LONG R3 IGF-I, also known as Growth Factor C, belongs to the insulin gene family and its structure is similar to insulin precursor protein. It has a good growth stimulating effect and promotes division, migration and differentiation of most cells. LONG-R3-IGF-I is an 83-amino acid analog of human IGF-I. Compared with intact human IGF-I, 13 amino acid residues have been added to the N-terminus, and especially importantly, the amino acid residue at position 3 has been replaced by Arg (hence the name R3) with natural Glu. Compared with natural human IGF-I, LONG-R3-IGF-I is similar to natural human IGF-I at higher free concentrations. Compared with natural human IGF-I, LONG-R3-IGF-I has a significantly lower binding capacity to human IGF-I binding proteins at higher free concentrations, thus greatly improving its biological activity.
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LONG-R3-IGF-I contains 83 amino acids and a recombinant human non-glycosylated peptide chain with a molecular weight of 9,200 daltons.IGF1 mediates a variety of growth-stimulating effects of growth hormone (GH; MIM 139250).LR3, a long-term analog of human IGF-1, is designed and manufactured specifically for use in mammalian cell cultures in support of large-scale production of recombinant biopharmaceuticals. . Previous studies have shown that growth hormone does not directly stimulate sulfate entry into cartilage, but rather through serum factors known as sulfation factors, later known as growth factors.
LONG-R3-IGF-I is the main protein involved in the cellular response to growth hormone (GH): that is, IGF-I responds to GH production and induces cellular activity, as exemplified by muscle growth or hyperplasia. This compound also makes the body more sensitive to insulin, the most powerful growth factor in the body.IGF-1 causes muscle cell proliferation, the actual division and formation of new muscle cells. Clinical studies have shown that LONG-R3-IGF-I plays an important role in childhood growth and continues to have an effect in adulthood. It is manufactured in the body and is at ideal levels during puberty. In most studies, the longest duration of activity in LONG-R3-IGF-I studies is 50 days, or 20 to 40 days. The most common range used in clinical studies is usually 20mcg to 120mcg per day.
Long R3 IGF-I is a modified form of Insulin-like Growth Factor-I (IGF-I).It has a variety of biological activities in vivo, and by binding to receptors on the cell surface, it can stimulate cell growth, proliferation and differentiation, and promote tissue repair and regeneration.
Its application in the human body
Long R3 IGF-I in the human body mainly involves the following areas:
Growth promotion
Long R3 IGF-I shows stronger growth promotion effects in vitro and in animal experiments. Compared with the natural form of IGF-I, LR3-IGF-I has a longer half-life and is able to exert growth promotion effects for a longer period of time. As a result, it is used by some athletes and fitness enthusiasts as a supplement to increase muscle mass and improve athletic performance.
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Repair and regenerative effects
LR3-IGF-I is thought to aid in tissue repair and regeneration and may have a potential role in post-traumatic injury recovery, repair of muscle damage, and nerve regeneration.
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Metabolic regulation
IGF-I plays an important role in metabolic processes. LR3-IGF-I may play a role in metabolic regulation, such as the regulation of fat metabolism and blood glucose stability.
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Disease treatment
The growth-promoting and repairing effects of LR3-IGF-I have attracted attention in the treatment of some diseases, such as muscle atrophy, fracture healing, chronic wound healing and so on, which may have potential applications.
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Long R3 IGF-I in Sports
There is a close relationship between Long R3 IGF-I and exercise in the following aspects:
Promote muscle growth and recovery
Exercise, especially strength training, can lead to micro-damage of muscle fibers.Long R3 IGF-I can stimulate the proliferation and differentiation of muscle satellite cells, promote the generation of new muscle fibers and repair of muscle damage, thus accelerating muscle recovery and growth.
Improve athletic ability
By promoting muscle growth and recovery, Long R3 IGF-I helps to improve athletes' athletic ability such as strength, endurance and explosive power. In addition, it may enhance athletic performance by improving muscle metabolism and reducing muscle fatigue.
Reducing sports injuries
Sports injuries are a common problem for athletes, and Long R3 IGF-I has the ability to promote tissue repair.
In conclusion, there is a close relationship between Long R3 IGF-I and exercise, and it may bring positive effects to athletes by promoting muscle growth and recovery, improving athletic performance, and mitigating sports injuries. However, its potential risks and side effects should be noted when used to ensure the safety and efficacy of the medication.