Bremelanotide powder (PT-141) is a synthetic peptide drug commonly known as PT 141 peptide, used as a therapeutic drug. Its chemical formula is C50H68N14O10, CAS 189691-06-3. White or grayish white crystalline powder. The solubility in water is 1 mg/mL, and the solubility in methanol is 2 mg/mL. It is a relatively stable compound, but may decompose or degrade under high temperature or humidity environments. Shaanxi BLOOM Tech Co., Ltd. has a pt 141 peptide available for sale. If you would like to know the pt 141 price or want to buy a pt 141 peptide, please send us an email. We have the best pt 141, and we are the best place to buy a pt 141. We can not only provide PT-141 powder, but also PT-141 Acetate, which is mainly composed of peptide 141 and CAS 1607799-13-2. We have 15 years of chemical production and research and development conditions, and we can also provide customized products. However, it should be noted that the products we provide are for laboratory use only, and anyone who uses bremiranide should first consult a professional doctor and follow their advice and prescription.
Customized Bottle Caps & Corks
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PT 141 COA
Bremelanotide Powder is a synthetic polypeptide hormone whose structure is similar to leptin, tyrosine and skin melanin that naturally exist in the human body. It is mainly used clinically in the treatment of sexual dysfunction, insomnia and other related diseases.
Sexual dysfunction
Sexual dysfunction is a common sexual health problem in both men and women, including erectile dysfunction, premature ejaculation, loss of libido, and more. Bremelanotide is an effective drug for the treatment of sexual dysfunction. It increases libido, promotes erection and prolongs the duration of sexual intercourse by promoting blood flow into the corpus cavernosum and vaginal tissues. Studies have shown that Bremelanotide can produce these effects by stimulating the Melanocortin-4 receptor (MC4R) in the central nervous system.
Bremelanotide was initially given to patients by subcutaneous injection, but an oral version of Bremelanotide, known as Bremelanotide oral film, was subsequently developed. This version of Bremelanotide produced strong libido in pre- and post-transition male and female patients. Therefore, Bremelanotide has a great application prospect in the treatment of sexual dysfunction.
Insomnia
Insomnia is a common sleep disorder, including difficulty falling asleep, waking up easily, and poor sleep quality. Bremelanotide is an effective drug for the treatment of insomnia, which improves the excitability of neurons by stimulating the release of dopamine and norepinephrine, thereby helping to fall asleep and prolong sleep time.
Studies have shown that Bremelanotide can improve insomnia symptoms when given to patients in the form of an oral or nasal spray. In a clinical trial, Bremelanotide nasal spray was tested in 48 healthy adults and found that Bremelanotide significantly reduced insomnia symptoms and improved sleep quality and duration.
Obesity
Bremelanotide is an appetite-regulating hormone that reduces appetite by stimulating MC4R in the central nervous system, thereby helping to reduce obesity symptoms. Studies have shown that Bremelanotide can reduce food intake, increase basal metabolic rate and reduce body weight.
In a Phase II clinical trial, Bremelanotide was tested in 90 obese patients and found that Bremelanotide could significantly reduce body weight and BMI. The trial also found that Bremelanotide has a very significant effect on appetite control in obese patients, so it has broad application prospects in obesity treatment.
Stress-induced cardiovascular disease
Stress cardiovascular disease is a heart and vascular disease associated with traumatic stress, such as acute coronary syndrome, myocardial infarction, etc. Bremelanotide improves neuronal excitability and cardiovascular health under stress by stimulating receptors such as norepinephrine receptors, dopamine receptors, and MC4R.
In a small-scale clinical trial, Bremelanotide was tested in 10 patients with stress-induced cardiovascular disease, and it was found that Bremelanotide could significantly improve the patients' heart rate variability and blood pressure response, and improve heart function and fitness.
Other clinical applications
In addition to the above applications, Bremelanotide can also be used as a skin softener, a scanning agent for body surfaces and internal organs, and regenerative medicine therapy. For example, Bremelanotide can promote wound healing, improve airway obstruction, etc. Moreover, the latest research shows that Bremelanotide can reduce the number of white fat cells and improve insulin sensitivity.
Synthesis Method
Synthesis of 5-hydroxytryptamine (5-HT)
First, use phenylcarboxylic acid (TPA) and benzaldehyde as raw materials, and carry out aromatic carbonylation reaction under the catalysis of sulfuric acid to obtain TPA benzoyl compound. This compound is then reacted with sodium nitrosate and hydrochloric acid to produce the 5-nitroTPA benzoyl compound. This compound is then reacted with iron and acetic acid to give the 5-hydroxyTPA benzoyl compound, serotonin.
Synthesis of Boc-L-Phe-D-Trp-Lys-OH
Link phenylalanine, tryptophan and lysine whose protecting group is tert-butoxycarbonyl (Boc) with an amide bond to form a tripeptide Boc-L-Phe-D-Trp-Lys-OH.
Synthesis of Boc-L-Phe-D-Trp-Lys(Boc)-OH
Reaction of Boc-L-Phe-D-Trp-Lys-OH with Boc2O and dimethylmethanesulfonamide (DMAP) to remove lysine Amino acid Boc protecting group, forming Boc-L-Phe-D-Trp-Lys(Boc)-OH.
Synthesis of Bremelanotide
react Boc-L-Phe-D-Trp-Lys(Boc)-OH with 5-hydroxytryptamine and N,N-dimethylformamide (DMF) in the presence of activated carbon to remove Boc protection base, forming Bremelanotide.
D-LAME is an illegal substance without any legal prospects for development. D-LAME and other psychedelics have serious physical and psychological hazards that can cause unintentional injury, hallucinations, delusions, anxiety, and more, so any attempt to use or prepare them is irresponsible.
Furthermore, since D-LAME is an illegal substance, its research and development will face severe legal and ethical constraints. Preparation, use and trade in violation of the law will have serious legal consequences and may raise public safety and health concerns.
In conclusion, D-LAME does not have any legitimate development prospects, its abuse will bring serious physical and psychological risks, and should not be supported or promoted in any form.
Chemical Properties
Bremelanotide powder (PT-141) is a synthetic polypeptide drug whose chemical structure is an oligopeptide consisting of 7 amino acids. The following are the chemical properties of Bremelanotide:
pKa value
Bremelanotide is a polypeptide, and its pKa value depends on its environmental conditions. The pKa value of Bremelanotide is about 4-5 in the environment of most organisms.
Hydrolysis
Bremelanotide is an oligopeptide with certain hydrolysis. It can be hydrolyzed into individual amino acids or smaller peptides under acidic or basic conditions.
Oxidation
Bremelanotide is an oligopeptide containing multiple amino acids, some of which are prone to oxidation, so it needs to maintain a certain oxidation stability during storage and use.
Bremelanotide (PT-141) is a synthetic peptide drug whose reactivity depends on its molecular structure and interaction with other compounds. The following are some reactive properties of Bremelanotide:
1. Hydrolysis reaction: Bremelanotide is an oligopeptide with certain hydrolysis properties, and can be hydrolyzed into individual amino acids or smaller peptides under acidic or alkaline conditions.
2. Oxidation reaction: Some amino acids contained in Bremelanotide are easy to oxidize, so it needs to maintain a certain oxidation stability during storage and use.
3. Condensation reaction: Bremelanotide can interact with other compounds through condensation reaction to form new compounds.
4. Reaction with acid and alkali: Bremelanotide contains some free amino acids, which can react with acid or alkali, affecting its solubility and chemical properties.
5. Interactions with other medicines: Bremelanotide may interact with other medicines, affecting their efficacy and side effects.
The above are some basic chemical properties of Bremelanotide. It should be noted that these properties can vary according to environmental conditions and the way the drug is prepared. Anyone using Bremelanotide should first consult a professional physician and follow the physician's advice and prescription.
What are the sales channels for this compound?
1.Pharmaceutical companies and biotechnology companies
R&D and production
Pharmaceutical and biotechnology companies typically have professional research and development teams dedicated to the development of this substance. They continuously optimize the structure and performance of their products through techniques such as synthetic chemistry and molecular biology. During the production process, these companies follow international standards such as GMP (Good Manufacturing Practice) to ensure the purity and quality of their products.
Sales and Distribution
Pharmaceutical and biotech companies typically sell it to medical institutions, research institutions, or professional chemical suppliers through their own sales networks or partnerships. They may also expand the product's visibility and sales channels through online platforms or exhibitions.
Compliance and Regulation
Pharmaceutical companies and biotechnology companies must comply with relevant national and regional laws and regulations when selling, including drug registration, production permits, sales permits, etc. They also need to undergo regular inspections and audits by regulatory agencies to ensure product compliance and safety.
2.Professional chemical supplier
Procurement and Storage
Professional chemical suppliers typically establish cooperative relationships with multiple pharmaceutical or biotechnology companies and procure from them. They have professional storage facilities that can ensure its stability and safety during storage.
Distribution and Customization
Professional chemical suppliers distribute their products to customers such as research institutions, pharmaceutical companies, and medical institutions through their own sales networks or partnerships. They also provide customized synthesis services that can synthesize substances with specific structures or properties according to the specific needs of customers.
Technical support and services
Professional chemical suppliers usually have a professional technical support team that can provide customers with technical consultation, experimental guidance, and other services related to it. They can also provide product manuals, safety data sheets, and other documents according to customer needs to ensure that customers can use and store them correctly.
3.Online sales platform
E-commerce platform
E-commerce platforms such as Alibaba and Amazon provide a wealth of product information. Customers can find products that meet their needs by searching keywords or browsing related categories. When purchasing on e-commerce platforms, customers can enjoy a convenient shopping process, fast logistics delivery, and comprehensive after-sales service.
Professional website
Some professional websites focused on chemical sales, such as Chemical Reagent Network and Biological Reagent Network, also provide sales services for this substance. These websites typically have more professional product information and stricter supplier audit mechanisms to ensure product quality and safety. When purchasing on professional websites, customers can enjoy more professional technical support and services, such as product consultation, experimental guidance, etc.
Frequently Asked Questions
What does bremelanotide do?
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Bremelanotide injection is used to treat hypoactive sexual desire disorder (HSDD) in premenopausal women who previously had no problems with sexual desire and that occurs in any type of stimulation, situation, or partner.
Should men not use bremelanotide?
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Bremelanotide injection should not be used for the treatment of HSDD in women who have gone through menopause, in men, or to improve sexual performance.
Is PT-141 the same as bremelanotide?
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PT-141, also known as Bremelanotide, is a synthetic peptide utilized to treat sexual dysfunction in both men and women. For men, PT-141 provides a unique solution for those facing sexual performance challenges by targeting the brain's centers for sexual response.
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