Naproxen Sodium(link:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/naproxen-sodium-powder-cas-26159-34-2.html), chemical formula C14H13NaO3, molecular weight 252.24 g/mol, CAS 26159-34-2. It exists in the form of white to off-white crystalline powder. It is solid at normal temperature and soluble in water and some other organic solvents. The melting point is about 260-265°C. This refers to the temperature range at which it changes from crystalline to liquid in the solid state. is an over-the-counter and nonsteroidal anti-inflammatory drug (NSAID) that is widely used for pain relief, inflammation, and fever reduction.
Naproxen Sodium (naproxicam sodium) is an over-the-counter and nonsteroidal anti-inflammatory drug (NSAID) with a wide range of clinical uses.
1. Pain relief:
Naproxen Sodium has analgesic properties and can be used to relieve mild to moderate pain. It works by suppressing the inflammatory response and reducing pain signaling. Therefore, Naproxen Sodium is often used to relieve headaches, toothaches, joint pains, muscle pains and other discomforts.
- Headaches and Migraines: Naproxen Sodium can be used to relieve various types of headaches and migraines. It works by reducing the inflammatory response and inhibiting pain transmission pathways.
- Arthritis and Rheumatoid Arthritis: Naproxen Sodium is commonly used to treat pain and inflammation caused by chronic inflammatory joint diseases such as arthritis and rheumatoid arthritis.
- Toothache: Naproxen Sodium can be used to relieve discomfort and inflammation caused by toothache.
- Muscle sprains and strains: Naproxen Sodium can be used to treat pain and inflammation from mild to moderate muscle sprains and strains.
2. Anti-inflammatory effect:
It is a non-steroidal anti-inflammatory drug with obvious anti-inflammatory effect. It reduces tissue inflammation by inhibiting the synthesis of inflammatory mediators, such as prostaglandins. This makes Naproxen Sodium very effective in treating inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, rheumatoid arthritis, etc.
- Inflammation-related diseases: Naproxen Sodium can be used to treat various inflammation-related diseases, such as synovitis, tendonitis, bone spurs, etc. It reduces inflammatory lesions and associated symptoms by inhibiting prostaglandin synthesis.
- Arthritis: Naproxen Sodium reduces joint swelling, pain and movement impairment caused by arthritis.
3. Antipyretic effect:
It can be used to lower body temperature and has an antipyretic effect. It reduces the rise in body temperature by changing the function of the body's temperature-regulating center. Therefore, Naproxen Sodium is often used to treat discomfort caused by fever.
- Fever: Naproxen Sodium can be used to reduce the increase in body temperature caused by fever. It normalizes body temperature through its effects on the central nervous system.
4. Women's health:
- Dysmenorrhea: Naproxen Sodium relieves abdominal pain and discomfort associated with dysmenorrhea.
- Endometriosis: Naproxen Sodium can be used to treat pain and inflammation caused by endometriosis.
5. Inflammation-related eye diseases:
- Conjunctivitis and Keratitis: Naproxen Sodium can be used to treat eye pain, congestion and inflammation caused by conjunctivitis and keratitis.
6. Anti-platelet aggregation effect:
Naproxen Sodium has the effect of inhibiting platelet aggregation, which can block platelet adhesion and aggregation, thereby reducing the risk of thrombosis. This makes Naproxen Sodium have certain applications in the treatment and prevention of cardiovascular and cerebrovascular diseases.
7. Gastrointestinal protection:
Naproxen Sodium can protect the gastrointestinal tract by reducing the inflammatory response and reducing the synthesis of prostaglandins. Therefore, compared with other NSAIDs, Naproxen Sodium has mild gastrointestinal adverse reactions and is more suitable for some patients who are sensitive to gastric mucosa.
8. Controls Arthritis Pain:
Naproxen Sodium can be used to manage arthritis pain, improve joint function and reduce joint swelling. It reduces joint pain, stiffness, and swelling and helps patients restore normal joint motion.
9. Prevent dysmenorrhea:
Naproxen Sodium can be used to relieve symptoms of dysmenorrhea. It can reduce abdominal pain and discomfort caused by dysmenorrhea, thereby improving the patient's quality of life.
10. For children with arthritis:
Naproxen Sodium is also used in the treatment of arthritis and other related diseases in children. Children's arthritis is a common rheumatic disease in children. Naproxen Sodium can relieve inflammation, reduce joint pain and swelling, and improve the quality of life of children.
The molecular formula of Naproxen Sodium (levoibuprofen sodium) is C14H13NaO3, and its analytical structural features mainly include the following aspects:
1. Basic structure: Naproxen Sodium is an organic acid salt composed of Naproxen (levoibuprofen) and sodium ions. Naproxen is a non-steroidal anti-inflammatory drug belonging to 2-naphthylacetic acid derivatives with strong pharmacological activity. Sodium ions form a salt structure with Naproxen, which improves the water solubility and stability of the drug.
2. Molecular structure: The molecular structure of Naproxen Sodium contains a benzene ring and a naphthalene ring. A carboxyl group (COOH) is attached to the benzene ring, while a methyl group and an acetate group are attached to the naphthalene ring. In addition, Naproxen Sodium also contains a sodium ion (Na+), which forms a salt bridge with the carboxyl group.
3. Stereostructure: Naproxen Sodium is a chiral compound with a chiral center (iral center). In the drug, only the left-handed (S) form of Naproxen is contained, and the right-handed (R) form of Naproxen has no pharmacological activity. Therefore, Naproxen Sodium is mainly composed of L-type Naproxen.
4. Water solubility and solubility: The salt form of Naproxen Sodium makes it have good water solubility, which is convenient for the preparation of preparations and the administration of drugs. Due to the presence of sodium ions, Naproxen Sodium can quickly dissolve in water and release Naproxen ions.
5. Analysis method: For the analysis of Naproxen Sodium, various techniques can be used for detection and identification. Commonly used methods include high performance liquid chromatography (HPLC), gas chromatography (GC), infrared spectroscopy (IR), nuclear magnetic resonance (NMR), etc. These analytical methods can determine the content, structure and purity of Naproxen Sodium.