Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 6-aminocaproic acid cas 60-32-2 in China. Welcome to wholesale bulk high quality 6-aminocaproic acid cas 60-32-2 for sale here from our factory. Good service and reasonable price are available.
6-Aminocaproic acid, molecular formula C6H13NO2, white or off-white crystalline powder at room temperature, no odor, slightly soluble in water, ethanol and chloroform, almost insoluble in ether and benzene. is a medicine also known as amikapic acid. It falls under the category of hemostatic drugs and is used in the treatment of heavy bleeding. It works by preventing fibrinolysis, thereby reducing the activity of lysinogen in the plasma, helping to control bleeding. It is also used to treat hereditary and acquired fibrinolysis and other coagulation disorders and to provide hemostatic control after surgery or trauma. It is also used in dental surgery and post-obstetric surgery for haemostatic control and has been widely used.
|
Chemical Formula |
C6H13NO2 |
|
Exact Mass |
131 |
|
Molecular Weight |
131 |
|
m/z |
131 (100.0%), 132 (6.5%) |
|
Elemental Analysis |
C, 54.94; H, 9.99; N, 10.68; O, 24.39 |
6-Aminocaproic acid is an amino acid drug. It was originally used to control bleeding and reduce the risk of bleeding. It has the effect of inhibiting the formation of fibrin polymers and inhibits fibrinogen activating enzyme in blood vessels. Therefore, it may be used to control or prevent bleeding after certain procedures or trauma, and to reduce the risk of thrombosis in high-risk patients. In addition, it is also used to treat patients with certain diseases, such as Haemophilia A and Von Willebrand's disease.
Anti fibrinolytic effect: It is an effective inhibitor of plasmin and plasminogen, which competitively binds to lysine residues on plasminogen to prevent clot lysis, inhibit plasminogen formation, and reduce fibrinolysis. This characteristic makes it widely used in the medical field. In surgical procedures, it can be used to control bleeding, especially in cases where fibrinolysis activity is increased, such as bleeding after visceral surgery in the prostate, liver, pancreas, lungs, and gynecological bleeding disorders. It can also be used to treat bleeding disorders such as hereditary fibrinolysis and primary thrombocytopenic purpura.
Hemostatic effect: It can inhibit the fibrinolytic system, thereby exerting a hemostatic effect. It can be used to treat certain severe bleeding caused by increased fibrinolytic activity, such as hemoptysis, gastrointestinal bleeding, etc.
Research purposes
Research on hemorrhagic diseases: It can be used to study the pathogenesis and treatment methods of hemorrhagic diseases. By studying its mechanism of action, we can gain a deeper understanding of the role of fibrinolysis in hemorrhagic diseases, providing a theoretical basis for the development of new hemostatic drugs.
Biochemical reagents: They can also be used as biochemical reagents for biochemical experiments and molecular biology research. Its specific chemical structure and properties make it an important component or adjuvant in certain biochemical reactions.
Organic synthesis: It is an important organic synthesis raw material that can be used to synthesize various organic compounds and pharmaceutical intermediates. Its amino and carboxyl functional groups make it widely applicable in organic synthesis.
Other industrial applications: In addition to the above-mentioned uses, it may also be applied in other industrial fields, such as raw materials or additives for dyes, coatings, plastics, and other industries. However, these applications may be relatively limited, and the specific application areas and methods may vary depending on the region and industry.
What are the side effects of this compound?
6-Aminocaproic acid, also known as ε - aminocaproic acid, aminocaproic acid, antifibrinolytic acid, or EACA, is an important monoamino carboxylic acid. It has attracted much attention in the biomedical field due to its unique mechanism of action, and like other drugs, it may also produce some side effects during use. The following is a detailed explanation of its side effects:
Digestive system side effects
Nausea and vomiting: It may cause irritation to the gastrointestinal tract, leading to symptoms of nausea and vomiting in patients. This side effect usually occurs shortly after the start of drug use and may worsen with continued use of the drug.
Diarrhea: Some patients may experience diarrhea after using this substance. This may be due to the stimulating effect of drugs on the intestinal mucosa, leading to accelerated intestinal peristalsis and reduced water absorption.
Abdominal discomfort: It may also cause abdominal discomfort, such as bloating, abdominal pain, and other symptoms. These symptoms may be caused by the direct effect of medication on gastrointestinal smooth muscle or indirectly through neuroendocrine mechanisms.
Neurological side effects
Headache: Some patients may experience headaches after use. This type of headache may manifest as mild to moderate dull or pulsating pain, sometimes accompanied by symptoms such as nausea and vomiting.
Dizziness: It may cause symptoms of dizziness in patients. This may be due to the impact of drugs on the central nervous system, leading to a decrease in blood pressure, insufficient cerebral blood supply, and other reasons.
Sleepiness and fatigue: A small number of patients may experience drowsiness and fatigue after use. This may be related to the inhibitory effect of drugs on the central nervous system, leading to symptoms such as mental fatigue and fatigue in patients.
Skin and allergic reactions
Rash: May cause skin allergies such as rash. These rashes may manifest in the form of erythema, papules, blisters, etc., accompanied by symptoms such as itching and pain.
Itching: Some patients may experience symptoms of skin itching after use. This may be due to the direct irritant effect of the medication on the skin or allergic reactions.
Urticaria: Urticaria is a common skin allergic reaction characterized by local or systemic wheals and itching. It may also cause the occurrence of urticaria.
Eye side effects&Skin and allergic reactions
Severe allergic reactions: In rare cases, it may cause severe allergic reactions, such as anaphylactic shock. This allergic reaction usually manifests as symptoms such as shortness of breath, laryngeal edema, and low blood pressure, and requires immediate medical treatment.
Conjunctival congestion: may cause irritation to the eyes, leading to conjunctival congestion. This side effect usually manifests as symptoms such as redness, pain, and tears in the eyes.
Respiratory system side effects
Dyspnea: In rare cases, it may cause respiratory symptoms such as difficulty breathing. This may be due to the irritant effect of the medication on the respiratory tract or allergic reactions.
Nasal congestion: Some patients may experience symptoms of nasal congestion after use. This may be related to the stimulating effect of the drug on the nasal mucosa.
Cardiovascular system side effects
Hypotension: When the dosage of the substance is too high or the intravenous administration speed is too fast, it may cause symptoms of hypotension in patients. This may be due to the inhibitory effect of drugs on the cardiovascular system.
Bradycardia: Similarly, it may also cause arrhythmia symptoms such as bradycardia. This may be related to the impact of drugs on the cardiac conduction system.
Hematological system side effects
Thrombosis: Due to its inhibitory effect on fibrinolysis, it may increase the risk of thrombosis. Especially for patients with a tendency towards thrombosis or a history of thrombotic vascular disease, caution should be exercised when using it.
Bleeding tendency: Although it is mainly used for hemostasis, bleeding tendency may also occur in certain situations, such as when the dosage is insufficient or when the patient has other bleeding disorders.
Other side effects
Muscle weakness: Some patients may experience symptoms of muscle weakness after use. This may be related to the effect of drugs on the neuromuscular junction.
Fever: It may also cause systemic symptoms such as fever. This may be due to the stimulating effect or immune response of the drug on the body.
Abnormal liver function: Long term or high-dose use may cause damage to the liver, leading to abnormal liver function. Therefore, liver function indicators should be regularly monitored during use.
Abnormal renal function: Similarly, long-term or high-dose use may also cause damage to the kidneys, leading to abnormal renal function. For patients with renal insufficiency, caution should be exercised when using and adjusting the dosage.
What are the sales channels for this compound?
6-Aminocaproic acid, as an important pharmaceutical intermediate, has relatively diversified sales channels. Here are some of the main sales channels:
1.Direct sales between pharmaceutical companies and chemical plants
Many pharmaceutical companies and chemical plants directly sell this substance. These companies usually have their own production facilities and R&D teams, which can provide high-quality products. Customers can directly contact these companies to learn about their product prices, specifications, quality, and other information, and make purchases.
2.Chemical distributors and agents
Chemical distributors and agents are also important sales channels for this substance. These distributors and agents typically establish partnerships with multiple pharmaceutical companies and chemical plants, providing customers with a diverse range of product choices. They usually have rich market experience and customer resources, and can provide professional consulting and after-sales service to customers.
3.E-commerce platform
With the rapid development of e-commerce, more and more suppliers are choosing to sell on e-commerce platforms. These platforms typically provide a convenient online shopping experience, where customers can easily browse and compare products from different suppliers and make online purchases. In addition, e-commerce platforms also provide rich payment methods and fast logistics services, making the procurement process more convenient.
4.Professional markets and exhibitions
Professional markets and exhibitions are also one of its important sales channels. In these occasions, suppliers can directly showcase their products and engage in face-to-face communication and interaction with potential customers. This helps to establish trust relationships and promote sales cooperation. In addition, professional markets and exhibitions also provide opportunities to understand industry trends, expand networks, and find partners.
5.International Trade and Cooperation
For customers in the international market, their suppliers usually cooperate through international trade channels. This includes signing international trade contracts, handling import and export procedures, providing international logistics services, etc. With the accelerated development of globalization, international trade cooperation has become an important component of the sale of this substance.
6.Collaboration between research institutions and universities
Due to its wide application value in the field of scientific research, some research institutions and universities will also become one of its sales channels. These institutions usually establish cooperative relationships with pharmaceutical companies and chemical plants to jointly carry out scientific research projects or provide teaching and experimental materials. Through this collaborative approach, it can be more widely applied in the fields of scientific research and teaching.
7.Other sales channels
In addition to the sales channels mentioned above, there are other ways to sell it. For example, some suppliers may use social media platforms to promote and attract the attention of potential customers; Alternatively, we can communicate and collaborate through professional forums and communities within the industry to expand our sales channels.
The history of 6-aminocaproic acid can be traced back to the 1930s, when scientists were in a flourishing stage of research on amino acids and proteins. In 1932, German chemists Fischer and L ö wenberg first synthesized 6-aminocaproic acid in the laboratory, but their potential biological significance was not recognized at the time. During this period, research mainly focused on the synthesis methods of compounds and the description of their basic physical and chemical properties, with almost no knowledge of their pharmacological activities. During World War II, medical research was greatly promoted, especially with a sharp increase in demand for trauma treatment and hemostatic methods. After the war, with the rapid development of biochemistry and molecular biology, scientists began to study the mechanisms of blood coagulation and fibrinolysis more systematically. In 1948, Swedish scientists Astrup and Permin discovered the phenomenon of fibrinolysis, laying the foundation for subsequent research on anti fibrinolytic drugs. In the early 1950s, researchers accidentally discovered that 6-aminocaproic acid had the property of prolonging clotting time while screening various amino acid derivatives. This discovery caught the attention of multiple research teams, including Japanese scientist Isamu Suda and American scientist Okamoto. They began to systematically study the effects of 6-aminocaproic acid on the blood system, marking the transition of this compound from a simple chemical cure to a potential therapeutic drug. The key breakthrough in the study of 6-aminocaproic acid occurred in 1957, when Japanese scientist Isamu Suda and his team first reported in detail the anti fibrinolytic activity of 6-aminocaproic acid. They found that this compound can significantly inhibit the process of fibrinolysis when studying the blood coagulation system. Almost at the same time, American scientist Okamoto independently discovered a similar effect and began to explore its molecular mechanism. In 1959, the Okamoto team proposed a preliminary theory of the mechanism of action of 6-aminocaproic acid, suggesting that it works by competitively inhibiting the activation of plasminogen. Fibrinogen is a key enzyme in the fibrinolytic system, which is converted into plasmin after being activated by tissue type plasminogen activator (t-PA) or urokinase type plasminogen activator (u-PA), thereby degrading fibrin. The structure of 6-aminocaproic acid is similar to lysine and can bind to the lysine binding site of plasminogen, preventing its binding to fibrin and subsequent activation processes. During this period, research also determined the optimal therapeutic dose and administration method of 6-aminocaproic acid. Clinical trials have shown that after intravenous injection, 6-aminocaproic acid can rapidly distribute throughout the body and be excreted in its original form through the kidneys within 4-6 hours. These pharmacokinetic properties make it an ideal short acting anti fibrinolytic drug. In 1962, the US Food and Drug Administration (FDA) approved 6-aminocaproic acid for clinical use under the trade name Amicar ®, Used for the treatment of bleeding caused by fibrinolysis, such as bleeding control in scenarios such as heart surgery, liver transplantation, and prostatectomy. This approval marks the official transition of 6-aminocaproic acid from laboratory to clinical practice, opening a new chapter in its widespread application in the medical field.
Hot Tags: 6-Aminocaproic Acid CAS 60-32-2, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, CHICAGO SKY BLUE 6B, 1 AMINO 2 NAPHTHOL 4 SULFONIC ACID, Cerium sulfate powder, Consumable, Iridium III chloride