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Mar. 25th 2025
1-Benzyl-3-piperidineol is a piperidine-based organic compound with significant biological activity. Its molecular structure is centered around a piperidine ring, with a benzyl substituent attached to the nitrogen atom and a hydroxyl group modified at the third carbon of the ring. This unique structure endows it with the rigidity of an aromatic ring, the basicity of the nitrogen atom, the hydrophilicity of the hydroxyl group, and the reactivity of the hydroxyl group. This compound exhibits amphiphilicity, capable of participating in hydrogen bonding interactions and also achieving hydrophobic binding through the aromatic ring. Therefore, it has attracted much attention in the field of medicinal chemistry and is often used as a key chiral building block or intermediate in the design and synthesis of high-value drugs (especially central nervous system drugs, such as anticholinergic agents and antihistamines). Its physicochemical properties are stable, but during synthesis and purification, attention should be paid to its sensitivity to air and the possibility of chiral centers caused by the hydroxyl group. It is mainly applied in neuroscientific research and lead compound optimization.
Additional information of chemical compound:
|
Chemical Formula |
C12H17NO |
|
Exact Mass |
191.13 |
|
Molecular Weight |
191.27 |
|
m/z |
191.13 (100.0%), 192.13 (13.0%) |
|
Elemental Analysis |
C, 75.35; H, 8.96; N, 7.32; O, 8.36 |
|
Boiling point |
140-142°C 6mm |
|
Density |
1,056 g/cm3 |
|
|
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Drug synthesis: 1-Benzyl-3-piperidinol is a key intermediate for the synthesis of certain drugs. For example, it can be used to synthesize drugs with analgesic, anti-inflammatory, or antidepressant activity. By modifying and transforming its chemical structure, compounds with specific pharmacological activities can be prepared for the treatment of various diseases.
Drug development: In the process of new drug development, it can be used as a starting material or intermediate to explore new drug candidates.By studying its biological activity, valuable clues and basis can be provided for drug design.
chemical synthesis
Organic synthesis reactions: It can participate in various organic synthesis reactions, such as substitution reactions, addition reactions, oxidation reactions, etc These reactions can further expand their chemical structure and generate compounds with different functional groups and properties.
Synthetic materials: In the fields of polymer materials, functional materials, etc., this compound can also be used as a synthetic raw material or additive to prepare materials with special properties.
Pesticide synthesis: It can also be used to synthesize certain pesticides for the control of agricultural pests.
Dyes and pigments: In the dye and pigment industry, it can also be used as a synthetic raw material or intermediate to prepare dyes and pigments with specific colors and properties.
Surfactant: Due to its unique chemical structure, it can also be used to prepare surfactants for improving the surface and interfacial properties of liquids.
Storage method of 1-Benzyl-3-piperidinol
1.Environment
- Temperature: It should be stored at room temperature or in an inert atmosphere, avoiding excessively high or low temperatures. The specific temperature range can be determined based on the product manual or supplier's recommendations.
- Humidity: Due to its hygroscopicity, it is necessary to maintain a dry storage environment and avoid contact with moisture or dampness.
2. Packaging and containers
- Sealing: Containers with good sealing should be used for storage to prevent the entry of air, moisture, and other impurities.
- Material selection: The material of the container should be compatible with the compound to avoid chemical reactions or contamination.
3.Lighting and Protection
- Dark storage: It should be stored in a dark environment, avoiding direct sunlight or strong light to prevent photochemical reactions.
- Protective measures: During storage and use, appropriate personal protective equipment such as gloves, goggles, etc. should be worn to reduce contact with the skin and eyes.
4. Storage period and labeling
- Storage period: Its storage period should be checked regularly and used within its validity period. Expired products may require special handling or disposal.
- Identification and labeling: Clear identification and labeling should be affixed to storage containers, including product name, CAS number, storage conditions, hazard warnings, etc., for easy identification and management.
5.Safety precautions
- Fire safety: It should be kept away from sources of fire and heat to avoid fire or explosion accidents.
- Leakage handling: In the event of a leakage, immediate measures should be taken to clean and dispose of it to prevent the leakage from polluting the environment or causing harm to personnel.
Safety and hazard
1-Benzyl-3-piperidinol, as a nitrogen-containing organic amine compound, is mainly harmful in the following aspects:
Environmental hazards
It poses a significant threat to the aquatic environment. If undiluted or in large quantities, the product comes into contact with groundwater, waterways, or sewage systems, it may have adverse effects on aquatic organisms and even damage aquatic ecosystems. Therefore, strict safety measures must be taken when handling and using this compound to prevent its leakage into the environment.
Health hazards
It may pose a threat to human health. It has a certain degree of acute toxicity and may cause harm to the human body through oral or other routes. In addition, it may also have irritating effects on the skin and eyes, and even cause respiratory irritation. Therefore, appropriate personal protective equipment such as gloves, goggles, etc. must be worn when in contact with the compound to reduce contact with the skin and eyes.
Other hazards
In addition to the above-mentioned hazards, there may also be other potential risks during storage and transportation. For example, improper storage conditions may lead to the decomposition of compounds or the production of harmful substances; During transportation, if there is a leak or accident, it may also cause harm to the environment and personnel.
In short, in order to reduce the danger caused by this compound, it is necessary to strictly comply with relevant safety regulations and operating procedures to ensure that the storage, transportation, and use of the compound are safe and controllable.Wear appropriate personal protective equipment when handling and using the compound to reduce contact with the skin and eyes.Regularly inspect and maintain storage containers to ensure their sealing and integrity, and prevent compound leakage.If a leak or accident occurs, immediate measures should be taken to clean and dispose of it to prevent the leaked material from polluting the environment or causing harm to personnel.
What are the alternatives to this compound?
Other piperidine compounds
3-hydroxypyridine: As a precursor or analog of this compound, 3-hydroxypyridine may have similar chemical properties in certain applications. However, due to the lack of benzyl groups, their reactivity and biological activity may differ.
Other substituted pyridine compounds: By changing the substituents on the pyridine ring, compounds with different chemical properties and biological activities can be obtained. These compounds may serve as substitutes for it in certain applications.
Other nitrogen-containing organic compounds
Amine compounds: Amine compounds with a nitrogen atom like structure may exhibit similar reactivity and biological activity in certain applications. These compounds may be obtained through different synthetic pathways and have different chemical properties.
Amide compounds: Amide compounds are also a type of nitrogen-containing organic compound that may have similar chemical properties to the compound in certain applications.
Other organic synthesis intermediates
In organic synthesis, there are many intermediates with similar structures or functions. These intermediates may be obtained through different synthetic pathways and exhibit similar properties in specific synthetic reactions.
Bioactive compounds
If it is used for drug synthesis or biological activity research, other compounds with similar biological activity may serve as alternatives. These compounds may be obtained through natural extraction or chemical synthesis.
Molecular Acoustics and Brain Wave Resonance
1-Benzyl-3-Piperidinol, as an important organic compound, has shown extensive potential for applications in drug synthesis, materials science, and other fields. In recent years, with the cross fusion of molecular acoustics and neuroscience research, the study of the interaction between the acoustic properties of compound molecules and physiological signals (such as brain waves) in organisms has gradually received attention.
Basic principles of molecular acoustics
Molecular Vibration and Sound Waves
Molecular acoustics is a discipline that studies the interaction between molecular vibrations and sound waves. When molecules are excited by external energy, they undergo vibration, which propagates in the form of sound waves. The vibration frequency, amplitude, and other characteristics of molecules determine their acoustic properties. For this substance, both the pyridine ring and benzyl portion in its molecular structure may undergo vibrations, resulting in specific acoustic signals.
Characterization of Molecular Acoustic Properties
Molecular acoustic properties can be characterized by various means, such as infrared spectroscopy, Raman spectroscopy, nuclear magnetic resonance, etc. These techniques can reveal the acoustic characteristics of molecules, such as vibration modes and frequencies. For this compound, the vibrational absorption peaks of specific chemical bonds in its molecule can be observed through infrared spectroscopy, thus understanding its molecular vibrational characteristics.
Research on Molecular Acoustic Properties
Infrared spectroscopy analysis
Through infrared spectroscopy analysis, vibrational absorption peaks of chemical bonds such as C-H, N-H, and O-H in the 1-Benzyl-3-Piperidinol molecule can be observed. The position, intensity, and other characteristics of these absorption peaks reflect the acoustic properties such as molecular vibration frequency and amplitude. For example, the stretching vibration of O-H bonds typically occurs within the range of 3200-3600 cm ⁻¹, while the stretching vibration of C-H bonds occurs within the range of 2800-3000 cm ⁻¹. By analyzing these absorption peaks, we can gain a deeper understanding of their molecular acoustic properties.
Raman spectroscopy analysis
Raman spectroscopy is another important means of studying the acoustic properties of molecules. Unlike infrared spectroscopy, Raman spectroscopy mainly reflects the bending vibration and rotational characteristics of chemical bonds in molecules. Through Raman spectroscopy analysis, the vibration modes of specific chemical bonds in the molecule can be observed, thereby further understanding its molecular acoustic properties.
Nuclear Magnetic Resonance Analysis
Nuclear magnetic resonance technology can reveal the spin state of atomic nuclei in molecules and their interactions with the surrounding environment. For it, nuclear magnetic resonance analysis can provide information about the spin states and chemical shifts of nuclei such as hydrogen and carbon atoms in molecules. These pieces of information help to understand the interaction mechanism between molecular vibrations and sound waves.
The basic principle of brainwave resonance
The generation and classification of brain waves
Brain waves are electrical signals generated by the activity of neurons in the brain, which are recorded through the scalp. According to different frequencies, brain waves can be divided into types such as delta waves (0.5-4 Hz), theta waves (4-8 Hz), alpha waves (8-13 Hz), beta waves (13-30 Hz), and gamma waves (>30 Hz). Different types of brain waves are associated with different functional states of the brain, such as delta waves associated with deep sleep, alpha waves associated with relaxed state, beta waves associated with alert state, etc.
The concept of brainwave resonance
Brain wave resonance refers to the phenomenon of frequency matching and phase synchronization between external signals (such as sound waves, light waves, etc.) and brain waves. When the frequency of external signals is similar to that of brain waves, resonance may occur between the two, thereby enhancing the brain's perception and response to specific frequency signals. This resonance phenomenon has broad research value and application prospects in the field of neuroscience.
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