Paeonol (2'-hydroxy-4'-methoxyacetophenone)(link:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/paeonol-powder-cas-552-41-0.html) is a natural organic compound with the chemical formula C9H10O3. Peony bark is the dry root bark of the Ranunculaceae plant Paeonia suffruticosa Andr., and is one of the commonly used traditional Chinese medicine in clinical practice. Paeonol, as the main medicinal component of Paeonia, has received increasing attention in recent years, with abundant research results in its physicochemical properties, pharmacological effects, and detection and extraction.
Pharmacological action:
Paeonol has certain potential value in the development and application of functional health products, but there is still a lack of systematic and in-depth toxicological safety evaluation data. This study examines the acute toxicity of paeonol to nematodes, as well as the impact of indicators such as exercise behavior, feeding behavior, and reproductive ability, in order to provide toxicological safety evaluation data for the development and utilization of functional health products related to paeonol. The movement behavior of nematodes is an indicator that reflects the basic functions of their body system, which is simple to operate, highly sensitive, easy to observe, low in cost, and short in cycle. The head swing frequency and body bending frequency of nematodes are often used as indicators to analyze their movement behavior; Feeding behavior can reflect whether the feeding of nematodes is influenced by exogenous drugs, and changes in reproductive ability reflect the impact of exogenous drugs on the reproductive physiological function of nematodes.
The experiment showed that after 24 hours of treatment with 100 and 200mg/L concentrations of paeonol on nematodes, there were no acute toxic effects; Paeonol can improve the head swinging and body bending ability of nematodes, enhance the activity of the body, and 100 mg/L of Paeonol has the best effect. Paeonol has no effect on the energy intake of nematodes, which can exclude the possibility that Paeonol can reduce the swallowing frequency of nematodes, thereby reducing the energy limitation of food intake and affecting physiological functions. Paeonol has no effect on reproductive ability, indicating that nematodes are still in a healthy state during its action. No toxic effect of paeonol on nematodes has been found, and it can significantly improve the movement ability of nematodes. It has certain potential application value in the development and application of functional health products.
Nature
It has analgesic, anti-inflammatory, antipyretic, and anti allergic effects. Paeonol has a significant analgesic effect on pain caused by physical or chemical factors such as tail pressure and acetic acid. Paeonol has a significant inhibitory effect on inflammatory reactions caused by carrageenan, egg white, formaldehyde, histamine, 5-hydroxytryptamine, bradykinin, xylene, and endotoxin. Paeonol has a significant antipyretic effect on the increase in body temperature caused by typhoid vaccine, triple vaccine, etc. It has an inhibitory effect on type II, III, and IV allergic reactions.
Principle of Action
It has sedative, hypnotic, antibacterial, anti-inflammatory, antioxidant, and blood pressure lowering effects. In terms of cosmetics; Paeonol can inhibit the production of O2- free radicals in cells, whiten the skin, reduce and fade the deposited pigments in the skin, eliminate stasis and spots, diminish inflammation, reduce swelling and pain, resist allergies, and viruses. It has good therapeutic and health effects on pigmentation, muscle pain, skin itching, psoriasis, banded rash, and eczema. In addition, it has good effects in toothpaste, mouthwash, tooth powder, and toothache water.
Discovery History:
1. Traditional medicinal history:
Paeonol was first applied in traditional Chinese medicine. In ancient China, Chuanxiong was widely used to treat symptoms such as dysmenorrhea, vasodilation, and rheumatism. Although people have long known the medicinal value of Ligusticum chuanxiong, significant progress was not made in the study of its active ingredients until the 20th century.
2. Extraction and identification:
In the early 20th century, scientists began to conduct in-depth research on Chuanxiong to determine its active ingredients. According to reports, in 1939, Japanese researchers successfully extracted Paeonol from Ligusticum chuanxiong for the first time and identified its chemical structure. They named the substance 'Peonol'.
3. Chemical research:
In the following decades, researchers conducted extensive chemical research on Paeonol. They continuously delve into the properties, structure, and activity of Paeonol through methods such as synthesis, extraction, and separation.
4. Pharmacology and pharmacodynamics research:
Pharmacological and pharmacological studies on Paeonol have shown that it has various biological activities, including antioxidant, anti-inflammatory, antibacterial, and anti-tumor effects. These studies provide a scientific basis for the clinical application of Paeonol.
5. Clinical research and application:
The clinical application of Paeonol is gradually receiving attention. Research has shown that Paeonol can be used to treat cardiovascular diseases, inflammatory diseases, and neurological diseases. In addition, Paeonol has also been developed as a raw material for cosmetics and health products.
Although the discovery history of Paeonol is relatively short, research on it is still ongoing due to its extensive biological activity and potential clinical application prospects.
Molecular structure analysis of Paeonol:
1. Structural features:
Paeonol belongs to the acetophenone class of compounds, with a benzene ring and an acetone group. Its molecular formula is C9H10O3, with a relative molecular weight of 166.17 g/mol.
2. Molecular structure:
The main structural features of Paeonol are as follows:
-Benzene ring: The Paeonol molecule contains a six membered benzene ring, which is composed of 6 carbon atoms and 5 hydrogen atoms. The positions 2 'and 4' on the benzene ring are connected to a hydroxyl group and a methoxy group, respectively.
-Acetone group: The Paeonol molecule contains an acetone group, which is a combination of one ketone group and two methyl groups. This group is connected to position 1 of the benzene ring.
3. Functional groups:
The functional groups in Paeonol molecules include hydroxyl (- OH) and methoxy (- OCH3). The presence of hydroxyl and methoxy groups endows Paeonol with many of its activity and pharmacological properties.
4. Optical activity:
Paeonol is a chiral molecule that may have stereoisomers. Its optical activity can be determined by measuring optical rotation.
5. X-ray crystal structure:
The X-ray diffraction study of Paeonol shows that its crystal structure is monoclinic.
6. Molecular model:
By using computational chemistry methods, a three-dimensional molecular model of Paeonol can be established. These models can be used to study their interactions and pharmacological mechanisms with other molecules.
Overall, the molecular structure of Paeonol is mainly characterized by benzene and acetone groups, with functional groups such as hydroxyl and methoxy groups. These structural features endow Paeonol with many interesting chemical properties and biological activities.