Nandrolone Phenylpropionate Powder CAS 62-90-8

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October 22, 2024

Nandrolone Phenylpropionate powder, It is white or almost white crystalline powder; It has a special smell. This product is soluble in ethanol, slightly soluble in vegetable oil, and almost insoluble in water. Melting point The melting point of this product is 93~99 ℃. Specific rotation Take this product, weigh it accurately, add dioxane to dissolve it and dilute it quantitatively to make a solution containing about 10mg per 1ml, and determine according to the law, the specific rotation is+48 ° to+51 °. A protein assimilation hormone, has a strong protein synthesis effect, which is 12 times higher than testosterone propionate, while the androgen activity is less, which is 1/2 of testosterone propionate. It can promote protein synthesis, inhibit protein heterogenesis, promote calcium and phosphorus deposition and bone tissue growth. After intramuscular injection of 100mg, the blood concentration reached the peak value in 1~2 hours, and the effect lasted for 1~2 weeks. Nandrolone phenylpropionate powder is a protein assimilation hormone drug, which can not only increase the synthesis of protein from amino acids, but also inhibit the decomposition of amino acids to produce urea, and has the function of promoting calcium accumulation in the body. Its assimilation is stronger and more lasting than other testosterone derivatives, while its male hormone effect is smaller. It is mainly used for protein deficiency, such as severe burns, difficult healing of patients with malignant tumors before and after surgery, severe osteoporosis, and significant growth retardation of premature infants.

Pharmacological effect: The protein assimilation effect of this product is 12 times that of testosterone propionate, while the androgen activity is less, 1.5 times that of the latter. Nandrolone phenylpropionate powder can promote protein synthesis and inhibit protein heterogenesis, and has the effects of calcium and phosphorus deposition and promoting bone tissue growth. The effect of intramuscular injection can be maintained for 1-2 weeks.

Pharmacokinetic metabolism: hormones are excreted through urine, mostly in the form of conjugation, while in the feces, hormones are mainly excreted in free form, while the main metabolite of norolone and norandrostenediol in the urine is 19 norandrosterone (19 NA).

Indications: Dermatology department is used for auxiliary treatment. The negative nitrogen balance caused by high-dose corticosteroids is used, and the protein in food is increased at the same time; It is also used for exfoliative dermatitis, pemphigus, dermatomyositis, scleroderma and senile skin pruritus. In addition, this product can be given to patients with severe burns, malignant tumors before and after surgery, fracture, difficult healing and severe osteoporosis, premature infants, significant growth retardation, dwarfism, severe malnutrition, anorexia, chronic diarrhea and other serious consumptive diseases, while other treatments are carried out. Breast cancer that is not suitable for surgery can reduce symptoms, functional uterine bleeding and uterine fibroids can be used.

Function and use: It is an anabolic hormone. Its main function is to promote protein synthesis, inhibit protein decomposition, make muscles grow, gain weight, and retain water, sodium, calcium, and phosphorus. Clinically, it is mainly used for cases with insufficient protein synthesis and increased protein decomposition, such as malnutrition, stunted children, severe burns, recovery period after surgery, fracture not easy to heal, osteoporosis in the elderly and chronic consumptive diseases (such as chronic liver and kidney diseases, advanced malignant tumors, hyperthyroidism and anemia); It is also used for the negative nitrogen balance caused by long-term massive use of glucocorticoid, but the protein content in food should be increased at the same time.

Nandrone Phenylpropionate powder (NPP) is a synthetic steroid that can be used to enhance muscle growth and promote bone development. The following is a possible synthesis route of NPP:
(1) First, phenylacetic acid and pyruvic acid are used for A esterification reaction to generate phenylpropionate.
(2) The diels-Alder reaction of phenylpropionate and 3-oxo-17-keto-5-ene was carried out to produce 1,4-cycloadduct.
(3) The acylation reaction of 1,4-cycloadduct is carried out to produce corresponding amide.
(4) The amide is converted into corresponding nitrates by nitroso chemical method.
(5) The nitro compound and the catalyst undergo hydrogenation reduction reaction to produce Nandrone Phenylpropaonate.
It should be noted that synthetic steroids are illegal, and the use of synthetic steroids without legal medical permission has serious risks and adverse consequences for health and health. This answer only provides theoretical knowledge of chemistry and should not be regarded as an encouragement or guide for the use and synthesis of NPP.

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