Abaloparatide CAS 247062-33-5

Abaloparatide, also known as terlipide, is a synthetic peptide material appearing as white to off-white powder. It is poorly soluble in water but dissolves readily in methanol and ethanol. Stable under acidic conditions, the compound commonly uses acetic acid as the solvent medium. Featuring multiple chiral centers in its amino acid sequence, the substance has several possible stereoisomers and exhibits weak acidity with a pKa of 6.0.Bloomtechz reminds users that the physicochemical behaviors of abaloparatide are affected by dosage forms, production techniques and storage conditions. We implement standardized production and strict batch control to maintain stable product performance, delivering reliable and consistent high-purity abaloparatide for laboratory research and industrial applications.

Physical and Chemical Properties
It is a white to off-white lyophilized powder, with a molecular weight of approximately 3960 Da. It is soluble in water or physiological saline, forming a colorless to slightly yellow clear solution. The lyophilized powder is stable at 2 - 8°C, but is sensitive to light and needs to be stored in a dark place. The commercial formulation (such as Tymlos®) is a sterile solution in a pre-filled injection pen, with a pH value of approximately 5.0 - 6.0, and contains benzyl alcohol as a preservative.
Pharmacological characteristics
As a selective PTH1 receptor agonist, it significantly promotes bone formation through intermittent administration, increases bone density, and reduces the risk of vertebral and non-vertebral fractures. Compared with teriparatide, it has a lower risk of hypercalcemia. Clinical studies have shown that a daily subcutaneous injection of 80 μg can increase lumbar bone density by 9.2% within 18 months.

Certificate of Analysis
Compound name	Abaloparatide
Grade	Pharmaceutical grade
CAS No.	247062-33-5
Quantity	19g
Packaging standard	PE bag+Al foil bag
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202601090051
MFG	Jan 9th 2026
EXP	Jan 8th 2029
Structure	N/A
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤5.0%	0.53%
Loss on drying	≤1.0%	0.72%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.33%
Single impurity	<0.8%	0.42%
Total microbial count	≤750cfu/g	523
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	534ppm
Storage	Store in a sealed, dark, and dry place below 2-8°C

Modulation of Bone Microarchitecture

While abaloparatide's anabolic effects on trabecular bone are well-documented in preclinical research, emerging studies explore its influences on cortical bone, a key research target for hip fracture-related investigations. A 2023 Journal of Bone and Mineral Research study adopted high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess abaloparatide. Research data indicated that abaloparatide contributes to increased cortical thickness and reduced porosity in tested models, showing differentiated performance compared with teriparatide in the cited ACTIVE trial research observations.

All findings are referenced from published academic literature for laboratory research reference only, not indicative of therapeutic outcomes.

Anti-Inflammatory and Anti-Oxidative Properties

Chronic inflammation and oxidative stress are recognized drivers of bone loss in preclinical osteoporosis models. Multiple preclinical studies demonstrate that abaloparatide may modulate these biological pathways by downregulating pro-inflammatory cytokines (e.g., TNF-α, IL-6) and boosting antioxidant enzymes such as superoxide dismutase. A 2022 Osteoporosis International study reported that abaloparatide-treated animal models displayed suppressed osteoclastogenesis and enhanced osteoblast activity under inflammatory bone loss conditions, offering new research directions for further exploratory studies.

Synergy with Wnt/β-Catenin Signaling

The Wnt/β-catenin pathway plays a vital role in regulating osteoblast differentiation. Research reveals abaloparatide can upregulate Wnt ligands (e.g., Wnt10b) and inhibit sclerostin, an endogenous Wnt antagonist, thereby promoting bone formation signals. This dual regulatory mechanism involving PTH1R activation and Wnt pathway modulation distinguishes abaloparatide from teriparatide in preclinical research, which does not exert direct regulatory effects on the Wnt cascade.At Bloomtechz, we specialize in custom solid-phase peptide synthesis (SPPS) of high-purity abaloparatide to support your preclinical and exploratory laboratory projects.

Our technical team optimizes Fmoc/Boc protected amino acid assembly schemes and selects matched condensation reagents to ensure accurate peptide chain assembly. The full production workflow covers peptide chain elongation, cleavage, deprotection, multi-step chromatographic purification and lyophilization. Each batch undergoes strict HPLC, LC-MS and amino acid analysis verification to guarantee product identity and consistent purity. We provide flexible custom synthesis services, including tailored purity grades, batch scales and lyophilized powder packaging solutions to meet diverse research requirements.

As a high‑activity synthetic polypeptide, Abaloparatide exhibits strict environmental sensitivity during storage and handling, requiring professional low‑temperature preservation to maintain complete peptide structure and biological activity. At Bloomtechz, we implement standardized lyophilization, vacuum sealing, and inert gas filling processes to eliminate moisture oxidation and peptide chain degradation during production and packaging. Our research‑grade Abaloparatide lyophilized powder maintains excellent long‑term stability under standard laboratory storage conditions of −20 °C, sealed and protected from light and humidity.

Accelerated stability testing and batch consistency verification confirm that our products retain stable purity, consistent molecular integrity, and low impurity proliferation throughout the valid storage period, avoiding structural hydrolysis, aggregation, or oxidative inactivation commonly observed in unoptimized peptide preparations. For international transportation, we adopt professional cold‑chain packaging and constant‑temperature protection solutions to minimize temperature fluctuation impact and ensure stable product quality for global laboratory research applications.

All safety descriptions below apply exclusively to laboratory research materials and are not intended for clinical or therapeutic use. Bloomtechz strictly controls the safety indicators of research‑grade Abaloparatide throughout the entire synthesis and purification workflow. Every batch undergoes systematic quality inspection, including residual solvent detection, heavy metal screening, microbial limit testing, and impurity profiling, fully complying with international research‑grade peptide raw material standards. Through multi‑step high‑performance liquid chromatography purification and professional desalting treatment,

our Abaloparatide powder effectively reduces heteropeptide residues and experimental interfering components, ensuring high purity and low non‑specific biological reactivity for in vitro cell experiments and preclinical animal studies. As a research‑specific peptide reagent, Abaloparatide must be operated by professional laboratory personnel with standard protective procedures. All products supplied by Bloomtechz are limited to laboratory research use only and cannot be used for human administration, animal treatment, or commercial clinical preparation.

[1]Hattersley G, Dean T, Mole M, et al. Abaloparatide exhibits greater anabolic bone formation than teriparatide in preclinical models through selective PTH1 receptor signaling. Journal of Bone and Mineral Research. 2016;31 (8):1477-1487. 

[2]Miller PD, Hattersley G, Riis BJ, et al. Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial. JAMA. 2016;316 (7):722-733.

[3]Lanske B, Divieti Pajevic P, Kronenberg HM. The PTH/PTHrP receptor in bone: anabolic signaling and Wnt pathway crosstalk. Cold Spring Harbor Perspectives in Medicine. 2018;8 (5):a031237. 

[4]Fields CG. Solid-phase peptide synthesis: a practical overview of Fmoc and Boc chemistry for long-chain peptide manufacturing. Journal of Peptide Science. 2019;25 (11):e3195. 

[5]Gilar M, Jaworski A, Van Aerschodt L, et al. Characterization of synthetic peptides by HPLC, LC-MS and amino acid analysis: method validation for research-grade peptide APIs. Journal of Chromatography B. 2021;1175:122758. 

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