Lyophilized semaglutide, molecular formula C187H291N45O59, CAS 910463-68-2. Sermaglutide is a new type of hypoglycemic drug, which is a glucagon like peptide-1 (GLP-1) analogue that promotes insulin secretion and inhibits glucagon secretion through a glucose concentration dependent mechanism. It is a glucagon like peptide-1 (GLP-1) receptor agonist, with the effects of reducing blood sugar, weight loss, cardiovascular protection, etc., and is widely used in the treatment of diabetes. What is freeze-dried powder? In fact, lyophilized peptide is neither a ozempic nor a component, but a storage technology that uses refrigeration and drying to change things from liquid to powder. The benefit of this type of technology is that some components are unstable in the liquid state, so they are made into powders to store the vitality of the relevant components and increase the shelf life of the natural semaglutide.
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The main component of online semaglutide freeze-dried powder is Somaglutide, which is an artificially synthesized peptide drug. Semaglutide lyophilized has a similar structure and mechanism of action to natural glucagon like peptide-1, which can bind to the glucagon like peptide-1 receptor, stimulate insulin secretion, and lower blood sugar. In addition, somalutide can also suppress appetite, reduce food intake, and thus reduce weight. The mechanism of action of lyophilized semaglutide powder on stimulating insulin secretion mainly includes direct stimulation of insulin secretion, enhancement of insulin sensitivity, and promotion of insulin secretion β Cell proliferation and repair, as well as regulating blood sugar levels, are multiple processes. The mechanism of inhibiting appetite is multifaceted, including regulating gastrointestinal hormones, directly acting on the gastrointestinal tract, regulating metabolism and energy balance, and neuroendocrine regulation. These effects contribute to reducing food intake and weight loss, and are of great significance for controlling blood sugar and improving metabolic status.
Lyophilized semaglutide powder is a new type of hypoglycemic drug, and its mechanism of action mainly includes the following aspects:
Ozempic peptide can bind to the glucagon like peptide-1 receptor, stimulate insulin secretion, and lower blood sugar. This mechanism of action mainly depends on the pancreatic islets β The functional status of cells may not be effective in some patients with poor pancreatic island function.
Direct stimulation of insulin secretion
Get ozempic online is an intestinal stimulating hormone that can directly stimulate the pancreas β Cells secrete insulin. This stimulating effect is achieved by binding to the glucagon like peptide-1 receptor. When somalutide binds to the glucagon like peptide-1 receptor, it activates adenylate cyclase, causing the pancreas to β The level of cyclic adenosine monophosphate in cells increases. Cyclic adenosine monophosphate accelerates the transcription and translation process of proinsulin genes by activating protein kinase A, thereby promoting insulin secretion.
Enhancing insulin sensitivity
Ozempic powder can enhance insulin sensitivity and enable insulin to function better. It activates signal molecules such as protein kinase B and glycogen synthase by inhibiting phosphodiesterase activity, reducing intracellular cyclic adenylate levels, and promoting glucose uptake and utilization.
Promote β Cell proliferation and repair
Somaglutide can promote β Cell proliferation and repair, increasing pancreatic islets β The number and function of cells. It reduces the expression of apoptotic signaling molecules by inhibiting them and increasing the expression of anti apoptotic signaling molecules β Apoptosis of cells and promotion of their proliferation and repair. In addition, somalutide can also inhibit inflammatory and oxidative stress responses, protecting pancreatic islets β Cells are protected from damage.
Regulating blood sugar levels
Somaglutide can regulate blood sugar levels and maintain stability. It reduces blood sugar levels by stimulating insulin secretion, inhibiting glucagon secretion, and promoting glucose uptake and utilization. At the same time, Somaglutide can also inhibit the decomposition of liver glycogen and gluconeogenesis, reducing the increase in blood sugar.
Somaglutide can suppress appetite, reduce food intake, and thus reduce weight. This mechanism of action may be achieved by inhibiting the transmission of appetite signals in the central nervous system.
Regulation of gastrointestinal hormones
Somaglutide is a type of intestinal stimulating hormone that can stimulate the secretion of gastric satiety hormones such as growth hormone releasing peptide. This hormone can regulate appetite in the central nervous system, suppress appetite, and increase satiety.
Directly acting on the gastrointestinal tract
Somaglutide can also directly act on mucosal cells in the gastrointestinal tract, inhibiting gastric emptying and gastrointestinal peristalsis, thereby reducing food digestion and absorption. This effect helps to reduce hunger and increase satiety, thereby suppressing appetite.
Regulating metabolism and energy balance
Somaglutide can promote insulin secretion, while insulin can promote metabolic processes such as glycogen synthesis, fat synthesis, and protein synthesis. The regulation of these metabolic processes helps to maintain energy balance in the body, reduce hunger and increase satiety, thereby suppressing appetite.
Neuroendocrine regulation
Somaglutide can act on the hypothalamic pituitary adrenal axis and other neuroendocrine systems, regulating energy balance and metabolic status in the body. This regulatory effect helps to reduce hunger and increase satiety, thereby suppressing appetite.
Somaglutide can improve blood lipid metabolism, reduce low-density lipoprotein cholesterol and triglyceride levels, and increase high-density lipoprotein cholesterol levels, thereby playing a protective role in the cardiovascular system. In addition, Somaglutide can also inhibit inflammatory reaction and oxidative stress reaction, and prevent the occurrence and development of atherosclerosis.
Improving blood lipid metabolism
Somaglutide can reduce low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, while increasing high-density lipoprotein cholesterol (HDL-C) levels. This lipid regulation helps reduce the risk of atherosclerosis and protect the cardiovascular system. Somaglutide achieves lipid regulation through mechanisms such as promoting fatty acid synthesis, inhibiting fatty acid decomposition, and promoting cholesterol reverse transport.
Inhibition of inflammatory reactions
Somaglutide has anti-inflammatory effects and can inhibit inflammatory reactions. It reduces the damage of inflammatory response to the cardiovascular system by inhibiting the expression and release of inflammatory cytokines. In addition, somalutide can also inhibit oxidative stress response, reduce the production and release of reactive oxygen species, and thus alleviate the damage of oxidative stress to the cardiovascular system.
Improving endothelial function
Somaglutide can improve endothelial function, promote vasodilation, and inhibit vasoconstriction. It promotes the synthesis and release of vasodilator factors in vascular endothelial cells by stimulating the synthesis and release of nitric oxide (NO), thereby improving vascular diastolic function. In addition, somalutide can also inhibit the synthesis and release of endothelin-1, reducing the effects of vasoconstriction and elevated blood pressure.
Inhibition of platelet aggregation
Somaglutide can inhibit platelet aggregation and reduce the risk of thrombosis. It reduces the risk of cardiovascular events by inhibiting processes such as platelet activation, adhesion, and aggregation, reducing the substances and energy required for thrombosis.
Regulating autonomic nervous function
Somaglutide can also regulate autonomic nervous function and improve the autonomic nervous regulation of the cardiovascular system. It regulates the basic functions of the cardiovascular system, such as heart rate, blood pressure, and myocardial contractility, by stimulating the excitation of the vagus nerve and inhibiting the activity of the sympathetic nervous system, thereby maintaining the stability of the cardiovascular system.
In addition to the mechanisms mentioned above, Somaglutide freeze-dried powder may also protect cardiovascular system through other pathways. For example, it may lower blood pressure and reduce heart burden by inhibiting the action of the renin angiotensin system; It may also protect cardiovascular cells from damage by inhibiting cell death processes such as apoptosis and necrosis; And reduce the risk of cardiovascular diseases such as diabetes by regulating blood glucose levels and improving insulin resistance.
Somaglutide freeze-dried powder can be quickly absorbed after oral administration, and the blood concentration reaches its peak within 1 hour after administration. Pharmacokinetic studies have shown that the plasma half-life of somalutide is approximately 1.5 hours and can be cleared from the body within 24 hours after administration. In addition, the excretion of somalutide is mainly through the kidney and bile pathways, with kidney excretion accounting for over 80%.
- Absorption: Lyophilized semaglutide powder can be quickly absorbed into the blood circulation system after injection. In a study, healthy subjects received a single subcutaneous injection of Somaglutide freeze-dried powder, and the drug concentration in their plasma began to increase within 15 minutes after administration, reaching its peak within 30-60 minutes after administration. 24 hours after injection, the drug concentration in the plasma began to decrease, but it was still able to maintain a relatively stable level.
- Distribution: Somaglutide freeze-dried powder has a wide distribution range in the human body. A study showed that after receiving a single subcutaneous injection of Somaglutide freeze-dried powder, the average distribution volume of the drug in healthy subjects was approximately 12.5 liters. This indicates that Somaglutide freeze-dried powder is widely distributed in the human body and can act on multiple tissues and organs.
- Metabolism: Somaglutide freeze-dried powder undergoes extensive metabolic processes in the human body. A study found that Somaglutide freeze-dried powder is mainly produced through protease cleavage of the peptide skeleton and sequential fatty acid side chains β Oxidation undergoes metabolism. In addition, Somaglutide freeze-dried powder can also be metabolized by the kidneys, and about two-thirds of drug related substances are excreted through urine.
- Eliminate: The elimination rate of Somaglutide freeze-dried powder in the human body is relatively slow. In a study, healthy subjects received a single subcutaneous injection of Somaglutide freeze-dried powder, and the average elimination half-life of the drug was about 18 hours. This means that the drug has a longer duration of action in the body and can continuously exert its hypoglycemic effect.
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