Best Growth Hormone Releasing Peptide CAS 87616-84-0

Best Growth Hormone Releasing Peptide (GHRP-6) is a type of polypeptide, whose general formula is: H-D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2. Among them, D-Ala represents D-type aspartic acid; D-2Nal represents D-type 2-naphthylalanine; D-Phe represents D-type phenylalanine; NH2 represents the C-terminal ending with an amine group. Different types of GHRP, such as GHRP-6, GHRP-2, and GHRP-3, have slightly different molecular structures, but their overall structural characteristics are similar. The main content of GHRP-6 Acetate is GHRP-6, which is generally a white or off-white crystalline powder, easily soluble in water and a small amount of concentrated hydrochloric acid, and insoluble in most organic solvents such as ethanol. The stability of GHRP-6 is greatly affected by factors such as pH value and temperature.

Promote the synthesis and release of growth hormone

 

Best Growth Hormone Releasing Peptide stimulates the production and release of GH by the cells of the anterior pituitary gland by binding to the growth hormone releasing hormone receptor (GHSR). Studying the growth hormone secretion characteristics of GHRP in normal and GH-deficient patients will help to understand the mechanism of GH regulation.

Regulate appetite and metabolism

 

GHRP can not only stimulate the synthesis and secretion of growth hormone, but also directly affect energy metabolism and appetite through the central nervous system and peripheral tissues. Studying the effect of GHRP on energy metabolism and appetite can provide new ideas for the treatment of diseases such as obesity and metabolic disorders.

Promote bone metabolism and maintain bone density

 

GH is an important hormone regulating bone metabolism, which can promote bone formation and maintain bone density. GHRP promotes bone metabolism and bone density by increasing the secretion of GH, and has the effects of anti-osteoporosis and improving growth and development.

Promote growth and development

 

GHRP can promote growth and improve growth retardation and other diseases by stimulating the secretion of GH. GHRP combined with growth hormone therapy has shown a synergistic effect in regulating growth and development, especially for diseases such as growth hormone deficiency and Turner syndrome.

Anti-aging

 

With age, the secretion of human growth hormone gradually decreases, resulting in a decrease in the level of GHRP in the body. As an exogenous growth hormone promoter, GHRP can supplement the deficiency of GHRP in the body, alleviate the aging process of the body, and thus have anti-aging effects.

Enhance immunity

 

Growth hormone plays an important regulatory role in the growth and function of immune cells in the body. By stimulating the synthesis and release of growth hormone, GHRP can enhance the body's immunity, reduce the risk of infection and alleviate diseases such as autoimmune diseases.

Improve cardiovascular health

 

GHRP can not only promote the synthesis and secretion of growth hormone, but also directly affect the function of the cardiovascular system. GHRP can lower blood pressure, improve blood lipids and improve myocardial contractility, thereby improving cardiovascular health.

Promote wound healing and tissue repair

 

Growth hormone plays an important role in wound healing and tissue repair. It can promote tissue regeneration and injury repair by stimulating the secretion of growth hormone and the release of related growth factors, especially for severe trauma such as fractures, wounds and burns.

Treatment of metabolic disorders and obesity

 

GHRP can not only stimulate the synthesis and secretion of growth hormone, but also directly affect energy metabolism and appetite through the central nervous system and peripheral tissues. Therefore, it has promising applications in regulating metabolic disorders and obesity.

GHRP-6 is the most widely used one in the GHRP family, and is mainly divided into the following steps:

• Synthesis of 1-phenyl-2-sulfated ethylene (benzene-1,2-disulfonic acid diethyl ester)

Dibenzoyl chloride was reacted with NaHSO3 to prepare ethyl 1-phenyl-2-sulfate. Then add NaI and potassium carbonate (K2CO3) to the mixed solvent, add 1-phenyl-2-sulfate ethyl ester and benzyl bromide, react to generate 1-phenyl-2-benzyloxyethane, and in weak acid Under the conditions of hydrolysis, 1-phenyl-2-sulfated ethylene.

• Synthesis of Boc-Phe-Gly-OH

Boc-Phe-Gly-OMe was obtained by condensing p-aminobenzimide and glycine monomethyl ester (Gly-OMe) in DMF/Guaiacol mixed solvent. It is subsequently hydrolyzed under acidic conditions to yield Boc-Phe-Gly-OH.

• Synthesis of GHRP-6

The produced 1-phenyl-2-sulfated ethylene was condensed with Boc-Phe-Gly-OH in N-methylpyrrolidone (NMP) under a nitrogen atmosphere to obtain the GHRP-6 precursor Boc-His(DNP)- D-Ala-Gly-Tyr(Bzl)-Ser(Bzl)-NH2. Subsequent treatment in a solution of TFA and trifluoroacetic acid (TFA:TFA=98:2) removed the N-terminal protecting group to obtain GHRP-6.

Dibenzoyl chloride and NaHSO3 reaction → 1-phenyl-2-sulfated ethylene preparation

Condensation of 1-phenyl-2-sulfated ethylene with Boc-Phe-Gly-OH → preparation of GHRP-6 precursor

GHRP-6 precursor deprotection group treatment → GHRP-6 preparation

Preparation of Boc-Tyr(tBu)-D-Ala-Asp-ALA-NH2→Preparation of GHRP-2 precursor

GHRP-2 precursor deprotection group treatment → GHRP-2 preparation

Preparation of Boc-Tyr(tBu)-D-Lys(tBu)-D-Ala-Phe-NH2→Preparation of GHRP-3 precursor

GHRP-3 precursor deprotection group treatment → GHRP-3 preparation

The chemical synthesis routes of Best Growth Hormone Releasing Peptide are described above. What they have in common is that the precursor of GHRP is first synthesized, and then the N-terminal protective group is removed to obtain the final product. The differences lie in different compositions of starting materials and precursors, as well as specific condensation and deprotection treatments. Due to the large number of GHRP family members, it is necessary to adjust according to different structures during specific synthesis. In general, the chemical synthesis route of GHRP is relatively complex and requires high-level chemical synthesis technology and equipment support.

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