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Syn ake powder, chemical name (2S)- β- Alanyl-L-prolyl-2,4-diamino-N - (phenylmethyl) butylamine acetate, abbreviated as Synake. Molecular formula C19H29N5O3.2 (C2H4O2), CAS 823202-99-9, white powder, is a small peptide mimicking active snake venom betting I, called syn ake peptide. The solubility of snake venom tripeptides depends on factors such as their molecular structure, solvent polarity, and ion strength. Most snake venom tripeptides have a certain solubility in polar organic solvents such as methanol, ethanol, and acetone. The solubility in water varies depending on the specific structure and charge state of the peptide. There is usually a clear absorption peak in the UV visible spectral region, and its wavelength depends on the number of conjugated double bonds in the peptide chain and the properties of the substituent. The concentration and purity of snake venom like tripeptides can be determined by UV visible spectroscopy. In addition, infrared spectroscopy can also be used for structural analysis of snake venom tripeptides, and the presence of functional groups such as hydrogen bonds, carbonyls, and amino groups in the peptide chain can be determined through the absorption peaks of infrared spectroscopy. Clinical trials have shown that snake venom peptides can reduce wrinkles by inhibiting muscle contraction and have excellent smooth and rapid wrinkle removal performance. Produce anti wrinkle cream for anti-aging, skin improvement, facial, neck, and hand care products. It can be added to beauty care products, such as lotion, facial mask, morning cream, eye essence, etc.
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Chemical Formula |
C21H33N5O5 |
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Exact Mass |
435 |
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Molecular Weight |
436 |
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m/z |
435 (100.0%), 436 (22.7%), 437 (2.5%), 436 (1.8%), 437 (1.0%) |
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Elemental Analysis |
C, 57.91; H, 7.64; N, 16.08; O, 18.37 |
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Syn ake powder (INCI name: Dipeptide Diaminobutyrylbenzylamide Diacetate, abbreviated as SYN-AKE) is a tripeptide molecule artificially synthesized by simulating the activity of snake venom toxin Waglerin-1. Its core mechanism of action is to block acetylcholine receptors at the neuromuscular junction, inhibit muscle contraction, and reduce dynamic wrinkles caused by facial expression muscle movement. Since its inception in the early 21st century, with its efficient, safe, and reversible characteristics, it has sparked revolutionary breakthroughs in the field of beauty and skincare, gradually expanding to multiple fields such as medicine, food, and agriculture, becoming a hot topic of interdisciplinary research.
1. Targeted therapy for dynamic wrinkles
Its core application scenario is targeted therapy for facial expressions such as crow's feet, forehead wrinkles, and nasolabial folds. Its mechanism of action is similar to botulinum toxin, but non-invasive anti wrinkle can be achieved through local application:
Neural signal blockade: By binding to the ε subunit of the muscle nicotinic acetylcholine receptor (nmAChR), acetylcholine is prevented from binding to the receptor, thereby blocking the transmission of neural excitation. This process leads to the inability of muscle cells to depolarize, the closure of sodium ion channels, and muscle relaxation.
Instant and long-lasting effects: In vitro experiments have shown that a concentration of 0.5mM snake venom tripeptide can reduce muscle cell contraction frequency by 36% within 1 minute, and by 82% after 2 hours, with the effect lasting for more than 48 hours. Clinical studies have confirmed that after continuous use of eye cream containing 4% snake venom tripeptide for 4 weeks, the depth of forehead wrinkles in subjects decreased by 50%, which was twice as effective as the placebo group.
Safety advantage: Compared with botulinum toxin, snake venom tripeptides do not penetrate the blood-brain barrier, have no systemic toxicity risk, and have reversible effects. Its safety has been verified in the market for more than 15 years and has been registered and recognized by the National Medical Products Administration.
2. Core components of anti-aging formula
Often compounded with peptides such as acetyl hexapeptide-8 and palmitoyl pentapeptide-4 to form a synergistic effect of "dynamic wrinkle inhibition+static wrinkle repair":
Dynamic wrinkle suppression: blocks nerve signal transmission and reduces muscle contraction frequency.
Static wrinkle repair: Acetyl hexapeptide-8 promotes collagen synthesis, while palmitoyl pentapeptide-4 enhances skin elastic fiber structure.
Clinical verification: DSM's clinical research on Asian women shows that a compound formula containing snake venom tripeptides can reduce the volume of wrinkles around the eyes by 21% and improve skin smoothness by 15% -20%.
3. Ingredient labels for high-end skincare products
Due to the high cost of raw materials (about 200000 yuan/kg in the domestic market), snake venom like tripeptides are mostly used in high-end eye creams, essence and other anti-aging products. For example:
Huilikang Snake Venom Peptide Eye Cream: With 4% snake venom tripeptide as the core ingredient, combined with nano gold particles, it claims to "fade fine lines around the eyes in 28 days".
Meibo snake venom peptide freeze-dried powder: uses freeze-drying technology to maintain activity, combined with hyaluronic acid, and focuses on the "instant lifting and tightening" effect.
1. Neural repair and analgesia
The neuromuscular blocking properties make syn ake powder potential in the field of nerve repair:
Neural injury repair: promoting peripheral nerve regeneration by regulating acetylcholine receptor activity. Animal experiments have shown that local injection of snake venom tripeptide can accelerate the recovery of motor function in rats with sciatic nerve injury.
Chronic pain treatment: As a substitute for local anesthetics, snake venom tripeptides can inhibit pain signal transmission. Preclinical studies have confirmed that its analgesic effect is comparable to lidocaine, but there is no risk of cardiac toxicity.
2. Promoting wound healing
Accelerate wound healing through the following mechanisms:
Anti inflammatory effect: Inhibits the NF - κ B signaling pathway and reduces the release of inflammatory factors such as TNF - α and IL-6.
Cell proliferation promotion: Activate the EGFR/MAPK pathway to promote the migration of fibroblasts and keratinocytes.
Clinical application: gel dressing containing snake venom tripeptide has been used for the treatment of diabetes foot ulcer, which can shorten the healing time by 30%.
3. Prescription drug development
Although currently mainly used as a cosmetic ingredient, its pharmacological activity has attracted attention in the pharmaceutical field
Osteoarthritis treatment: Relieve joint pain by inhibiting chondrocyte apoptosis and matrix degradation. Animal experiments have shown that injecting snake venom tripeptides into the joint cavity can reduce the area of cartilage damage by 40%.
Oral mucosal ulcer: Oral spray containing snake venom tripeptide can form a protective film, inhibit bacterial growth and promote mucosal repair, reducing the ulcer healing time from 7 days to 4 days.
Food Industry: Natural Preservatives and Nutritional Fortification
1. Food preservatives
Antibacterial activity makes it a new type of natural food preservative:
Antibacterial spectrum: The minimum inhibitory concentration (MIC) for common foodborne pathogens such as Escherichia coli, Staphylococcus aureus, and Salmonella is 10-50 μ g/mL.
Application scenario: Adding 0.1% snake venom tripeptide to meat products can extend the shelf life from 7 days to 14 days while maintaining the freshness and tenderness of the meat.
Advantages: Compared to chemical preservatives such as potassium sorbate, snake venom tripeptides have no carcinogenic risk and are resistant to high temperature treatment.
2. Nutritional fortifiers
Its amino acid composition (including essential amino acids such as lysine and arginine) gives it the potential for nutritional enhancement:
Functional foods: added to sports drinks, can promote muscle protein synthesis and accelerate recovery after exercise.
Special medical use food: For postoperative patients, it can improve nutrient absorption efficiency and reduce the incidence of complications.
Agriculture and Industry: Innovative Applications of Green Technologies
1. Biological pesticides
Insecticidal activity provides new ideas for agricultural pest control:
Mechanism of action: By disrupting the acetylcholine receptors at the neuromuscular junction of insects, it leads to paralysis and death of pests.
Application effect: The LC50 (half lethal concentration) for Lepidoptera pests such as cotton bollworm and cabbage caterpillar is 5-10 μ g/mL, with killing efficiency comparable to chemical pesticides, but without pesticide residue risk.
Market prospects: The European Union has approved snake venom tripeptides as a biopesticide ingredient for organic agriculture cultivation.
2. Modification of polymer materials
Biocompatibility makes syn ake powder an ideal additive for functionalizing polymer materials:
Biosensor: The electrode material prepared by composite with polypyrrole increases the sensitivity of glucose detection by three times.
Drug carrier: PLGA nanoparticles loaded with snake venom tripeptides can achieve targeted neurotransmitter regulation for the treatment of Parkinson's disease.
3. Feed additives
In animal husbandry, it can improve animal growth performance:
Meat quality improvement: Adding 0.05% snake venom tripeptide to pig feed can increase the diameter of the longest dorsal muscle fiber by 15% and make the meat more tender.
Immune enhancement: Reduce the incidence of diarrhea in weaned piglets by 20% and decrease the use of antibiotics.
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Remark: BLOOM TECH(Since 2008), ACHIEVE CHEM-TECH is our subsidiary of us.
The chemical synthesis methods of snake venom like tripeptides usually involve multi-step organic synthesis reactions, including condensation reactions, hydrolysis reactions, deprotection reactions, etc. The following are the general steps for the chemical synthesis of snake venom tripeptides:
1. Design synthesis route: Based on the amino acid sequence of the target snake venom tripeptide, design a reasonable synthesis route. Develop a detailed synthesis plan considering factors such as the selection of protective groups, types of condensation reagents, and reaction conditions.
2. Prepare raw materials and reagents: According to the designed synthesis route, prepare the required amino acids, protective groups, condensation reagents, catalysts, and other raw materials and reagents. Ensure that all raw materials and reagents are of high quality and purified.
3. Implement condensation reaction: Mix amino acids with amino protection groups and amino acids with carboxyl protection groups, and carry out peptide bond condensation reaction under the action of appropriate condensation reagents and catalysts. The condensation reaction usually needs to be carried out under certain temperature and pressure conditions, and parameters such as reaction time and solvent ratio need to be controlled.
4. Monitoring condensation reaction: During the condensation reaction process, it is necessary to regularly monitor the reaction process and determine whether the reaction is complete through techniques such as thin-layer chromatography, mass spectrometry analysis, or nuclear magnetic resonance. If the reaction is incomplete, it is necessary to extend the reaction time or adjust the reaction conditions.
5. Separation and purification of intermediate products: After completing the condensation reaction, the generated peptide needs to be separated from the reaction mixture. This step is usually achieved through methods such as column chromatography or recrystallization. By controlling the composition and flow rate of the eluent, high purity intermediate products can be obtained.
6. Implementing deprotection reaction: After obtaining the intermediate product, the protective group needs to be removed in order to proceed with the next synthesis reaction. The conditions for deprotection reactions depend on the protective groups used, and typically require the selection of appropriate acids or bases as catalysts. Control the conditions of the deprotection reaction to ensure that the protective groups can be completely removed while avoiding peptide breakage or degradation.
7. Monitoring deprotection reactions: Similar to condensation reactions, the reaction process also needs to be monitored during deprotection reactions. Determine whether the protective group has been completely removed through techniques such as nuclear magnetic resonance. If the deprotection is not complete, it is necessary to extend the reaction time or adjust the reaction conditions.
8. Repeat the above steps: Based on the designed synthesis route, repeat the steps of condensation reaction, separation and purification, deprotection reaction, etc. until the complete snake venom like tripeptide is synthesized. Strict control of reaction conditions and parameters is required at each step to ensure high-quality products are obtained.
9. Quality testing and identification: After completing the synthesis of snake venom like tripeptides, quality testing and identification are required to ensure that the purity and structure of the product match expectations. This step is usually completed through methods such as nuclear magnetic resonance, mass spectrometry, and high-performance liquid chromatography.
10. Safety assessment: During the synthesis process of syn ake powder, attention should be paid to laboratory safety and environmental protection issues. Conduct safety assessments on the chemical reagents and intermediates used, take necessary protective measures, and ensure that the experimental operations comply with relevant regulations and specifications.
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