Zearalenone CAS 17924-92-4

Corn F-2 toxin poisoning is divided into acute poisoning and chronic poisoning. In acute poisoning, animals exhibit excitement, restlessness, unsteady walking, muscle tremors throughout the body, and sudden collapse and death. At the same time, mucosal cyanosis can be observed, and there is no significant change in body temperature. Animals stand still, with feces that are as thin as water, foul smelling, gray brown in color, and mixed with intestinal mucus. Frequent urination, appearing pale yellow. At the same time, it also manifests as swelling of the external genitalia, mental exhaustion, decreased appetite, abdominal pain, and diarrhea. During the autopsy, lymph node edema, gastrointestinal mucosal congestion and edema, mild liver swelling, hard texture, and pale yellow color can also be found.

In chronic poisoning, the main toxicity to female livestock is greater. It can cause swelling of the external genitalia of female livestock. The phenomenon of congestion, stillbirth, and delayed miscarriage occurs on a large scale, accompanied by the phenomenon of mummified fetuses. 50% of female livestock suffer from ovarian cysts, increased frequency of estrus and false estrus, enlarged breasts in breeding females, spontaneous lactation, and induction of mastitis, leading to a decrease in conception rate. At the same time, it can also cause foreskin fluid accumulation, loss of appetite, severe fat loss, and poor growth in male livestock.

At present, there is no specific drug for treating animal F-2 toxin poisoning. It is necessary to immediately stop feeding suspicious feed during production and test the feed to determine whether it contains F-2 toxin. For livestock that have already been poisoned, certain treatment should also be given to reduce losses. For animals with acute poisoning, methods such as intravenous bloodletting and fluid replacement can be used to strengthen the heart. The specific therapy is to take 10% concentration of Na2SO4300-500g orally once, and bleed 200-1000mL from the vein according to the type and size of the animal. At the same time, administer 500-1000mL of 10% glucose, 500-1000mL of 5% glucose, 60mL of 40% urotropin, 500-1000mL of dextrose, and 110000 units of phenol triphosphate for intravenous infusion. Use VK again. 10mL one-time intramuscular injection. For animals with acute poisoning, administering a certain amount of clearing medicine is also a beneficial method for detoxification and protecting the gastrointestinal tract.

For animals with chronic poisoning, the moldy feed should be stopped first, followed by oral administration of mung bean and Sophora flavescens decoction, intravenous injection of glucose and sodium camphor sulfonate, and intramuscular injection of VA, VD, VE, and progesterone. For the treatment of external genitalia, 0.1% potassium permanganate can be used to wash swollen genitalia, and 3% iodine solution can be used to wipe the broken area. Generally, animals with chronic poisoning tend to have normal physiological indicators after 3 to 12 months of treatment, but the use of androgens and tocopherols during the treatment process is not effective.

Corn zearalenone has certain residues and accumulation in the body, and the time for the toxin to be metabolized out of the body is generally six months, causing significant losses and a long time. So, it is very necessary to take necessary anti-virus measures. Firstly, control the quality of feed. The direct cause of F-2 toxin poisoning in general is the presence of mold in the feed, especially in corn, wheat, soybeans contaminated with F-2 toxin. So, when using feed mainly made from these raw materials, attention should be paid to testing, and once discovered, they should not be used again. Secondly, pay attention to the storage of feed. In some areas of the south, the hot and rainy climate provides a favorable environment and conditions for the reproduction of mold, therefore, improper storage can also cause contamination by Fusarium graminearum.

For these feeds, they should be stored in a dry and ventilated environment, and some artificial methods should be taken to prevent contamination by red mold. Thirdly, moldy feed is generally no longer used. If actual conditions still require its use, the feed can be soaked in 10% lime water for one day and night, then washed repeatedly with clean water, and mixed with boiling water before feeding. At the same time, it should be noted that the dosage should not exceed 40%.