Selamectin Topical Solution

Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of selamectin topical solution in China. Welcome to wholesale bulk high quality selamectin topical solution for sale here from our factory. Good service and reasonable price are available.

Selamectin topical solution, developed by Pfizer Animal Health (now part of Zoetis), addressed this gap by offering a single, easy-to-administer topical solution with broad-spectrum activity. Approved by the U.S. Food and Drug Administration (FDA) in 1999 for use in dogs and cats, it quickly became a staple in veterinary practice due to its efficacy, safety, and convenience. Unlike oral antiparasitics, which may be refused by pets, or injectables, which require veterinary administration, selamectin's topical formulation allows pet owners to apply it at home, improving treatment adherence.

Parasitic infestations pose significant threats to the health and well-being of companion animals. Ectoparasites such as fleas (Ctenocephalides felis) and ticks (e.g., Ixodes scapularis) not only cause discomfort through itching and skin irritation but also transmit diseases like Lyme disease and flea-borne typhus. Endoparasites, particularly heartworms (Dirofilaria immitis), can lead to life-threatening cardiovascular damage in dogs and cats. Traditional antiparasitic treatments often required multiple products to target different parasite types, increasing the risk of non-compliance and drug interactions.​

 

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Selamectin Spray

 

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Selamectin Topical Solution

Additional information of chemical compound:

Selamectin COA

Certificate of Analysis
Compound name	Selamectin
CAS No.	220119-17-5
Grade	Pharmaceutical grade
Quantity	Customized
Packaging standard	Customized
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202601090056
MFG	Jan 12th 2026
EXP	Jan 8th 2029
Structure
TEST STANDARD	GB/T24768-2009 Industry. Stnndard
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤4.5%	0.30%
Loss on drying	≤1.0%	0.15%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.5%
Single impurity	<0.8%	0.48%
Residue on ignition	<0.20%	0.064%
Total microbial count	≤750cfu/g	80
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	400ppm
Storage	Store in a sealed, dark and dry place; Sealed in dry,Room Temperature

Approved Uses in Companion Animals​

Selamectin topical solution is approved for use in dogs and cats of various ages and weights, with specific indications varying slightly between species. Below is a detailed breakdown of its approved uses, based on FDA and European Medicines Agency (EMA) labeling.​

 

 

Use in Dogs​

In dogs, selamectin is indicated for the prevention and treatment of the following parasitic infestations:​

Flea Control: Selamectin kills adult fleas (Ctenocephalides felis) within 36 hours of application and prevents flea eggs from hatching for up to 30 days. This breaks the flea life cycle, reducing infestations in both the pet and the home environment. It is also effective against flea larvae in the environment, as the drug is transferred from the dog's skin to bedding and carpets.​

Tick Control: It is approved for the treatment and prevention of infestations by several tick species, including Ixodes scapularis (deer tick, vector of Lyme disease), Dermacentor variabilis (American dog tick, vector of Rocky Mountain spotted fever), and Rhipicephalus sanguineus (brown dog tick, vector of Ehrlichiosis). Selamectin kills ticks within 48 hours of attachment, reducing the risk of disease transmission.​Heartworm Prevention: Administered monthly, selamectin kills the third-stage larvae (L3) of Dirofilaria immitis, which are transmitted to dogs via mosquito bites. By eliminating L3 larvae before they mature into adult worms, it prevents heartworm disease-a condition that can cause heart failure, lung damage, and death.​

Intestinal Parasite Control: Selamectin topical solution treats and controls infections by two common intestinal roundworms: Toxocara canis and Toxascaris leonina. These parasites can cause diarrhea, weight loss, and malnutrition in puppies, and can also be transmitted to humans (zoonotic risk).​Mite Infestations: It is effective against sarcoptic mange (caused by Sarcoptes scabiei var. canis), a highly contagious skin disease that causes intense itching, hair loss, and crusting. Selamectin also treats demodicosis (caused by Demodex canis) in dogs, although severe cases may require additional therapy.​The approved age for dogs is 6 weeks and older, with no upper age limit. Dosage is based on body weight, with formulations available for dogs weighing 3 lbs (1.36 kg) and above.​

Use in Cats​

In cats, selamectin has similar indications, with some species-specific differences:​

Flea Control: Like in dogs, selamectin kills adult fleas (Ctenocephalides felis) within 36 hours and prevents egg hatching for 30 days. It is particularly useful in cats, which are often more sensitive to flea bites and may develop flea allergy dermatitis (FAD)-a severe inflammatory skin condition triggered by flea saliva.​

Tick Control: It is approved for the prevention and treatment of infestations by Ixodes scapularis, Dermacentor variabilis, and Rhipicephalus sanguineus in cats. While ticks are less common in cats than in dogs, they still pose a risk of disease transmission.​

Heartworm Prevention: Monthly administration kills L3 heartworm larvae, preventing heartworm disease in cats. Unlike dogs, cats are not natural hosts for heartworms, and most infected cats do not develop adult worms. However, even larval migration can cause lung damage (heartworm-associated respiratory disease, HARD), making prevention critical.​

Intestinal Parasite Control: Selamectin treats infections by Toxocara cati (the most common intestinal roundworm in cats) and Ancylostoma tubaeforme (hookworm). Both parasites are zoonotic, with Toxocara cati posing a risk of visceral larva migrans in humans, especially children.​

Mite Infestations: It is effective against Otodectes cynotis (ear mites), a common cause of ear inflammation and itching in cats. Selamectin is applied topically to the skin, but it distributes to the ear canal, killing mites within 7 days. It also treats Notoedres cati (feline scabies), a rare but highly contagious mite infestation that causes crusting lesions on the face and ears.​

Cats as young as 6 weeks old can use selamectin, with formulations available for cats weighing 2 lbs (0.91 kg) and above.

Proper application of selamectin topical solution is essential to ensure its efficacy and minimize the risk of adverse effects. Below are step-by-step guidelines for pet owners, based on manufacturer recommendations.​

Overdosing on selamectin is rare, as the drug has a wide therapeutic index (the ratio of the toxic dose to the therapeutic dose). However, it can occur if a pet is given a dosage intended for a larger animal or if multiple applications are administered within a short period. Signs of overdose include severe neurological effects (e.g., seizures, coma), severe vomiting, or diarrhea.​If an overdose is suspected, pet owners should contact their veterinarian or an animal poison control center immediately. Treatment typically involves supportive care, such as fluid therapy to maintain hydration, antiemetics to control vomiting, and anticonvulsants if seizures occur. Most pets recover fully with prompt treatment.

Oral macrocyclic lactones (e.g., ivermectin, milbemycin oxime) are widely used for heartworm prevention and intestinal parasite control. However, they have several limitations compared to selamectin:​

• Spectrum of Activity: Oral macrocyclic lactones are primarily effective against endoparasites (heartworms, intestinal roundworms) and have limited activity against ectoparasites. Selamectin, by contrast, targets both ectoparasites and endoparasites, eliminating the need for multiple products.​

• Safety in Sensitive Breeds: As mentioned earlier, ivermectin is toxic to collie-type dogs with the ABCB1 mutation. Selamectin is safe for these breeds, making it a better choice for pet owners with sensitive breeds.​
• Adherence: Oral medications may be refused by pets, especially those with food aversions. Selamectin's topical formulation is easier to administer, improving compliance.​

However, oral macrocyclic lactones have one advantage: they are not affected by bathing or swimming, as they are absorbed systemically. Selamectin, while water-resistant, may have reduced efficacy if the pet is bathed too soon after application.​

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