

2. Food grade products
The content of hyaluronic acid in the human body is about 15g, which plays an important role in physiological activities. The content of hyaluronic acid in the skin decreases, the skin's water retention function weakens, it appears rough and wrinkles appear; Reduced hyaluronic acid in other tissues and organs can lead to arthritis, arteriosclerosis, pulse disorders, and brain atrophy. The reduction of hyaluronic acid in the human body can lead to premature aging.

3. Beauty effect
Removing wrinkles
Due to factors such as age, smoking, compression during sleep, and gravitational pull, the loss of hyaluronic acid in the skin can gradually lead to a decrease in collagen and elastic fibers in the dermis, causing skin sagging and facial wrinkles. Injecting hyaluronic acid can effectively solve various wrinkles:

Hyaluronic acid beauty application for wrinkles (between eyebrows) and crow's feet
Excessive furrowed brow lines often do not achieve satisfactory results when injected with botulinum toxin alone, and the effect is even better when injected with hyaluronic acid.

Hyaluronic acid cosmetic application for mouth wrinkles
The patterns generated when pouting, although dynamic, can be filled with hyaluronic acid to achieve a good effect.
Hyaluronic acid cosmetic application for nasolabial folds (nasolabial folds)
The elimination of nasolabial folds is the most commonly used purpose of hyaluronic acid in wrinkle removal. According to the depth and location of the wrinkles on the nose, approximately 2 injections of macromolecules are required.

The injection site includes the outer nasal wing depression, nasolabial folds themselves, and the lower outer side of the lips.

Hyaluronic acid cosmetic application for wrinkles around the mouth
Including fine lines around the mouth, which are dry lines around the lips caused by long-term dehydration; This includes nasolabial folds, which are the areas where saliva flows through the corners of the mouth. Some form small bracket folds, while others form large bracket folds (connected to the nasolabial groove).

Shaping
Rhinoplasty: Although the development of rhinoplasty technology has reached a certain level, since the use of hyaluronic acid injection for rhinoplasty, the advantages of hyaluronic acid rhinoplasty such as fast molding, no need for surgery, and painlessness have posed certain challenges to implant rhinoplasty and other rhinoplasty procedures.
Chin augmentation: The popular V-shaped face nowadays can be easily achieved by starting from the chin. Pure hyaluronic acid powder can also solve the problem of chin retraction.

Fill the face
Aging can cause changes in the distribution of subcutaneous tissue, with depressions around the temporal region, cheeks, eye sockets, eyebrow arch, and lips, as well as the appearance of tear troughs. Hyaluronic acid is popular for facial filling, including tear troughs, nasolabial folds, and puppet lines (the three "eight" lines in women), and the effect is also quite good.

Lip augmentation: Generally speaking, people's lips will shrink with age, wrinkles will appear, and the corners of the mouth will also sag due to aging. Hyaluronic acid filling for lip augmentation has received certain praise.
Fill in dents
Hyaluronic acid can also be used to fill some acne scars, scars caused by trauma, surgery, and asymmetry of congenital defects.

4. Skin care
Hyaluronic acid is already present in the skin, which can help the skin absorb moisture from the body and surface layer, and enhance the skin's ability to retain water for a long time. When hyaluronic acid absorbs moisture, it creates a moist environment for elastic fibers and collagen, giving the skin elasticity.

However, hyaluronic acid in the skin begins to be lost after the age of 25, with only 65% remaining at the age of 30 and 25% remaining at the age of 60. The skin's moisture also dissipates with hyaluronic acid, losing elasticity and luster, leading to wrinkles and aging over time.

The production process and technology of hyaluronic acid determine the difference in quality. Therefore, the product produced from the correct source must be used to have therapeutic effect. Generally speaking, there are three methods of refining:

1. Animal tissues:

 

The main raw materials are chicken crowns, bovine eyes and vitreous bodies. Degrease and dehydrate the raw materials with acetone or ethanol, soak and filter them with distilled water, then treat them with sodium chloride aqueous solution and chloroform solution, then add trypsin to obtain mixed solution after heat preservation, and finally treat and purify them with ion exchanger to obtain refined hyaluronic acid. The extraction rate of this method is very low, only about 1%, and the separation process is complex, resulting in the high price of hyaluronic acid, up to 5000 US dollars / kg, which limits the large amount of hyaluronic acid used in cosmetics.

2. Microbial fermentation:

 

Take glucose as the carbon source fermentation liquid, and ferment in the culture medium for 48 hours. After the fermentation, filter and remove the mycelium and impurities, and then use simple operations such as alcohol precipitation method to obtain high-purity products. The advantage of hyaluronic acid produced by fermentation method is that the molecular weight can be set according to the commercial design. The key of fermentation method is the selection of strains, such as Streptococcus and Lactococcus.

3. Chemical synthesis:

 

Natural enzyme polymerization; Firstly, the "hyaluronic acid oxazacyclopentene derivative" was synthesized by using polysaccharide polymer, then water decomposing enzyme was added to produce the complex of derivative and enzyme, and finally, the enzyme was removed in the reaction solution at 90 ° C to synthesize hyaluronic acid. The production cost of hyaluronic acid can be greatly reduced by artificial synthesis, but its structure is not pure.

It is also a product of pure hyaluronic acid powder, which has obvious influence on the effect due to the difference in raw material source and manufacturing technology. The concentration of the product can not be used as a reference for selecting the product. The purity, molecular weight and 3D three-dimensional structure will directly affect the water absorption effect of hyaluronic acid. Generally, the larger the molecular weight and the more complete the network structure, the better the water absorption effect Health care products and cosmetics are popular in the market, but hyaluronic acid made by many manufacturers is cheap, but it may not be effective. Some people even promote oral hyaluronic acid, which is absorbed by the stomach and intestines and then decomposed into small molecules of carbohydrates and amino acids. It must be produced in the skin and connective tissue through autosynthesis and other steps, and its effect must be discounted.

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