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Mog (35-55) (Myelin Oligodendrocyte Glycoprotein) is a membrane protein located in the myelin sheath of the central nervous system, particularly expressed abundantly in the plasma membrane of oligodendrocytes. It is a glycoprotein, which means its molecular structure contains both protein and sugar chain components. The protein part is mainly composed of amino acid sequences, forming a stable three-dimensional structure through specific folding and conformation. The sugar chain part attaches to the protein and affects the function and stability of myelin oligodendrocyte glycoproteinthrough glycosylation modification. At the molecular level, MOGs have specific amino acid sequences and glycosylation sites.
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Catalog Overview
Mog (35-55) COA
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| Certificate of Analysis | ||
| Compound name | Mog (35-55) | |
| Grade | Pharmaceutical grade | |
| CAS No. | 149635-73-4 | |
| Quantity | 39g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090035 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.54% |
| Loss on drying | ≤1.0% | 0.42% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.52% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below -15°C | |
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These sequences and sites determine the biological activity of myelin oligodendrocyte glycoproteinthrough, its interactions with other molecules, and its localization on the cell membrane. As a membrane protein, MOG has transmembrane properties, with one part located inside the cell and the other part located outside the cell. This characteristic enables myelin oligodendrocyte glycoproteinthrough to participate in intracellular and extracellular signal transduction and material exchange processes. Myelin oligodendrocyte glycoproteinthrough plays an important role in maintaining cell homeostasis and regulating cell function.
MOG plays a crucial role in maintaining myelin structure and function, and is associated with various central nervous system demyelinating diseases.Mog (35-55) (Myelin Oligodendrocyte Glycoprotein) is an important membrane protein primarily expressed on the surface of oligodendrocytes in the central nervous system. It plays a crucial role in maintaining the normal structure and function of the myelin sheath and is involved in various biological processes. The following is a detailed description of all functions of myelin oligodendrocyte glycoproteins.
1. Formation and maintenance of myelin sheath
Myelin oligodendrocyte glycoproteinthrough is one of the main components of myelin sheath and is crucial for its formation and maintenance. The myelin sheath is a layer of lipid film wrapped around the outer layer of nerve fibers, which has protective and insulating effects and can accelerate the transmission of nerve signals. MOG participates in the assembly and stabilization of myelin sheaths by interacting with other myelin related proteins. It can promote the deposition and arrangement of myelin lipids, forming a dense myelin structure, thereby ensuring the normal function of nerve fibers.
2. Intercellular information exchange
Myelin oligodendrocyte glycoproteinthrough, as a membrane protein, is located on the cell surface and can interact with other cells or extracellular matrix. Through recognition and binding with other molecules, myelin oligodendrocyte glycoproteinthroughparticipates in the process of intercellular information exchange. It may act as a receptor or ligand for signal transduction, participating in signal transduction and regulation of the nervous system. This intercellular information exchange is of great significance for maintaining the normal function of the nervous system and coordinating the activity of neurons.
3. Axon protection and regeneration
Oligodendrocytes form myelin sheaths by wrapping axons, providing protection and nutritional support for axons. As an important component of the myelin sheath, MOG plays a crucial role in protecting axons. It can prevent axons from external damage and invasion of harmful substances, maintain the structural integrity and functional stability of axons. In addition, in axonal injury or disease conditions, myelin oligodendrocyte glycoproteinthrough may also participate in axonal regeneration, promoting neuronal repair and recovery function.
4. Immune regulation and disease association
In recent years, an increasing number of studies have shown that MOG is closely related to immune disorders in the central nervous system. In demyelinating diseases such as multiple sclerosis (MS), the presence and abnormal expression of anti myelin oligodendrocyte glycoproteinthrough antibodies are considered one of the important factors in the pathogenesis of the disease. These antibodies may attack the MOG in the myelin sheath, leading to myelin damage and loss, thereby causing neurological dysfunction. Therefore, studying the role of myelin oligodendrocyte glycoproteinthrough in immune regulation is of great significance.
5. Neurodevelopment and plasticity
The expression and regulation of MOG play an important role in the growth, differentiation, and formation of synaptic connections of neurons during the development of the nervous system. By regulating the expression level of myelin oligodendrocyte glycoproteinthrough, it can affect neuronal migration, axonal growth, and synaptic formation. In addition, MOG may also be involved in the plasticity process of the nervous system, that is, the ability of neurons to adaptively adjust their structure and function during environmental changes or learning experiences.
6. Interactions with other molecules
As a glycoprotein, the sugar chain portion of myelin oligodendrocyte glycoproteinthrough may interact with other molecules, thereby affecting its function and stability. In addition, MOG may interact with other myelin related proteins, cytoskeletal proteins, and extracellular matrix proteins to jointly maintain the structure and function of the myelin sheath. These interactions may involve multiple signal transduction pathways and molecular regulatory mechanisms, and further research is needed to reveal their detailed processes.
7. Neural regeneration and repair
When the nervous system is damaged or invaded by diseases, nerve regeneration and repair are key processes for restoring function. MOG, as an important component of the myelin sheath, may be involved in this process. By promoting the proliferation and differentiation of oligodendrocytes, as well as regulating the regeneration and remodeling of myelin sheaths, MOG helps to restore the normal structure and function of nerve fibers. Meanwhile, myelin oligodendrocyte glycoproteinthrough may also promote the recovery and reconstruction of the nervous system through interactions with other regeneration related factors.
8. Regulation of neural signal transduction
The presence of myelin sheath makes the transmission of neural signals more rapid and effective. MOG, as a key component of the myelin sheath, plays an important role in regulating neural signal transduction. By maintaining the structural integrity and functional stability of the myelin sheath, MOG can ensure efficient transmission of neural signals on nerve fibers. In addition, myelin oligodendrocyte glycoproteinthrough may also participate in the regulation of neural signal transduction by interacting with other signaling molecules, thereby affecting the overall function of the nervous system.
9. Participate in the development and maturation of the nervous system
During the development of the nervous system, the expression level of mog (35-55) gradually increases with the maturation of neurons and the formation of myelin sheaths. This indicates that myelin oligodendrocyte glycoproteinthrough plays an important role in the development and maturation of the nervous system. By regulating the expression and function of myelin oligodendrocyte glycoproteinthrough, it can affect the developmental process and maturation status of the nervous system, providing new ideas for the prevention and treatment of neurological diseases.
Mog (35-55),The myelin oligodendrocyte glycoprotein (35-55) fragment plays an important role in neuroscience research, and its development prospects are mainly reflected in the following aspects:
The increasing importance of scientific research tools-In depth study of neurological diseases: The myelin oligodendrocyte glycoprotein (35-55) fragment, as an important component of central nervous myelin, is a key tool for studying the pathogenesis of neurological diseases such as multiple sclerosis (MS). With the deepening of research on diseases such as MS, the application of myelin oligodendrocyte glycoprotein (35-55) fragments will become more widespread, which will help reveal the pathogenesis of diseases and provide new targets for treatment.
Constructing an autoimmune disease model-The myelin oligodendrocyte glycoprotein (35-55) fragment can induce experimental autoimmune encephalomyelitis (EAE) and other autoimmune disease models, providing a platform for researchers to study the pathogenesis and potential treatment methods of autoimmune diseases. In the future, with the deepening of research on autoimmune diseases, the application of myelin oligodendrocyte glycoprotein (35-55) fragments in constructing disease models will become more diverse.The key role of drug development and evaluation-New drug development: The myelin oligodendrocyte glycoprotein (35-55) fragment has high immunogenicity and can trigger specific immune responses.
This characteristic makes it an important reagent for evaluating the effectiveness of new drugs or therapies. In the future, in the process of drug development, myelin oligodendrocyte glycoprotein (35-55) fragments will be used more to screen and validate the effectiveness of candidate compounds, accelerating the process of new drug launch.Personalized Medicine: With the development of precision medicine and personalized medicine, biomarkers such as myelin oligodendrocyte glycoprotein (35-55) fragments will play a more important role in disease diagnosis and treatment.
By detecting the levels of related biomarkers such as myelin oligodendrocyte glycoprotein (35-55) fragments in patients' bodies, more precise personalized treatment plans can be provided for patients.Market demand and growth potential-Increased market demand: With the aging of the population and the rise of the incidence rate of nervous system diseases, the demand for neuroscience research tools such as myelin oligodendrocyte glycoprotein (35-55) fragments will continue to increase.
This will promote the research and production of myelin oligodendrocyte glycoprotein (35-55) fragment related products to meet market demand.Technological innovation and industrial upgrading: With the continuous progress and innovation of biotechnology, the detection methods and applications of biomarkers such as myelin oligodendrocyte glycoprotein (35-55) fragments will become more diversified and precise. This will promote industrial upgrading and technological innovation in the field of neuroscience, providing new opportunities for the development of myelin oligodendrocyte glycoprotein (35-55) fragments.
Challenges and coping strategies faced-Although the myelin oligodendrocyte glycoprotein (35-55) fragment has broad development prospects, it also faces some challenges such as high preparation costs and poor stability. To address these challenges, the following strategies can be adopted:Optimization of preparation process: By improving the preparation process and reducing production costs, the efficiency and yield of myelin oligodendrocyte glycoprotein (35-55) fragments can be increased, and their market price can be reduced.Improving stability: By improving storage methods and adding stabilizers, the stability of myelin oligodendrocyte glycoprotein (35-55) fragments can be enhanced.
FAQ
A: MOG35-55 is a 35 to 55 amino acid peptide fragment of myelin oligodendrocyte glycoprotein in the central nervous system. It is a self antigenic peptide with high encephalitis activity and can specifically activate T and B cell immune responses in the body. It is a classic tool peptide in neuroimmune research.
A: The MOG35-55 core is used to construct an experimental autoimmune encephalomyelitis (EAE) model in rodents, simulating the pathological characteristics of multiple sclerosis. It can also be used for the analysis of neuroimmune mechanisms, exploration of the pathogenesis of autoimmune encephalopathy, screening and efficacy evaluation of anti-inflammatory and neuroprotective drugs.
A: MOG35-55 can induce autoimmune inflammatory reactions in the body, activate relevant signaling pathways to enhance blood-brain barrier permeability, promote inflammatory cell infiltration into central nervous system tissues, attack myelin sheath structures, cause demyelination damage, interfere with normal transmission of nerve impulses, and form neuropathological changes similar to multiple sclerosis.
A: MOG35-55 has strong stability and good repeatability in modeling, and can induce recurrent remission type neurological disorders. Pathologically, it presents patchy demyelination characteristics; The modeling cycle is controllable, highly adaptable to experimental animals such as mice and rats, and does not damage the basic physiological functions of normal organisms, making it suitable for long-term mechanism and drug intervention research.
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