MK-7 Intermediate (Melanotan II Intermediate) is a crucial chemical precursor in the chemical preparation process of the peptide drug Melanotan II (PT-141). It is not the final drug with biological activity on its own, but rather a chemical building block representing the core cyclic structure of the drug. It must undergo subsequent specific synthetic steps in a professional laboratory to be transformed into the finished product of Melanotan II that can be used for research or medical purposes. This intermediate is only for compliant scientific research and industrial production. Without approval from the drug regulatory agency, it must not be directly used on humans. Its procurement, storage, and use must strictly comply with relevant chemical management regulations.
|
Chemical Formula |
C16H14O2 |
|
Exact Mass |
238 |
|
Molecular Weight |
238 |
|
m/z |
238 (100.0%), 239 (17.3%), 240 (1.4%) |
|
Elemental Analysis |
C, 80.65; H, 5.92; O, 13.43 |
|
|
|
Multi channel sources
MK-7 intermediate comes from a wide range of sources, but the main sources are meat and natto.Vitamin K2 (MK-7) is mainly redistributed in the liver through low-density lipoprotein, which is rapidly cleared in the liver with the same lipoprotein as the carrier.Studies have shown that the side chain of vitamin K2 (MK-7) is longer than that of vitamin K2 (MK-4). Therefore, it can exist in the human body for a long time, and its bioavailability in extrahepatic tissues is higher.Effective usage level of finished products: 1. Vitamin K2 (MK-7) belongs to μ G / D level (microgram level), once a day, 90 micrograms each time;
2. Vitamin K2 (MK-4) belongs to the mg / D level (mg level), 15 mg three times a day (equivalent to 45000 micrograms a day), and the required dosage is 500 times that of vitamin K2 (MK-7).Synthetic vitamin K2 (MK-7) can be obtained by natural extraction or chemical synthesis. Main uses of the finished product: for osteoporosis, improving arterial calcification and treating Parkinson's disease.The functions of vitamin K2 (MK-4) and vitamin K2 (MK-7) are similar, but through the comparison of the experimental data of the finished products, it is found that vitamin K2 (MK-7) is far superior to vitamin K2 (MK-4) in terms of biological activity, bioavailability and efficacy.
Melting point 42-45° C , Boiling point 109.7 ° C , Density 1.25 ( 14 % aq. ) , Refractive index n20 / D 1.378 , Storage Conditions Refrigerator , Acidity coefficient ( pKa ) -4.06 ± 0.40 ( Predicted ) , stable. Incompatible with strong oxidizing agents. , Hazardous mark C, N, T, Xn , Hazard category code 34-43-50-20 / 21 / 22-50 / 53-23 / 24 / 25-42 / 43 , Safety instructions 26-36 / 37 / 39-45-60-61-24-28-36 / 37-23 , Transport of dangerous goods No.UN 1760 8 / PG 2 , WGK Germany 1 , RTECS NX8156850 , HazardClass 8 ,Packing Group III.
We are the supplier of MPA.
Remark: BLOOM TECH(Since 2008), ACHIEVE CHEM-TECH is our subsidiary of us.
There are two main methods for synthesizing MK7 intermediates (MPA): one is extracted from natural substances, and the other is obtained through chemical synthesis methods.
MPA can be extracted from plants such as rye and wheat.
The MPA in these plants is mainly present in leaves and fruits. The extraction methods include solvent extraction, supercritical fluid extraction, etc.
Among them, solvent extraction method uses solvents such as ethanol to extract plants, and then obtains MPA through steps such as crystallization and separation.
The supercritical fluid extraction method uses fluids such as supercritical carbon dioxide as extractants, which has the advantages of being non-toxic and pollution-free.
Extraction: Firstly, extract MPA from natural substances containing MPA (such as rye, wheat, etc.). Extraction typically uses organic solvents such as ethanol or ether. During the extraction process, physical dissolution occurs, transferring MPA from natural substances to solvents.
|
|
|
Separation: The extracted mixture undergoes separation steps to separate the solvent and MPA. This step usually uses distillation or crystallization methods. During the distillation process, solvents and MPA are separated based on their differences in boiling points. The crystallization process is achieved by lowering the temperature of the mixture, causing MPA to precipitate in crystalline form.
Purification: After the separation step, the MPA obtained may also contain other impurities. In order to improve the purity of MPA, purification is necessary. Purification can be achieved through methods such as recrystallization and chromatographic separation. Recrystallization is the process of gradually increasing the purity of MPA through repeated crystallization. Chromatographic separation utilizes the distribution differences between different substances in the stationary and mobile phases to separate MPA from other substances.
Architectural design & planning cepteur sint occaecat cupidatat proident, taken possession of my entire soul, like these sweet mornings of spring which I enjoy with my whole...Architectural design & planning cepteur sint occaecat cupidatat proident, taken possession od my entire soul, like these sweet mornings of spring which I enjoy with my whole Lorem ipsum dolor sit ament, consectetur adipisicing elit,sed do eiusmod tempor incididunt labore et dolore magna aliqua. it enim ad minim veniam.
Architectural design & planning cepteur sint occaecat cupidatat proident, taken possession of my entire soul, like these sweet mornings of spring which I enjoy with my whole...Architectural design & planning cepteur sint occaecat cupidatat proident, taken possession od my entire soul, like these sweet mornings of spring which I enjoy with my whole Lorem ipsum dolor sit ament, consectetur adipisicing elit,sed do eiusmod tempor incididunt labore et dolore magna aliqua. it enim ad minim veniam.
MK 7 Intermediate Application Usage
Synthetic vitamins
The core intermediate of K2 MK-7 is an essential synthetic substrate for the preparation of vitamin K2 MK-7. With its unique chemical structure, it can efficiently synthesize high-purity MK-7 products through a series of chemical reactions such as addition, cyclization, and purification. It is the basic raw material for industrial large-scale production of this active substance.
Dietary nutrition and health food ingredients
Vitamin K2 MK-7 synthesized from this intermediate is often added to bone and vascular health foods.
Can promote the effective deposition of calcium in bone tissue, enhance bone toughness, and reduce osteoporosis and joint loss in middle-aged and elderly people; Simultaneously regulating blood lipid metabolism in the body, assisting in maintaining vascular elasticity and circulatory health.
Application in the field of pharmaceutical research and development
Can be used for the research and development of orthopedic and cardiovascular drugs.
Based on the pharmacological properties of its synthetic products, it participates in regulating the coagulation mechanism of the body, regulating the transport and metabolism of calcium elements in the body, and providing core raw material support for the construction of drug active structures and pharmacological experiments for related diseases.
Food and animal feed
The active ingredients obtained from deep processing of nutritional reinforcement can be used as food nutrition supplements , aded to dairy products, meal replacements.
And functional snacks to supplement daily nutrition; It can also be mixed into animal husbandry feed to promote the normal growth and development of animal bones, improve meat quality and breeding output quality.
Fine chemical derivative products
The prepared molecules have good chemical reactivity and can participate in various organic synthesis reactions to derive fine chemical compounds such as terpenes and lipids. They are widely suitable for the research and production scenarios of daily chemical skincare raw materials, bioactive preparations, and other products.
chemical fabrication
(1) Dissolution: The MPA in natural substances (such as rye) is dissolved in solvents such as ethanol or ether. The dissolution process can be expressed as: MK-7+Solvent → MK-7 Solvent
(2) Separation: The solvent and MPA are separated by methods such as distillation or crystallization. The reaction formula for the distillation process can be expressed as: Solvent+Heat → Vapor Solvent, and the reaction formula for the crystallization process can be expressed as: MK-7 Solvent+Heat → MK-7 Crystal+Liquid Solvent
(3) Purification: Separate MPA from other impurities through methods such as recrystallization or chromatographic separation. The reaction formula for the recrystallization process can be expressed as MK-7 Crystal+Heat → MK-7 Crystal, and the reaction formula for the chromatographic separation process can be expressed as MK-7+Mobile Phase → MK-7 Mobile Phase+Stationary Phase
chemical compositing
Chemical synthesis is another method for obtaining MPA. This method usually uses pentadiene as the raw material and undergoes a series of reaction steps to obtain MPA. The specific synthesis route is as follows:
(1) 3-Chloro-1,2-pentadiene was obtained from pentadiene through reaction steps such as chlorination and dehydrochlorination.
(2) React 3-chloro-1,2-pentadiene with alkali to obtain 3-chloro-1,2-pentanediol.
(3) Hydrogenation reduction of 3-chloro-1,2-pentanediol yields 3-hydroxy-1,2-pentanediol.
(4) Oxidize 3-hydroxy-1,2-pentanediol to obtain 3-oxo-1,2-pentanediol.
(5) Dehydrogenate 3-oxo-1,2-pentanediol to obtain MPA.
|
|
|
|
|
Oxidation reaction: The obtained 3-hydroxy-1,2-pentanediol is subjected to oxidation reaction under the action of an oxidant to obtain 3-oxo-1,2-pentanediol. Oxidants can choose from nitric acid, chromic acid, etc.
CH2OHCH2CHOHCH2OH + OX → CH2OHCOCHOHCH2OH
Dehydrogenation reaction: The obtained 3-oxo-1,2-pentanediol is dehydrogenated with hydrogen gas under certain temperature and pressure conditions under the action of a catalyst to obtain MK-7 Intermediate. Catalysts can choose metal catalysts, such as nickel, palladium, etc.
CH2OHCOCHOHCH2OH + H2 → CH3CH=CHCOOH
Security Recommendations
Follow the recommended intake
For the supplementation of vitamin K2 (MK-7), the recommended intake range by world-renowned academic or professional institutions should be followed. Although the current recommended intake range for children is 45-50 micrograms per day (MK-7 form), the specific recommended intake for adults and specific populations may vary.
Monitoring health status
During the supplementation of vitamin K2 (MK-7), one should closely monitor their health status. If any discomfort or suspected side effects occur, supplementation should be stopped immediately and a doctor should be consulted.
Choose a reliable brand
When purchasing vitamin K2 (MK-7) supplements, it is recommended to choose products from reliable brands and suppliers to ensure their quality and safety.
Pay attention to individual differences
Individual sensitivity and demand for vitamin K2 may vary. Therefore, it is recommended to consult a doctor or nutritionist before supplementing, especially for individuals with specific health conditions or those taking other medications.
FAQ
1. What is MK7 Intermediate?
MK 7 Intermediate is a key intermediate in the chemical synthesis process of the synthetic peptide drug melanotan II (also known as PT-141 or the active metabolite of Bremelanotide). It is not the final finished drug itself, but rather a necessary chemical precursor or building block for the production of melanotan II. Its chemical name is usually Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH or a similar structure, representing the core cyclic structure of melanotan II.
2. What is the function of MK 7 Intermediate?
As a chemical intermediate, the main "function" of MK 7 Intermediate is to be used in laboratory research and large-scale production of melanotan II. Researchers and pharmaceutical manufacturers convert it through subsequent chemical reaction steps into the bioactive melanotan II product. It is not used for human consumption and does not have the physiological effects reported for melanotan II, such as enhancing sexual desire or treating sexual dysfunction.
3. Can MK- 7 Intermediate be used on humans?
Absolutely not. MK- 7 Intermediate is a chemical product intended solely for research purposes. It has not undergone any purification, safety and efficacy evaluations by any drug regulatory agencies (such as FDA, EMA), and may contain unknown impurities or residual solvents, posing potential risks to human health. Any act of selling, promoting or using it as a finished peptide product on humans is illegal and dangerous.
4. What should be noted when purchasing MK -7 Intermediate?
If you are a purchasing representative from a compliant research institution or a synthesis laboratory, you should ensure:Clear purpose: It is exclusively used for legitimate scientific research or industrial production, and never for human use.Supplier qualifications: Procure from reputable suppliers who can provide detailed chemical safety data sheets (MSDS) and purity analysis certificates (CoA).Compliance: Adhere to all relevant laws and regulations of the country/region regarding the purchase, storage, and use of chemicals. Ordinary consumers are not and cannot legally purchase such intermediates.
Hot Tags: mk-7 intermediate cas 97804-50-7, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, 1-Bromohexadecane, Trimethyl Phosphate CAS 512 56 1, tert Butyldimethylsilyl chloride, Synthetic Chemical, 4 Methoxyphenylacetone CAS 122 84 9, 1 2 Naphthoquinone 4 sulfonic acid sodium salt