OXONIC ACID POTASIUM SALT,also known as potassium oxalate, 1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylic acid, 4,6-dihydroxy-1,3,5-thiazide-2-carboxylic acid potassium salt, potassium oxonate (OXO), potassium oxohydride, potassium otatiracetam, etc., usually appears as a white crystalline powder, but some sources describe it as a gray white solid. Slightly soluble in water and dilute hydrochloric acid, soluble in sodium hydroxide solution, insoluble in methanol and chloroform. It is relatively stable at room temperature, but should avoid contact with strong acids, bases, and other chemical substances to prevent chemical reactions. As an organic acid salt, it has the chemical properties of general organic acid salts, such as the ability to undergo displacement reactions with metal ions. It is one of the components of the anti-cancer drug S-1. S-1 is an oral fluorouracil derivative anticancer agent mainly used for the treatment of gastrointestinal malignancies such as gastric cancer and colorectal cancer. Potassium oxonate plays a role in inhibiting the toxic side effects of the anti-tumor drug Tegafur in S-1, thereby improving patient tolerance and therapeutic efficacy. It is also a uricase inhibitor that can inhibit the metabolism of uric acid and is used to induce experimental models such as hyperuricemia in rats. In addition, potassium oxonate can also inhibit the gastrointestinal toxicity caused by 5-fluorouracil (5-FU) without losing its anti-tumor activity.
OXONIC ACID POTASSIUM SALT CAS 2207-75-2
Product Code: BM-2-5-000
English Name: Oxonic Acid Potassium Salt
CAS No.: 2207-75-2
Molecular formula: C4H2KN3O4
Molecular weight: 195.17
EINECS No.: 218-627-5
MDL No.：MFCD00010565
Hs code: 29349990
Analysis items: HPLC>99.0%, LC-MS
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Manufacturer: BLOOM TECH Changzhou Factory
Technology service: R&D Dept.-4
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What is OXONIC ACID POTASIUM SALT?
OXONIC ACID POTASSIUM SALT, Also known as potassium oxalate, it is a compound with multiple uses, especially playing an important role in medicine, scientific research, and certain specific industrial fields. The following is a detailed explanation of its purpose:
OXONIC ACID POTASSIUM SALT is one of the important components of the anti-cancer drug S-1. S-1 is an oral fluorouracil derivative anticancer agent composed of Tegafur, Gimeracil, and potassium oxonate in a certain proportion. This drug is mainly used to treat gastrointestinal malignancies such as gastric cancer and colorectal cancer. In S-1, the main function of potassium oxonate is to inhibit the toxic side effects of the anti-tumor drug Tegafur, improve patient tolerance and therapeutic efficacy. Tigafur produces some toxic metabolites during its metabolism in the body, such as fluorouracil deoxyribonucleoside triphosphate (FdUMP). These metabolites may cause damage to the patient's body, such as bone marrow suppression, gastrointestinal reactions, etc. Potassium oxonate, as a uricase inhibitor, can inhibit the production and excretion of these toxic metabolites, thereby reducing the toxic side effects on patients. It can inhibit the metabolism of uric acid, thereby inducing hyperuricemia in animal models such as rats. This characteristic makes potassium oxonate of significant application value in the study of diseases related to uric acid metabolism. In addition to being a component of S-1, potassium oxonate can also be used alone to inhibit gastrointestinal toxicity caused by 5-fluorouracil (5-FU). Potassium oxonate can alleviate the toxic side effects of 5-FU and improve patient tolerance without affecting its anti-tumor activity.
Research field
Potassium oxonate, as a uricase inhibitor, is an important tool for studying uric acid metabolism pathways. By inhibiting the activity of uricase, the accumulation of uric acid in the body can be observed, and the physiological and pathological processes of uric acid metabolism can be studied. Potassium oxonate can also be used to study the kinetics of enzymatic reactions. By changing the concentration of potassium oxonate, the degree of inhibition of uricase activity can be observed, and kinetic parameters such as the Michaelis constant (K ₘ) of the enzymatic reaction can be calculated. Potassium oxonate has a unique chemical structure and can be used as an intermediate in organic synthesis. Organic compounds with specific structures and functions can be synthesized through chemical reactions with other compounds. In the field of drug synthesis, potassium oxonate is also used as a raw material or intermediate for synthesizing certain bioactive drug molecules. For example, when synthesizing certain anti-cancer or anti-inflammatory drugs, it may be necessary to utilize the chemical properties of potassium oxonate for specific chemical transformations.
In the field of chemical analysis, OXONIC ACID POTASSIUM SALT can be used as a chelating agent or precipitant for certain metal ions, for quantitative determination of metal ion content. In addition, potassium oxonate may also have certain potential applications in fields such as electroplating and corrosion protection. Potassium oxonate is often used to induce hyperuricemia in animal models such as rats. This model has important application value in studying the pathogenesis, treatment and drug screening of uric acid metabolism related diseases (such as gout, hyperuricemic nephropathy, etc.). In addition to hyperuricemia models, potassium oxonate may also be used to induce other disease models related to uric acid metabolism. These models help researchers gain a deeper understanding of the relationship between uric acid metabolism and disease occurrence and development. Potassium oxonate has a certain antioxidant effect, which can clear free radicals in the body and reduce oxidative stress damage to cells. This characteristic makes potassium oxonate have certain potential in the development and application of antioxidants. Potassium oxonate can also inhibit inflammatory reactions and reduce tissue damage caused by inflammation. This characteristic makes potassium oxonate valuable in the development and application of anti-inflammatory drugs. Potassium oxonate can inhibit platelet aggregation and prevent the formation of blood clots. This characteristic makes potassium oxonate have certain application prospects in the treatment and prevention of cardiovascular diseases.
Conclusion
OXONIC ACID POTASIUM SALT, as a compound with multiple uses, plays an important role in medicine, scientific research, and certain specific industrial fields. In the field of medicine, potassium oxonate is one of the important components of the anti-cancer drug S-1, which can inhibit the toxic side effects of anti-tumor drugs and improve patient tolerance; At the same time, it also has the function of a uricase inhibitor, which can be used to induce hyperuricemia models and study uric acid metabolism pathways. In the field of scientific research, potassium oxonate is an important tool for biochemical research and chemical synthesis; In the industrial field, it may also be applied in certain specific areas. However, it should be noted that potassium oxonate is currently only used for scientific experiments and is strictly prohibited for clinical medical and other non scientific purposes. When using potassium oxonate, safety operating procedures and environmental regulations should be strictly followed to ensure personal safety and environmental protection. In the future, with the continuous deepening of research on potassium oxonate and the continuous advancement of technology, its application prospects will be even broader.