Myristoyl Hexapeptide-23

Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of myristoyl hexapeptide-23 in China. Welcome to wholesale bulk high quality myristoyl hexapeptide-23 for sale here from our factory. Good service and reasonable price are available.

Myristoyl Hexapeptide-23 is a cationic lipopeptide synthesized via solid-phase methods. As a biomimetic synthetic lipopeptide, it works through multiple synergistic effects like targeting antibacterial action, regulating sebum, soothing inflammation, and promoting collagen production. Bloomtechz leverages its own synthesis lines, mature quality control systems, and global supply chain capabilities to provide global cosmetics formulators, skincare brands, and raw material distributors with a one-stop peptide raw material solution, from sample testing and small-scale customization to large-scale supply.

Certificate of Analysis
Compound name	Myristoyl Hexapeptide-23
Grade	Pharmaceutical grade
CAS No.	N/A
Quantity	18g
Packaging standard	PE bag+Al foil bag
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202601090056
MFG	Jan 9th 2026
EXP	Jan 8th 2029
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤5.0%	0.58%
Loss on drying	≤1.0%	0.65%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.68%
Single impurity	<0.8%	0.74%
Total microbial count	≤750cfu/g	188
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	500ppm
Storage	Store in a sealed, dark, and dry place below 2-8°C

As an independent peptide synthesis brand, Bloomtechz handles the full process of Myristoyl Hexapeptide-23 in-house, from amino acid raw material input, solid-phase coupling, N-terminal myristoylation, multi-step HPLC purification, sterilizing filtration, low-temperature lyophilization, to final packaging. We don't outsource synthesis or purification, and we can flexibly cover anything from small R&D samples to large-scale industrial orders. Plus, we include the 'C. acnes antibacterial bioactivity' in our batch release system, which is a unique capability tailored for this application.

C. acnes is a facultative anaerobic Gram-positive rod that resides in the anaerobic environment of hair follicle sebaceous glands. Its cell membrane phospholipids, especially the negatively charged phosphatidylglycerol and cardiolipin, are present in much higher proportions compared to skin commensals like Staphylococcus epidermidis and coagulase-negative staphylococci. In contrast, the cell membrane of S. epidermidis is richer in zwitterionic phospholipids, and its membrane surface has much lower net negative charge than pathogenic C. acnes strains. Gram-positive bacteria lack an outer membrane, so the cell membrane is directly exposed, and the membrane surface charge density directly determines the initial electrostatic adsorption strength of cationic lipopeptides.

This substance's peptide backbone carries three lysine residues, which are protonated at physiological pH, giving the molecule a high positive charge density. When the lipopeptide enters the follicle microenvironment, it preferentially anchors via electrostatic attraction to the negatively charged sites on the C. acnes membrane. Since the S. epidermidis membrane has low negative charge, the initial binding via electrostatic adsorption is much lower, and the lipopeptide molecules hardly accumulate in large amounts on the commensal membrane. This acts as the first layer of selective screening and is also a differentiating feature that many similar lipopeptides don't have.
The second layer of recognition comes from the 'membrane lipid phase transition and hydrophobic insertion threshold.'

C. acnes has evolved to live long-term in sebaceous follicles rich in glycerides and free fatty acids, so its cell membrane has a higher saturated fatty acid content, higher phase transition temperature, and more rigid membrane. The myristoyl (C14) fatty chain has the right hydrophobic length to insert into the rigid phospholipid bilayer of C. acnes. Shorter chains (C10, C12) lack sufficient hydrophobic force to stably embed into the membrane, while longer chains (C16 stearoyl modifications) drastically reduce lipopeptide water solubility, causing precipitation in aqueous formulations and making it difficult to penetrate the water-lipid microenvironment of follicles. This is the underlying rationale for choosing C14 myristoyl modification-not merely to enhance skin penetration, but to precisely match the hydrophobic insertion threshold of the C. acnes cell membrane.

After the substance binds to the C. acnes cell membrane, the myristoyl chain of the lipopeptide inserts into the phospholipid bilayer, altering the arrangement of membrane lipids and forming temporary, non-permanent transmembrane ion channels, causing hydrogen and potassium ions to leak across the membrane, which leads to a rapid collapse of the PMF. Once the PMF collapses, C. acnes' energy metabolism system is paralyzed. Even if the bacteria don't immediately lyse and die, they can't synthesize, transport, or release virulence factors like lipases and proteases. Without the ability to secrete these virulence substances, they no longer continuously stimulate follicular keratinocytes, cutting off the source of inflammatory signals.

This mechanism explains a common phenomenon seen in certain formulations: in in vitro colony counting experiments, the bacterial reduction is limited, but in cell co-culture models, the release of pro-inflammatory factors induced by C. acnes is significantly reduced. The root cause is that sub-MIC levels of Myristoyl Hexapeptide-23 inhibit bacterial virulence output rather than directly killing all the bacteria.

When the concentration of lipopeptides in the local follicle keeps rising and reaches the MBC (minimum bactericidal concentration) threshold, large amounts of lipopeptides accumulate on the membrane surface, disturbing the phospholipid bilayer in a 'carpet model' way. The membrane structure loses its continuity, forming large lipid defects, and intracellular potassium ions, ATP, and nucleic acids leak out in large amounts. The bacteria can't maintain internal stability and eventually die irreversibly.

Bloomtechz produces using full solid-phase peptide synthesis with N-terminal myristoylation, multi-stage reverse-phase HPLC purification, and low-temperature lyophilization. The table below provides a side-by-side comparison of various peptides across multiple dimensions, including target action, effect on C. acnes, biofilm inhibition, impact on skin microbiome, impurity risk, formulation compatibility, quality control logic, production capacity, and supporting services. This helps R&D teams quickly identify differences and provides a complete reference for selecting ingredients for adult acne and oily-sensitive skin formulas. The information here is for reference only.

1. Zhang, Y., et al. (2021). Amphipathic Lipopeptide Modulation of Cutibacterium acnes Membrane Potential and Virulence Factor Secretion. Journal of Cosmetic Dermatology, 20(8), 2560-2568.
2.Lee, J., & Park, S. (2022). Membrane Lipid Specificity of Cutibacterium acnes: Basis for Selective Targeting by Cationic Lipopeptides. Journal of Bacteriology, 204(12), e00321-22.
3. Cosmetic Raw Material Safety & Technical Specification
Personal Care Products Council (PCPC). (2023). Technical Guidelines for Safety Evaluation of Myristoyl Peptide Active Ingredients. Washington: PCPC Official Press.
4. Kim, H., et al. (2022). Anti-Biofilm Activity of Myristoyl Hexapeptide-23 Against Drug-Resistant Cutibacterium acnes Isolates. Skin Pharmacology and Physiology, 35(4), 210-218.

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