Epitalon(link:https://www.bloomtechz.com/synthetic-chemical/peptide/epitalon-powder-cas-307297-39-8.html) is a structurally simple peptide consisting of four amino acids (alanine, glutamine, lysine and aspartic acid). The chemical formula of Epitalon is C14H22N4O9, the relative molecular weight is 390.34g/mol, CAS 307297-39-8. For the white powder. Epitalon has high solubility in water and can be dissolved in acidic and alkaline solutions. It can also be dissolved in ethanol, dimethyl sulfoxide, acetone and other solvents. However, it has low solubility in non-polar solvents such as chloroform and benzene. Epitalon Peptide has numerous chemical properties and historical traces, which are described in detail below.
Chemical properties:
1. Structural and stereochemical characteristics:
Epitalon consists of four amino acids connected in a specific order, including two amine groups and two carboxyl groups. This means that Epitalon is a peptide molecule with two amino termini and two carboxyl termini. The essential structure of Epitalon is a cyclic peptide with two internal amine groups and two external carboxyl groups. During the synthesis of Epitalon, its amino and carboxyl termini are often protected to avoid side reactions during the reaction.
2. Thermal stability and light stability:
Epitalon has good thermal stability and is not easy to degrade at high temperature. However, it has poor photostability and is prone to photochemical reaction and inactivation.
3. pH value and state of charge:
Depending on the nature of its amino and carboxyl groups, Epitalon can change its charge state by adjusting the pH. When the pH value is less than or equal to 2, Epitalon will exist in its charged ion form, and when the pH value is greater than or equal to 12, Epitalon will be in a neutral state. In the intermediate pH range, Epitalon may be charged, molecular, or both, depending on the interaction between Epitalon in solution and its surrounding environment.
4. Chemical reaction:
The peptide bond of Epitalon can undergo hydrolysis reaction to break the peptide chain. In addition, Epitalon can be modified by amide bond condensation and ester bond hydrolysis. These chemical reactions provide a means to modify the structure and function of Epitalon, enhancing its biological activity and stability. For example, some peptide derivatives similar to Epitalon were prepared, such as Cyclo-Pro-Gly, Cyclo-Pro-Pro and Cyclo-Pro-Gly-Pro, etc.
In summary, Epitalon is a peptide molecule with good thermal stability and acid-base solubility. Its chemical structure is simple, with ring structure characteristics. The amino and carboxyl termini of Epitalon can be chemically modified by protection reactions. Due to its special chemical properties, Epitalon has been widely studied for the development of medicines and health products.
Epitalon is a peptide composed of four amino acids, which has various health care effects such as delaying aging, improving immunity and improving sleep quality. It was discovered and intensively studied by Russian scientist Vladimir Khavinson in the late 1980s.
1. Vladimir Khavinson's career and research background:
Vladimir Khavinson is a well-known Russian scientist, born in 1946, studied at Leningrad (now St. Petersburg) Medical University, and later obtained a doctorate in medicine. He studied and worked extensively in the scientific community and made important contributions to the fight against cancer in his early years. In the mid-1980s, he began to study the molecular biological mechanism of lifespan and began to explore the role of peptide hormones on human physiological functions.
2. Discovery of Epitalon:
In the late 1980s, Khavinson studied a particularly long-lived population—Split elders. This group lives in the Split district in northern Russia, and their average life expectancy is about 20 years longer than the general population of the same age. Khavinson conducted in-depth research on the physical condition and physiological characteristics of this group, and carried out laboratory studies by taking blood samples from them. He finally discovered that the blood of the elderly in Split is rich in a peptide hormone, which can promote the release of growth hormone in the human body, which may play a role in various physiological functions such as enhancing immunity and delaying aging. effect.
Subsequently, Khavinson began to study this peptide hormone in depth, and finally discovered Epitalon in 1991. He analyzed the composition of Epitalon using the cobalt method invented by Linus Pauling, the Nobel Prize winner in chemistry in 1953, and confirmed that it was a peptide composed of four amino acids. He also further studied the chemical properties, biological functions and clinical applications of Epitalon.
3. Clinical application of Epitalon:
Khavinson's research on Epitalon shows that it can promote the release of human growth hormone, thereby improving sleep, enhancing immunity, delaying aging and other effects. He also found that Epitalon can promote cell metabolism, increase the ability of cells to synthesize proteins, reduce blood cholesterol levels, and alleviate the symptoms of neurodegenerative diseases, etc.
Khavinson's discovery aroused widespread concern in the medical community and set off an upsurge of Epitalon research in Russia and other countries. At present, Epitalon has been widely used in the field of medical care, such as an anti-aging agent, immunomodulator, and adjuvant drug for tumor treatment. It is also used as a health supplement that people take orally or inject to maintain good health.
Epitalon is a peptide hormone composed of four amino acids, which can promote the release of human growth hormone, thereby helping to delay aging, improve sleep, and enhance immunity, etc. The discovery of Epitalon began in the late 1980s. It was Vladimir Khavinson’s research on the elderly population in Split. He discovered a peptide hormone that can promote the release of human growth hormone, and finally discovered and determined the chemical structure of Epitalon. Epitalon's research is expected to provide new treatment and prevention options for the fields of medicine and healthcare.