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Tmcp-indole, full name (1H-Indol-3-yl) (2,2,3,3-tetramethylcyclopropyl) methanone, CAS number 895152-66-6, molecular formula C16H19NO, is composed of 16 carbon atoms, 19 hydrogen atoms, 1 nitrogen atom, and 1 oxygen atom. The LogP value of this compound is relatively high, indicating that it is more soluble in organic solvents and less soluble in water. Due to its polarity and high molecular weight, the solubility of this compound in water may be low. However, it may have good solubility in organic solvents such as ethanol, acetone, or dimethyl sulfoxide. Can be used as monomers or raw materials for synthesizing polymer materials. Polymer materials with specific properties such as high temperature resistance, wear resistance, and corrosion resistance can be prepared through polymerization reactions. These materials have broad application prospects in fields such as aerospace, automotive manufacturing, electronics, and electrical appliances.
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Chemical Formula |
C16H19NO |
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Exact Mass |
241.15 |
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Molecular Weight |
241.33 |
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m/z |
241.15 (100.0%), 242.15 (17.3%), 243.15 (1.4%) |
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Elemental Analysis |
C, 79.63; H, 7.94; N, 5.80; O, 6.63 |
Tmcp-indole, as 1H-indol-3-yl (2,2,3,3-tetramethyl-cyclopropyl) ketone (hereinafter referred to as the compound) has broad application potential in the field of biochemistry, mainly due to its unique chemical structure and biological activity.
Enzyme inhibitor:
Enzyme inhibitors are a class of compounds that can inhibit enzyme activity and have important application value in biochemical research. This compound can reduce the catalytic activity of enzymes by binding to their active sites, thereby achieving regulation of specific biochemical processes in living organisms.
Anti-tumor enzyme inhibitor:
Research has shown that this compound can serve as an inhibitor of certain anti-tumor enzymes. By inhibiting the activity of these enzymes, the growth and division of tumor cells can be blocked, thereby achieving anti-tumor effects. This application provides new ideas and methods for tumor treatment.
Neuroprotective enzyme inhibitor:
In addition, the compound can also serve as an inhibitor of neuroprotective enzymes. By inhibiting the activity of certain enzymes in the nervous system, neuronal damage and death can be reduced, thereby protecting the nervous system from disease. This application is of great significance for the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, etc.
Receptor agonists and antagonists:
Receptors are proteins on the cell membrane or inside the cell that can recognize and bind to specific signaling molecules (such as hormones, neurotransmitters, etc.), thereby triggering biochemical reactions within the cell. This compound can act as an agonist or antagonist of certain receptors, affecting cellular function by modulating receptor activity.
Hormone receptor agonists:
This compound can mimic the structure and function of certain hormones, activate hormone receptors upon binding, and trigger a series of biochemical reactions. This application can be used to regulate the endocrine function of the body and treat certain hormone deficiencies or hormone related diseases.
Neurotransmitter receptor antagonists:
In addition, the compound can also act as an antagonist of neurotransmitter receptors. By binding to neurotransmitter receptors, the activation of receptors by neurotransmitters can be blocked, thereby regulating the function of the nervous system. This application is of great significance for the treatment of neurological disorders such as depression and anxiety.
Biomarkers:
Biomarkers are chemical substances or biomolecules used to detect, monitor, or evaluate the health status of living organisms. This compound can serve as one of the candidate molecules for certain biomarkers, and by introducing specific functional groups or structural modifications, compounds with specific biological recognition abilities can be prepared.
Tumor markers:
Research has shown that this compound can bind to surface markers of certain tumor cells, thereby achieving specific recognition of tumor cells. This application can be used for early diagnosis, efficacy monitoring, and prognosis evaluation of tumors.
Neurodegenerative disease biomarkers
In addition, this tmcp-indole can also serve as one of the candidate molecules for neurodegenerative disease biomarkers. By binding to proteins related to neurodegenerative diseases, early diagnosis and monitoring of the disease can be achieved. This application is of great significance for the prevention and treatment of neurodegenerative diseases.
Drug screening and research and development
Drug screening is one of the important stages in the drug development process. This compound can serve as a tool or model molecule for drug screening, evaluating the activity, selectivity, and toxicity of drugs by binding to drug targets.
High throughput drug screening:
In high-throughput drug screening, this compound can serve as one of the model molecules for evaluating the activity of a large number of candidate drugs. Through binding experiments with drug targets, compounds with potential pharmacological effects can be quickly screened, providing strong support for subsequent drug development.
Drug target validation:
In addition, this compound can also be used for the validation of drug targets. Through binding experiments with known drug targets, the existence and activity of the targets can be confirmed, providing scientific basis for subsequent drug development.
Biomolecular modification and functionalization:
Biomolecular modification and functionalization are important research directions in the field of biochemistry. This compound can serve as a modifier or functionalizing agent, which can alter the properties and functions of biomolecules by introducing specific functional groups or structural modifications.
Nucleic acid modification:
In addition, the compound can also be used for the modification of nucleic acids. By binding with nucleic acids, the structure and stability of nucleic acids can be altered, thereby affecting their gene expression and function. This application is of great significance for fields such as gene therapy, gene diagnosis, and genetic engineering.
Efficiency leap Precision and stability
Protein modification:
This compound can bind to proteins and affect their function by altering their conformation or activity. This application can be used to prepare protein drugs or biomaterials with specific functions.
Biomolecular recognition and separation:
Biomolecular recognition and separation is one of the important technologies in the field of biochemistry. This compound can serve as a recognition molecule or separation medium, achieving recognition and separation of biomolecules through specific interactions.
Affinity chromatography:
In affinity chromatography, the compound can act as a ligand to bind with the chromatography medium for the separation and purification of biomolecules with specific properties. By specifically binding to the target molecule, efficient and rapid separation can be achieved.
In addition, the compound can also be used for the preparation of biosensors. By binding with target molecules, specific recognition and detection of biomolecules can be achieved. This application is of great significance for fields such as environmental monitoring, food safety, and disease diagnosis.
With the continuous development of biochemical technology and the deepening of research on this compound, we can expect its application in the field of biochemistry to be more extensive and in-depth. However, there are also some challenges and problems in the application process.
In the application process, it is necessary to pay attention to the biocompatibility and safety issues of the compound. Through rational chemical design and biological experimental verification, its stability and safety in living organisms can be ensured.
In addition, it is necessary to conduct in-depth research on the mechanism of action and targets of this compound. By understanding its interaction mode and regulatory mechanism with target molecules, scientific basis and guidance can be provided for its application in the field of biochemistry.
Finally, interdisciplinary collaboration and innovation are important driving forces for the application of this compound in the field of biochemistry. Through cross integration and collaborative innovation with fields such as chemistry, biology, and medicine, its application areas can be expanded and the rapid development of related technologies can be promoted.
Tmcp-indole has a wide range of application examples and potential in the field of biochemistry. By conducting in-depth research on its mechanism of action and targets, focusing on biocompatibility and safety issues, and strengthening interdisciplinary cooperation and innovation, we can expect its application in the field of biochemistry to be more extensive and in-depth in the future.
What does the molecular structure of this compound look like?
Indole ring:
- The indole ring is a bicyclic structure consisting of a benzene ring and a five membered nitrogen-containing pyrrole ring.
- The lone pair electrons of nitrogen participate in the formation of aromatic rings, making indole aromatic.
- The substituent position on the indole ring may affect its biological activity.
Tetramethylcyclopropyl ketone group:
- Tetramethylcyclopropyl is a cyclopropyl structure with four methyl substituents.
- The ketone group (C=O) is connected between the tetramethylcyclopropyl group and the indole ring, forming a connecting bridge.
- The presence of tetramethylcyclopropyl ketone group may give it specific spatial configuration and chemical properties.
What are the preventive measures and strategies for the side effects of this compound?
Precautions and countermeasures
Follow the doctor's advice on medication
When using (if it does represent a certain medication), be sure to follow the doctor's advice and do not increase the dosage or change the medication method on your own.
Pay attention to side effects
During use, closely monitor the body's reactions. If any discomfort symptoms occur, stop taking the medication immediately and seek medical attention.
Regular monitoring of liver and kidney function
Patients who have been using it for a long time should have their liver and kidney function monitored regularly in order to promptly detect and address potential liver and kidney dysfunction.
Maintaining a healthy lifestyle
While using medication, maintaining a healthy lifestyle such as a balanced diet, moderate exercise, and adequate sleep can help reduce the side effects of medication and improve treatment effectiveness.
Frequently Asked Questions
Here are five frequently asked questions (FAQs) about Tmcp-indole (CAS 895152-66-6) with detailed answers:
1. What is the chemical structure and molecular formula of Tmcp-indole?
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Answer: Tmcp-indole, or (1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone, consists of an indole ring (a fused benzene-pyrrole structure) attached to a tetramethylcyclopropyl ketone group. Its molecular formula is C₁₆H₁₉NO, with a molecular weight of 241.33 g/mol. The compound is characterized by high lipophilicity (LogP ≈ 2.17) and limited water solubility, but it dissolves well in organic solvents like ethanol, acetone, or dimethyl sulfoxide (DMSO).
2. What are the primary applications of Tmcp-indole in research and industry?
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Answer: Tmcp-indole is primarily used as a biochemical research tool and a building block for polymer synthesis. Its indole core structure makes it valuable for studying enzyme inhibition, particularly in targeting enzymes involved in cancer-related signaling pathways (e.g., Akt-NFκB, caspase activation). Additionally, its high thermal stability and resistance to wear/corrosion enable its use in developing advanced polymer materials for industrial applications.
3. Is Tmcp-indole safe to handle, and what precautions should be taken?
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Answer: While Tmcp-indole is not classified as a hazardous material under standard safety guidelines, it may act as an irritant to skin and eyes. Laboratory safety protocols recommend wearing gloves, goggles, and protective clothing when handling the compound. Avoid inhalation or ingestion, and work in a well-ventilated area. In case of contact, rinse thoroughly with water and seek medical attention if irritation persists.
4. How does Tmcp-indole relate to indole-based natural products or drugs?
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Answer: Tmcp-indole belongs to the broader family of indole derivatives, which include many bioactive natural products (e.g., tryptophan, serotonin, melatonin) and pharmaceuticals (e.g., indole alkaloids with anti-inflammatory, antiviral, or anticancer properties). Unlike natural indoles, Tmcp-indole is a synthetic compound designed for specific biochemical applications, such as enzyme inhibition or polymer modification, rather than direct therapeutic use.
5. Where can I purchase Tmcp-indole, and what purity levels are available?
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Answer: Tmcp-indole is commercially available from chemical suppliers like Shaanxi Bloom Tech Co., Ltd. and other specialty distributors. It is typically sold with HPLC purity ≥99%, ensuring high-quality research-grade material. The compound is exported globally to markets including the USA, Europe, and Asia, with packaging options ranging from milligram to kilogram quantities depending on demand.
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