Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of thiophosgene cas 463-71-8 in China. Welcome to wholesale bulk high quality thiophosgene cas 463-71-8 for sale here from our factory. Good service and reasonable price are available.
Thiophosgene, also known as carbon dichloride sulfide, is an inorganic compound with the chemical formula of cscl2. It is a reddish liquid with pungent smell and soluble in water. It is an intermediate for the preparation of acaricide butyl ether urea, an important intermediate for the preparation of thiocarbamate pesticides and herbicides, and an important intermediate for the preparation of thiocarbamate pesticides and herbicides. For organic synthesis. It is used for the synthesis of various heterocycles. React with aromatic primary amine to synthesize isothiocyanate vinegar. Reduce ketimine to a monochlorinated isothiocyanate.
|
Chemical Formula |
CCl2S |
|
Exact Mass |
114 |
|
Molecular Weight |
115 |
|
m/z |
114 (100.0%), 116 (63.9%), 118 (10.2%), 116 (4.5%), 118 (2.9%), 115 (1.1%) |
|
Elemental Analysis |
C, 10.45; Cl, 61.67; S, 27.89 |
Neutralize with 5% sodium hydroxide aqueous solution or soda ash, and then add water. It is suggested to use controlled incineration method or safe burial method for disposal. Damaged containers are forbidden to be reused and should be buried in specified places.
Flammable in case of open fire and high heat. It can react with oxidant. It reacts with acid and emits toxic and corrosive fumes. It is decomposed by high heat and emits toxic gases. If the flow rate is too fast, it is easy to generate and accumulate static electricity. Its vapor is heavier than air, and can spread to a considerable distance at a lower place. It will catch fire and burn back when encountering a fire source. In case of high heat, the internal pressure of the container increases, and there is a risk of cracking and explosion.
Carbon monoxide, carbon dioxide, hydrogen chloride, sulfur oxide.
Firefighters must wear filter gas masks (full face masks) or isolation respirators, and wear full body fire and gas protective clothing to extinguish the fire in the upwind direction. Move the container from the fire site to an open place as far as possible. Spray water to keep the containers at the fire site cool until the end of fire fighting. If the container in the fire site has changed color or generated sound from the safety pressure relief device, it must be evacuated immediately.
Fog water, foam, dry powder, carbon dioxide, sand.
Synthetic sulfur thiophosgene:
1. It is obtained by reduction and elimination of perchloromethyl mercaptan. Add potassium iodide to perchloromethyl mercaptan, tetrachloroethane, water and mixture, stir, inject sulfur dioxide at room temperature, automatically heat up in the reaction, adjust the ventilation, and maintain the temperature at 50-70 ℃. Stop aeration when the temperature of the reaction solution no longer rises and sulfur dioxide is no longer significantly absorbed. Cool and stand still, separate the organic layer for fractionation, and collect the fractions below 76 ℃ to obtain sulfur phosgene.
2. Sulfur phosgene is produced by the reduction of perchloromethyl mercaptan.
Potassium iodide is added to the mixture of perchloromethyl mercaptan, tetrachloroethane and water, stirred, and sulfur dioxide is introduced at room temperature. The temperature rises automatically in the reaction, and the ventilation is adjusted to maintain the temperature at 50 ~ 70 ℃. When the temperature of the reaction liquid no longer rises and the sulfur dioxide is no longer obviously absorbed, stop aeration, cool and stand still, separate the organic layer for fractionation, and collect the fraction below 76 ℃ to get sulfur phosgene.
3. Preparation of sulfur perchloride. Put 500 grams (398 ml, 6.58 moles) of dry carbon disulfide in a 5-liter bottle, and add 0.5 grams of iodine to it. Use running water to cool the outside of the bottle. Inject dry chlorine at a rate of no more than 25 ℃ until the liquid weighs 1770 grams (17.9 moles of chlorine). The time required is about 40 hours. The product is a mixture of impure sulfur perchloride and sulfur chloride, which is a dark red liquid.
Sulfur phosgene (chemical formula: CCl ₂ S, CAS number: 463-71-8), also known as dichlorosulfide carbon or thiocarbonyl chloride, is a red liquid with a strong pungent odor. It has a density of 1.5085 g/cm ³ (15/4 ℃) and a boiling point of 73.5 ℃. It is soluble in ether and decomposes when in contact with water or alcohol, producing toxic gases such as hydrogen sulfide and hydrogen chloride. Its chemical properties are active, reducing, and can react with oxygen, halogens, metals, etc., decomposing into sulfur dioxide and oxygen at high temperatures. Based on these characteristics, sulfur phosgene has shown wide application value in organic synthesis, pesticide production, pharmaceutical and chemical industries, environmental protection, and new materials fields.
It is an important intermediate in the field of organic synthesis, and its unique sulfur chlorine bond (S-Cl) and thiocarbonyl (C=S) structure make it a key reagent for constructing sulfur-containing compounds.
1. Synthesis of isothiocyanate compounds
Reacting with amine compounds can generate isothiocyanates, which are precursors for the synthesis of biologically active molecules such as thiourea and thiourea. For example, in drug synthesis, isothiocyanates can be used to construct the thioamide structure of anti-tumor drugs, enhancing the binding ability of drugs with target proteins.
2. Construction of heterocyclic compounds
Participate in the synthesis of sulfur-containing heterocycles such as thiazole and thiazide. For example, reacting with alpha halogenated ketones can generate 2-aminothiazole, which is widely present in antibiotics and antifungal drugs. In addition, thiophosgene can also be used to synthesize thiolactams as a candidate molecule for enzyme inhibitors.
3. Preparation of Thiocarbamate Compounds
Reacting with alcohols and amines can generate thioamino esters, which have herbicidal and insecticidal activities. For example, thiocarbamate herbicides (such as glyphosate) control weed growth by inhibiting plant acetyl CoA carboxylase, blocking fatty acid synthesis.
The application proportion in the field of pesticides exceeds 40%, and it is the core raw material for preparing acaricides, insecticides, and herbicides.
1. The synthesis of acaricide butyl ether urea
Butylurea is a broad-spectrum acaricide that disrupts energy metabolism by inhibiting the mitochondrial respiratory chain complex II of mites. As an intermediate, it reacts with hydroxylamine to form urea thioformate ester, which is further cyclized to obtain butyl ether urea. This process has the advantages of high atomic economy and minimal by-products.
2. Thiocarbamate insecticides
The reaction with sec butanol and dimethylamine can generate insecticides and insecticides, and its mechanism of action is to interfere with the activity of insect neurotransmitter acetylcholinesterase, leading to nerve conduction blockade.
Compared to organophosphate insecticides, thiocarbamate esters have the characteristics of fast degradation rate and low residue, which is in line with the development trend of green pesticides.
3. Research and development of herbicides
Thiocarbamate herbicides (such as glyphosate) involved in synthesis achieve selective weed control by inhibiting plant cell division. In addition, sulfur phosgene can also be used to synthesize new herbicides such as isoxazolene, with its target being hydroxyphenylpyruvate dioxygenase (HPPD), which blocks carotenoid synthesis and leads to weed whitening and death.
The application in the pharmaceutical field accounts for about 20%, mainly used for the synthesis of antibiotics, vitamins, and hormone drugs.
1. Synthesis of antibiotic intermediates
The key intermediate involved in the synthesis of cephalosporin antibiotics is 7-aminocephalosporanic acid (7-ACA). By reacting thiophosgen with penicillin G potassium salt and introducing thioformate ester groups, 7-ACA is obtained through subsequent cyclization and oxidation, providing a precursor for semi synthetic cephalosporins.
2. Production of Vitamin B1 (Thiamine)
Reacting with acetone and sodium cyanide can generate the thiazole ring portion of vitamin B1. Vitamin B1, as a coenzyme, participates in carbohydrate metabolism, and its deficiency can lead to beriberi. The synthesis of vitamin B1 by sulfur phosgene method has the advantages of short steps and high yield.
3. Synthesis of hormone drugs
Thio derivatives used for synthesizing steroid hormone drugs. For example, in the synthesis of progesterone analogs, the introduction of thioformate ester groups enhances the specificity of drug receptor binding and improves biological activity.
The application in the field of environmental protection is gradually becoming prominent, and its strong oxidizing and reactive properties make it an effective tool for treating pollutants.
1. Sulfur containing wastewater treatment
It can react with sulfides (such as H ₂ S, S ² ⁻) in wastewater to generate elemental sulfur precipitation, reducing the toxicity of wastewater. For example, in the treatment of sulfur-containing wastewater in the petrochemical industry, sulfur phosgene serves as an oxidant to oxidize sulfides into elemental sulfur while reducing itself to sulfur dioxide, which can be further treated by absorption with alkaline solution.
2. Waste gas purification
Can be used to remove nitrogen oxides (NOx) from industrial waste gas. Under the action of a catalyst, it reacts with NO to generate N ₂ and CO ₂, achieving harmless treatment of nitrogen oxides. This technology is suitable for high NOx emission scenarios such as coal-fired power plants and steel plants.
3. Adsorption of heavy metal ions
Thiophosgene modified adsorbent materials (such as activated carbon and silica) have high selective adsorption capacity for heavy metal ions (such as Pb ² ⁺, Cd ² ⁺). Its mechanism of action is the formation of stable complexes between sulfur atoms in sulfur phosgene and heavy metal ions, achieving the separation and recovery of heavy metals.
With the rise of new energy vehicles and renewable energy industries, there is enormous potential for application in the field of new materials. It is expected that the market size will reach 4.8 billion yuan by 2030, with an average annual compound growth rate of 19%.
1. Synthesis of high-performance polymers
The polysulfide rubber involved in synthesis has characteristics such as oil resistance, solvent resistance, and aging resistance, and is widely used in fields such as automotive seals and spacecraft fuel tank liners. In addition, sulfur phosgene can also be used to synthesize sulfur-containing epoxy resins, improving the material's heat resistance and mechanical strength.
2. Preparation of conductive materials
Reacting with metal nanoparticles such as silver and copper can generate thiometal compounds, which can be used as conductive fillers to prepare flexible conductive thin films. This material has application prospects in fields such as touch screens and wearable devices.
3. Development of Functional Coatings
Titanium dioxide (TiO ₂) nanoparticles modified with sulfur phosgene exhibit photocatalytic activity and can degrade organic pollutants in the air, such as formaldehyde and benzene. By incorporating it into coatings, self-cleaning and antibacterial functional coatings can be prepared for use in building exterior walls, hospitals, and other scenarios.
Hot Tags: thiophosgene cas 463-71-8, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, N Ethoxycarbonyl 2 ethoxy 1 2 dihydroquinoline, 2 Chloro 4 6 dimethoxypyrimidine, 4 Propylphenylboronic Acid CAS 134150 01 9, 5 IODOINDOLE CAS 16066 91 4, Cytidine 5 diphosphate disodium salt, 5 6 Dimethoxy 1 indanone CAS 2107 69 9