Buserelin Injection

Its primary use is in the application of assisted reproductive technology (ART), especially in in in vitro fertilization (IVF) and egg donation processes. The principle of its action is to simulate the activation of LHRH, which promotes changes in the levels of gonadotropins in the body, thereby achieving precise regulation of the ovaries.

1. Regulation of ovarian stimulationDuring IVF, it is usually used in combination with other follicle stimulating hormones (FSH or hMG) to inhibit the secretion of endogenous LHRH.

By inhibiting the stimulation of the pituitary gland by the hypothalamus, early release of gonadotropin (LH) can be avoided, thereby ensuring synchronous development of follicles. This control can optimize the maturation process of follicles, reduce the risk of early ovulation, and ensure the optimal timing for egg retrieval.

In clinical practice, it is commonly used for regulatory effects in long protocols and short protocols. In rectangular cases, it is usually used at the beginning of the ovulation induction cycle to suppress LHRH secretion in the body until the follicle is fully developed and ready for egg retrieval.

Short term plans use it to regulate the ovarian stimulation process, and usually a shorter period of drug application can reduce the side effects of the drug.

2. Protection of luteal function
During the ART process, it can also help maintain and protect luteal function through its regulatory effect on luteinizing hormone. Research has shown that by regulating the LHRH receptor, LH levels can be reduced, thereby avoiding premature LH peaks, reducing the risk of early luteal function decline, and ultimately improving the success rate of implantation after embryo transfer.

Through this mechanism, physiological support is provided for embryo transfer during the ART process, increasing the chances of embryo survival and development. Therefore, both long cycle and short cycle ART can play multiple roles in optimizing follicular development, promoting corpus luteum formation, and improving pregnancy success rates.

Endometriosis is a common gynecological disease characterized by the presence of endometrial like tissue in other areas outside the uterine cavity. As a LHRH agonist, it can effectively inhibit estrogen levels in the body and reduce hormone levels secreted by the ovaries by inhibiting the function of the hypothalamic pituitary gonadal axis, thereby treating endometriosis.

1. Relieve pathological pain

Buserelin injection reduces hormone levels in the body by long-term inhibition of estrogen synthesis, thereby alleviating pain caused by endometriosis.

Clinical studies have shown that it can effectively alleviate pain symptoms in patients during and outside the menstrual cycle, such as pelvic pain, sexual pain, and defecation pain. When used for a long time, patients' symptoms are significantly improved, which helps to improve their quality of life.

2. Treatment of functional infertility

Due to functional infertility often associated with endometriosis, reducing the size of ectopic endometrial tissue in the affected area can effectively improve women's fertility.

After hormone levels are suppressed, the growth of endometriosis is temporarily 'dormant', thereby reducing adhesions and lesions in the abdominal cavity, improving fallopian tube function, and increasing the chance of pregnancy. Some studies have shown that post-remedy patients have significantly improved pregnancy and live birth rates during subsequent ART remedy.

Although its application focuses on reproductive medicine, its application in male reproductive system diseases is also of great significance. By reducing testosterone levels, hormone dependent diseases such as prostate cancer can be effectively treated. It inhibits the LHRH signal, reduces the synthesis of gonadotropins in the testes, thereby reducing the secretion of testosterone and inhibiting the growth of cancer cells.

1. Inhibit the growth of prostate cancer cells

The occurrence of prostate cancer is closely related to the stimulation of androgens. As a LHRH agonist, it can reduce the level of testosterone in the body, thereby inhibiting the growth of prostate cancer cells. Research has shown that it can be used in combination with other androgen antagonists to improve remedy efficacy, especially for patients with advanced prostate cancer. The combination therapy with anti androgen therapy has significant clinical effects and can significantly improve the survival and quality of life of patients.

2. Improve clinical symptoms

In the remedy of prostate cancer, its application is not only to inhibit the proliferation of cancer cells by reducing hormone levels, but also to alleviate clinical symptoms caused by changes in androgen levels. For example, prostate cancer patients often have symptoms such as frequent urination and difficulty urinating. By regulating hormone levels, these discomfort symptoms can be alleviated and the overall health status of the patient can be improved.

Buserelin is also widely used in the remedy of other endocrine disorders, especially in the remedy of menstrual disorders caused by endocrine disorders, polycystic ovary syndrome (PCOS), and other issues. By regulating the levels of gonadotropins, it is possible to restore the patient's normal endocrine function, promote hormone balance, and help restore the regularity of the menstrual cycle.

Treatment for Polycystic Ovary Syndrome (PCOS)
The role in the remedy of PCOS is mainly reflected in inhibiting the excessive secretion of LHRH, reducing the synthesis of androgens in the ovaries, and improving the pathological state of polycystic ovary syndrome. During the remedy process, it can help restore ovulation function, improve irregular menstrual cycles in patients, and create favorable conditions for pregnancy. Especially when combined with other ovulation inducing drugs, the effect is more significant.