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Ganirelix Acetate is a synthetic bioactive peptide with the molecular formula C80H113ClN20O13, CAS 123246-29-7, and a relative molecular weight of 1570.71 g/mol. A white or almost white crystalline powder. The infrared spectrum displays a series of characteristic peaks to characterize its molecular structure. Mainly used for treating infertility. It has broad application value in medical research, especially playing an important role in the research fields of reproductive health, in vitro fertilization technology, premature birth, and other diseases. With the deepening of research and the development of clinical trials, its application prospects will be even broader.
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Customized Bottle Caps And Corks:
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Chemical Formula |
C80H112ClN17O13 |
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Exact Mass |
1554 |
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Molecular Weight |
1555 |
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m/z |
1554 (100.0%), 1555 (86.5%), 1556 (37.0%), 1556 (32.0%), 1557 (27.7%), 1558 (11.8%), 1557 (10.4%), 1555 (6.3%), 1556 (5.4%), 1559 (3.1%), 1556 (2.7%), 1557 (2.3%), 1557 (2.3%), 1558 (2.2%), 1557 (2.0%), 1558 (1.7%), 1556 (1.1%) |
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Elemental Analysis |
C, 61.78; H, 7.26; Cl, 2.28; N, 15.31; O, 13.37 |
Ganirelix Acetate has multiple uses in medical research, and the following are its main aspects:
1. Reproductive health research:
Used as an antagonist in reproductive health research, primarily to inhibit the release of gonadotropins. This enables researchers to precisely control hormone levels under laboratory conditions, thereby better understanding the physiological and pathological processes of the reproductive system. By using it, scientists can study the effects of hormones on processes such as follicle development, ovulation, and corpus luteum formation, further revealing the working mechanisms of the reproductive system.
2. IVF technology:
In IVF programs, it is used to inhibit the secretion of luteinizing hormone, thereby preventing premature luteinizing hormone peaks. This is particularly important for the research and treatment of controlled ovarian hyperstimulation syndrome (OHSS), as OHSS is often associated with a sharp increase in luteinizing hormone levels. By using GanirelixAcetate, researchers and doctors can better understand and manage complications such as OHSS, thereby improving the success rate of in vitro fertilization.
3. Premature birth research:
In addition to its applications in reproductive health and in vitro fertilization technology, it is also used in premature birth research. Its antagonistic effect on gonadotropin-releasing hormone helps to slow down uterine contractions, prolong pregnancy, and provide more growth and maturation time for the fetus. This is of great significance for the research and treatment of complications related to premature birth, which can help improve the quality of life and health status of premature infants.
Basic Information
Acetic acid ganrelic is a synthetic peptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH). Its chemical name is N-acetyl-3- (2-naphthalene) - D-alanyl-4-chloro-D-phenylalanyl-3- (3-pyridine) - D-alanyl-L-serinyl-L-tyrosyl-N6- [bis (ethylenemethylene)] - D-lysyl-L-leucyl-N6- [bis (ethylenemethylene)] - L-lysinyl-L-prolyl-D-propanamide acetate. Acetic acid Ganeric injection is a colorless clear solution, typically with a specification of 0.5ml: 0.25mg (calculated as Ganeric).
Main mechanism of action
Acetic acid ganrelic is a GnRH antagonist that competitively blocks the gonadotropin-releasing hormone (GnRH) receptor on pituitary gonadotropic cells and subsequent transduction pathways. It produces a rapid and reversible inhibitory effect on the secretion of gonadotropins. This mechanism of action results in significant therapeutic effects and clinical value of acetic acid ganciclovir before and after female IVF egg retrieval.
Multiple uses in medical research
1. Prevent premature onset of luteinizing hormone (LH) peak
Among women receiving controlled ovarian stimulation (COS) regimen with assisted reproductive technology (ART), acetic acid ganciclovir is used to prevent premature LH peak. The LH peak is a key event in the ovarian stimulation cycle, which marks the maturation of follicles and the imminent ovulation. However, during the ART process, premature LH peaks can lead to premature ovulation of follicles, thereby reducing the success rate of conception. Acetic acid ganrelic effectively prevents premature LH peak by inhibiting the secretion of LH in the anterior pituitary gland, ensuring that follicles can develop normally to the mature stage.
2. Promote follicular development
Acetic acid ganciclovir plays an important role in promoting follicular development. It helps women obtain mature follicles during ART by precisely controlling hormone levels. In patients receiving COS treatment, the combination of acetic acid and follicle stimulating hormone (FSH) can significantly improve the quantity and quality of follicles. This is of great significance for improving pregnancy rates and embryo quality.
3. Inducing amenorrhea
Acetic acid injection of Ganarik can simulate the pituitary peak secretion pattern caused by the release of normal physiological conditions, leading to the cessation of follicle development and gradual degeneration, thereby achieving the effect of inducing amenorrhea. In some cases, such as endometriosis, uterine fibroids, and other gynecological diseases, inducing amenorrhea can be an effective treatment method. Acetic acid ganrelic alleviates related symptoms and improves patients' quality of life by inhibiting ovarian function and reducing estrogen levels.
4. Treatment of endometriosis
Acetic acid ganciclovir has also shown significant clinical efficacy in the treatment of endometriosis. Endometriosis is a common gynecological disease that can cause symptoms such as pelvic pain and infertility. Acetic acid ganrelic reduces estrogen production by downregulating endogenous GnRH levels, thereby decreasing the proliferation rate of endometrial cells and the probability of new blood vessel formation. This helps alleviate pain, control disease progression, and improve the patient's fertility.
5. Prevention of Polycystic Ovary Syndrome (PCOS)
Acetic acid ganciclovir, as a GnRH antagonist, can prevent the occurrence of polycystic ovary syndrome. PCOS is a common endocrine and metabolic disorder that can lead to symptoms such as ovulation disorders and hyperandrogenism in women. Acetic acid ganrelic improves ovarian function and fertility by inhibiting the secretion of gonadotropins in the anterior pituitary gland, reducing androgen levels. This is of great significance for the treatment of PCOS patients.
6. Reduce or prevent ovarian hyperstimulation syndrome (OHSS)
OHSS is a common complication during the ART process, which can lead to symptoms such as ascites, electrolyte imbalance, and difficulty breathing. Acetic acid garenicol reduces the incidence of OHSS by inhibiting ovarian function and decreasing the production of estrogen. In addition, acetic acid ganciclovir can also stabilize the subsequent treatment of IVF, allowing some younger ovulation induction patients to alleviate or avoid OHSS symptoms.
7. Improve the success rate of assisted reproductive technology
The application of acetic acid ganirik in assisted reproductive technology can significantly improve the conception rate and embryo quality. It ensures the normal development of follicles to the mature stage and improves the quality and quantity of eggs by precisely controlling hormone levels. This is of great significance for improving the success rate of assisted reproductive technology. In addition, acetic acid garenicol can also reduce the occurrence of complications such as OHSS and ectopic pregnancy, thereby further improving the fertility of patients.
Acetic acid, as an important bioactive compound, has a wide range of applications in pharmaceuticals, biotechnology, and medical research. This method provides a simple way to prepare high-purity Ganirelix Acetate and glycyrrhetinic acid, which is not only easy to operate but also suitable for industrial production. The following are the detailed steps:
(1) Mix the crude product of Ganrike with an appropriate amount of acetic acid aqueous solution, stir evenly, until the crude product of Ganrike is completely dissolved. The chemical equation for this step is:
C80H113ClN18O13 + C2H4O2 → C80H113ClN18O13 (Acetic acid Ganrike).
(2) Slowly add ethyl acetate solution and adjust the pH value of the mixture to the appropriate range (usually 4.5-5.5), so that Ganirek and acetic acid form a salt. The chemical equation for this step is:
C80H113ClN18O13 + C2H5NO2 → C80H113ClN18O13-C2H5NO2 (Acetic acid Garnier acetate)+ H2O
(3) Precipitate the mixed solution, filter it after complete precipitation, and obtain the solid of Ganrike acetate.
(1) Dissolve the obtained Ganaric acetate in an appropriate amount of acetic acid aqueous solution to form a uniform solution.
(2) Purify by chromatography. Select appropriate chromatographic column fillers, such as silica gel, activated carbon, etc. Wash with acetic acid aqueous solution as the mobile phase. Separation and purification were achieved based on the difference in adsorption performance between Ganiric acetate and other impurities. Collect the eluent, concentrate and crystallize to obtain acetic acid ganerik crystals.
(1) Dry the obtained acetic acid garnet crystals to remove residual moisture and solvents. Vacuum drying or oven drying methods can be used, with a temperature controlled between 30-50 ℃ until there are no water stains on the surface of the crystal.
(2) The dried crystals undergo quality testing to ensure that the purity meets the predetermined standard (such as 99.82%). High performance liquid chromatography, gas chromatography, or mass spectrometry can be used for detection. Meanwhile, measure the maximum single impurity content to ensure it is below the allowable value (such as 0.04%).
Advantages and Innovation Points:
1. This method only uses acetic acid aqueous solution and acetic acid acetonitrile solution system as eluents throughout the process, avoiding the use of toxic and harmful organic solvents and making it more environmentally friendly.
2. The crude product of Ganarike was purified by chromatography after salt conversion, resulting in high purity of acetic acid Ganarike with extremely low maximum single impurity content.
3. The entire preparation process does not introduce additional ions, ensuring the purity and quality of the product.
4. Easy to operate, without the need for complex equipment and conditions, suitable for industrial production.
Market demand
The demand for assisted reproductive technology is increasing: With the increasingly prominent problem of infertility, the demand for assisted reproductive technology is constantly growing. As an antagonist of follicle stimulating hormone (FSH) therapy, this substance can effectively prevent premature ovulation and improve the success rate of assisted reproductive technology. Therefore, its market demand is expected to continue to grow.
With the intensification of global population aging, fertility issues have become a focus of attention for more and more families. This further promotes the development of assisted reproductive technology and provides a broader market space for related drugs.
Market competition
At present, there are multiple brands of products on the market with certain price differences. Brand awareness and price advantage will become key factors in market competition. With the continuous advancement of medical technology, the research and innovation of new drugs will become an important direction for market competition. Enterprises need to continuously increase research and development investment, improve product quality and efficacy, in order to meet market demand.
Technological innovation
Developing more convenient and efficient drug delivery methods, such as oral and transdermal patches, will help improve patient medication adherence and comfort. Exploring the combination therapy of this substance with other drugs to improve treatment efficacy and reduce side effects will provide a broader space for its application in the market.
Policies and regulations
The adjustment of drug approval policies in various countries will directly affect the market access and launch time of such new drugs. Enterprises need to closely monitor policy developments and adjust market strategies in a timely manner. Strengthening intellectual property protection and safeguarding the legitimate rights and interests of enterprises will provide strong guarantees for their continuous innovation and market expansion.
Development Trends
With the popularization of assisted reproductive technology and the increasing trend of population aging, the market size of this compound is expected to continue to expand.
With the continuous advancement and innovation of medical technology, its administration methods, combination therapy regimens, etc. will be continuously optimized and improved to meet the needs of more patients.
With the integration and opening up of the global medical market, these new drugs will gradually move towards the international market, bringing more development opportunities for enterprises.
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