Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of argipressin injection in China. Welcome to wholesale bulk high quality argipressin injection for sale here from our factory. Good service and reasonable price are available.
Argipressin injection is a synthetic drug formulation that simulates the natural antidiuretic hormone effect in the human body, achieving dual functions of vasoconstriction and antidiuretic. Its core component, arginine vasopressin, activates the V1a receptor in vascular smooth muscle and the V2 receptor in renal tubules, exerting effects on vasoconstriction, hypertension, water reabsorption, and urine output reduction, respectively.
In clinical applications, it is mainly used in two scenarios: one is to treat central diabetes insipidus (non renal), by enhancing the permeability of renal tubules to water and correcting polyuria symptoms; The second is to control esophageal variceal bleeding and utilize its potent vasoconstrictive effect to reduce the risk of bleeding. In addition, the drug can also be used as an adjuvant therapy for postoperative abdominal distension and to disperse intestinal gas before abdominal X-ray examination.
Our product
Argipressin COA
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| Certificate of Analysis | ||
| Compound name | Argipressin | |
| Grade | Pharmaceutical grade | |
| CAS No. | 113-79-1 | |
| Quantity | 50g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090069 | |
| MFG | Jan 9th 2025 | |
| EXP | Jan 8th 2028 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.54% |
| Loss on drying | ≤1.0% | 0.42% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.52% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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Argipressin injection (AVP), also known as antidiuretic hormone (ADH), is a nine peptide hormone synthesized by hypothalamic neurons and released by the posterior pituitary gland. It plays a central role in water and salt balance, blood pressure regulation, and stress response in the human body.
Biological synthesis pathway: from gene expression to molecular assembly of active hormones
The synthesis of AVP begins with neuroendocrine cells in the hypothalamic supraoptic nucleus and paraventricular nucleus, and the process can be divided into four stages:
Gene transcription and precursor protein synthesis
The AVP gene is located in a specific region of the chromosome and encodes a precursor AVP protein consisting of 164 amino acids. This precursor contains four functional domains: signal peptide, AVP nine peptide sequence, neurophysin II, and copeptin. The signal peptide guides the precursor into the endoplasmic reticulum and is cleaved, forming a 145 amino acid pro AVP.
Intracellular processing and folding
Pro AVP undergoes protease hydrolysis in the Golgi apparatus to produce AVP nonapeptide (Cys Tyr Phe Gln Asn Cys Pro Arg Gly-NH2), neurotrophin transporter protein, and coptin. Among them, the formation of disulfide bonds (Cys1-Cys6) in AVP is the key to its active conformation, which enables AVP to stably bind to receptors.
Axon transport and storage
The processed AVP binds to the neurotrophin transporter protein to form secretory granules, which are transported along the axon of the hypothalamic pituitary tract to the posterior pituitary gland and stored in the Herring bodies. Carrier proteins not only protect AVP from enzymatic hydrolysis, but also regulate its release efficiency.
Enzymatic activation and release
When the body needs it, the pituitary gland releases AVP into the bloodstream through exocytosis. AVP rapidly binds to V1a and V2 receptors in target organs (kidneys, blood vessels, etc.) in the bloodstream, exerting physiological effects. Its half-life is only 15-20 minutes and requires continuous synthesis to maintain its function.
Secretion regulation mechanism: multi-level feedback network ensures steady state
The secretion of AVP is controlled by a triple mechanism of neural, humoral, and self-regulation, with the core goal of maintaining stable plasma osmotic pressure (280-300 mOsm/kg) and blood volume (approximately 5 L).
Osmotic pressure regulation: Accurately sensing changes in extracellular fluid osmotic pressure
The osmoreceptors in the hypothalamic supraoptic nucleus and paraventricular nucleus are highly sensitive to changes in osmotic pressure, and only 1% fluctuation can trigger argipressin injection release. When plasma osmotic pressure increases (such as dehydration):
Depolarization of osmoreceptor cells activates voltage-gated calcium channels, promoting the release of AVP secretory granules.
AVP promotes the insertion of aquaporin 2 (AQP2) into the renal collecting duct through V2 receptors, increasing water reabsorption, reducing urine output, and decreasing plasma osmotic pressure.
On the contrary, hypotonic state inhibits AVP secretion and increases urine output to restore osmotic pressure balance.
Blood volume regulation: reflex regulation of pressure receptors
Reduced blood volume (such as bleeding) stimulates AVP secretion through the following pathways:
Cardiopulmonary pressure receptors: The tension receptors in the left atrium and pulmonary veins detect a decrease in blood volume and transmit signals to the hypothalamus through the vagus nerve, promoting the release of AVP.
Arterial pressure receptors: Pressure receptors in the carotid sinus and aortic arch sense a decrease in blood pressure and activate AVP secretion through sympathetic nervous system.
Renin angiotensin system (RAAS): Decreased blood volume activates renin secretion, and angiotensin II directly stimulates hypothalamic AVP synthesis.
AVP induces vascular smooth muscle contraction through V1a receptors, increases blood pressure, reduces free water clearance, and restores blood volume.
Other regulatory factors: stress, pain, and drug effects
Stress response: Stress states such as pain, trauma, and emotional tension activate the hypothalamic pituitary adrenal axis (HPA axis), promote the coordinated release of AVP and corticotropin releasing hormone (CRH), and enhance cortisol secretion to cope with stress.
Drug action: Ethanol inhibits AVP secretion, leading to diuresis; Lithium salts, norepinephrine, and other substances indirectly affect the AVP effect by interfering with renal tubular function or receptor signal transduction.
Circadian rhythm: AVP secretion fluctuates between day and night, with higher levels at night, which may be related to the sleep wake cycle.
Pathological abnormalities and clinical significance: dual consequences of secretion disorders
Abnormal AVP secretion can lead to two main diseases: excessive secretion leads to water retention, and insufficient secretion leads to dehydration.
Arginine vasopressin secretion disorder syndrome (SIADH)
Due to tumors (such as small cell lung cancer), central nervous system damage (encephalitis, traumatic brain injury), or drug (carbamazepine) stimulation, there is an abnormal increase in AVP secretion, leading to:
Water retention: hemodilution, decreased blood sodium (<130 mmol/L), brain edema and convulsion in severe cases.
Elevated urine sodium: the kidney excretes more sodium to compensate for water retention, but cannot correct hyponatremia.
Treatment requires limiting water intake, using diuretics (such as tolvaptan) to block V2 receptors, or treating the underlying cause.
Diabetes insipidus
Central diabetes insipidus: Hypothalamic or pituitary lesions (tumors, trauma) lead to impaired AVP synthesis or release, manifested as polyuria (>5 L/d), restlessness, and low specific gravity urine. The main treatment is replacement with desmopressin (DDAVP).
Renal diabetes insipidus: Deficiency of renal V2 receptor or AQP2, insensitive to AVP, commonly seen in genetic diseases or drug (lithium salt) damage. Treatment requires a large amount of hydration and the use of thiazide diuretics to reduce urine output.
AVP abnormalities in cardiovascular diseases
The level of AVP in patients with heart failure increased significantly, and the perfusion pressure was maintained through vasoconstriction and water retention in the early stage, but the long-term high AVP state aggravated the pre and post load of the heart, forming a vicious circle. V1a receptor antagonists (such as Konivatan) can improve the prognosis of heart failure.
The biosynthesis and secretion regulation of arginine vasopressin is a model of precise collaboration in the neuroendocrine system, and its core mechanism achieves steady-state maintenance through osmotic pressure and blood volume feedback loops. Future research can further explore:
A deep understanding of the AVP regulatory network not only provides theoretical basis for water salt metabolism disorders and cardiovascular diseases, but also opens up new paths for developing treatment strategies for neuroendocrine diseases.
Frequently Asked Questions
Why do men need vasopressin to fall in love?
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Building Vasopressin Levels
Once a man makes a commitment, regardless of its nature, testosterone levels decrease, which then allows oxytocin to effectively connect with vasopressin. This connection is crucial for men to bond deeply with their partners, fostering emotional closeness and long-term attachment.
What are the symptoms of lack of arginine vasopressin?
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Common symptoms include frequent urination, intense thirst, nighttime urination, and dehydration. Diagnosis involves urine and blood tests, water deprivation testing, and an MRI of the pituitary region. Treatment includes desmopressin to replace vasopressin and monitoring fluid and electrolyte balance.
What does vasopressin do in love?
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Vasopressin is linked to behavior that produces long-term, monogamous relationships. The differences in behavior associated with the actions of the two hormones may explain why passionate love fades as attachment grows.
What foods are very high in arginine?
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L-arginine is an amino acid that helps the body build protein. Your body usually makes all the L-arginine it needs. L-arginine is also found in most protein-rich foods, including fish, red meat, poultry, soy, whole grains, beans and dairy products. As a supplement, L-arginine can be used orally and topically.
Why do diabetics pee a lot at night?
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When there's too much sugar in your blood, which happens if you have diabetes, your kidneys have to work harder to get rid of it. This forces them to make more urine. The process doesn't stop just because you're snoozing. Diabetes can also damage your kidneys or bladder.
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