3-Bromobenzotrifluoride is a chemical substance, molecular formula C7H4BrF3, colorless and transparent liquid. Insoluble in water, soluble in ethanol and ether. It is used as medicine and pesticide intermediate. It is mainly used in the production of pesticides and pharmaceuticals, such as synthetic weight loss drug Fenfluramine. It is used as the production of liquid crystal products and the intermediate of liquid crystal materials.
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Chemical Formula |
C7H4BrF3 |
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Exact Mass |
224 |
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Molecular Weight |
225 |
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m/z |
224 (100.0%), 226 (97.3%), 225 (7.6%), 227 (7.4%) |
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Elemental Analysis |
C, 37.37; H, 1.79; Br, 35.51; F, 25.33 |
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3-Bromobenzotrifluoride has a variety of uses. The following are some main application fields:
Due to its unique chemical structure and properties, it can serve as an intermediate for the synthesis of certain dyes. In the dye industry, dyes with specific colors and properties can be prepared through further chemical processing and modification, which can be used as additives in coatings to improve their corrosion resistance and heat resistance. Meet the needs of textile, printing and other fields.
As a pesticide intermediate
This compound has important application value in pesticide synthesis. It can be used as an intermediate in organic synthesis to synthesize various organic compounds, such as drugs, dyes, pesticides, etc. It can also be used as a starting material or intermediate for synthesizing pesticides, and can react with other compounds to produce pesticide products with insecticidal, bactericidal, or herbicidal activity. These pesticide products play an important role in agricultural production, helping to improve crop yield and quality.
In the field of medicine, this compound is also used as an intermediate for synthesizing certain drugs. By modifying and altering its chemical structure, drug molecules with specific pharmacological activities can be prepared for the treatment of various diseases. For example, it can be used to synthesize weight loss drugs such as fenfluramine, contributing to the development of the pharmaceutical industry. It can also be used as a monomer for polymers, such as for the preparation of polytrifluoromethylstyrene. It contains trifluoromethyl and can be used as a precursor for preparing various fluorinated organic compounds. It can also be used as a metal surface treatment agent to improve the wettability, corrosion resistance, and wear resistance of metal surfaces.
other purposes
In addition to the above purposes, it can also be used in the production of products in the liquid crystal industry as an intermediate for liquid crystal materials. In addition, it can also be used in the field of organic synthesis as a raw material or reagent for synthesizing other organic compounds. It contains trifluoromethyl in its molecule, therefore it has certain special properties and applications, mainly used in organic synthesis, polymer preparation, fluorinated organic compound preparation, and other fields.
What equipment is required for the laboratory storing this substance
Safe storage equipment
Chemical storage cabinet (chemical drug cabinet): Professional chemical storage cabinets that meet safety standards should be selected, with functions such as fire prevention, explosion prevention, and leakage prevention. The interior of the cabinet should be sprayed with epoxy resin and subjected to high temperature treatment to prevent corrosion by chemical substances. The storage cabinet should be equipped with adjustable shelves to allow for free space adjustment according to storage needs. At the same time, there should be an anti overflow layer board design to prevent accidental liquid leakage. Adopting a three-point linkage door lock to ensure safety. There should be reflective labels on the outside of the cabinet for quick identification in low light or fire situations.
Leakage emergency response equipment: Leakage control pads, leakage collection buckets, and other equipment should be equipped to quickly collect and handle leaked chemicals. The laboratory should be equipped with eye wash stations and emergency shower devices for immediate flushing in case chemicals splash onto the eyes or skin.
Environmental monitoring and alarm equipment
Combustible gas alarm: used to monitor the concentration of combustible gases such as bromotrifluorotoluene in the air, and immediately sound an alarm once it exceeds the safety threshold. It should be installed at the entrance, interior, and potential leakage areas of the storage room.
Temperature and humidity monitor: used to monitor the temperature and humidity of the storage room, ensuring that chemicals are stored under suitable conditions. When the temperature and humidity exceed the set range, an alarm should be triggered.
Personal protective equipment
Protective clothing: Choose chemical protective clothing that has functions such as corrosion resistance and penetration resistance. It is necessary to equip according to the number of laboratory personnel and job requirements. And choose gloves that are resistant to chemical corrosion, such as nitrile gloves, latex gloves, etc. It should be ensured that each experimenter has suitable gloves available.
Goggles and face shields: used to protect the eyes and face from chemical splashes. Equip according to the number of laboratory personnel and job requirements.
Other auxiliary equipment
Ventilation equipment: Choose explosion-proof ventilation equipment, such as explosion-proof exhaust fans, explosion-proof air conditioners, etc. Maintain air circulation in the storage room, reduce chemical concentration, and prevent accumulation and explosion.
Fire extinguishing equipment: Select appropriate fire extinguishing equipment based on the chemical properties of bromotrifluorotoluene, such as dry powder fire extinguishers, carbon dioxide fire extinguishers, etc. Equip according to the storage area and quantity of chemicals.
Safety signs and warning signs: used to remind laboratory personnel to pay attention to the safe storage and use of chemicals, prevent misoperation and accidents. It should be posted at the entrance, interior, and potential leakage areas of the storage room.
How effective is fenfluramine in weight loss and do it have any side effects?
Weight loss effect
3-Bromobenzotrifluoride is mainly used to synthesize fenfluramine, which is not only suitable for simple obesity, but also for obese patients with hypertension, diabetes, coronary heart disease and anxiety.
Fenfluramine mainly acts on the central nervous system, inhibits appetite, and achieves the goal of weight loss. It is not only used for simple obesity, but also for obese patients with diabetes, hypertension, cardiovascular disease and anxiety. After 12 weeks of medication, the average abdominal circumference can be reduced by 10cm and the average weight can be reduced by 6kg. Mainly used as an appetite suppressant, it enhances satiety and reduces food intake through the action of dopamine receptor agonists in the central nervous system. This is the main way for it to achieve weight loss effects. This drug can also increase metabolic rate, accelerate fat burning, and help with weight control. It can stimulate the secretion of adrenaline, putting the body in a "fight or flight" state, thereby increasing energy expenditure and achieving weight loss goals. It has a slight sedative effect and can alleviate sleep disorders caused by obesity, indirectly assisting in weight loss. Due to its diuretic effect, it can promote the elimination of water from the body, achieve the goal of reducing swelling, and thus visually reduce weight.
Side effect
Neurological symptoms: including dizziness, nausea, drowsiness, dry mouth, etc., which may affect the patient's daily life and work.
Cardiovascular system symptoms, such as palpitations, may pose a threat to the patient's cardiovascular health in severe cases.
Urinary system symptoms: May cause difficulty urinating, as medication may act on the detrusor muscle of the bladder, leading to detrusor muscle weakness.
Visual system symptoms: There may be blurred vision, which is due to the possible action of drugs on the central nervous system of the brain, causing damage to the central nervous system.
Other serious side effects: In extreme cases, fenfluramine may cause serious adverse reactions such as coma.
Matters needing attention
Drug use: Fenfluramine is a prescription drug and must be used under the guidance of a doctor. Do not purchase or take it on your own.
Monitoring physical condition: During medication, patients should regularly monitor their weight changes and overall health status. If any discomfort symptoms occur, they should seek medical attention promptly.
Taboo population: Pregnant women, patients with glaucoma, epilepsy, and depression are prohibited from using fenfluramine. Breastfeeding women, high-altitude operators, drivers, and other individuals should use it with caution.
In 1947, American chemist William T. Miller first reported the synthesis method of phenyltrifluoromethane at Cornell University. Phenyltrifluoromethane was successfully prepared through the halogen exchange reaction (Halex reaction) between benzoyl chloride and hydrogen fluoride catalyzed by SbF. This discovery has sparked a research boom in aromatic trifluoromethyl compounds. The main challenges faced in early synthesis include harsh reaction conditions (high temperature and high pressure), high catalyst toxicity, and difficult product separation. In the 1950s, with the development of the theory of aromatic electrophilic substitution reactions, researchers began to attempt direct halogenation of phenyltrifluoromethane. In 1953, the research team of DuPont first reported the bromination reaction of phenyltrifluoromethane under iron catalysis, obtaining mixed brominated products. Due to the strong electron withdrawing effect of trifluoromethyl, bromination mainly occurs at the meta (3rd) position, but the product selectivity is still not ideal (3-bromo-2-bromo-≈ 4:1). In 1958, German chemist Georg Schiemann improved the bromination method by using N-bromosuccinimide (NBS) as the bromine source and successfully increasing the selectivity of 3-Bromobenzotrifluoride products to 85% under the initiation of benzoyl peroxide (BPO). This method laid the foundation for the systematic research of 3-BBTF. 1963 marked an important turning point in the research of 3-BBTF. American chemist Robert Haszeldine published a key paper in the Journal of the Chemical Society, reporting the first highly selective synthesis of 3-BBTF through the diazotization bromination reaction (Sandmeyer reaction) of 3-aminophenyltrifluoromethane. This method has the following advantages: regioselectivity>98%, reaction yield up to 75-80%, product purity>99%. Reaction mechanism studies have shown that the electron transfer process between diazonium salt intermediates and cuprous bromide is the key step determining selectivity. This discovery solves the problem of poor selectivity in direct bromination methods. In the 1970s, with the development of modern analytical techniques, the structure of 3-BBTF was accurately characterized:
- In 1972, its molecular weight (225 Da) was first confirmed by gas chromatography-mass spectrometry (GC-MS)
- 1975: Nuclear magnetic resonance techniques (¹⁹ F NMR and ¹ H NMR) were applied for the analysis of this compound
- In 1978, the crystal structure was determined by X-ray single crystal diffraction (Cambridge Crystallographic Database entry number: BROMBT01)
These technological advancements not only validate the structure of compounds, but also provide important tools for subsequent research on reaction mechanisms.
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