Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of acepromazine maleate 10 mg in China. Welcome to wholesale bulk high quality acepromazine maleate 10 mg for sale here from our factory. Good service and reasonable price are available.
Acepromazine maleate 10 mg, as a widely used medication in veterinary clinical practice, plays an important role in animal sedation, anesthesia assistance, anti shock and other aspects. It belongs to the class of phenothiazine derivatives, and since entering the veterinary field in the late 1950s, it has become one of the commonly used drugs in veterinary medicine due to its unique pharmacological effects and good clinical efficacy.
Stability and Storage Conditions:
The stability of acetylpromethazine maleate injection is greatly affected by storage conditions. Generally speaking, it should be stored in the dark and at room temperature to prevent drug decomposition and failure. During transportation, it is also necessary to follow conventional transportation conditions to avoid adverse effects such as severe vibrations and high temperatures on the medication. If a stock solution needs to be prepared in advance, it is recommended to store equal portions of the solution in sealed small bottles at -20 ° C, which can usually be used for up to one month. Before use and opening the sample bottle, the product should be allowed to equilibrate at room temperature for at least 1 hour to ensure the stability and effectiveness of the drug.
Our product
Additional information of chemical compound:
| Product Name | Acepromazine Maleate Tablets | Acepromazine Maleate Injection |
| Product Type | Tablets | Injection |
| Product Purity | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable |
| Product Package | Customizable |
Customizable |
Acepromazine Maleate +. COA
 |
||
Certificate of Analysis |
||
|
Compound name |
Acepromazine Maleate | |
|
CAS No. |
3598-37-6 | |
|
Grade |
Pharmaceutical grade | |
|
Quantity |
Customized | |
|
Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
|
Lot No. |
20250109001 |
|
|
MFG |
Jan 12th 2025 |
|
|
EXP |
Jan 8th 2029 |
|
|
Structure |
|
|
| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
|
Item |
Enterprise standard |
Analysis result |
|
Appearance |
White or almost white powder |
Conformed |
|
Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
|
Heavy Metals |
Pb≤0.5ppm |
N.D. |
|
As≤0.5ppm |
N.D. | |
|
Hg≤0.5ppm |
N.D. | |
|
Cd≤0.5ppm |
N.D. | |
|
Purity (HPLC) |
≥99.0% |
99.5% |
|
Single impurity |
<0.8% |
0.48% |
|
Residue on ignition |
<0.20% |
0.064% |
|
Total microbial count |
≤750cfu/g |
80 |
|
E. Coli |
≤2MPN/g |
N.D. |
|
Salmonella |
N.D. | N.D. |
|
Ethanol (by GC) |
≤5000ppm |
400ppm |
|
Storage |
Store in a sealed, dark and dry place at-20 degrees |
|
|
|
||
Acepromazine maleate 10 mg is a commonly used medication in veterinary clinical practice, and its common specifications have clear characteristics in terms of dosage form, content, packaging, etc., as follows:
1. Formulation specifications
Acetylpromethazin maleate injection is usually an injection, with a common specification of 2 milliliters per vial, which facilitates accurate extraction and injection of drugs by veterinarians in clinical practice. The content of active ingredient acetylpromazine maleate in each injection is generally 20 milligrams, which means 13.5 milligrams is equivalent to 10 milligrams of acetylpromazine. The design of this dosage form specification not only considers the effectiveness and stability of the drug, but also facilitates veterinary use.
2. Content specification
There may be certain differences in the content specifications of acetylpromethazin maleate injection produced by different manufacturers. In addition to the common 20mg/2ml specifications mentioned above, there may be other specifications of products on the market, such as 10mg/1ml. These products of different specifications meet the needs of different animal species, different medical conditions, and different medication requirements. Veterinarians should choose appropriate specifications for drugs based on specific circumstances.
3. Packaging specifications
There are also various packaging specifications for acetylpromazine maleate injection. The common packaging form is single independent packaging, where each injection is sealed in a separate package to ensure the hygiene and safety of the drug. In addition, there may be packaging forms of multiple units in a box, such as 5 units/box, 10 units/box, etc. This packaging form facilitates the storage and transportation of drugs, as well as the bulk procurement and use by veterinarians.
4. Special specifications and customization
In addition to the common specifications mentioned above, some manufacturers may also produce special specifications of acetylpromethazin maleate injection according to market demand and customer requirements. For example, for certain large animals or special conditions, larger doses of medication may be required, and manufacturers may provide products with higher content or larger packaging specifications. In addition, some research institutions or laboratories may also need to customize specific specifications of acetylpromethazin maleate injection to meet their special experimental needs.
Specifications selection and usage precautions:
Veterinarians should fully consider factors such as the animal's weight, condition, medication purpose, dosage, and administration method when selecting the specifications for acetylpromethazin maleate injection. For small animals such as dogs, cats, etc., a specification of 20 milligrams/2 milliliters is usually sufficient to meet the needs; For large animals such as horses, cows, etc., larger doses of drugs may be required, and products with higher content or larger packaging specifications should be selected. At the same time, during use, veterinarians should strictly follow the drug instructions or recommendations of veterinarians to avoid excessive use or insufficient administration.
Common synthesis methods
Acepromazine maleate 10 mg, as an important chemical substance, has a wide range of applications in the fields of medicine and others. The common synthesis methods mainly revolve around the reaction between acetylpromazine and maleic acid. The following will provide a detailed introduction to several possible synthesis pathways and key points.
Synthesis Method Based on Acetylpromazine Intermediate
1. Synthesis of Acetylpromazine
Starting material selection: The synthesis of acetylpropazine usually starts with phenothiazine compounds and introduces the desired substituents through a series of chemical reactions. For example, synthesis can be carried out using 2-bromothiophenol or phenothiazine itself as starting materials.
Optimization of reaction conditions: In the process of synthesizing acetylpromazine, it is necessary to strictly control the reaction conditions, such as temperature, pressure, reaction time, etc., to ensure the efficient progress of the reaction and the purity of the product. At the same time, it is necessary to choose suitable catalysts and solvents to promote the progress of the reaction.
Product purification: The synthesized acetylpromazine intermediate needs to be purified to remove impurities and unreacted raw materials. Common purification methods include recrystallization, column chromatography, etc.
2. Reaction of Acetylpromazine with Maleic Acid
Reaction principle: Acetylpromazine can react with maleic acid under appropriate conditions to form acetylpromazine maleate. This reaction usually belongs to the category of acid-base neutralization reaction or esterification reaction.
Reaction condition control: In order to ensure the smooth progress of the reaction, it is necessary to strictly control the reaction conditions. For example, precise control is required for reaction temperature, molar ratio of reactants, reaction time, etc. In addition, suitable solvents and catalysts need to be selected to promote the reaction and increase the yield of the product.
Product separation and purification: After the reaction is complete, the product needs to be separated from the reaction mixture by appropriate methods. Common separation methods include extraction, distillation, etc. The crude product obtained from separation still needs further purification treatment, such as recrystallization, column chromatography, etc., to obtain high-purity acetyl triazine maleic acid ester.
Synthesis strategy based on maleic acid derivatives
In addition to using acetylpromazine as an intermediate for synthesis, it is also possible to consider using maleic acid derivatives as raw materials for synthesis. This method may involve the reaction of maleic acid with other compounds to generate reactive maleic acid derivative intermediates, which are then reacted with acetylpromazine or its precursors.
1. Synthesis of maleic acid derivatives
Raw material selection: Maleic anhydride, maleic monoester, etc. can be selected as raw materials for synthesizing maleic acid derivatives.
Reaction conditions: By controlling reaction conditions such as temperature, pressure, catalyst, etc., maleic acid reacts with appropriate reagents to generate the desired maleic acid derivatives.
2. Reaction of maleic acid derivatives with acetylpromazine
Reaction type: This reaction may belong to esterification reaction, amidation reaction, etc., depending on the structure and reaction conditions of the maleic acid derivative.
Reaction optimization: In order to improve the yield and purity of the product, it is necessary to optimize the reaction conditions. For example, adjusting the molar ratio of reactants, reaction temperature, reaction time, etc.
The pharmacokinetics related content is as follows:
(1) Absorption:
There are various ways of administering Acepromazine maleate 10 mg to cats, including intravenous, intramuscular, subcutaneous, and oral administration. There are differences in drug absorption under different administration routes, but there is currently a lack of detailed information on specific pharmacokinetic parameters such as absorption rate and degree. However, a peak effect can occur approximately 5-15 minutes after intravenous injection and 15-30 minutes after intramuscular injection, which to some extent reflects the speed at which the drug enters the systemic circulation.
(2) Distribution:
After entering the body, acetylpromazine maleate will be widely distributed in various tissues and organs. Its sedative effect originates from the inhibition of the ascending activation system of the brainstem reticular formation, indicating that the drug can penetrate the blood-brain barrier and enter the central nervous system, acting on relevant receptors to exert pharmacological effects. Meanwhile, the distribution of drugs in other tissues and organs can also affect their efficacy and the occurrence of adverse reactions, but specific parameters such as distribution volume and tissue binding rate are not yet clear.
(3) Metabolism:
At present, there is relatively little information on the metabolic pathways, metabolites, and enzymes of acetylpromazine maleate in the body. Drugs undergo a series of biotransformation processes in the body, which may generate metabolites with different pharmacological activities. The production and elimination of these metabolites can also affect the overall efficacy and safety of drugs.
(4) Excretion:
Similarly, there is a lack of detailed research data on pharmacokinetic parameters such as the excretion pathway, excretion rate, and clearance rate of acetylpromazine maleate. Drugs and their metabolites may be mainly excreted through the kidneys in the form of urine, or may be excreted into the intestine through bile, but the specific excretion mechanism and influencing factors are still unclear.
Its disturbance on membrane physical properties: from "fluidity" to "phase transition"
Acepromazine malate, as a classic derivative of phenothiazine, has been widely used in veterinary clinical practice since the 1950s as a sedative, anti anxiety drug, and antihistamine. Its chemical essence is an organic compound formed by the salt formation of phenothiazine ring and maleic acid, with a molecular formula of C ₁₉ H ₂ N ₂ OS · C ₄ H ₄ O ₄, a molecular weight of 442.57, and a gray white or yellow crystalline powder at room temperature. Although its pharmacological effects, such as alpha adrenergic receptor antagonism and dopamine receptor inhibition, have been extensively studied, there are still many unsolved mysteries regarding its disturbance mechanism on the physical properties of cell membranes, especially its dynamic effects from membrane fluidity to phase transition.
Molecular basis and membrane interaction
Membrane embedding characteristics of phenothiazine ring
The core structure of phenothiazine compounds is a tricyclic conjugated system, and their hydrophobic side chains (such as 3- (dimethylamino) propyl) endow the molecule with strong membrane affinity. Acetyl triazine maleate is embedded into the phospholipid bilayer of the cell membrane through the planar structure of the phenothiazine ring, with hydrophobic tails penetrating deep into the membrane core and hydrophilic maleic acid groups located on the membrane surface. This "amphiphilic" distribution allows it to interfere with the arrangement order of membrane lipids.
Dopamine receptor antagonism and membrane signal transduction
Acetylpromazine inhibits central nervous system excitability by blocking dopamine D ₂ receptors, but this process may indirectly affect membrane signal transduction. For example, D ₂ receptor activation can regulate phospholipase C (PLC) activity, thereby affecting membrane phospholipid metabolism. The antagonistic effect of acepromazine may decrease the dynamic fluidity of membrane lipids by inhibiting the PLC pathway and reducing the generation of diacylglycerol (DAG).
α - adrenergic receptor blockade and membrane tension regulation
The α - κ receptor antagonist effect of acetylpromazine can lead to vascular smooth muscle relaxation, which is closely related to changes in membrane tension. Activation of alpha ₁ receptors increases the hydrolysis of phosphatidylinositol 4,5-diphosphate (PIP ₂) through the Gq protein coupling pathway, generating inositol triphosphate (IP ∝) and DAG, promoting membrane lipid fluidity. Acetylpromazine may reduce membrane tension and affect the bending stiffness of the membrane by blocking this pathway.
Dynamic regulation of membrane fluidity at a dose of 10 mg
Experimental evidence of membrane fluidity
Membrane fluidity is a physical parameter that describes the mobility of membrane lipids and membrane protein side chains, typically measured by fluorescence polarization or electron paramagnetic resonance (EPR) techniques. Under the action of 10 mg of acetylpromethazine maleate, the following phenomena were observed in the experiment:
Decreased fluorescence polarization value: Using 1,6-diphenyl-1,3,5-hexane (DPH) as a fluorescent probe, it was found that the fluorescence polarization value of the treated membrane significantly decreased, indicating an enhanced mobility of the membrane lipid side chains.
Narrowing EPR spectral linewidth: Using 5-nitrooxystearic acid (5-NS) as a spin label, the EPR spectral linewidth decreased from 3.2 G to 2.8 G, further confirming an increase in membrane fluidity.
Molecular mechanism of enhanced liquidity
Dysregulation of phosphatidylcholine (PC) arrangement: Acetylpromazine disrupts the ordered arrangement of PC molecules by inserting into the membrane lipid bilayer, increasing the gaps between lipid molecules and promoting side chain movement.
Changes in cholesterol distribution: Cholesterol is a key regulator of membrane fluidity. Acetylpromazine may reduce its orderliness by interacting with cholesterol, thereby enhancing membrane fluidity.
Conformational changes of membrane proteins: Acetylpromazine can induce conformational changes of membrane proteins (such as sodium potassium pumps and calcium channels), reduce the interaction between proteins and lipids, and indirectly enhance membrane fluidity.
Hot Tags: acepromazine maleate 10 mg, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale