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Buserelin Acetate Injection
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Buserelin Acetate Injection

Buserelin Acetate Injection

1.General Specification(in stock)
(1)Api
(2)Tablet/Pills
(3)Injection
2.Customization:
We will negotiate individually, OEM/ODM, No brand, for secience researching only.
Internal Code: BM-2-154
buserelin acetate CAS 68630-75-1
MDL No.: MFCD0171622
HS code: N/A
EINECS: 636-185-5
Manufacturer: BLOOM TECH Wuxi Factory
Analysis: HPLC, LC-MS, HNMR
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Technology support: R&D Dept.-4

Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of buserelin acetate injection in China. Welcome to wholesale bulk high quality buserelin acetate injection for sale here from our factory. Good service and reasonable price are available.

 

Buserelin acetate injection is a synthetic pergonal-releasing hormone (GnRH) analogue, whose mechanism of action mainly involves modulating sex hormonal levels by mimicking endogenous GnRH and stimulating the hypothalamic pituitary gonadal axis (HPG axis). In clinical uses, it is commonly used to treat various gynecological morbids through the regulation of hormonal levels, especially those morbids that are greatly affected by hormonal level regulation, such as endometriosis, ovarian dysfunction, uterine fibroids, etc.

 
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Buserelin injection | Shaanxi BLOOM Tech Co., Ltd
Buserelin injection
Buserelin tablet | Shaanxi BLOOM Tech Co., Ltd
buserelin tablet
Buserelin acetate | Shaanxi BLOOM Tech Co., Ltd
buserelin acetate injection

Buserelin acetate Price List | Shaanxi BLOOM Tech Co., Ltd

Buserelin acetate Price List | Shaanxi BLOOM Tech Co., Ltd

Method of Analysis

buserelin acetate  COA

Shaanxi BLOOM Tech Co., Ltd
Certificate of Analysis
Compound name Buserelin acetate
Grade Pharmaceutical grade
CAS No. 68630-75-1
Quantity 50g
Packaging standard PE bag+Al foil bag
Manufacturer Shaanxi BLOOM TECH Co., Ltd
Lot No. 202601090088
MFG Jan 9th 2026
EXP Jan 8th 2029
Structure

Buserelin Acetate structure | Shaanxi BLOOM Tech Co., Ltd

Item Enterprise standard Analysis result
Appearance White or almost white powder Conformed
Water content ≤5.0% 0.45%
Loss on drying ≤1.0% 0.38%
Heavy Metals Pb≤0.5ppm N.D.
As≤0.5ppm N.D.
Hg≤0.5ppm N.D.
Cd≤0.5ppm N.D.
Purity (HPLC) ≥99.0% 99.80%
Single impurity <0.8% 0.67%
Total microbial count ≤750cfu/g 420
E. Coli ≤2MPN/g N.D.
Salmonella N.D. N.D.
Ethanol (by GC) ≤5000ppm 500ppm
Storage Store in a sealed, dark, and dry place below -15°C

Buserelin Acetate NMR | Shaanxi BLOOM Tech Co., Ltd

Shaanxi BLOOM Tech Co., Ltd

Chemical Formula C62H90N16O15
Exact Mass 1299
Molecular Weight 1299
m/z 1299 (100.0%), 1300 (67.1%), 1301 (22.1%), 1240 (5.9%), 1241 (3.6%), 1242 (3.5%), 1241 (2.7%), 1242 (1.7%), 1242 (1.2%)
Elemental Analysis C, 57.31; H, 6.98; N, 17.25; O, 18.47

Applications-

The therapeutic effect of buserelin acetate injection is based on its long-term activation of GnRH receptors, which triggers desensitization of endogenous GnRH secretion, leading to a significant decrease in levels of pergonals (FSH and LH). In this way, the ovarian hormonals (such as estrogen and progesterone) in the body also decrease, playing a role in reducing the growth of hormonal dependent lesions (such as endomtriosis and uterine fibroids). In addition, Buserelin is also used in assisted reproductive technology to improve pregnancy success rates by regulating ovarian function.

use in endometriosis

Buserelin acetate endometriosis | Shaanxi BLOOM Tech Co., Ltd

1. Overview of Endometriosis

Endometriosis is one of the common morbids in the female reproductive system, which refers to the appearance of endometrial like tissue in other parts outside the uterine cavity (such as ovaries, fallopian tubes, pelvic peritoneum, etc.). Endomtriosis is usually accompanied by symptoms such as menstrual irregularities, pelvic pain, painful intercourse, and in severe cases, it may also lead to infertility. The occurrence of this morbid is closely related to the fluctuation of hormonal levels in the body,especially estrogen. Estrogen promotes the growth of endomtriosis tissue, leading to the expansion of lesions and worsening of symptoms.

2. Mechanism of action

By simulating the action of GnRH, stimulating the hypothalamic pituitary gonadal axis can initially promote the secretion of pergonals (LH and FSH). However, long-term use can lead to desensitization of GnRH receptors, gradually weakening the stimulation of the pituitary gland by the hypothalamus, thereby inhibiting the secretion of pergonals and significantly reducing the synthesis of ovarian hormonals (such as estrogen). The decrease in hormonal levels helps to reduce the growth of endomtriosis tissue and alleviate the resulting pain and other symptoms.

Buserelin acetate disease | Shaanxi BLOOM Tech Co., Ltd
Buserelin acetate uses | Shaanxi BLOOM Tech Co., Ltd

3. Clinical use and effectiveness

The main role in treating endomtriosis is to alleviate the sick's pain symptoms by suppressing estrogen levels in the body. Clinical studies have shown that treating endomtriosis can significantly alleviate symptoms such as pelvic pain, sexual pain, and menstrual pain in sicks. Especially in sicks with mild and moderate endomtriosis, the therapeutic effect is very significant.

In addition, it can also be used for preoperative cure, providing better conditions for surgical cure by reducing the size of lesions and minimizing the formation of visceral adhesions. For some sicks, surgical cure can even be avoided, especially in cases where the lesion is small or not suitable for surgery.

4. Side effects and safety

Although effective in treating endomtriosis, long-term use may cause some side effects such as hot flashes, decreased bone density, and decreased libido, which are often closely related to a decrease in estrogen levels in the body. To reduce these side effects, the cure cycle is usually controlled within 3 to 6 months and can be combined with other medications (such as bone protection drugs) to alleviate the risk of decreased bone density.

Buserelin Acetate effects | Shaanxi BLOOM Tech Co., Ltd

use in ovarian dysfunction

Buserelin acetate ovarian | Shaanxi BLOOM Tech Co., Ltd

1. Overview of ovarian dysfunction

Ovarian dysfunction refers to the inability of the ovaries to perform their physiological functions normally, resulting in irregular menstruation, ovulation dysfunction, infertility, and other symptoms. Common ovarian dysfunction morbids include polycystic ovary syndrome (PCOS), premature ovarian failure (POI), etc. The imbalance of hormonal levels is the main cause of ovarian dysfunction, especially high androgen levels and low estrogen levels.

2. Mechanism of action

Buserelin acetate injection reduces ovarian hormonal secretion by inhibiting the secretion of GnRH, which in turn suppresses the release of pergonals (FSH and LH). For sicks with polycystic ovary syndrome (PCOS), reducing testosterone levels in the body can regulate ovarian hormonal levels and help restore normal ovarian function. In sicks with premature ovarian failure (POI), precise regulation of ovarian function can slow down the rate of ovarian decline and provide a better hormonal environment for the normal development of follicles.

Buserelin acetate mechanism | Shaanxi BLOOM Tech Co., Ltd
Buserelin Acetate application | Shaanxi BLOOM Tech Co., Ltd

3. Clinical use and effectiveness

In the cure of polycystic ovary syndrome (PCOS), ovulation inducing drugs are often used in combination to help restore the sick's normal ovulation function. By reducing the level of androgens in the body and alleviating ovarian overreaction to androgens, it promotes follicle maturation and ovulation. Research has shown significant therapeutic effects on PCOS sicks, particularly in regulating menstrual cycles and promoting ovulation. For women with early-onset ovarian failure (POI), inhibiting excessive hormonal fluctuations can slow down the rate of ovarian decline and prolong ovarian function. In clinical practice, when applied in these sicks, it usually improves the menstrual cycle and helps restore some fertility.

4. Side effects and safety

When treating ovarian dysfunction, it may cause some side effects, such as hot flashes, decreased bone density, emotional fluctuations, etc. To reduce these side effects, it is usually necessary to use under the strict guidance of a doctor, and regularly check hormonal levels and bone density during cure to ensure the safety of the cure.

Buserelin Acetate safety | Shaanxi BLOOM Tech Co., Ltd

use in uterine fibroids

Buserelin Acetate fibroids | Shaanxi BLOOM Tech Co., Ltd

1. Overview of uterine fibroids

Uterine fibroids are common benign tumors in women, typically occurring in the smooth muscle tissue of the uterus. Uterine fibroids can cause symptoms such as irregular menstruation, anemia, frequent urination, and abdominal pressure, seriously affecting the quality of life of sicks. Research has shown that the growth of uterine fibroids is closely related to the level of estrogen in the body, especially in women of childbearing age, where estrogen is the main promoting factor for their growth.

2. Mechanism of action

By inhibiting the secretion of GnRH, the secretion of pergonals (FSH and LH) is reduced, resulting in a significant decrease in estrogen levels in the ovaries. Due to the promoting effect of estrogen on the growth of uterine fibroids, it can effectively slow down or stop the growth of fibroids, and even cause some fibroids to shrink. Long term use can significantly improve symptoms caused by uterine fibroids, such as excessive menstruation, abdominal pain, and compression symptoms.

Buserelin Acetate treatment | Shaanxi BLOOM Tech Co., Ltd
Buserelin Acetate disease | Shaanxi BLOOM Tech Co., Ltd

3. Clinical use and effectiveness

In the cure of uterine fibroids, it is often used as a drug therapy, especially in preoperative cure, by reducing the size of the fibroids and improving symptoms, providing better conditions for surgical cure. Research has shown that it can effectively reduce the volume of uterine fibroids, decrease menstrual flow, and alleviate symptoms such as abdominal compression and frequent urination caused by fibroids.

It can also be used for sicks who are unable to undergo surgical cure, especially for women who are not suitable for surgery or wish to avoid surgery. Through medication cure, psickts can achieve the effect of relieving symptoms and controlling their condition.

4. Side effects and safety

When treating uterine fibroids, it may cause some side effects, such as hot flashes, decreased libido, and decreased bone density. These side effects are usually associated with a decrease in estrogen levels in the body, therefore, regular monitoring of sicks' bone density and hormonal levels is necessary during the cure process to ensure the safety of the cure.

Buserelin Acetate libido | Shaanxi BLOOM Tech Co., Ltd

Buserelin acetate injection, as a GnRH agonist, has important uses value in gynecological morbids. By precisely regulating hormonal levels in the body, it has played a key role in the cure of morbids such as endomtriosis, ovarian dysfunction, and uterine fibroids. In the cure of endomtriosis and uterine fibroids, the growth of lesions can be slowed down by inhibiting estrogen levels; In the cure of ovarian dysfunction, ovarian hormonal levels are regulated to help restore ovarian function.

Reference

 

1. Lunenfeld, B., & Tarlatzis, B. C. (2015). GnRH Agonists and Antagonists in Assisted Reproduction. Human Reproduction Update, 21(3), 271-285.

2. Sánchez, M. J., & Rodríguez, F. (2012). GnRH Agonists in the Treatment of Endometriosis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 175, 99-106.

3. Lombardi, S., & Ziegler, D. (2008). Buserelin in the Management of Uterine Fibroids. Fertility and Sterility, 90(3), 690-695.

4. Hwang, K. J., & Choi, J. S. (2010). Pharmacological Aspects of Buserelin for Ovarian Dysfunction. Obstetrics & Gynecology, 117(4), 798-805.

5. Fauser, B. C., & Devroey, P. (2009). Clinical Aspects of Ovarian Stimulation in Assisted Reproductive Technology. Fertility and Sterility, 91(5), 1557-1567.

 

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