Loperamide Powder, also known as 4-p-chlorobenzene-4-hydroxy-N, N-dimethyl - α, α - diphenyl-1-p-piperidinyl butyramide, is a chemical drug that belongs to the category of anti diarrheal drugs. It is widely used in clinical practice to treat acute and chronic diarrhea caused by various etiologies due to its potent antidiarrheal effect. Loperamide powder usually exists in the form of white or off white powder, odorless, and easily soluble in certain organic solvents such as methanol, chloroform, and glacial acetic acid, with lower solubility in water. This drug or its formulation is widely used in clinical practice to treat acute and chronic diarrhea caused by various etiologies. Loperamide may interact with other drugs, such as increasing the risk of pseudomembranous colitis when used in combination with antibiotics. Therefore, when using loperamide, the doctor should be informed of any other medications being used.
Loperamide Powder CAS 53179-11-6
Product Code: BM-2-5-107
English Name: Loperamide
CAS No.: 53179-11-6
Molecular formula: c29h33cln2o2
Molecular weight: 477.04
EINECS No.: 258-416-5
MDL No.：MFCD00600388
Hs code: 28273985
Analysis items: HPLC>99.0%, LC-MS
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Manufacturer: BLOOM TECH Changzhou Factory
Technology service: R&D Dept.-4
We provide Loperamide Powder CAS 53179-11-6, please refer to the following website for detailed specifications and product information.
What is the purpose of Loperamide Powder?
Loperamide Powder(https://en.wikipedia.org/wiki/Loperamide), As an important chemical drug, its main use is concentrated in the medical field, especially as an antidiarrheal drug, widely used in the treatment of various acute and chronic diarrhea. The following is a detailed explanation of its purpose:
Acute diarrhea is usually caused by food poisoning, indigestion, intestinal infections, and other reasons, with symptoms including increased frequency of bowel movements and thin stool. Loperamide powder can rapidly inhibit intestinal peristalsis, reduce intestinal fluid secretion, and effectively alleviate symptoms of acute diarrhea. Loperamide is rapidly absorbed after oral administration, usually reaching its peak blood concentration within 4-6 hours, and can quickly exert its antidiarrheal effect. Due to its insignificant effect on the central nervous system and low systemic absorption, loperamide has a high safety profile in the treatment of acute diarrhea.
Treating chronic diarrhea
The causes of chronic diarrhea are diverse, including ulcerative colitis, Crohn's disease, non-specific colitis, irritable bowel syndrome, etc. These diseases often lead to sustained contraction of intestinal smooth muscle and excessive secretion of intestinal fluid, causing long-term diarrhea. The long-lasting anti diarrheal effect of loperamide makes it one of the preferred drugs for the long-term treatment of chronic diarrhea. By continuously inhibiting intestinal peristalsis and intestinal fluid secretion, loperamide can significantly improve the symptoms and quality of life of patients with chronic diarrhea. Loperamide can not only quickly alleviate diarrhea symptoms, but also reduce the recurrence of chronic diarrhea by regulating intestinal function.
After partial gastrectomy and intestinal resection, patients often experience diarrhea symptoms, which may be due to intestinal dysfunction caused by surgery. Loperamide can rapidly inhibit intestinal peristalsis, reduce intestinal fluid secretion, effectively alleviate postoperative diarrhea symptoms, and promote patient recovery.
After ileostomy, patients may experience symptoms such as increased frequency of bowel movements and thin stools. Loperamide can reduce the amount and frequency of bowel movements, increase stool consistency and hardness, thereby improving the quality of life of patients. Loperamide has also shown good therapeutic effects on functional diarrhea that is ineffective with other antidiarrheal drugs.
What is the preparation method of loperamide powder?
Loperamide,also known as 4-p-chlorobenzene-4-hydroxy-N, N-dimethyl - α, α - diphenyl-1-piperidinyl butyramide, is a medication used to treat acute and chronic diarrhea. The preparation process of Loperamide Powder requires strict control of reaction conditions and product quality to ensure the efficacy and safety of the drug. The following is its detailed preparation method:
Reaction materials and reagents
2,2-diphenyl-4-bromobutyric acid is a key intermediate for the preparation of loperamide, which has stable chemical properties and is easy to undergo subsequent acylation and amination reactions. Dimethylamine, as a raw material for amination reaction, reacts with 2,2-diphenyl-4-bromobutyric acid to generate dimethyl - (tetrahydro-3,3-diphenyl-2-furylidene) ammonium bromide. 4-hydroxy-4-chlorophenylpyridine is an important raw material for the condensation reaction with dimethyl - (tetrahydro-3,3-diphenyl-2-furylidene) ammonium bromide to produce loperamide. Isopropanol and hydrogen chloride are used for the salt formation reaction of loperamide to produce loperamide hydrochloride, which is then crystallized, filtered, and other steps to obtain Loperamide Powder. In addition, some auxiliary reagents are required, such as solvents (such as dichloromethane, toluene, etc.), catalysts (such as PTSA, etc.), bases (such as solid sodium bicarbonate, etc.), and desiccants (such as anhydrous sodium sulfate, etc.), for the dissolution, catalysis, neutralization, and drying steps in the reaction process.
Preparation steps
The preparation process of Loperamide Powder mainly includes the following steps:
Dissolve 2,2-diphenyl-4-bromobutyric acid in a suitable solvent (such as dichloromethane), then add an acylation reagent (such as oxidized sulfoxide chloride) and perform the acylation reaction at an appropriate temperature. During the reaction process, it is necessary to control the reaction temperature and time to ensure the complete progress of the acylation reaction. After the reaction is complete, the acylation product is obtained through steps such as washing and drying.
Dissolve the acylation product in a suitable solvent (such as toluene), then add dimethylamine and carry out amination reaction at appropriate temperature and pressure. During the reaction process, it is necessary to control the reaction temperature, pressure, and reaction time to ensure the complete progress of the amination reaction. After the reaction is complete, the amination product, dimethyl - (tetrahydro-3,3-diphenyl-2-furylidene) ammonium bromide, is obtained through washing, drying, and other steps.
Dissolve dimethyl - (tetrahydro-3,3-diphenyl-2-furylidene) ammonium bromide and 4-hydroxy-4-chlorophenylpyridine in a suitable solvent (such as toluene or isopropanol) and perform a condensation reaction under alkaline conditions. During the reaction process, it is necessary to control the reaction temperature, the amount of alkali used, and the reaction time to ensure the complete progress of the condensation reaction. After the reaction is complete, loperamide is obtained through washing, drying, and other steps.
Dissolve loperamide in isopropanol, then add hydrogen chloride gas or hydrogen chloride solution, and perform salt formation reaction at an appropriate temperature. During the reaction process, it is necessary to control the reaction temperature, the amount of hydrogen chloride used, and the reaction time to ensure the complete progress of the salt formation reaction. After the reaction is complete, crystals of loperamide hydrochloride are obtained through crystallization, filtration, and other steps.
Dry the crystals of loperamide hydrochloride at an appropriate temperature to remove residual solvents and moisture. The dried crystals are crushed into powder by a grinder to obtain Loperamide Powder.
Conclusion
The preparation process of Loperamide Powder involves multiple reaction steps and complex control of reaction conditions. By strictly controlling reaction conditions, conducting product purification and quality control, adopting safety and environmental measures, and optimizing and improving preparation processes, high-quality Loperamide can be prepared. This drug has significant efficacy and safety in treating acute and chronic diarrhea, providing effective treatment options for clinical patients.