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Toltrazuril Injection is an efficient antigen parasite drug widely used in the field of animal medicine, mainly for the prevention and treatment of diseases caused by parasites such as coccidia. Belonging to triazine ketone compounds, it has broad-spectrum anti coccidial activity. Its unique mechanism of action achieves efficient killing of nematodes by interfering with cell nuclear division, mitochondrial function, and endoplasmic reticulum structure. The drug is metabolized stably in the body, and the long-acting metabolite TOLSO ₂ can sustainably exert its therapeutic effect for up to 72 hours, ensuring the therapeutic effect. Suitable for the prevention and control of various animal coccidiois, including but not limited to poultry: it has a strong inhibitory effect on various Eimeria species in poultry such as chickens and turkeys. Ruminant animals: used for the treatment of coccidial diarrhea in lambs, calves, and other animals. Pigs: Prevention and treatment of spore coccidiois in piglets. Companion animals: Treat canine and feline coccidiois, and also have a certain effect on the yolk sac stage of feline toxoplasmosis.
Our product
Additional information of chemical compound:
| Product Name | Toltrazuril Injection | Toltrazuril Powder |
| Product Type | Injection | Powder |
| Product Purity | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable |
| Product Package | Customizable | Customizable |
Our Product
Toltrazuril +. COA
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Certificate of Analysis |
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Compound name |
Toltrazuril | |
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CAS No. |
69004-03-1 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.5% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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Toltrazuril Injection, as a broad-spectrum triazine based anticoccidial drug, has a wide range of application value in the field of animal medicine. It achieves efficient killing of various protozoa by interfering with the nuclear division, mitochondrial function, and endoplasmic reticulum structure of nematodes.
Scope of indications
1. Poultry coccidiois
Core indications:
Chicken coccidiois: It has a strong inhibitory effect on various types of Eimeria, including E. acervulina, E. brunetti, E. maxima, E. necrotrix, and E. tenella.
Turkey coccidiois: targeting turkey gland Eimeria, turkey Eimeria, and turkey small Eimeria.
Other poultry: Infection with Eimeria goose and Eimeria truncata.
Clinical effect:
Experimental data shows that after medication, the mortality rate of cecal coccidiois is significantly reduced, and the amount of egg sacs excreted is reduced by more than 90%.
Recommended solution: Mixed administration, adding 25mg of Tocilizumab per liter of water (equivalent to 200L of 100ml injection mixed with water), for 2 consecutive days, can effectively control explosive coccidiois.
2. Ruminant coccidiosis
Lamb coccidiois diarrhea:
During the high incidence period in spring, lambs aged 7-30 days are susceptible, manifested as bloody stools, dehydration, and growth arrest.
Treatment plan: Subcutaneous injection of 7.5mg/kg body weight, repeated once every 7 days, with a cure rate of over 85%.
Calf Cryptosporidiosis:
Combined use with sulfonamide drugs can shorten the course of illness and reduce the duration of diarrhea.
Caution: Pregnant cows should not be used to avoid affecting the fetus through the placenta.
3. Porcine coccidiosis
Spore coccidiois in piglets:
Pigs aged 7-14 days have a high incidence of yellow diarrhea, dehydration, and weight loss.
Prevention plan: Adding 50mg/kg Tocilizumab to the feed of sows from 3 days before delivery to 7 days after delivery can reduce the infection rate of piglets by 70%.
Treatment plan: Oral solution 20mg/kg body weight, once a day, for 3 consecutive days.
4. Parasitic diseases in companion animals
Canine and cat coccidiois:
3-6 month old young pets are susceptible, manifested as mucous bloody stools, dehydration, and malnutrition.
Treatment plan:
Dogs: 10-20mg/kg body weight orally, single dose for 3-4 week old puppies can prevent it.
Cats: Take 15mg/kg body weight orally once a day for 3-6 consecutive days.
Special indication: In the stage of feline toxoplasmosis, 5-10mg/kg body weight orally for 2 consecutive days.
Parasitic diseases of pets:
Lizards (such as the maned lion lizard): 5-15mg/kg body weight orally for 3 consecutive days to treat coccidiois infection.
Raptors: Take 7mg/kg body weight orally for 2-3 days to control coccidiois.
Latest research progress (2025)
1. Expansion of anti Toxoplasma mechanism
Dual action mode:
Direct destruction: Transmission electron microscopy shows the disintegration of the insect membrane structure.
Metabolic blockade: dTMP levels decreased by 67% and dUMP accumulation increased by 2.3 times.
Animal protection effect:
Mouse acute infection model: 100% survival rate.
The rate of brain cyst formation decreased by 92%.
2. Development of new formulations
Nanocrystal technology:
The particle size is controlled between 100-200nm, and the bioavailability is increased to 68%.
The sustained release effect is extended to 96 hours.
Transdermal drug delivery system:
Microneedle array patch: The peak time of blood drug concentration is shortened to 0.5 hours.
Skin retention increased by 40%.
1. Interference with pyrimidine metabolism network
The research conducted by the Chinese Academy of Agricultural Sciences team in Pesticide Biochemistry and Physiology reveals that Toltrazuril Injection inhibits the proliferation of Toxoplasma gondii through a dual mechanism:
(1) Directly inhibit key enzyme activity:
Inhibition of dUTP enzyme (deoxyuridine triphosphate) expression by 5.8 times leads to accumulation of dUTP (deoxyuridine triphosphate) and triggers DNA strand breaks
Inhibit TMK (thymidine kinase) expression by 3.2-fold, block dTMP (deoxythymidine monophosphate) synthesis, and reduce DNA replication materials by 67%
(2) Metabolite synergy:
The metabolite TOLSO ₂ maintains an effective concentration in the body for 72 hours, continuously inhibiting the pyrimidine salvage synthesis pathway
Metabolomics analysis showed a 2.3-fold increase in dUMP (deoxyuridine monophosphate) levels, further disrupting nucleotide balance
2. Destruction of organelle structure and function
Mitochondrial damage:
Inhibit respiratory chain complex II (succinate dehydrogenase), block ATP synthesis, and cause energy metabolism breakdown in the insect body
Transmission electron microscopy observation shows mitochondrial cristae rupture and a decrease in matrix electron density
Endoplasmic reticulum stress:
Induce swelling of the endoplasmic reticulum to 3-5 times its normal diameter, forming vacuolated structures
Activate unfolded protein response (UPR), triggering programmed cell death of the parasite
4. Cellular level effects
Nuclear fission inhibition: By interfering with microtubule protein polymerization, it blocks the nuclear fission of fission bodies and small gametophytes, causing the parasite to stagnate in the G2/M phase.
Mitochondrial damage: Inhibits respiratory chain complex II (succinate dehydrogenase), leading to interruption of ATP synthesis and collapse of energy metabolism in the parasite.
Endoplasmic reticulum stress: induces swelling of the endoplasmic reticulum to 3-5 times its normal diameter, forming vacuolized structures, activating unfolded protein response (UPR), and triggering programmed cell death of the parasite.
3. Interference with cell division cycle
Nuclear fission block:
Inhibit the nuclear division of schizonts and small gametophytes, causing the parasite to stagnate in the G2/M phase
Immunofluorescence staining showed that microtubule protein polymerization was blocked, and the spindle could not form
Inhibition of cell wall synthesis:
Blocking the secretion of small gametophyte wall forming bodies results in the inability of spores to obtain protective envelopes
1. Intervention in asexual reproduction cycle
Developmental stage mechanism and effect indicators
During the reproductive period of schizonts, inhibition of nuclear fission in the schizonts leads to an 82% reduction in the number of schizonts
Blocking the formation of small gametophyte walls during gamete reproductive period reduces the survival rate of gametophytes by 95%
Sporization stage interferes with spore membrane structure, resulting in a 76% decrease in spore formation rate
2. Regulation of Host Parasite Interaction
Immune escape blockade:
Inhibit surface antigen variation of coccidiois and enhance host T cell recognition
The experiment showed that the titer of IgG antibodies in infected chicken flocks increased by 3.2 times
Inhibition of organizational invasion:
Reduce the invasion rate of intestinal mucosal epithelial cells by 91% (in vitro experiment)
Reduce liver cell parasite load by 87% (mouse model)
Pharmacokinetics and Time of Action
1. Characteristics of internal processes
Absorption distribution:
The oral bioavailability of poultry is 52%, while intramuscular injection reaches 89%
Organizational distribution concentration: Liver (12.3 μ g/g)>Kidney (8.7 μ g/g)>Intestine (6.2 μ g/g)>Muscle (1.5 μ g/g)
Metabolic conversion:
Main metabolic pathway: hepatic CYP450 enzyme hydroxylation
Active metabolite: TOLSO ₂ (anti coccidiois activity is 1.8 times that of the original drug)
2. Persistent effect mechanism
Long term effect foundation:
The half-life of metabolite TOLSO ₂ is 72 hours, which is 6 times that of the original drug
Intestinal hepatic circulation prolongs drug action time, while maintaining 30% activity in fecal excreta
Residual risk:
24 days after discontinuation of medication, residual amount in chest muscle: 0.12 μ g/g (EU MRL standard is 0.01 μ g/g)
Suggest extending the rest period for broiler chickens to 19 days
Drug resistance prevention and control mechanism
1. Current status and trends of drug resistance
Global resistance rate:
2020: 12% -18%
By 2025, it will increase to 28% -35% (due to cross resistance to Dexmedetomidine)
Drug resistance mutation site:
Y268S mutation in cytb gene leads to a 40% decrease in drug binding affinity
Overexpression of P-gp increases drug efflux threefold
2. Implementation of prevention and control strategies
Rotating medication plan:
Sequence 1: Toltrazuril (4 weeks) → Dexmedetomidine (4 weeks) → Nikarbazine (4 weeks)
Sequence 2: Toltrazuril (3 weeks) → Maduramycin (3 weeks) → Changshan Ketone (3 weeks)
Shuttle medication mode:
Pre growth stage (1-21 days old): Toltrazuril Injection
Late stage of growth (22-42 days old): Monensin
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