CJC-1295 with DAC, also known as Growth Hormone Releasing Factor (GRF MOD 1-29) or GRF, is a modified form of GHRH. It consists of 29 amino acids, derived from the 44-amino acid long version of GHRH by removing 15 amino acids. The addition of Drug Affinity Complex (DAC) significantly extends its duration of action, allowing it to remain active in the body for up to 14 days, much longer than CJC-1295 without DAC. It should be made clear that cjc-1295 without DAC, which is considered to be an ordinary cjc-1295 without DAC, is actually a wrongly named mod GRF. When the peptide does not contain DAC, CJC 1295 no DAC is no longer regarded as CJC, which may confuse many people. Mod GRF is actually a modified version of tera substituted peptide of original GRF 1-29, commonly known as sermorelin.
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CJC-1295 COA
An experiment on CJC DAC:
Cjc-1295 DAC (GHRH) 2mg vial
Growth hormone-releasing hormone (GHRH)
98% + purity
CJC with DAC on behalf of the drug affinity complex provides 2mg lyophilized powder. This is a drug-grade research peptide containing 30 amino acids.
DAC CJC 1295 has been used as a growth hormone peptide. It is most commonly used to stimulate the pituitary gland to release growth hormones. Studies have shown that growth hormone is responsible for several important functions in the body. This includes increased muscle mass as well as improved bone mineral density and higher IGF-1 levels. Therefore, by taking CJC-1295 with DAC, your body can also increase these aspects of health.
Chemists can modify peptides to extend half-life or the time in subjects before they are destroyed. This makes proteins easier to study and has proved to prolong the biological activity of reducing metabolic clearance.
This peptide is most suitable for infrequent injection because it can stay in the subject's system for a longer time to produce growth hormones. For 2mg vials, the lyophilized powder should be reconstructed by adding 2ml bacteriostatic water. Gently add water and let the solution mix for a few seconds (do not shake). Once the bacteriostatic water is added to the vial, the solution should be kept in the refrigerator and can now be used for testing and research purposes.
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Research Applications in Muscle Growth and Strength Enhancement
In exercise science, muscle mass and strength are core indicators for evaluating athletic ability, and CJC-1295 with DAC has been extensively and in-depth studied in this field.
Research on muscle hypertrophy mechanisms: By elevating GH and IGF-1 levels, it promotes muscle protein synthesis and inhibits muscle proteolysis, particularly enhancing training-induced muscle hypertrophy after resistance exercise. Studies typically enroll young healthy subjects, elderly sarcopenic populations, and strength-trained athletes. Indicators such as muscle cross-sectional area, muscle volume, and 1RM strength are measured to assess its pro-hypertrophic effects under different training loads, while exploring its synergistic mechanisms with resistance training.
For example, 1–2 weekly injections of CJC-1295 with DAC during a resistance training cycle can significantly increase the rate of muscle protein synthesis, leading to a greater magnitude of muscle fiber growth compared to training alone.
Research on muscle mass maintenance: Targeting muscle loss in endurance athletes due to long-term training, CJC-1295 with DAC can reduce muscle catabolism during endurance exercise by maintaining IGF-1 levels. Studies have shown that supplementation with this peptide during endurance training (e.g., long-distance running, cycling) lowers the levels of muscle damage markers (e.g., creatine kinase), while improving muscular endurance and extending time to exhaustion. This provides a theoretical basis for developing training regimens that preserve muscle and enhance performance in endurance sports.
Research on muscle health in special populations: CJC-1295 with DAC serves as a research tool to promote muscle recovery in elderly athletes and individuals in the post-injury rehabilitation phase. Elderly populations experience reduced muscle mass and strength due to declining GH secretion; studies have found that this peptide elevates IGF-1 levels in elderly subjects, enhances muscle contractile function, and reduces fall risk. After exercise injury, it accelerates the repair of muscle tears, contusions, and other injuries by activating satellite cells, shortening the time to return to training.
Research Applications in Accelerating Post-Exercise Recovery
Rapid post-exercise recovery is critical for ensuring training continuity and avoiding overtraining. CJC-1295 with DAC demonstrates prominent research value in muscle damage repair, fatigue elimination, and metabolic recovery.
Research on muscle damage repair mechanisms: High-intensity training causes muscle fiber microdamage, triggering an inflammatory response and muscle soreness. CJC-1295 with DAC promotes the clearance of inflammatory factors and accelerates muscle fiber regeneration via the GH/IGF-1 axis, while increasing collagen synthesis to enhance the strength of muscle connective tissue. In research, it is often used in combination with peptides such as BPC-157 to explore synergistic repair effects.
For instance, in a rat model of eccentric exercise-induced injury, the combined use of CJC-1295 with DAC and BPC-157 significantly reduces muscle inflammation and accelerates muscle healing, providing experimental evidence for combined interventions after exercise injury.
Fatigue elimination and energy metabolism recovery: Exercise fatigue is associated with energy substrate depletion, metabolic waste accumulation, and hormonal imbalance. This peptide elevates GH levels to promote hepatic glycogen synthesis and accelerate the clearance of metabolic waste such as lactic acid, while regulating sleep quality. GH is secreted abundantly during deep sleep, and the long-acting GH stimulation by CJC-1295 with DAC helps extend deep sleep duration and improve sleep architecture, thereby accelerating the elimination of central and peripheral fatigue.
Studies have confirmed its ability to shorten the duration of post-exercise fatigue and improve readiness for subsequent training by monitoring indicators such as blood lactate clearance rate, glycogen recovery rate, and sleep electroencephalogram in subjects.
Research on joint and soft tissue injury repair: Joint, tendon, and ligament injuries are common in sports. CJC-1295 with DAC enhances the proliferation and matrix synthesis of chondrocytes and tenocytes by promoting IGF-1 secretion, improving the repair capacity of joints and soft tissues. In research on injury in contact sports such as basketball and football, it is used to explore non-surgical treatment regimens for injuries such as tendinitis and ligament tears. Studies have shown that it increases blood circulation at the injury site, enhances tissue nutrient supply, promotes the orderly arrangement of collagen fibers, and improves the mechanical properties of repaired tissues.
Research Applications in Body Composition Remodeling
Body composition (e.g., body fat percentage, lean body mass ratio) exerts a significant impact on athletic performance, and CJC-1295 with DAC is widely applied in research on optimizing body composition through fat loss and muscle gain.
Research on fat loss mechanisms and effects: Through GH and IGF-1, this peptide enhances lipolysis in adipose tissue, promoting triglyceride breakdown into fatty acids for energy production, while inhibiting adipocyte differentiation and proliferation-with a particularly significant effect on reducing visceral fat. In studies on obese athletes or athletes in sports requiring rapid fat loss (e.g., combat sports, gymnastics), it is often combined with a low-calorie diet and aerobic training.
Measurements of body fat percentage, visceral fat area, and blood lipid levels show that the experimental group using CJC-1295 with DAC achieves a significantly higher rate of fat loss than the control group without significant muscle loss, achieving the ideal effect of fat loss while preserving muscle.
Research on lean body mass ratio optimization: For sports requiring high lean body mass (e.g., rugby, weightlifting), CJC-1295 with DAC helps athletes increase their lean body mass ratio during training cycles to enhance strength and explosive power. In research, body composition is measured via dual-energy X-ray absorptiometry (DXA). It is found that 2 weekly injections of this peptide combined with resistance training leads to a 3%–5% increase in lean body mass and a 2%–4% decrease in body fat percentage after 8 weeks, with muscle strength positively correlated with lean body mass gain-verifying its effectiveness in body composition optimization.
Research on metabolic adaptability: Long-term athletic training alters the body's metabolic pattern. CJC-1295 with DAC enhances insulin sensitivity and improves glucose and lipid metabolism by regulating the GH/IGF-1 axis, making the body more prone to an anabolic state. In studies on pre-diabetic athletes or obese subjects with metabolic disorders, this peptide lowers fasting blood glucose and insulin levels and improves glucose uptake capacity, providing a new direction for improving metabolic health through the combination of exercise and peptide intervention.
Biosynthetic Method
The biosynthesis method uses the gene manipulation technology in the organism to transform the genetically engineered strain into a CJC1295 production plant, which is an emerging CJC1295 synthesis method. The biosynthesis method of JC-1295 is synthesized by genetic engineering technology in Escherichia coli and other recombinant expression systems. This method usually includes gene cloning, construction of recombinant plasmids, transformation and expression of E. coli, purification and quality control steps. This method can introduce the target gene from the foreign source into the DNA inside the bacterium, and use the organism's own metabolic pathway to synthesize the required CJC1295. Compared with the traditional chemical synthesis method, the biosynthesis method does not need to use chemical reagents, does not produce environmental pollution and product impurities, and also has higher yield and purity. It is a very promising method for the production of CJC1295.
During the biosynthesis of CJC-1295, the gene sequence corresponding to CJC-1295 needs to be obtained from the human genome first. This step can be achieved by various methods, such as PCR amplification, high-throughput sequencing and other technologies.
Cloning the CJC-1295 gene into an appropriate expression vector, generally choose an expression vector that can be expressed in Escherichia coli, such as pET series plasmids. These expression vectors usually contain promoters, initiators, terminators, selective resistance genes, multiple cloning sites and other elements.
The above recombinant plasmid was transformed into Escherichia coli, and after a series of operations such as induction, the cell produced CJC-1295 polypeptide, and at this time CJC-1295 had been embedded in the polypeptide chain. At this stage, the bacteria need to be optimized and cultivated to achieve the best production efficiency and toxicity control.
Through a series of separation and purification steps such as centrifugation, lysis, column chromatography, ultrafiltration, electrophoresis, and dialysis, high-purity CJC-1295 can be obtained. Among them, column chromatography is the most commonly used method in this step, and reversed-phase high-performance liquid chromatography (RP-HPLC) or ion exchange chromatography (IEX) column is usually selected for separation. In column chromatography, CJC-1295 is separated by gradient elution, and then the purified product is detected and identified by mass spectrometry and other tools.
The last step is to control the quality of the synthesized CJC-1295. This process mainly includes testing the physical and chemical properties, biological activity, and structural identification of CJC-1295. Among them, the detection of physical and chemical properties mainly includes appearance, pH value, solubility, amino acid analysis, etc.; the detection of biological activity mainly includes in vivo and in vitro growth hormone release experiments, etc.; structural identification is through mass spectrometry, nuclear magnetic resonance, amino acid sequence analysis and other tools CJC-1295 was identified to confirm its quality and purity.
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The primary effects of CJC-1295 with DAC include enhanced secretion of growth hormone in the bloodstream, promotion of muscle growth and strength, effective fat burning, improved skin quality with rejuvenation and wrinkle smoothing, increased bone density, and positive effects on sleep, regeneration, and vitality. It is often administered through intramuscular or subcutaneous injection, typically at bedtime, and its cycle duration is not restricted.
Frequently Asked Questions
Does CJC-1295 help with weight loss?
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CJC 1295/Ipamorelin supports weight loss through multiple mechanisms: Increased Fat Metabolism: Enhances lipolysis (fat breakdown), especially in hard-to-target areas like hips, thighs, and abdomen.
What are the potential side effects of CJC-1295?
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While CJC-1295 is generally well-tolerated, it is important to be aware of potential side effects such as:
Headaches.
Nausea.
Fatigue.
Water retention.
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