Tirzepatide is a novel biosimilar developed by Lilly and Boehringer Ingelheim, which belongs to the class of dual hormone (GLP-1/GCG) receptor agonists. The drug is a long-acting GLP-1 receptor agonist with agonistic effects on glucagon-like peptide-1 (GLP-1) and glucagon family peptide (GCG) at the same time, and is effective in the treatment of 2 It shows great potential in diabetes, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatopancreatitis (NAPCD), obesity and cardiovascular disease.
1.General Specification(in stock)
(1)API(Pure powder)
(2)Tablets
(3)Injection
(4)Capsules
(5)Oral Drops
(6)Spray
2.Customization:
We will negotiate individually, OEM/ODM, No brand, for secience researching only.
Analysis: HPLC, LC-MS, HNMR
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We provide tirzepatide Injection, please refer to the following website for detailed specifications and product information.
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1. Lower blood sugar levels:
Tirzepatide is a long-acting GLP-1 receptor agonist that has shown great potential in the treatment of type 2 diabetes. It promotes insulin secretion, reduces glucagon and insulin resistance, and helps control blood sugar levels. In a clinical trial at the General Hospital of Tianjin Medical University, the HbA1c level of the Tirzepatide treatment group was reduced by 2.29%, but the lowering effect on patients with poor blood sugar levels, hypercholesterolemia and hypertriglyceridemia significantly.
2. Improve non-alcoholic fatty liver disease (NAFLD):
Tirzepatide also shows great potential in the treatment of NAFLD. In a Lilly-sponsored study, patients treated with Tirzepatide saw a 59 percent reduction in liver fat compared with placebo, and it also had positive effects in patients with NASH. Tirzepatide improves fatty acid metabolism and reduces insulin resistance and inflammation, factors that have been linked to the development of NAFLD.
3. Reduce obesity:
Tirzepatide has also been extensively studied for the management of obesity. In a randomized, double-blind, placebo-controlled trial, patients treated with Tirzepatide lost an average of approximately 11.3% of their body weight. In another study, Tirzepatide could be combined with other anti-obesity drugs to enhance their weight loss effects.
4. Reduce the risk of cardiovascular disease:
Many studies have shown that Tirzepatide is beneficial for cardiovascular diseases. In a study sponsored by Lilly, Tirzepatide treatment group had a 40% reduction in heart risk, mainly due to lower total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels, but also reduced systolic blood pressure.
5. Reduce non-alcoholic steatopancreatitis (NAPCD):
It was recently found that GLP-1 and its analogues also have the effect of improving NAPCD. In the study of NAPCD mouse model, it was proved that Tirzepatide can not only alleviate pathological changes through the GLP-1/GCG dual agonist pathway, but also reduce insulin resistance, and intervene in the regulation mechanism of death signals that cause apoptosis. to the therapeutic effect.
6. Improve insulin sensitivity:
Tirzepatide's dual hormone (GLP-1/GCG) receptor agonist mechanism increases insulin sensitivity. The drug increases insulin secretion from the pancreas and reduces glucagon and insulin resistance, helping to control blood sugar levels.
7. Reduce inflammation:
The therapeutic effect of Tirzepatide is not only to control diseases such as diabetes by improving metabolic regulation, but also to reduce the inflammatory response. This effect is particularly evident in the treatment of obesity and cardiovascular disease, as these diseases are closely related to inflammatory responses.
8. Enhance insulin secretion:
The potentiating effect of Tirzepatide on insulin secretion has also been extensively studied. By promoting the release of insulin-like peptides in the gastrointestinal tract and increasing the effects of insulin, the drug helps control blood sugar levels and improve metabolic regulation.
9. Reduce appetite:
The therapeutic effects of Tirzepatide are also associated with reducing appetite. Experiments have found that the drug can reduce food intake, appetite and cravings for high-calorie foods, helping to control weight and reduce obesity.
10. Treat various diseases:
Overall, Tirzepatide is a very versatile drug that can be used in the treatment of type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatopancreatitis (NAPCD), obesity and cardiovascular diseases, etc. field. Although further studies are needed to confirm its safety and efficacy, Tirzepatide's research results in the above areas have made people full of expectations.
Tirzepatide is a drug with broad application prospects and can be used to treat type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatopancreatitis (NAPCD), obesity and cardiovascular diseases. Although further research is still needed to confirm its safety and efficacy, the research results of this new type of biosimilar in the above fields have made people full of expectations.
Tirzepatide is a polypeptide molecule containing multiple amino acid residues, and its reaction properties are affected by many factors, such as temperature, pH value, light, etc. The following will summarize the reaction properties of Tirzepatide from the aspects of chemical reaction, redox reaction, acid-base reaction, hydrolysis reaction, addition reaction and so on.
The polypeptide structure of Tirzepatide makes it chemically reactive and can react chemically with some reagents. For example, Tirzepatide can undergo a carbonyl reduction reaction with carbon monoxide (CO) in the presence of a palladium catalyst to produce a steroid intermediate. In addition, Tirzepatide can also introduce various functional groups through substitution reactions, such as introducing alkyl groups, alcohol groups, acyl groups, etc. These reactions usually need to be carried out under appropriate reagents, catalysts and reaction conditions to obtain satisfactory yields and product purity.
Tirzepatide contains multiple amino acid residues and unnatural amino acids with some redox reactivity. For example, Tirzepatide can undergo oxidation in the presence of oxygen or oxidizing agents to form some oxidation products. In addition, in the presence of reducing agents or under reducing conditions, Tirzepatide can also undergo reduction reactions, thereby reducing molecular weight and biological activity. These reactions have an important impact on the stability and efficacy of Tirzepatide, so care should be taken to avoid these reactions during storage and use.
Since Tirzepatide contains multiple amino acid residues, it has certain acid-base properties and can undergo neutralization reactions with some acids or bases. For example, at lower pH values, the amino groups of Tirzepatide are protonated to form positively charged ions, while at higher pH values, they are deprotonated to form negatively charged ions. These changes will affect the solubility, stability and efficacy of Tirzepatide, so it is necessary to store and use Tirzepatide at an appropriate pH.
Since Tirzepatide contains multiple peptide bonds, it also has some hydrolytic reactivity. In the presence of water or hydrolytic enzymes, the peptide bonds of Tirzepatide can be hydrolyzed by water or hydrolytic enzymes to decompose into monomeric amino acids. These reactions will reduce the biological activity and stability of Tirzepatide, so care should be taken to avoid these reactions during storage and use.
Since Tirzepatide contains multiple double bonds (such as Pro and Gln residues), it also has certain addition reactivity. For example, Tirzepatide can undergo addition reaction with some electrophiles (such as sodium nitrite, diazomethane, etc.) to introduce different functional groups and functional units. These reactions need to be performed under appropriate reagents, catalysts, and reaction conditions to obtain satisfactory yields and product purity.
In summary, Tirzepatide is a polypeptide molecule containing multiple amino acid residues, and its reactivity properties are affected by various factors. Tirzepatide has certain chemical reactivity, redox reactivity, acid-base reactivity, hydrolysis reactivity and addition reactivity, and care should be taken to avoid these reactions during storage and use to ensure its efficacy and safety.