Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of ergothioneine tablet in China. Welcome to wholesale bulk high quality ergothioneine tablet for sale here from our factory. Good service and reasonable price are available.
Ergothioneine tablets are premium dietary supplements focused on long-lasting cellular-level maintenance. Their core active ingredient, ergothioneine, is a rare natural amino acid derivative that the human body cannot synthesize on its own. Unlike ordinary antioxidant supplements, ergothioneine features a human-specific targeted delivery mechanism mediated by the OCTN1 transporter protein, which enables it to accumulate precisely in vulnerable cells of the skin, nervous system, internal organs and other tissues, delivering targeted effects with an extended retention duration inside cells.Distinct from short-acting topical anti-aging skincare products, the tablets deliver full-body rejuvenation from within. They ameliorate skin photoaging, dullness, fine lines, sallow complexion and sagging; meanwhile, they relieve physical fatigue caused by chronic stress and staying up late, and restore the homeostasis of nervous and immune systems.
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Ergothioneine COA
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| Certificate of Analysis | ||
| Compound name | Ergothioneine | |
| Grade | Pharmaceutical grade | |
| CAS No. | 497-30-3 | |
| Quantity | 44g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090088 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.32% |
| Loss on drying | ≤1.0% | 0.17% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.80% |
| Single impurity | <0.8% | 0.41% |
| Total microbial count | ≤750cfu/g | 500 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 750ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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| Chemical Formula | C9H15N3O2S |
| Exact Mass | 229.09 |
| Molecular Weight | 229.30 |
| m/z | 229.09 (100.0%), 230.09 (9.7%), 231.08 (4.5%), 230.09 (1.1%) |
| Elemental Analysis | C, 47.14; H, 6.59; N, 18.33; O, 13.95; S, 13.98 |
What is the role of ERGO in the body
Potent Antioxidant Activity
Neutralizes Reactive Oxygen Species (ROS): ERGO scavenges free radicals like hydroxyl radicals (·OH), peroxynitrite (ONOO⁻), and singlet oxygen (¹O₂), which are implicated in cellular damage, aging, and chronic diseases.
Stability Under Oxidative Conditions: Unlike vitamin C or glutathione, ERGO remains stable in biological systems, enabling prolonged antioxidant protection.
Metal Chelation: ERGO binds to transition metals (e.g., iron, copper) that catalyze ROS production, reducing oxidative stress indirectly.
Anti-Inflammatory Effects
Inhibits Pro-Inflammatory Cytokines: ERGO suppresses the production of inflammatory markers like TNF-α, IL-6, and NF-κB, which are elevated in conditions such as arthritis, cardiovascular disease, and neurodegenerative disorders.
Modulates Immune Response: By reducing oxidative stress in immune cells (e.g., macrophages, T-cells), ERGO helps maintain immune homeostasis and prevents chronic inflammation.
Neuroprotective Properties
Crosses the Blood-Brain Barrier (BBB): ERGO's accumulation in the brain protects neurons from oxidative damage, a key factor in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's.
Supports Mitochondrial Function: ERGO preserves mitochondrial integrity in neurons, enhancing energy production and reducing apoptosis (cell death).
Promotes Autophagy: ERGO may stimulate autophagy, a cellular cleanup process that removes misfolded proteins and damaged organelles, which are hallmarks of neurodegeneration.
Core Physiological Functions
Targeted Antioxidation and Oxidative Stress Regulation
Ergothioneine (EGT) is a rare natural amino acid. As an oral dietary supplement tablet, ergothioneine tablets feature core advantages over conventional antioxidants thanks to their unique molecular structure and human-specific transporters. The human body expresses OCTN1, a high-affinity specific transporter protein that actively accumulates circulating ergothioneine in cells and tissues subject to the severest oxidative stress, enabling targeted antioxidation-unlike passive diffusion of ordinary antioxidant substances.
This ingredient efficiently neutralizes multiple potent oxidizing toxicants in the body including hydroxyl radicals, singlet oxygen, and peroxynitrite. It also chelates transition metal ions such as iron and copper to block chain oxidative damage triggered by the Fenton reaction, mitigating cellular oxidative deterioration at the source.Compared with conventional antioxidants like vitamin C and anthocyanins, ergothioneine boasts superior chemical stability, with an in-vivo retention period exceeding 72 hours. It generates no redox rebound effects, sustainably maintains intracellular redox balance, and effectively alleviates systemic oxidative stress induced by prolonged late nights, environmental pollution, ultraviolet radiation, and high-pressure work.
Mitochondrial Protection and Cellular Anti-Aging
Mitochondria serve as the hub of cellular energy metabolism and the primary source of oxidative free radicals. Impaired mitochondrial function constitutes a core driver of cellular senescence and physical deterioration.Transported into cells via OCTN1, ergothioneine precisely targets mitochondrial structures, stabilizes mitochondrial membrane potential, reduces mitochondrial DNA damage, and inhibits activation of mitochondrial apoptotic pathways. Long-term supplementation with the tablets effectively slows telomere shortening in somatic cells, delays cellular senescence, and mitigates chronic age-related bodily wear and tear.
Meanwhile, it repairs impaired cellular metabolic functions, boosts cellular energy synthesis, and relieves sub-health conditions such as persistent fatigue and sluggish metabolism, delivering cellular-level support for long-term anti-aging.
Relevant studies have confirmed that ergothioneine is one of the very few natural protective compounds capable of stable accumulation in human mitochondria, and is recognized by academia as a core component of the "longevity vitamin".
Immune Modulation and Organ Protection
It exert mild yet potent immune-regulating effects.
By shielding immune cells from oxidative damage, they preserve normal activity of lymphocytes and macrophages, strengthen innate and adaptive immunity, boost the body's resistance to external pathogens, and lower the incidence of seasonal colds and recurrent inflammation.For organ protection, this compound delivers targeted protection to vital organs including the liver, kidneys, and cardiovascular system.
For the liver: It eliminates hepatic oxidative free radicals, alleviates liver injury caused by pharmaceuticals, alcohol and metabolic toxins, and helps sustain normal hepatocyte metabolism.
For the cardiovascular system: It inhibits oxidative senescence of vascular endothelial cells, reduces lipid peroxidation deposition, and preserves vascular elasticity and patency.
For the kidneys: It eases oxidative metabolic burden, safeguards renal tubular cells, and cuts risks of chronic metabolic damage.
Additionally, it suppresses the release of systemic chronic inflammatory factors, relieves low-grade chronic inflammation, and ameliorates various physical discomforts stemming from metabolic disorders.
Practical Application Scenarios Across Multiple Fields
Daily Wellness and Sub-Health Conditioning
Within modern wellness practices, ergothioneine tablets stand as core dietary supplements tailored to sub-health conditions prevalent among contemporary populations. Office workers today commonly face prolonged sedentary lifestyles, chronic sleep deprivation, sustained mental stress and irregular diets, leading to widespread issues including excessive oxidative stress, metabolic disorders, compromised immunity and listlessness.Daily standardized supplementation with it permanently clears accumulated oxidative toxins, regulates bodily metabolism, and alleviates sub-health symptoms such as persistent fatigue, poor sleep quality, memory loss and dull complexions.
Featuring mild, non-irritating properties suitable for long-term oral conditioning, it differs from short-acting wellness products.Through cumulative long-term effects, it gradually repairs chronic bodily damage and restores physiological homeostasis, catering to young and middle-aged adults' wellness demands for daily anti-aging, fatigue relief and physical fitness improvement.
Industry clinical data indicates that a daily intake of 25 mg or higher pure ergothioneine significantly optimizes human cellular metabolism and ameliorates sub-health states.
Skin Anti-Aging and Internal Oral Skin Brightening Care
It represent core oral skincare products that deliver holistic inner-to-outer skin maintenance, distinct from surface-only repair via topical skincare products. Ultraviolet radiation triggers massive free radical generation in skin, resulting in melanin deposition, collagen loss, sagging and fine lines. Ergothioneine penetrates the basal layer of skin cells to eliminate internal oxidative free radicals, suppress hyperactivity of melanocytes, reduce pigment deposition, brighten skin tone and fade sallow dullness.
Furthermore, it protects dermal fibroblasts, promotes synthesis of collagen and elastic fibers, slows cutaneous aging, diminishes dry fine lines, and enhances skin firmness and translucency. For sensitive skin populations, it repairs skin barrier cells, mitigates redness, sensitivity and inflammation triggered by external irritants, and reduces photodamage to the skin.
Oral ergothioneine care has now become a mainstream dual internal-external anti-aging solution in the skincare industry, meeting anti-aging skincare demands across all age groups.
Adjuvant Intervention for Chronic Diseases and Elderly Wellness
For middle-aged and elderly populations, it serve as supplementary conditioning products for chronic disease management and geriatric wellness. Aging leads to diminished activity of the human OCTN1 transporter protein, insufficient endogenous ergothioneine synthesis, and continuous accumulation of oxidative damage, which readily induces age-related ailments including vascular aging, metabolic syndrome and weakened immunity.Long-term oral intake of the tablets compensates for endogenous synthesis deficits, persistently protects cardiovascular endothelial cells, lowers risks of arteriosclerosis and lipid deposition, and assists in stabilizing lipid and blood glucose metabolism.
It also slows oxidative senescence of cranial nerve cells, preserves neuronal activity, mitigates age-related memory decline and slow reaction speeds, and reduces risks of neurodegenerative disorders.
Moreover, by inhibiting systemic chronic inflammation, it alleviates mild osteoarticular inflammation and metabolic fatigue in seniors, comprehensively improving their quality of life. Derived from natural, safe ingredients, the tablets are suitable for long-term geriatric wellness administration.
Physical Function Repair for Athletic Populations
Intense physical training generates abundant reactive oxygen free radicals in athletes, which easily trigger muscular oxidative damage, post-workout soreness and slow physical recovery. Ergothioneine tablets rapidly eliminate excess free radicals post-exercise, alleviate oxidative stress injury to muscle cells, accelerate muscle repair, relieve lactic acid buildup and muscular soreness, and shorten recovery cycles.
Meanwhile, it safeguards mitochondrial function during exercise, boosts cellular energy metabolic efficiency, enhances athletic endurance, and reduces physical fatigue and functional loss caused by overtraining. It addresses the physical recovery and performance maintenance needs of fitness enthusiasts and professional athletes.
Artificial Chemical Synthesis
Core Technological Workflow of Chemical Synthesis
Artificial chemical synthesis addresses production capacity shortfalls of biosynthetic extraction. It utilizes basic amino acids such as cysteine and histidine as core substrates to synthesize ergothioneine monomers via multi-step organic catalytic reactions.
The core workflow proceeds as follows: First, functional group protection reactions lock active substrate moieties; sequential catalytic reactions including methylation, cyclization, desulfurization and hydrolysis construct ergothioneine's characteristic imidazole thioether molecular structure. Final chromatographic purification, recrystallization and drying yield high-purity ergothioneine powder.
All reaction parameters are artificially controllable throughout synthesis. This method features short production cycles, high output efficiency, low raw material costs, and independence from natural cultivation constraints, enabling large-scale mass production to meet supply demands for affordable mass-market formulations and industrial raw materials.
Properties and Application Boundaries of Chemically Synthesized Products
Chemically synthesized ergothioneine achieves purity exceeding 98%, with stable output and outstanding cost performance, yet bears notable drawbacks relative to biosynthetic products. Chemical synthesis tends to generate minor isomers and reaction impurities, resulting in slightly lower molecular activity and bioavailability than natural biosynthetic L-ergothioneine.
Trace catalytic reagents may remain in low-grade chemically synthesized products, mandating rigorous purification and testing prior to deployment in food and pharmaceutical applications.
At present, chemically synthesized ergothioneine is predominantly used as raw material for skincare products and general daily chemical additives. Deeply purified high-purity chemically synthesized ergothioneine can be legally applied to manufacture affordable the tablets, serving as a vital mass-production supplement in the current market.
Microbial Fermentation Synthesis
Microbial fermentation synthesis represents an innovative, high-efficiency green synthesis technology that combines the safety of biosynthesis with the high yield of chemical synthesis, emerging as a key R&D and promoted manufacturing process across the industry.
This technology screens high-yield engineered strains including ergothioneine-overproducing yeast and molds, optimizes fermentation medium formulas and culture conditions, and employs microbial metabolic engineering pathways to direct ergothioneine synthesis.
Strain modification via artificial mutagenesis and genetic engineering drastically elevates microbial ergothioneine synthesis efficiency and accumulation concentration. Post-fermentation procedures such as centrifugation, extraction, purification and drying produce finished raw materials.
Boasting green safety, high productivity, efficiency and controllable costs, this process yields natural active L-ergothioneine free of impurity residues, positioning it as the mainstream synthesis route for ergothioneine tablet raw materials in the future.
Frequently Asked Questions
Is ergothioneine better than NMN?
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Numerous experiments have shown that ergothioneine not only has similar functions to NMN, such as promoting energy metabolism and improving body functions, but also performs better and is safer in terms of anti-aging and anti-oxidation.
Is ergothioneine safe for skin?
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Ergothioneine has been found to play a significant role in the remodelling of the skin barrier function helping to keep skin hydrated and helping to prevent dehydration. Ergothioneine is known to inhibit the collagen destructing enzyme MMP-1.
Does ergothioneine help with aging?
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Background Ergothioneine (ergothioneine) is a naturally occurring antioxidant with emerging evidence supporting its role in cellular protection and anti-aging. However, clinical data on its cosmetic benefits remain limited.
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