The first antiandrogen was discovered as early as the 1960s. Antiandrogens are essential for patients with hormonal problems like benign prostatic hyperplasia, acne, hirsutism, male alopecia, prostate cancer, and hypersexuality. A variety of antiandrogens have been found, but only a part of antiandrogens have been used in the clinic. Antiandrogens act as binding antibodies to androgen receptors in reactive tissues to block or reduce the physiological effects of testosterone and dihydrotestosterone (DHT). In other words, they inhibit or block the function of testosterone and DHT. Ru58841 powder (or ru-58841) is a kind of antiandrogen complex. Ru58841 has been used as an external treatment for male alopecia, acne and hirsutism.
The physiological function of which is contrary to dutasteride and finasteride compounds. It does not prevent DHT production but only interferes with androgen receptors. Androgen receptors are expressed in many tissues in the body. They are also present in the scalp and hair follicles. There are more androgen receptors in hair loss follicles than in non-hair loss follicles. Let's look at the correlation between the normal function of the androgen receptor and ru58841 on androgen alopecia. Imagine that the oval above is your hair follicle or skin cell. Typically, testosterone will enter the cell, and if there are 5 α, the Reductase is converted to DHT. Next, both attach to androgen receptors. After that, the androgen receptor runs to the nucleus, producing several processes. What ru58841 does is: ru58841 binds itself to the androgen receptor and then makes two androgens (DHT + testosterone) inoperative. If you observe, it is not surprising that people born with androgen receptor deficiency will not have the problem of male alopecia because there is no functional androgen receptor and androgen is useless.
Ru58841 is designed as a local antiandrogen. Ru58841 is used as a local antiandrogen. I want to know that blocking the function of androgen receptors in the whole body is not an intelligent choice. Still, it can only stop the androgen receptors in the scalp and hair follicles. Because the half-life of ru58841 is very short, only 1 hour, it is very suitable for aga. It only works on the scalp or skin. Another advantage is that the structure of this complex is different from all-natural steroids in the body. This is a non-steroidal antiandrogen/chemical structure and does not interfere with hormonal concentration. Most countries have not officially recognized ru58841. It can only be used as a research chemical, so only researchers can buy it for research.
Ru58841 powder side effects ru58841 applies to the scalp and is absorbed by hair follicles. In theory, it can enter the blood and affect other body parts. However, no systemic side effects were found in the study of local application in monkeys. However, some people who try ru58841 powder claim that they have experienced some side effects caused by the use of Ru, including skin irritation, decreased libido, primary dysfunction, nausea, red eyes, dizziness and headache.