Dopamine powder is an important bioactive substance, chemically named 3,4-dihydroxyphenylethylamine hydrochloride, belonging to the catecholamine neurotransmitter class. It plays a critical role in the central nervous system and peripheral tissues, participating in regulating physiological processes such as motor control, cognitive function, emotional regulation, reward mechanisms, and cardiovascular function. In the medical field, dopamine is used to treat conditions such as shock, heart failure, and hypotension; In scientific research, it serves as an important tool for studying the mechanism of neurotransmitter action; In the industrial field, it is used for synthesizing drugs, pesticides, and polymer materials. It appears as a white or off white crystalline powder with a slightly bitter taste, easily soluble in water, soluble in methanol and hot 95% ethanol, and also soluble in aqueous solutions of hydrogen oxides. It is almost insoluble in ether, petroleum ether, chloroform, benzene, and toluene. It is sensitive to light and air and needs to be protected from light. During transportation, dopamine should be packaged with moisture-proof and light proof packaging materials, and appropriate protective measures should be taken to prevent it from being subjected to external forces such as impact, compression, and vibration. The transportation temperature should be controlled within the specified range to ensure the quality and stability of dopamine .
Dopamine Powder CAS 51-61-6
Product Code: BM-2-5-058
Product Name: Dopamine
CAS Number: 51-61-6
MF:C8H11NO2
Molecular weight: 153.18
EINECS Number: 200-110-0
Analysis project: HPLC>99.0%,GC-MS
HS code: Confirmation required
Main markets: United States, Australia, Brazil, Japan, Germany, Indonesia, United Kingdom, New Zealand, Canada, etc.
Manufacturer: Bowen Technology Xi'an Factory
Technical Services: R&D Department-2
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What are dopamine powder drugs used for?
Dopamine powder(https://en.wikipedia.org/wiki/Dopamine) is an important neurotransmitter and hormone, chemically named 4- (2-aminoethyl) -1,2-benzenediol. In the body, dopamine is synthesized from tyrosine through multi-step enzymatic reactions and mainly functions in the central nervous system and peripheral sympathetic nerve endings. The following are its uses:
Dopamine powder is one of the important drugs for treating shock in clinical practice. Its mechanism of action mainly includes: stimulating β - κ receptors, enhancing myocardial contractility, and increasing cardiac output.
Low dose (<2 μ g/kg/min): mainly stimulates dopamine receptors (D ₁ receptors), dilates renal, mesenteric, and coronary blood vessels, increases renal blood flow and urine output, and improves renal function.
Medium dose (2-10 μ g/kg/min): While enhancing myocardial contractility, it also has a certain stimulating effect on β ₂ receptors, leading to mild dilation of peripheral blood vessels.
High dose (>10 μ g/kg/min): mainly stimulates alpha receptors, causing strong constriction of peripheral blood vessels, increasing blood pressure, and increasing cardiac afterload. Dopamine improves the hemodynamic status of patients with cardiogenic shock by enhancing myocardial contractility and increasing cardiac output. On the basis of sufficient fluid resuscitation, dopamine can be used to increase blood pressure and improve tissue perfusion. However, its use is controversial as it may increase the risk of arrhythmia and requires careful evaluation. After supplementing blood volume, if blood pressure remains unstable, dopamine can be used as an adjuvant therapy to maintain blood pressure by constricting peripheral blood vessels.
Clinical application
Dopamine can enhance myocardial contractility, increase cardiac output, reduce pre - and post cardiac load, and improve symptoms of heart failure. Commonly used for the treatment of acute decompensated heart failure (ADHF), especially in patients with hypotension or renal insufficiency. Low dose dopamine can prevent and treat acute kidney injury (AKI) by dilating renal blood vessels, increasing renal blood flow. However, recent studies have shown that its efficacy is controversial and may increase the risk of arrhythmia, therefore it is not recommended for routine use. In cardiac surgery, dopamine can be used to maintain blood pressure and cardiac output, ensuring surgical safety. After cardiopulmonary resuscitation (CPR), if the patient has hypotension or cardiac dysfunction, dopamine can be used as one of the vasoactive drugs to support circulatory function. Dopamine improves kidney function by increasing renal blood flow and urine output, especially for patients with acute kidney injury accompanied by oliguria or anuria. However, its long-term efficacy and safety still require further research. In neonatal intensive care, dopamine is commonly used to treat hypotension, especially in premature infants and low birth weight infants. Improve tissue perfusion by increasing myocardial contractility and vascular tension.
The mechanism of action of dopamine in the central nervous system is an important field of neuroscience research. Dopamine powder is commonly used for studying the role of dopamine in behavior, learning, memory, and reward mechanisms through intraventricular injection or microdialysis techniques. Cell culture: used to cultivate dopaminergic neurons and study their development, differentiation, and function. Molecular biology research: as a probe, studying the expression, distribution, and function of dopamine receptors. Dopamine is an important tool for studying dopamine receptor agonists and antagonists. Study the signal transduction mechanism and drug targets of dopamine receptors through in vitro experiments and animal models. Dopamine plays a crucial role in neurodegenerative diseases such as Parkinson's disease (PD). Dopamine is used for establishing disease models: by inhibiting dopamine synthesis or destroying dopaminergic neurons, a Parkinson's disease animal model is established. Drug screening: Evaluating the impact of potential therapeutic drugs on dopamine metabolism and receptor function.
Application in drug development&Applications in other fields
Dopamine is used for screening and developing drugs targeting dopamine receptors. Evaluate the affinity, selectivity, and functional effects of candidate drugs on dopamine receptors through in vitro experiments and animal models. Dopamine is used to develop novel drug delivery systems, such as nanoparticles, liposomes, and polymer carriers, to enhance the bioavailability and targeting of dopamine and reduce systemic adverse reactions. Dopamine is used to study its metabolic pathways and enzyme kinetics, evaluate drug interactions and metabolic stability.
Dopamine is used to develop biosensors based on electrochemical or optical principles to detect dopamine levels in biological samples for disease diagnosis and drug monitoring. Dopamine is used to prepare biocompatible and functional biomaterials, such as dopamine modified polymers, hydrogels and nanoparticles, for tissue engineering and drug delivery. Dopamine is used to study plant growth regulation and soil microbial activity, and to evaluate its potential applications in agriculture and environmental remediation.
Conclusion
Dopamine powder, as an important bioactive substance, has wide application value in clinical treatment, scientific research, drug development, and other fields. Its clinical applications include the treatment of shock, heart failure, acute kidney injury, etc; In scientific research, dopamine is used in neuroscience, pharmacology, and neurodegenerative disease research; In drug development, it is used for screening and developing new drugs; In other fields, it can be used for biosensors, biomaterials, and agricultural environmental science. In the future, with the deepening of research and the advancement of technology, the application prospects of dopamine will be even broader.