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Sodium Hyaluronate Powder(sodium hyaluronic acid powder ). Pure sodium hyaluronate is white to milky white powder and soluble in water. Compound sodium hyaluronate is an inherent component of the human body. It is a non species specific glucuronic acid. Sodium hyaluronic acid is widely present in the placenta, amniotic fluid, lens, articular cartilage, skin, and dermis; In organs, distributed in the cytoplasm and intercellular matrix, it plays a lubricating and nourishing role in cells and cellular organs. Meanwhile, sodiumhyaluronate provides a microenvironment for cell metabolism. It is a gel made of natural hyaluronic acid in human body, which is used to promote cell regeneration and wrinkle removal. The moisturizing effect is the most important role of sodium hyaluronate in cosmetics. Compared to other moisturizing agents, the relative humidity of the surrounding environment has little effect on their moisturizing properties. To improve its stability, sodium salt is added to hyaluronic acid to form sodium hyaluronate, which can achieve better results.
Sodium hyaluronate can absorb a large amount of water, and its molecules can combine with hundreds of times their own weight to form a breathable moisturizing film on the surface of the skin, reducing the loss of skin moisture through the skin and providing long-lasting and deep moisturizing effects, keeping the skin hydrated, smooth, and delicate for a long time. Widely added in various skin care products, such as lotion, face cream, essence, facial mask, etc., it is one of the core ingredients of many moisturizing products. Sodium hyaluronate with different molecular weights also has different moisturizing effects. Small molecule sodium hyaluronate can penetrate into the dermis layer, promote water circulation inside the skin, and increase skin moisture content from the inside out.
It can promote the proliferation and differentiation of skin cells, accelerate the repair and reconstruction of damaged tissues, help restore the barrier function of the skin, enhance the skin's resistance, and reduce external environmental damage to the skin, such as resisting UV rays, pollutants, and other damage to the skin It is often used in skin care products for damaged skin or sensitive skin, such as soothing and repairing cream, special lotion for sensitive skin, etc., which can relieve skin irritation such as redness, itching, tingling, etc., improve the sensitive state of the skin, and make the skin more healthy and stable
As age increases, the content of hyaluronic acid in the skin decreases, leading to a weakening of the skin's water retention function and the formation of wrinkles. Sodium Hyaluronate Powder can increase skin moisture content, improve skin elasticity and water retention. Its aqueous solution has strong viscoelasticity and lubricity. When applied to the surface of the skin, it can form a moisturizing and breathable film, keeping the skin moisturized and shiny, thereby reducing the appearance of wrinkles. In addition, it can penetrate into the dermis layer, promote blood microcirculation, facilitate the absorption of nutrients by the skin, and further enhance the anti wrinkle effect. It is commonly used in anti-aging essence, anti wrinkle cream, eye mask and other products. Through long-term use, it can help fade the fine lines and wrinkles on the face, improve the skin tightness, and make the skin look younger and more energetic.
Treatment for dry eye syndrome
Dry eye syndrome is a disease caused by insufficient secretion or rapid evaporation of tears, resulting in dryness and damage to the ocular surface. Sodium hyaluronate eye drops can supplement the water on the eye surface, form a layer of moisturizing gel like film on the eye surface, increase the stability of the tear film, and thus reduce the sense of dryness, foreign body and other uncomfortable symptoms of the eyes. Its hydrophilicity can absorb and retain water, providing a moist environment for ocular surface cells. It is one of the commonly used drugs for treating dry eye syndrome, and the frequency and dosage of use depend on the severity of the condition. Patients with mild dry eye syndrome may use 1-2 drops 3-4 times a day; Severe patients may need to increase the frequency of use. Long term use can significantly improve patients' eye comfort and enhance their quality of life.
In cataract surgery, the anterior chamber space between the cornea and the lens can be filled to maintain the depth of the anterior chamber. This helps with the operation of surgical instruments, avoiding instrument contact and damage to important tissues such as corneal endothelial cells. Its viscosity and gel like properties can play a buffering role and prevent the sharp change of intraocular pressure during operation. During corneal transplantation, it can protect the donor corneal endothelial cells and reduce mechanical damage during surgical procedures. At the same time, it can also help the donor cornea better adhere to the recipient's eye bed, improving the success rate of transplantation.
Food and Health Products
Improving taste and quality: It has strong water absorption and retention properties, and can be added to food to maintain its moisture, prevent drying and spoilage, and extend the shelf life of food. It can also improve the texture and taste of food, increase the viscosity and smoothness of food, make food more delicate, soft, and elastic, and enhance the overall quality of food. For example, adding sodium hyaluronate to yogurt can make it thicker and have a richer taste; When used in jelly, it can make the jelly more chewy and chewy.
As a moisturizer: In baked goods such as bread, cakes, etc., sodium hyaluronate can maintain the moisture of the product, making it softer and more moist, delaying the aging rate of bread, and extending the shelf life. For some foods that require freshness and taste, such as fruit slices, meat products, etc., it can also have a good moisturizing effect, reduce water loss, and maintain the original flavor and taste of the food.
Increasing stability: In beverages, it can be used as a thickener and stabilizer to prevent the precipitation and stratification of ingredients, making the beverage more uniform and stable. For example, adding it to some fruit juice drinks and tea drinks can improve the stability of the drinks and maintain consistency in their appearance and taste.
drug delivery system
Subcutaneous injection and intramuscular injection: For some protein drugs or vaccines, they can be mixed with drugs as excipients for subcutaneous or intramuscular injection. At the injection site, a local drug reservoir can be formed, which slowly releases the drug and prolongs its absorption process. For example, adding sodium hyaluronate to insulin injection formulations can slow down insulin release, simulate the secretion process of insulin under physiological conditions, and better control blood sugar levels.
Intravenous injection: When administered intravenously, drugs encapsulated in sodium hyaluronate powder can remain relatively stable in the bloodstream. Its hydrophilicity and colloidal properties help prevent drugs from being rapidly degraded by enzymes in the blood, while also avoiding non-specific adsorption of drugs on the blood vessel wall. For example, some chemotherapy drugs coated with sodium hyaluronate can reduce damage to vascular endothelial cells and achieve targeted delivery of drugs by binding to tumor cell surface receptors upon reaching tumor tissue.
Eye administration: Local eye drops are a common method of administration in the treatment of eye diseases. As an ocular drug delivery carrier, it can increase the residence time of drugs on the ocular surface. Its high viscosity can form a protective film on the ocular surface, reducing the flushing effect of tears and thus improving the bioavailability of the drug. For example, for drugs used to treat glaucoma, using them as carriers can prolong the contact time between the drug and eye tissue, enhancing the drug's ability to lower intraocular pressure.
Nasal administration: The nasal mucosa has abundant blood vessels and lymphatic vessels, which are a good pathway for drug absorption. It can serve as a carrier for nasal administration, enhancing the adhesion and permeation ability of drugs on the nasal mucosa. Its hydrophilicity helps drugs dissolve in nasal secretions and prevents them from being cleared too quickly by the nasal mucosa. For example, for some drugs used to treat brain diseases, nasal administration and the use of sodium hyaluronate as a carrier can allow the drug to bypass the blood-brain barrier and directly enter brain tissue, improving the therapeutic effect of the drug.
Agricultural applications
Seed coating: It has good moisturizing and adhesive properties and can be used for seed coating. Coated seeds can better retain moisture in the soil, improve germination and survival rates, especially in arid or semi-arid areas, where this effect is more significant. In addition, it can also serve as a carrier for nutrients and plant growth regulators, slowly releasing these substances to provide sustained nutrient supply for seed germination and seedling growth, promoting the robust growth of seedlings.
Plant tissue culture: Adding sodium hyaluronate during plant tissue culture can improve the physical properties of the culture medium, increase its viscosity and moisture retention, facilitate the fixation of plant tissues and slow release of nutrients, create a more suitable environment for the growth and differentiation of plant tissues, and improve the success rate of tissue culture and the quality of seedlings.
Soil improvement: It can absorb a large amount of water, and when applied to soil, it can increase soil water retention, reduce water evaporation and loss, and increase soil moisture content. At the same time, it can promote the formation of soil aggregates, improve soil structure and aeration, facilitate the growth and development of plant roots, and enhance soil fertility and sustainable utilization.
Plant protection: It can be used as a natural plant protectant to form a protective film on the surface of plants, reducing water loss and preventing plants from being subjected to drought stress. In addition, this protective film can also block the invasion of pathogens and pests, reduce the probability of plant diseases and pests, and play a certain physical defense role.
Agricultural product preservation: Due to its excellent moisturizing and preservation properties, it can be used for the preservation of agricultural products.
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Specific rotation D25 – 74° ( c = 0.25 in water ) : Rapport et al., J. Am. Chem. Soc. 73, 2416 ( 1951 ) , Storage condition -20 ° C , Solubility H2O : 5 mg / mL, clear, colorless , Form Powder , Color White to cream , pH ( 2g / l, 25 °C ) : 5.5-7.5 , Water soluble SOLUBLE , stable. Incompatible with strong oxidizing agents. , InChIKeyMAKUBRYLFHZREJ-JWBQXVCJSA-M , Dangerous goods sign B, Xi , Hazard category code 36 / 37 / 38 , Safety instructions 22-24 / 25-36 / 37 / 39-27-26 , WGK Germany 3 , RTECS MT7250000 , F 3-10.
The skincare function of sodium hyaluronate mainly depends on its molecular weight and dosage. In general, the larger the molecular weight of sodium hyaluronate, the greater the mutual entanglement between molecules, forming a wider molecular network. The moisturizing and breathable film formed on the skin surface makes the skin moist and shiny, with nutritional, wrinkle resistant, and rejuvenating effects. Generally, with a molecular weight of over 2 million Da, water storage, moisturizing, and UV resistance are the main methods; 1.2~1.6 million Da is the most commonly used and cost-effective sodium hyaluronate; 200000~400000 Da is to reduce its molecular weight by enzymolysis on the basis of conventional molecular weight, increase its fluidity, and make it play a better moisturizing effect in essence solution; Molecules with a molecular weight of less than 10000 Da can penetrate deep into the stratum corneum of the skin, achieving the function of deep hydration.
Commonly used sodium hyaluronate powder include:
Oligomeric sodium hyaluronate (molecular weight less than 10000 Da);
Small molecule sodium hyaluronate (molecular weight 10000 Da to 1 million Da);
Medium molecular weight sodium hyaluronate (molecular weight 1 million Da to 1.8 million Da);
Large molecule sodium hyaluronate (molecular weight>1.8 million Da);
When the dosage of sodium hyaluronate is generally above 0.1%, molecular folding will occur, forming a continuous three-dimensional network and generating various physiological effects. Data shows that 0.1% sodium hyaluronate has a moisturizing effect.
When 0.1% sodium hyaluronate with different molecular weights is added, it can increase the skin moisture content. The higher the HA molecular weight, the lower the skin moisture content; Oligomeric HA has the strongest effect on increasing skin moisture content. As the molecular weight of HA increases, the amount of skin water loss decreases; High molecular weight HA has the best effect in preventing skin moisture loss. It can also reduce transdermal water loss (TEWL), thereby achieving a moisturizing effect. The combination of sodium hyaluronate with different molecular weights can have a synergistic effect and exhibit better moisturizing effects.
Oligomeric sodium hyaluronate, due to its small molecular weight, can enter deep into the skin through pores and intercellular spaces to the dermis for deep moisturizing. In addition, data shows that adding 0.0008% has a certain soothing effect; Adding 0.1% has certain anti-inflammatory effects; Adding 1% has a repairing effect.
The hydrolysis of high molecular weight sodium hyaluronate using acid-base or biological enzymes to obtain hyaluronic acid with smaller molecular weight is called "hydrolyzed sodium hyaluronate". The hydrolyzed sodium hyaluronate obtained through enzymatic hydrolysis process has better biological activity and is much more expensive. Conventional commercially available hydrolyzed sodium hyaluronate with a molecular weight of less than 10000 Daltons. The hydrolyzed ultra small molecule sodium hyaluronate can inhibit various inflammatory factors, including TGF- α, IL-1 α And IL-6 can quickly penetrate the epidermis, reach the dermis, eliminate free radicals, reduce inflammatory factor activity, inhibit inflammatory reactions, repair damaged cells, and resist skin inflammation and sensitivity caused by various stimuli.
Sodium hyaluronate cross-linked polymer is an ultra-high molecular weight polymer obtained through cross-linking reaction of sodium hyaluronate, with a dense network structure. The cross-linking reaction causes local high aggregation and folding of HA macromolecules, which can combine with more water molecules and form a growth protective film on the skin surface. The skin feels smooth and elastic, and has multiple functions such as water locking, water storage, isolation, and protection. Can be used as a free radical scavenger to alleviate pain and blisters after exposure to sunlight; Can be applied to cosmetics and hair products; It can also be used as a delivery system for water-soluble or oil-soluble active substances. The cross-linked hyaluronic acid not only increases its relative molecular weight but also its volume, forming a network structure; The morphology is transformed from sol to gel, and its structure and function are strengthened.
Acetylated sodium hyaluronate is obtained by acetylation reaction of sodium hyaluronate and has the following effects:
High skin absorption:
It has excellent skin affinity and can firmly adhere to the skin, exerting long-lasting moisturizing and softening effects.
Double moisturizing power:
It can exert double moisturizing power and quickly combine moisture in a short period of time, increasing skin moisture content and keeping the skin hydrated for 12 hours.
Repair skin barrier:
Not only can it promote the proliferation of epidermal cells, but it can also repair damaged epidermal cells, enhance the function of the epidermal stratum corneum barrier, and improve the skin's natural resistance.
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