Testosterone Enanthate Powder CAS 315-37-7

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October 22, 2024

Testosterone Enanthate powder is a synthetic steroid hormone, chemical name: Testosterone Enanthate, also known as Testosterone Heptanoate. Molecular formula: C26H40O3, CAS 315-37-7, molecular weight: 400.59 g/mol. Usually present in the form of white or slightly yellow crystalline powder. The melting point is approximately 34-39 ° C. This is the temperature at which a substance changes from solid to liquid. It has good oil solubility, but is almost insoluble in water. It can be dissolved in a variety of organic solvents, such as ethanol, Dimethyl sulfoxide and acetone. Relatively stable under conventional storage conditions. However, it is sensitive to light, heat, and oxygen, so prolonged exposure to sunlight or high temperatures should be avoided. Commonly used in the fields of medicine and sports.

The structural characteristics of Testosterone Enanthate:

1. Chemical structure:
The chemical structure of Testosterone Enanthate is the connection between testosterone molecules and octanoate groups. The octanoic acid ester group is formed by esterification reaction between octanoic acid and hydroxyl groups. This connection increases the solubility and durability of Testosterone Enanthate.
2. Molecular structure:
The basic structure of Testosterone Enanthate is testosterone molecule, which is a tetracyclic steroid compound. It contains two methyl groups, one ethane group, and one acetylene group. At 17 β The position has a hydroxyl group and an octanoic acid ester group.
3. Space configuration:
The spatial configuration of Testosterone Enanthate enables it to bind to the Androgen receptor in the human body. This combination triggers a series of physiological reactions, including promoting gonadal development and the formation of sexual characteristics.

According to Xinhua News Agency, Chinese scientists have made great efforts to tackle key problems and recently determined that testosterone heptanoate is the ideal contraceptive for men.

Testosterone Enanthate powder is a hormone ester, which can inhibit the pituitary gland and promote the release of gonadotropin, thereby reducing the endogenous testosterone secreted by testicular interstitial cells, and ultimately blocking spermatogenesis. When the Animal Institute of the Chinese Academy of Sciences conducted experiments on monkeys, it was found that testosterone heptanoate was injected once a week. After one week, the sperm cells of monkeys began to apoptosis, and reached the peak in the fifth week. The clinical trial of 308 volunteers also showed that the effect of testosterone heptanoate contraceptive on Asian men was significantly higher than that of Caucasians. In this study, although there is no racial difference in the sperm reduction rate, Asians are more sensitive than Caucasians to the inhibition of spermatogenesis caused by hormones. More than 95% of Asians can achieve azoospermia, while the drug is only effective for 40% to 70% of Caucasians.

Does testosterone heptanoate injection affect sexual life in men? The researchers said that the vast majority of people who were injected with testosterone heptanoate had no sperm or severe oligospermia in their semen examination, but their sexual ability was not affected. After drug withdrawal, the normal spermatogenesis ability of all subjects was recovered, which would not affect their sexual life.

For example, in adults, the withdrawal of testosterone enanthate in testis caused by exogenous testosterone heptate is accompanied by severe inhibition of FSH, However, in rats, there is no significant inhibition of FSH; in addition, the administration of ethane dimethylsulfonate (EDS) almost completely destroys the Leydig cells of rats (thus almost completely inhibits the level of testosterone heptanoate in testes) It will also raise the FSH level. Perhaps, whether in humans or rats, withdrawal of testosterone heptanoate in testes will lead to loose or shedding of spermatogenic cells. However, due to severe inhibition of human FSH, the production of early spermatogenic cells is reduced, and the phenomenon of loose or shedding of spermatogenic cells is not very obvious. In rats, because FSH is not inhibited or even increased, a large number of spermatogenic cells continue to be produced at the early stage, so the arrangement of spermatogenic cells is loose or shedding will be obvious. (Note: FSH can partially maintain spermatogenesis to round sperm cell stage.) Another possible factor is that the cell combination of human seminiferous tubules (the stage of spermatogenic cells) is spirally distributed in the seminiferous tubules, while it is segmental distributed in rats. Intuitively, it may be easier to split between the seminiferous cell clusters with segmental distribution. This supplementary study also showed that no matter in the testosterone heptanoate group or the control group, most of the seminiferous tubules (equivalent to most of the length of the seminiferous tubules) had a group of spermatogenic cells protruding into the lumen, and there was no obviously degenerated or pyknotic nucleus in the cell group. The reason or significance of this phenomenon needs further analysis. Since both groups have this phenomenon, it is unlikely that the phenomenon seen in the testosterone heptanoate group is caused by the withdrawal of testosterone in the testis. After the inhibition of testosterone heptanoate in the rat testes, clusters of spermatogenic cells can also be seen in 8% of the seminiferous tubules (the control group did not have this phenomenon), but there are often obvious pyknotic nuclei in these cell clusters.

One possibility is that this phenomenon is related to the spiral distribution of the staging (cell combination) of human sperm epithelium. In the process of testicular biopsy, a small incision is made on the testicular capsule, so that the seminiferous tubules in the testicle protrude (because the testicular internal pressure is high, it is actually "extrusion"); During this process, the seminiferous tubules may be deformed, and the wall of the seminiferous tubules may be folded, causing the spermatogenic cell mass to protrude into the lumen. This is also a possible explanation. This explanation is supported by the fact that a small number of Sertoli nuclei can be seen in the seminiferous cell mass that protrudes into the seminiferous tubule. If this explanation is valid, Testosterone enanthate powder leads to a problem worthy of attention: do not regard this phenomenon as abnormal in the clinical pathological examination using testicular biopsy tissue blocks.

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