Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of ergothioneine powder in China. Welcome to wholesale bulk high quality ergothioneine powder for sale here from our factory. Good service and reasonable price are available.
Ergothioneine powder is a sulfur - containing, water - soluble compound with the chemical formula C₉H₁₅N₃O₂S. It has a unique structure consisting of a histidine - derived imidazole ring fused to a thiazolidine ring, with a sulfur atom in the thione form (C = S). This structure gives ergothioneine (Thiasine) its characteristic chemical properties, including its stability under a wide range of pH and temperature conditions.
One of the most notable features of thiasine is its high redox potential, which makes it an effective antioxidant. It can exist in two tautomeric forms: the thione form (the more stable form under physiological conditions) and the thiol form. The thione form can readily react with reactive oxygen species (ROS) and reactive nitrogen species (RNS), neutralizing them and preventing oxidative damage to cells and tissues.
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Products Information
| Product Name | Ergothioneine Powder | Ergothioneine Tablet | |
| Product Type | Powder | Tablet | |
| Product Purity | >95% (HPLC) | >95% | |
| Product Specifications | 1g; 10g; 100g; 1kg | Customizable | |
| Product Form | Organic synthesis | Customizable | |
Ergothioneine COA
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| Certificate of Analysis | ||
| Compound name | Ergothioneine | |
| Grade | Pharmaceutical grade | |
| CAS No. | 497-30-3 | |
| Quantity | Customized | |
| Packaging standard | Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White to off-white | Conformed |
| Water content | ≤5.0% | 0.16% |
| Loss on drying | ≤1.0% | 0.23% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | >95% | 99.66% |
| Single impurity | <0.8% | 0.15% |
| Total microbial count | ≤750cfu/g | 30 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 200ppm |
| Storage | -80°C, 2 years; -20°C, 1 year (Sealed storage, away from moisture) | |
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| Shaanxi Chuzhan is a technology enterprise specializing in the research and development, production of chemicals and equipment customization services, providing OEM/ODM full-chain solutions. We offer flexible full-process customized services, from formula research and development to equipment selection, all can be deeply adapted according to customer requirements. Support full-cycle technical collaboration from small-scale trials, medium-scale trials to large-scale production, equipped with a professional engineering team to provide process optimization suggestions, and can customize packaging labels according to the brand requirements of customers. | ||
| Chemical Formula | C9H15N3O2S |
| Exact Mass | 229.09 |
| Molecular Weight | 229.30 |
| m/z | 229.09 (100.0%), 230.09 (9.7%), 231.08 (4.5%), 230.09 (1.1%) |
| Elemental Analysis | C, 47.14; H, 6.59; N, 18.33; O, 13.95; S, 13.98 |
Biological Functions
Antioxidant Activity
The most well - known biological function of ergothioneine powder is its antioxidant activity. As mentioned earlier, thiasine can react with ROS and RNS, such as hydroxyl radicals, superoxide anions, peroxynitrite, and singlet oxygen, to neutralize them and prevent oxidative damage to lipids, proteins, and DNA. Unlike some other antioxidants, thiasine is relatively stable after donating an electron or hydrogen atom, allowing it to participate in multiple antioxidant cycles.
Ergothioneine also has the ability to chelate metal ions, such as iron and copper, which can catalyze the generation of ROS through Fenton - type reactions. By binding to these metal ions, thiasine helps to reduce the formation of free radicals and protect cells from oxidative stress.
Anti - Inflammatory Effects
In addition to its antioxidant activity, thiasine has been shown to have anti - inflammatory effects. Oxidative stress and inflammation are closely linked processes, and by reducing oxidative stress, thiasine can indirectly modulate the inflammatory response.
Studies have demonstrated that thiasine can inhibit the production of pro - inflammatory cytokines, such as tumor necrosis factor - alpha (TNF - α), interleukin - 6 (IL - 6), and interleukin - 1 beta (IL - 1β), in various cell types and animal models.Ergothioneine may also interact with signaling pathways involved in inflammation, such as the nuclear factor - kappa B (NF - κB) pathway, which plays a central role in the regulation of inflammatory gene expression. By inhibiting NF - κB activation, thiasine can suppress the production of inflammatory mediators and reduce tissue inflammation.
Neuroprotective Effects
The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption, high content of unsaturated fatty acids, and relatively low levels of antioxidant defenses. Ergothioneine's ability to cross the blood - brain barrier and its potent antioxidant and anti - inflammatory properties make it a promising neuroprotective agent.
Studies have shown that thiasine can protect neurons from oxidative damage induced by various toxins and stressors, such as amyloid - beta peptides, which are associated with Alzheimer's disease.
It may also promote neuronal survival and function by regulating neurotrophic factor expression and synaptic plasticity.
Cardiovascular Protective Effects
Oxidative stress and inflammation are key factors in the development of cardiovascular diseases, such as atherosclerosis, hypertension, and heart failure. Ergothioneine's antioxidant and anti - inflammatory properties suggest that it may have cardiovascular protective effects.
Animal studies have demonstrated thatthiasine supplementation can reduce the formation of atherosclerotic plaques, lower blood pressure, and improve endothelial function. These effects may be mediated by the inhibition of oxidative stress - induced endothelial dysfunction, the reduction of inflammatory cell infiltration into the vessel wall, and the modulation of lipid metabolism.
Health Applications
Neuroprotection
The brain is highly susceptible to oxidative stress due to its high oxygen consumption, rich lipid content, and relatively low levels of antioxidant defenses. Ergothioneine's ability to cross the blood - brain barrier makes it an ideal candidate for neuroprotective applications. Studies have shown that it can protect neurons from oxidative damage induced by various factors, such as amyloid - beta peptides associated with Alzheimer's disease.
In animal models, ergothioneine powder supplementation has been found to reduce cognitive decline and improve memory function. It may act by scavenging reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the brain, thereby preventing lipid peroxidation, protein oxidation, and DNA damage. Additionally, thiasine can modulate neuroinflammatory processes by inhibiting the production of pro - inflammatory cytokines, which are often elevated in neurodegenerative diseases.
This dual action of antioxidant and anti - inflammatory effects makes thiasine a promising therapeutic agent for the prevention and treatment of conditions like Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
Cardiovascular Protection
Oxidative stress and inflammation play crucial roles in the development of cardiovascular diseases, including atherosclerosis, hypertension, and heart failure. Ergothioneine's antioxidant properties can help reduce the oxidation of low - density lipoprotein (LDL) cholesterol, a key step in the formation of atherosclerotic plaques.
By preventing LDL oxidation, thiasine can inhibit the recruitment of inflammatory cells to the vessel wall and reduce the progression of atherosclerosis.
Moreover, thiasine can improve endothelial function by promoting the production of nitric oxide (NO), a vasodilator that helps maintain normal blood pressure and blood flow. It may also reduce blood pressure by inhibiting the activity of the renin - angiotensin - aldosterone system (RAAS), a hormonal system that regulates blood pressure. Animal studies have demonstrated that thiasine supplementation can lower blood pressure, reduce the size of myocardial infarcts, and improve cardiac function after ischemic injury, suggesting its potential as a cardiovascular protective agent.
Eye Health
The eyes are constantly exposed to environmental stressors such as ultraviolet (UV) radiation, which can generate ROS and cause oxidative damage to the retina and other ocular tissues. Age - related macular degeneration (AMD) is a leading cause of blindness in older adults, and oxidative stress is a major contributing factor to its development.
Ergothioneine's ability to cross the blood - retina barrier allows it to accumulate in the eye and provide antioxidant protection. Studies have shown that higher dietary intake of thiasine is associated with a reduced risk of AMD. It may protect the retina by scavenging ROS, preventing lipid peroxidation in the photoreceptor cells, and reducing inflammation in the retinal pigment epithelium. Ergothioneine supplements or fortified eye - care products may therefore be beneficial in preventing and slowing the progression of AMD and other age - related eye diseases.
Absorption and Distribution in the Body
Once ingested, thiasine is absorbed in the small intestine through a specific transporter called the organic cation/carnitine transporter 2 (OCTN2). This transporter is highly selective for thiasine and is responsible for its efficient uptake into cells. After absorption, thiasine is distributed throughout the body, with higher concentrations found in tissues that are exposed to high levels of oxidative stress, such as the liver, kidneys, eyes, and skin.
Ergothioneine has a long half - life in the body, estimated to be around 30 days, which suggests that it is stored in tissues and can provide sustained antioxidant protection over time. It can cross the blood - brain barrier and the placental barrier, indicating its potential role in protecting the brain and the developing fetus from oxidative damage.
Ergothioneine powder is a unique and potent antioxidant with diverse biological functions and potential health benefits. Its ability to scavenge ROS, chelate metal ions, protect against UV radiation, exhibit anti-inflammatory effects, and provide neuroprotection makes it a promising candidate for the prevention and treatment of various diseases, including cardiovascular disease, eye diseases, skin conditions, cognitive decline, and aging-related disorders.
However, more research is needed to confirm its efficacy and safety in humans, develop efficient production methods, and determine the optimal dosage and treatment regimen. With further research and development, thiasine may emerge as a valuable tool in the pursuit of better health and longevity.
Sources of Ergothioneine
Dietary Sources
Since humans cannot synthesize thiasine, they must obtain it from their diet. The richest dietary sources of thiasine are mushrooms, particularly species such as shiitake (Lentinula edodes), oyster mushrooms (Pleurotus ostreatus), and king oyster mushrooms (Pleurotus eryngii). Other food sources include black and red beans, oats, and certain types of meat, such as pork liver and chicken breast, although the levels of thiasine in these foods are generally lower compared to mushrooms.
The thiasine content in mushrooms can vary significantly depending on the species, growing conditions, and processing methods. For example, wild - grown mushrooms may have higher thiasine levels than cultivated ones, and cooking methods such as boiling or steaming can cause some loss of thiasine, while drying may help preserve it.
Synthesis
Classification of Mainstream Synthetic Routes
Industrial production of thiasine adopts three primary approaches: total chemical synthesis, chemoenzymatic synthesis, and microbial fermentation synthesis.
Extraction from natural mushrooms suffers from extremely low yields; it is only applied for small-scale laboratory preparation and cannot support large-scale commercial manufacturing.
Total chemical synthesis was developed at an early stage, yet it faces challenges including chiral racemization and rigorous impurity control. Featuring eco-friendly characteristics, microbial fermentation has become the dominant production route for raw materials used in cosmetics and dietary supplements.
Chemoenzymatic Synthesis (Biomimetic Route)
This route utilizes L-histidine as the starting material. The precursor histidine betaine is first prepared via chemical reactions. L-histidine undergoes reductive amination and methylation to form a quaternary ammonium betaine intermediate.
Subsequently, rationally engineered EgtB oxidase and EgtE lyase facilitate the formation of the C–S bond on the imidazole ring under mild aqueous conditions, catalysing the generation of L-ergothioneine.
Compared with purely chemical synthesis, this strategy drastically reduces racemic by-products, proceeds under mild reaction parameters, and delivers markedly improved overall yield.
Microbial Fermentation Synthesis Process
The fermentation method relies on genetically engineered strains equipped with the complete egt biosynthetic gene cluster. Strains utilize glucose and amino acids as carbon and nitrogen sources to autonomously accomplish intracellular methylation and sulfur incorporation.
The fermentation broth is subjected to centrifugation and ultrafiltration to remove bacterial impurities. Subsequent purification steps comprise ion-exchange chromatography, nanofiltration for desalination, cooling crystallization, and final vacuum freeze-drying to yield white powder.
No highly toxic alkylating reagents are required throughout the workflow, resulting in lower risks of heavy metal residues and organic solvent contamination.
FAQ
What does it do in the body?
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Ergothioneine (ERGO) is a potent dietary antioxidant amino acid, first discovered in 1909 in Ergot fungus. It has been shown to be an effective antioxidant partly because of the stability of its thione form which predominates at physiological pH (Fig. 1), making it resistant to autoxidation.
What foods are high in it?
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Ergothioneine can also be obtained through the diet. Mushrooms contain the highest levels of ergothioneine, especially, king oyster, maitake, oyster, shiitake, and porcini mushrooms. Other foods rich in ergothioneine include liver, black beans, red beans, and oat bran.
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