3-Cyanophenylboronic acid is a highly valuable multifunctional core component in the field of organic synthesis. The boronic acid group (-B(OH)₂) and the cyano group (-CN) positioned next to each other on the benzene ring give it unique chemical reactivity and structural advantages, making it widely useful in cutting-edge areas like pharmaceuticals, new materials, and chemical biology. As a high-quality fine chemicals service provider, Bloomtechz focuses on the research and production of high-end organic intermediates. With strict quality control, customized services, and a stable supply system, we provide global customers with high-purity, highly stable 3-cyanophenylboronic products to support all kinds of advanced research and industrial projects.
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Chemical Formula |
C14H24S |
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Exact Mass |
224 |
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Molecular Weight |
224 |
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m/z |
224 (100.0%), 225 (15.1%), 226 (4.5%), 226 (1.1%) |
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Elemental Analysis |
C, 74.93; H, 10.78; S, 14.29 |
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The 3-cyanophenylboronic acid produced by Bloomtechz is an important organic compound. Its unique chemical properties come from the cyanide and boronic acid groups in its structure. The cyanide makes the compound highly reactive, while the boronic acid group gives it good water solubility. This combination of traits allows it to play a unique role in chemical reactions.
As a signal transmission medium
It can also serve as a signal transmission medium, playing a role in transmitting signals in chemical sensors. By reacting with the target substance, its chemical properties or physical state can be changed, thereby triggering the signal transduction mechanism of the sensor.
Specific examples:
Fluorescence sensor:
By utilizing its interaction with certain fluorescent substances, a fluorescence sensor can be prepared. When the target substance reacts with it, it changes the luminescent properties of the fluorescent substance, thereby achieving detection of the target substance. This fluorescent sensor can be applied in fields such as biomolecule detection and environmental monitoring.
Electrochemical sensor:
By fixing it on the electrode surface, an electrochemical sensor can be prepared. When the target substance reacts with it, it changes the charge state or current magnitude on the electrode surface, thereby achieving detection of the target substance. This electrochemical sensor can be applied in fields such as water quality monitoring and food safety.
Specific application cases in the field of chemical sensors
Case 1: Preparation And Application Of Hydrogen Peroxide Sensor
Preparation process:
Fix 3-cyanophenylboronic cid or its derivatives on the electrode surface to form a sensing film.
By optimizing the preparation conditions of the sensing membrane, such as concentration, temperature, time, etc., the performance of the sensor can be improved.
Connect the prepared sensor to an electrochemical workstation for performance testing.
Application example:
Environmental monitoring: Use hydrogen peroxide sensors to monitor the concentration of hydrogen peroxide in the atmosphere and evaluate air quality.
Food processing: In the process of food processing, hydrogen peroxide sensors are used to monitor the residual amount of hydrogen peroxide to ensure food safety.
Case 2: Preparation and Application of Glucose Sensor
Preparation process:
Combine itself or its derivatives with fluorescent substances to form fluorescent sensing materials.
Fix fluorescent sensing materials on a carrier, such as glass or plastic sheets, to form a sensor. By optimizing the preparation conditions of fluorescent sensing materials and the structure of the sensor, the performance of the sensor can be improved.
Application example:
Medical diagnosis: glucose sensor is used to monitor the glucose concentration in diabetes patients, providing an important basis for treatment.
Sports Health: During exercise, glucose sensors are used to monitor athletes' blood sugar levels, evaluate exercise effectiveness and health status.
Case 3: Preparation and Application of Enzyme Sensors
Preparation process:
Combine it with enzymes to form enzyme sensing materials.
Fix the enzyme sensing material on the electrode surface to form an enzyme sensor.
By optimizing the preparation conditions of enzyme sensing materials and the structure of the sensor, the performance of the sensor can be improved.
Application example:
Biomolecular detection: using enzyme sensors to detect specific molecules in biological samples, such as proteins, nucleic cids, etc.
Environmental pollution monitoring: using enzyme sensors to monitor the concentration of pollutants in the environment, such as heavy metal ions, organic pollutants, etc.
Application in detection and measurement
Application in glucose detection
3-cyanophenylboronic acid can also be used as a probe for specific detection of trace amounts of glucose in urine.
Specific examples:
Glucose detection probe: Add 3-cyanophenylboronic cid pinal ester to the reaction flask and dilute HCl for hydrolysis. Through a series of chemical reactions and extraction processes, 3-cyanophenylboronic cid can ultimately be obtained. The specific reaction between 3-cyanophenylboronic cid and glucose can be used to detect trace amounts of glucose in urine.
This method has the advantages of high sensitivity and specificity, which provides strong support for the diagnosis of diabetes and other diseases.
Application in environmental monitoring
3-cyanophenylboronic cid can also be used for detection and measurement in environmental monitoring. For example, it can be applied to water quality monitoring to assess water quality by detecting the content of specific pollutants in the water.
Specific examples:
Water quality monitoring: By utilizing the specific reaction between 3-cyanophenylboronic cid and target pollutants, the determination of pollutant content in water can be achieved.
This method has the advantages of easy operation and high sensitivity, providing a powerful tool for water quality monitoring. Meanwhile, 3-cyanophenylboronic cid can also be used in atmospheric environmental monitoring to evaluate air quality by detecting the content of specific pollutants in the atmosphere.
Application in food safety testing
In the field of food safety testing, 3-cyanophenylboronic cid also has a wide range of applications. For example, it can be applied to the detection of harmful substances such as additives and pesticide residues in food.
Specific examples:
Food additive detection: By utilizing the specific reaction between 3-cyanophenylboronic cid and target food additives, the content of additives in food can be determined.
This method has the advantages of high accuracy and good reproducibility, providing strong support for food safety testing.
Pesticide residue detection: reacting 3-cyanophenylboronic cid with pesticide residues containing specific functional groups, and accurately determining the residual amount of pesticides in food by detecting the generation of reaction products. This method provides a new idea and approach for pesticide residue detection.
Bloomtechz found that 3-cyanobenzene has an active cyano group, and neither organolithium reagents nor Grignard reagents can be used to make 3-cyanobenzoic acid. The Miyaura borylation reaction is a type of reaction where aryl or alkenyl halides or triflate derivatives react with bis(pinacolato)diboron in the presence of a palladium catalyst to produce the corresponding boronic ester. This reaction works under mild conditions, doesn't require low temperatures or separation from oxygen and water, and has good functional group tolerance. It partially overcomes the limitations of using highly reactive Grignard and lithium reagents to make these compounds. The reactants can include groups like cyano, nitro, amino, hydroxyl, ester, or carbonyl. Aryl esters can be made in one step, and these esters can be made from substituted aryl halides. Below, using 3-bromobenzonitrile as the starting material and bis(pinacolato)diboron (B2Pin2) as the borylating agent, 3-cyanobenzyl silane was prepared via the Miyaura borylation reaction under mild conditions. The effects of different catalysts and bases on yield were studied, and the resulting products were analyzed and characterized. ...
Synthesis of 3-Cyanophenylboronic Acid
Method 1:
Compound 3 (2.00g, 8.73mmol) and NaIO 4 (5.60g, 26.19mmol) were added to a mixed solution of tetrahydrofuran (40mL) and water (10mL), and reacted at room temperature for 30 minutes. 1mol/L of HCl aqueous solution (6.10mL) was added, and the reaction continued for 2.5 hours. Most of the tetrahydrofuran and ethyl acetate (10mL) were evaporated under reduced pressure × 3) Extract, merge organic phases and wash with saturated sodium chloride solution, dry with anhydrous sodium sulfate, evaporate under reduced pressure to obtain solvent. The crude product is separated and purified by column chromatography, and 0.96g of the product is obtained using petroleum ether/ethyl acetate (5:1, v/v) as eluent, with a yield of 75.00%. It is a white solid.
Method 2:
Add 3 cyanophenylboronic cid pinacol ester to the reaction flask and add dilute HCl dropwise for hydrolysis. The solution first generates precipitation, and as the precipitation gradually disappears, adjust the pH value of the system to 1. Add a 25% mass fraction of NaOH solution dropwise to the solution until the pH value is 13, and stir for 1 hour. Separate the liquid, extract the organic phase with 15 mL of 10% NaOH by mass, merge the aqueous phase, and extract the alkaline solution twice with 15 mL of THF. Adjust the pH value of the obtained alkaline solution with dilute HCl, and turbidity will begin to form. Gradually, flocculent substances will appear, and the pH value will be adjusted to 5.0. Extract the aqueous phase with 70 mLTHF, spin dry the organic phase, and purify to obtain 3 cyanophenylboronic cid.
Bloomtechz Production Advantages
3-Cyanophenylboronic acid is a highly versatile and valuable bifunctional aromatic intermediate in modern organic synthesis. As a professional developer and manufacturer of high-end fine chemical intermediates, Bloomtechz focuses on independent R&D, standardized mass production, and customized support for this product, providing high-purity, low-impurity, and batch-stable quality products to research institutions and industrial manufacturers worldwide.
Bloomtechz has built a differentiated core advantage in the production and manufacturing of this product. The company has abandoned traditional extensive production methods and adopted its own optimized low-temperature synthesis and gradient purification processes. This effectively removes various impurities such as raw material residues, boric acid by-products, and organic contaminants at the source, allowing the product to reach pharmaceutical- and electronic-grade standards for high-end applications.
At the same time, strict molecular stability control is implemented throughout the production process, thoroughly solving industry pain points such as common boric acid products being prone to oxidation, hydrolysis, and short shelf life, significantly improving product storage stability and practical reliability. In terms of quality control, Bloomtechz has built a complete closed-loop quality system covering four core areas: raw material selection, real-time monitoring of synthesis reactions, comprehensive testing of finished products, and full traceability of batch data.
Every batch of 3-cyanophenylboronic acid undergoes rigorous tests including high-performance liquid chromatography for purity, moisture testing, and impurity spectrum analysis, providing customers with comprehensive and authoritative quality reports. The standardized and meticulous quality management system completely eliminates batch-to-batch performance differences, ensuring consistent reaction performance for customer experiments, research, and industrial production. At the same time, the company has flexible scalable production capabilities that can adapt to scenarios from small laboratory pilot runs to large-scale industrial production,
fully meeting the diverse needs of scientific research and industrial-scale manufacturing.In addition, Bloomtechz offers comprehensive one-stop professional technical services.
Its experienced chemical R&D team provides customers with guidance on product storage standards, experimental operation tips, synthesis application plans, and also supports customized specifications and special packaging services. With excellent product quality, mature production processes, flexible supply capabilities, and professional support services, Bloomtechz has become a reliable long-term partner in the global supply chain for this product, continuously empowering technological innovation and industrial upgrading in fields such as pharmaceutical research, new materials, and life sciences.
Frequently Asked Questions
How does your company ensure batch-to-batch stability of 3-Cyanophenylboronic Acid?
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Bloomtechz abandons the traditional rough production model and uses a dedicated low-temperature synthesis and gradient purification process to produce 3-Cyanophenylboronic Acid. We follow a closed-loop quality control system throughout, standardizing control over raw material selection, reaction parameters, and impurity levels. Each batch undergoes a full set of tests including HPLC purity, moisture content, and impurity profile, effectively preventing batch color differences and purity deviations, ensuring stability for customers' R&D and production.
Can you provide customized one-stop purchasing services for 3-Cyanophenylboronic Acid?
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Bloomtechz offers full-process one-stop customized services for 3-Cyanophenylboronic Acid, supporting fine-tuning purity, packaging as needed, and custom quality inspection reports. We also provide dedicated technical consultants to assist from product selection and experimental guidance to after-sales technical support, so customers don't need to coordinate multiple parties, efficiently matching both research and industrial production scenarios.
How does the product avoid the common issues of hydrolysis and deterioration in boronic acid products?
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To address the issues of hydrolysis and oxidation that 3-Cyanophenylboronic Acid faces in the industry, we optimize stabilization processes during production and strictly control temperature and humidity. The finished product comes in moisture-proof and light-proof packaging that isolates air and water, with clear storage conditions and shelf life indicated, maximizing product activity and effectively preventing deterioration or loss of efficacy during storage and use.
What special protection is applied to the product's transport packaging?
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Bloomtechz customizes transport packaging for 3-Cyanophenylboronic Acid according to its physical and chemical characteristics. The inner layer uses sealed moisture-proof aluminum foil bags, the middle layer has thick shock-absorbing materials, and the outer layer is a sturdy crush-resistant carton. This setup prevents damage or moisture problems caused by bumps, humidity, or compression during transportation, while also complying with chemical transport labeling to ensure safe delivery.
Can mass production orders ensure both supply timeliness and product quality?
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Our company has a standardized mass production line that can flexibly handle small trial batches as well as large industrial orders. Production uses uniform processes and quality standards, with fully traceable data to ensure mass-produced products match the quality of small samples. Combined with a stable storage and logistics system, we can accurately manage delivery times, efficiently meeting customers' large-scale production needs.
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